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87 results

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Page 1
SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant.
Guo H, Yu X, Liu Y, Paik DT, Justesen JM, Chandy M, Jahng JWS, Zhang T, Wu W, Rwere F, Zhao SR, Pokhrel S, Shivnaraine RV, Mukherjee S, Simon DJ, Manhas A, Zhang A, Chen CH, Rivas MA, Gross ER, Mochly-Rosen D, Wu JC. Guo H, et al. Sci Transl Med. 2023 Jan 25;15(680):eabp9952. doi: 10.1126/scitranslmed.abp9952. Epub 2023 Jan 25. Sci Transl Med. 2023. PMID: 36696485 Free PMC article.
The common aldehyde dehydrogenase 2 (ALDH2) alcohol flushing variant known as ALDH2*2 affects 8% of the world's population. ...Clinical assessment of endothelial function showed that human participants carrying ALDH2*2 exhibited impaired vasodi …
The common aldehyde dehydrogenase 2 (ALDH2) alcohol flushing variant known as ALDH2*2 affects 8% of the world's …
Genetic influences on alcohol flushing in East Asian populations.
Cho Y, Lin K, Lee SH, Yu C, Valle DS, Avery D, Lv J, Jung K, Li L, Smith GD, China Kadoorie Biobank Collaborative Group, Sun D, Chen Z, Millwood IY, Hemani G, Walters RG. Cho Y, et al. BMC Genomics. 2023 Oct 24;24(1):638. doi: 10.1186/s12864-023-09721-7. BMC Genomics. 2023. PMID: 37875790 Free PMC article.
BACKGROUND: Although it is known that variation in the aldehyde dehydrogenase 2 (ALDH2) gene family influences the East Asian alcohol flushing response, knowledge about other genetic variants that affect flushing symptoms is limited. METHODS: We …
BACKGROUND: Although it is known that variation in the aldehyde dehydrogenase 2 (ALDH2) gene family influences the East Asian alco …
Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population.
Oze I, Matsuo K, Hosono S, Ito H, Kawase T, Watanabe M, Suzuki T, Hatooka S, Yatabe Y, Hasegawa Y, Shinoda M, Tajima K, Tanaka H. Oze I, et al. Cancer Sci. 2010 Aug;101(8):1875-80. doi: 10.1111/j.1349-7006.2010.01599.x. Epub 2010 Apr 23. Cancer Sci. 2010. PMID: 20518787 Free PMC article.
Some Japanese exhibit facial flushing after drinking alcohol. Facial flushing was considered to be caused by acetaldehydemia. ...Facial flushing was less useful to predict UAT cancer risk than genotyping ALDH2 polymorphis …
Some Japanese exhibit facial flushing after drinking alcohol. Facial flushing was considered to be caused …
Polymorphism in ALDH2-genotype in Japanese men and the alcohol-blood pressure relationship.
Tsuritani I, Ikai E, Date T, Suzuki Y, Ishizaki M, Yamada Y. Tsuritani I, et al. Am J Hypertens. 1995 Nov;8(11):1053-9. doi: 10.1016/0895-7061(95)00222-B. Am J Hypertens. 1995. PMID: 8554727
Inherited deficiency of ALDH2 activity is found in half of Japanese, and is characterized by "Oriental flushing" after alcohol consumption. The aim of the present study is to evaluate the influence of the genetic polymorphism in alcohol m …
Inherited deficiency of ALDH2 activity is found in half of Japanese, and is characterized by "Oriental flushing" after alco …
Association of ALDH2 polymorphism with sensitivity to acetaldehyde-induced micronuclei and facial flushing after alcohol intake.
Kim JS, Kim YJ, Kim TY, Song JY, Cho YH, Park YC, Chung HW. Kim JS, et al. Toxicology. 2005 Jun 1;210(2-3):169-74. doi: 10.1016/j.tox.2005.01.016. Toxicology. 2005. PMID: 15840430
Facial flushing following alcohol intake was analyzed to determine if it was correlated with ALDH2 gene polymorphisms. ...A significant association was observed between the ALDH2 genotype and alcohol-induced facial flushi …
Facial flushing following alcohol intake was analyzed to determine if it was correlated with ALDH2 gene polym …
Aldehyde dehydrogenase-2 as a therapeutic target.
Kimura M, Yokoyama A, Higuchi S. Kimura M, et al. Expert Opin Ther Targets. 2019 Nov;23(11):955-966. doi: 10.1080/14728222.2019.1690454. Epub 2019 Nov 16. Expert Opin Ther Targets. 2019. PMID: 31697578 Review.
Introduction: Aldehyde dehydrogenase-2 (ALDH2) is a main contributor of the alcohol elimination process. Functional polymorphism in the ALDH2 gene and its inactive form causes unpleasant flushing responses after alcohol consumption and pr …
Introduction: Aldehyde dehydrogenase-2 (ALDH2) is a main contributor of the alcohol elimination process. Functional polymor …
ALDH2 variance in disease and populations.
Chen CH, Kraemer BR, Mochly-Rosen D. Chen CH, et al. Dis Model Mech. 2022 Jun 1;15(6):dmm049601. doi: 10.1242/dmm.049601. Epub 2022 Jun 24. Dis Model Mech. 2022. PMID: 35749303 Free PMC article.
The ALDH2*2 missense variant that commonly causes alcohol flushing reactions is the single genetic polymorphism associated with the largest number of traits in humans. ...However, the interaction between alcohol and ALDH2-related p …
The ALDH2*2 missense variant that commonly causes alcohol flushing reactions is the single genetic polymorphi …
Impacts of interactions between ADH1B and ALDH2 genotypes on alcohol flushing, alcohol reeking on the day after drinking, and age distribution in Japanese alcohol-dependent men.
Yokoyama A, Yokoyama T, Matsui T, Mizukami T, Kimura M, Matsushita S, Higuchi S, Maruyama K. Yokoyama A, et al. Pharmacogenet Genomics. 2020 Apr;30(3):54-60. doi: 10.1097/FPC.0000000000000395. Pharmacogenet Genomics. 2020. PMID: 32084087
METHODS: The study subjects were 4107 Japanese alcohol-dependent men who underwent alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotyping: 4051 patients were asked about their current or former tendency to experience facial flushing after dri …
METHODS: The study subjects were 4107 Japanese alcohol-dependent men who underwent alcohol dehydrogenase-1B and aldehyde dehyd …
Exploring the utility of alcohol flushing as an instrumental variable for alcohol intake in Koreans.
Cho Y, Kwak S, Lewis SJ, Wade KH, Relton CL, Smith GD, Shin MJ. Cho Y, et al. Sci Rep. 2018 Jan 11;8(1):458. doi: 10.1038/s41598-017-18856-z. Sci Rep. 2018. PMID: 29323248 Free PMC article.
In this study, the causal effect of alcohol intake on hypertension in 2,011 men and women from the Ansan-Ansung cohort was estimated using an instrumental variable (IV) approach, with both a phenotypic and genotypic instrument for alcohol intake: alcohol f …
In this study, the causal effect of alcohol intake on hypertension in 2,011 men and women from the Ansan-Ansung cohort was estimated …
Evaluation of the use of self-reported facial flushing and ethanol patch test for ALDH2 genotypes.
Ishibashi T, Taguchi A, Yamamoto Y, Harada S. Ishibashi T, et al. Nihon Arukoru Yakubutsu Igakkai Zasshi. 2010 Oct;45(5):464-76. Nihon Arukoru Yakubutsu Igakkai Zasshi. 2010. PMID: 21222353
It is generally assumed that subjects with ALDH2*1/1 do not exhibit flushing symptoms after alcohol intake, but recent studies have revealed discordance in ALDH2 genotypes with self-reported facial flushing and the ethanol patch te …
It is generally assumed that subjects with ALDH2*1/1 do not exhibit flushing symptoms after alcohol intake, but recent …
87 results