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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
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1992 3
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1994 5
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1998 5
1999 6
2000 3
2001 2
2002 1
2003 11
2004 8
2005 7
2006 4
2007 12
2008 5
2009 5
2010 7
2011 9
2012 8
2013 7
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183 results

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Page 1
Prescription of Controlled Substances: Benefits and Risks.
Preuss CV, Kalava A, King KC. Preuss CV, et al. 2025 Jul 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. 2025 Jul 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. PMID: 30726003 Free Books & Documents.
This drug can cause severe respiratory depression and death, particularly when mixed with other drugs or alcohol. Fentanyl has a high potential for addiction. Hydrocodone: Hydrocodone is a Schedule II semi-synthetic opioid medication used to treat pain. ...Dependence: Phys …
This drug can cause severe respiratory depression and death, particularly when mixed with other drugs or alcohol. Fentanyl has a high …
Withdrawal from chronic alcohol impairs the serotonin-mediated modulation of GABAergic transmission in the infralimbic cortex in male rats.
Vlkolinsky R, Khom S, Vozella V, Bajo M, Roberto M. Vlkolinsky R, et al. Neurobiol Dis. 2024 Sep;199:106590. doi: 10.1016/j.nbd.2024.106590. Epub 2024 Jul 10. Neurobiol Dis. 2024. PMID: 38996987 Free PMC article.
This inhibitory control is regulated by various neuromodulators, including 5-hydroxytryptamine (5-HT; serotonin). We used chronic intermittent ethanol vapor inhalation exposure, a model of AUD, in male Sprague-Dawley rats to induce alcohol dependence (Dep) followed …
This inhibitory control is regulated by various neuromodulators, including 5-hydroxytryptamine (5-HT; serotonin). We used chronic intermitte …
Selectively counteracting cerebellar adaptations to chronic alcohol exposure reduces acute alcohol withdrawal severity in C57BL6/N mice.
McLean NA, Shippell Stiles SN, Harder AE, Erikson CM, Lee GJ, Schnalzer D, Ernst M, Mihovilovic MD, Giannotti G, Rossi DJ. McLean NA, et al. Neuropharmacology. 2025 Nov 1;278:110595. doi: 10.1016/j.neuropharm.2025.110595. Epub 2025 Jul 19. Neuropharmacology. 2025. PMID: 40691915 Free PMC article.
A critical component of Alcohol Use Disorder (AUD) is alcohol (EtOH) withdrawal and consequent aversive withdrawal symptoms that generate negative reinforcement for renewed EtOH consumption to alleviate such symptoms. ...During acute withdrawal, …
A critical component of Alcohol Use Disorder (AUD) is alcohol (EtOH) withdrawal and consequent aversive withdrawal …
Alcohol withdrawal is associated with a downregulation of large-conductance Ca2+-activated K+ channels in rat inferior colliculus neurons.
N'Gouemo P, Morad M. N'Gouemo P, et al. Psychopharmacology (Berl). 2014 May;231(9):2009-18. doi: 10.1007/s00213-013-3346-8. Epub 2013 Nov 17. Psychopharmacology (Berl). 2014. PMID: 24241791 Free PMC article.
RATIONALE: Large conductance calcium-activated potassium (BK(Ca) or K(Ca)1.1) channels are well-known molecular targets for the action of alcohol and therefore may play an important role in the pathogenesis of alcohol withdrawal syndrome. ...CONCLUSIONS: The …
RATIONALE: Large conductance calcium-activated potassium (BK(Ca) or K(Ca)1.1) channels are well-known molecular targets for the action of …
Protein kinase C epsilon-mediated modulation of T-type calcium channels underlies alcohol withdrawal hyperexcitability in the midline thalamus.
Shan HQ, Smith T, Klorig DC, Godwin DW. Shan HQ, et al. Alcohol Clin Exp Res (Hoboken). 2024 Jul;48(7):1278-1288. doi: 10.1111/acer.15342. Epub 2024 May 13. Alcohol Clin Exp Res (Hoboken). 2024. PMID: 38740544 Free PMC article.
BACKGROUND: Millions of people struggle with alcohol use disorder (AUD). Abrupt abstinence after a period of chronic alcohol use can precipitate the alcohol withdrawal syndrome (AWS), which includes hyperexcitability and, potentially, seizures. We have …
BACKGROUND: Millions of people struggle with alcohol use disorder (AUD). Abrupt abstinence after a period of chronic alcohol u …
Transdermal clonidine: therapeutic considerations.
Sica DA, Grubbs R. Sica DA, et al. J Clin Hypertens (Greenwich). 2005 Sep;7(9):558-62. doi: 10.1111/j.1524-6175.2005.04133.x. J Clin Hypertens (Greenwich). 2005. PMID: 16227779 Free PMC article.
Transdermal clonidine was approved by the US Food and Drug Administration in 1984 for the treatment of mild-to-moderate hypertension alone or in combination with a diuretic. Clonidine is released from the patch at a constant rate and thus displays a pharmacokinetic pattern …
Transdermal clonidine was approved by the US Food and Drug Administration in 1984 for the treatment of mild-to-moderate hypertension alone o …
Clonidine and modification of perioperative outcome.
Wallace AW. Wallace AW. Curr Opin Anaesthesiol. 2006 Aug;19(4):411-7. doi: 10.1097/01.aco.0000236141.15852.0b. Curr Opin Anaesthesiol. 2006. PMID: 16829723 Review.
RECENT FINDINGS: Clonidine has been used for many purposes, including reduction of blood pressure in hypertension, reduction in alcohol and drug withdrawal phenomena, reduction in nicotine withdrawal symptoms during smoking cessation, analgesia, reduction in …
RECENT FINDINGS: Clonidine has been used for many purposes, including reduction of blood pressure in hypertension, reduction in alcohol …
Altered voltage-gated calcium channels in rat inferior colliculus neurons contribute to alcohol withdrawal seizures.
N'Gouemo P. N'Gouemo P. Eur Neuropsychopharmacol. 2015 Aug;25(8):1342-52. doi: 10.1016/j.euroneuro.2015.04.008. Epub 2015 Apr 14. Eur Neuropsychopharmacol. 2015. PMID: 25914156 Free PMC article.
Currents and seizure susceptibility were evaluated in control animals 3h after alcohol intoxication, as well as 3h (before AWS), 24h (when AWS susceptibility is maximal), and 48h (when AWS susceptibility is no longer present) after alcohol withdrawal. ...CaV …
Currents and seizure susceptibility were evaluated in control animals 3h after alcohol intoxication, as well as 3h (before AWS), 24h …
Nitrate tolerance.
Parker JO. Parker JO. Am J Cardiol. 1985 Dec 27;56(17):28I-31I. doi: 10.1016/0002-9149(85)90705-2. Am J Cardiol. 1985. PMID: 3934952
Preliminary hemodynamic studies suggest that short periods of nitrate withdrawal restore the hemodynamic effect of the nitrates, and it is postulated that intermittent nitrate therapy may be desirable in the management of angina. ...These findings, plus evidence that with …
Preliminary hemodynamic studies suggest that short periods of nitrate withdrawal restore the hemodynamic effect of the nitrates, and …
Ethanol-induced inhibition of NMDA receptor channels.
Wirkner K, Poelchen W, Köles L, Mühlberg K, Scheibler P, Allgaier C, Illes P. Wirkner K, et al. Neurochem Int. 1999 Aug;35(2):153-62. doi: 10.1016/s0197-0186(99)00057-1. Neurochem Int. 1999. PMID: 10405999 Review.
The mechanism of ethanol action has been investigated by means of patch-clamp recording of ionic currents and fura-2 measurement of intracellular Ca2+ concentration in cell culture systems; the subunit composition of NMDA receptors and their influence on the effect …
The mechanism of ethanol action has been investigated by means of patch-clamp recording of ionic currents and fura-2 measureme …
183 results