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Page 1
Genetic and epigenetic control of RKIP transcription.
Datar I, Tegegne H, Qin K, Al-Mulla F, Bitar MS, Trumbly RJ, Yeung KC. Datar I, et al. Among authors: al mulla f. Crit Rev Oncog. 2014;19(6):417-30. doi: 10.1615/critrevoncog.2014012025. Crit Rev Oncog. 2014. PMID: 25597352 Review.
RKIP is a proven tumor metastasis suppressor gene and investigating the mechanisms of transcriptional regulation of RKIP is therefore of immense clinical importance. In this review, we discuss the basal expression of RKIP in various tissues and the genetic as …
RKIP is a proven tumor metastasis suppressor gene and investigating the mechanisms of transcriptional regulation of RKIP is th …
RKIP: much more than Raf kinase inhibitory protein.
Al-Mulla F, Bitar MS, Taqi Z, Yeung KC. Al-Mulla F, et al. J Cell Physiol. 2013 Aug;228(8):1688-702. doi: 10.1002/jcp.24335. J Cell Physiol. 2013. PMID: 23359513 Review.
The disruption of RKIP in a wide range of pathologies, including cancer, Alzheimer's disease, and pancreatitis, makes it an exciting target for individualized therapy and disease-specific interventions. ...Specific biological and functional niches are highlighted to focus …
The disruption of RKIP in a wide range of pathologies, including cancer, Alzheimer's disease, and pancreatitis, makes it an exciting …
Regulation of the MAPK pathway by raf kinase inhibitory protein.
Vandamme D, Herrero A, Al-Mulla F, Kolch W. Vandamme D, et al. Among authors: al mulla f. Crit Rev Oncog. 2014;19(6):405-15. doi: 10.1615/critrevoncog.2014011922. Crit Rev Oncog. 2014. PMID: 25597351 Review.
However, RKIP's functions related to the MAPK signaling are far more complex. Newer data indicate that by modulating different protein-protein interactions, RKIP is involved in fine-tuning cell signaling, modulating ERK dynamics, and regulating cross talk between di …
However, RKIP's functions related to the MAPK signaling are far more complex. Newer data indicate that by modulating different protei …
Changes in Expression of Tumor Suppressor Gene RKIP Impact How Cancers Interact with Their Complex Environment.
Figy C, Guo A, Fernando VR, Furuta S, Al-Mulla F, Yeung KC. Figy C, et al. Among authors: al mulla f. Cancers (Basel). 2023 Feb 2;15(3):958. doi: 10.3390/cancers15030958. Cancers (Basel). 2023. PMID: 36765912 Free PMC article. Review.
In this review, we will discuss the changes in TME and the ramifications on metastasis upon altered expression of tumor metastasis suppressor gene RKIP in breast cancer cells....
In this review, we will discuss the changes in TME and the ramifications on metastasis upon altered expression of tumor metastasis suppresso …
RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13.
Datar I, Feng J, Qiu X, Lewandowski J, Yeung M, Ren G, Aras S, Al-Mulla F, Cui H, Trumbly R, Arudra SK, De Las Casas LE, de la Serna I, Bitar MS, Yeung KC. Datar I, et al. Among authors: al mulla f. PLoS One. 2015 Aug 26;10(8):e0134494. doi: 10.1371/journal.pone.0134494. eCollection 2015. PLoS One. 2015. PMID: 26308852 Free PMC article.
RKIP has been identified as a metastasis suppressor gene. Expression of RKIP is low in cancer metastases. ...Together, our findings indicate that RKIP inhibits cancer cell invasion, in part, via MMP13 inhibition. These data also implicate RKIP in the r …
RKIP has been identified as a metastasis suppressor gene. Expression of RKIP is low in cancer metastases. ...Together, our fin …
RKIP and cellular motility.
Al-Mulla F. Al-Mulla F. J Cell Physiol. 2012 Jul;227(7):2969-70. doi: 10.1002/jcp.23011. J Cell Physiol. 2012. PMID: 21898407 No abstract available.
Raf kinase inhibitor protein (RKIP) blocks signal transducer and activator of transcription 3 (STAT3) activation in breast and prostate cancer.
Yousuf S, Duan M, Moen EL, Cross-Knorr S, Brilliant K, Bonavida B, LaValle T, Yeung KC, Al-Mulla F, Chin E, Chatterjee D. Yousuf S, et al. Among authors: al mulla f. PLoS One. 2014 Mar 21;9(3):e92478. doi: 10.1371/journal.pone.0092478. eCollection 2014. PLoS One. 2014. Retraction in: PLoS One. 2021 Jun 10;16(6):e0253350. doi: 10.1371/journal.pone.0253350. PMID: 24658061 Free PMC article. Retracted.
The treatment of DU145 prostate, but not PC3 prostate or MDA-231 breast, cancer cell lines with ENMD-1198 or MKC-1 dramatically increased expression of RKIP. Overexpression of RKIP sensitized PC3 and MDA-231 cells to MTI-induced apoptosis. ...RKIP plays a cri …
The treatment of DU145 prostate, but not PC3 prostate or MDA-231 breast, cancer cell lines with ENMD-1198 or MKC-1 dramatically increased ex …
RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration.
Datar I, Qiu X, Ma HZ, Yeung M, Aras S, de la Serna I, Al-Mulla F, Thiery JP, Trumbly R, Fan X, Cui H, Yeung KC. Datar I, et al. Among authors: al mulla f. Oncotarget. 2015 Nov 17;6(36):39050-61. doi: 10.18632/oncotarget.5176. Oncotarget. 2015. PMID: 26375811 Free PMC article.
We also show that the expression levels of RKIP and CCL5 are inversely correlated among clinical human breast cancer samples. Using a mouse allograft breast cancer transplantation model, we highlight that ectopic expression of RKIP significantly decreases tumor vasc …
We also show that the expression levels of RKIP and CCL5 are inversely correlated among clinical human breast cancer samples. Using a …
Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis.
Hagan S, Al-Mulla F, Mallon E, Oien K, Ferrier R, Gusterson B, García JJ, Kolch W. Hagan S, et al. Among authors: al mulla f. Clin Cancer Res. 2005 Oct 15;11(20):7392-7. doi: 10.1158/1078-0432.CCR-05-0283. Clin Cancer Res. 2005. PMID: 16243812
However, in lymph node metastases, RKIP expression was highly significantly reduced or lost (P = 0.000003). No significant correlations were observed between RKIP expression and histologic type, tumor differentiation grade, size, or estrogen receptor status. ...R …
However, in lymph node metastases, RKIP expression was highly significantly reduced or lost (P = 0.000003). No significant correlatio …
RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility.
al-Mulla F, Bitar MS, Taqi Z, Rath O, Kolch W. al-Mulla F, et al. Mol Biosyst. 2011 Mar;7(3):928-41. doi: 10.1039/c0mb00208a. Epub 2010 Dec 23. Mol Biosyst. 2011. PMID: 21180766
RKIP-1 is a metastasis suppressor that is frequently downregulated in aggressive cancers. ...Moreover, RKIP depletion accelerates the time from nuclear envelop breakdown (NEB) to anaphase markedly, while the upregulation of RKIP shortened the NEB to anaphase …
RKIP-1 is a metastasis suppressor that is frequently downregulated in aggressive cancers. ...Moreover, RKIP depletion accelera …
20 results