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Delivery of ALX-0171 by inhalation greatly reduces respiratory syncytial virus disease in newborn lambs.
Larios Mora A, Detalle L, Gallup JM, Van Geelen A, Stohr T, Duprez L, Ackermann MR. Larios Mora A, et al. Among authors: van geelen a. MAbs. 2018 Jul;10(5):778-795. doi: 10.1080/19420862.2018.1470727. MAbs. 2018. PMID: 29733750 Free PMC article.
Respiratory syncytial virus (RSV) is a common cause of acute lower respiratory disease in infants and young children worldwide. ...ALX-0171 is a trivalent Nanobody targeting the hRSV fusion (F) protein and its therapeutic potential was evaluated in newborn lambs inf …
Respiratory syncytial virus (RSV) is a common cause of acute lower respiratory disease in infants and young children worldwide …
Effects of formalin-inactivated respiratory syncytial virus (FI-RSV) in the perinatal lamb model of RSV.
Derscheid RJ, Gallup JM, Knudson CJ, Varga SM, Grosz DD, van Geelen A, Hostetter SJ, Ackermann MR. Derscheid RJ, et al. Among authors: van geelen a. PLoS One. 2013 Dec 6;8(12):e81472. doi: 10.1371/journal.pone.0081472. eCollection 2013. PLoS One. 2013. PMID: 24324695 Free PMC article.
Respiratory syncytial virus (RSV) is the most frequent cause of bronchiolitis in infants and children worldwide. ...The FI-RSV-vaccinated lambs exhibited several key features of RSV vaccine-enhanced disease, including reduced RSV titers in bronc …
Respiratory syncytial virus (RSV) is the most frequent cause of bronchiolitis in infants and children worldwide. ...The FI- …
Sucrose stabilization of Respiratory Syncytial Virus (RSV) during nebulization and experimental infection.
Grosz DD, van Geelen A, Gallup JM, Hostetter SJ, Derscheid RJ, Ackermann MR. Grosz DD, et al. Among authors: van geelen a. BMC Res Notes. 2014 Mar 18;7:158. doi: 10.1186/1756-0500-7-158. BMC Res Notes. 2014. PMID: 24642084 Free PMC article.
BACKGROUND: Respiratory syncytial virus (RSV) is a common respiratory pathogen that can cause severe pneumonia. In vivo studies of RSV can be difficult due to variation in viral infection and disease severity in some animal models. ...
BACKGROUND: Respiratory syncytial virus (RSV) is a common respiratory pathogen that can cause severe pneumonia. In vivo studie …
Kinetics of Respiratory Syncytial Virus (RSV) Memphis Strain 37 (M37) Infection in the Respiratory Tract of Newborn Lambs as an RSV Infection Model for Human Infants.
Larios Mora A, Detalle L, Van Geelen A, Davis MS, Stohr T, Gallup JM, Ackermann MR. Larios Mora A, et al. Among authors: van geelen a. PLoS One. 2015 Dec 7;10(12):e0143580. doi: 10.1371/journal.pone.0143580. eCollection 2015. PLoS One. 2015. PMID: 26641081 Free PMC article.
RATIONALE: Respiratory syncytial virus (RSV) infection in preterm and newborn infants can result in severe bronchiolitis and hospitalization. The lamb lung has several key features conducive to modeling RSV infection in human infants, including susceptibility …
RATIONALE: Respiratory syncytial virus (RSV) infection in preterm and newborn infants can result in severe bronchiolitis and h …
Increased concentration of iodide in airway secretions is associated with reduced respiratory syncytial virus disease severity.
Derscheid RJ, van Geelen A, Berkebile AR, Gallup JM, Hostetter SJ, Banfi B, McCray PB Jr, Ackermann MR. Derscheid RJ, et al. Among authors: van geelen a. Am J Respir Cell Mol Biol. 2014 Feb;50(2):389-97. doi: 10.1165/rcmb.2012-0529OC. Am J Respir Cell Mol Biol. 2014. PMID: 24053146 Free PMC article.
Because hypoiodous acid, but not OSCN(-), inactivates respiratory syncytial virus (RSV) in cell culture, we used a lamb model of RSV to test whether potassium iodide (KI) could enhance this system in vivo. ...Inhibition of LPO activity significantly increased …
Because hypoiodous acid, but not OSCN(-), inactivates respiratory syncytial virus (RSV) in cell culture, we used a lamb model …
Human respiratory syncytial virus memphis 37 causes acute respiratory disease in perinatal lamb lung.
Derscheid RJ, van Geelen A, Gallup JM, Kienzle T, Shelly DA, Cihlar T, King RR, Ackermann MR. Derscheid RJ, et al. Among authors: van geelen a. Biores Open Access. 2014 Apr 1;3(2):60-9. doi: 10.1089/biores.2013.0044. Biores Open Access. 2014. PMID: 24804166 Free PMC article.
Respiratory syncytial virus (RSV) is the leading cause of hospitalization due to respiratory illness among infants and young children of industrialized countries. ...We and others have shown mild disease in perinatal lambs with either a bovine or a human A2 strain o …
Respiratory syncytial virus (RSV) is the leading cause of hospitalization due to respiratory illness among infants and young c …
Exogenous administration of vascular endothelial growth factor prior to human respiratory syncytial virus a2 infection reduces pulmonary pathology in neonatal lambs and alters epithelial innate immune responses.
Olivier AK, Gallup JM, van Geelen A, Ackermann MR. Olivier AK, et al. Among authors: van geelen a. Exp Lung Res. 2011 Apr;37(3):131-43. doi: 10.3109/01902148.2010.484518. Epub 2011 Feb 11. Exp Lung Res. 2011. PMID: 21309731 Free PMC article.
Human respiratory syncytial virus (RSV) affects thousands of children every year. Vascular endothelial growth factor (VEGF) is a regulator of vasculogenesis, pulmonary maturation, and immunity. In order to test the extent to which VEGF may alter RSV infection …
Human respiratory syncytial virus (RSV) affects thousands of children every year. Vascular endothelial growth factor (VEGF) is …
Human respiratory syncytial virus Memphis 37 grown in HEp-2 cells causes more severe disease in lambs than virus grown in Vero cells.
Derscheid RJ, van Geelen A, McGill JL, Gallup JM, Cihlar T, Sacco RE, Ackermann MR. Derscheid RJ, et al. Among authors: van geelen a. Viruses. 2013 Nov 22;5(11):2881-97. doi: 10.3390/v5112881. Viruses. 2013. PMID: 24284879 Free PMC article.
Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in infants and young children. ...The neonatal lamb pulmonary development and physiology is similar to that of infants, and sheep are susceptible to ovine, bovine, or human strains of RSV
Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in infants and young children. ...The neonatal lam …
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