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Page 1
ACG Clinical Guideline: Alcohol-Associated Liver Disease.
Jophlin LL, Singal AK, Bataller R, Wong RJ, Sauer BG, Terrault NA, Shah VH. Jophlin LL, et al. Am J Gastroenterol. 2024 Jan 1;119(1):30-54. doi: 10.14309/ajg.0000000000002572. Epub 2023 Sep 1. Am J Gastroenterol. 2024. PMID: 38174913 Free PMC article.
With harmful alcohol use as the primary risk factor, increasing alcohol use over the past decade has resulted in rapid growth of the ALD-related healthcare burden. ...Corticosteroids are currently the only available therapeutic with proven efficacy for patients with …
With harmful alcohol use as the primary risk factor, increasing alcohol use over the past decade has resulted in rapid growth …
Hepatocellular carcinoma.
Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, Gores G. Llovet JM, et al. Nat Rev Dis Primers. 2016 Apr 14;2:16018. doi: 10.1038/nrdp.2016.18. Nat Rev Dis Primers. 2016. PMID: 27158749 Free article. Review.
The main risk factors for developing HCC are well known and include hepatitis B and C virus infection, alcohol intake and ingestion of the fungal metabolite aflatoxin B1. Additional risk factors such as non-alcoholic steatohepatitis are also emerging. ...
The main risk factors for developing HCC are well known and include hepatitis B and C virus infection, alcohol intake and ingestion o …
Classifying neurocognitive disorders: the DSM-5 approach.
Sachdev PS, Blacker D, Blazer DG, Ganguli M, Jeste DV, Paulsen JS, Petersen RC. Sachdev PS, et al. Nat Rev Neurol. 2014 Nov;10(11):634-42. doi: 10.1038/nrneurol.2014.181. Epub 2014 Sep 30. Nat Rev Neurol. 2014. PMID: 25266297 Free article. Review.
These disorders have diverse clinical characteristics and aetiologies, with Alzheimer disease, cerebrovascular disease, Lewy body disease, frontotemporal degeneration, traumatic brain injury, infections, and alcohol abuse representing common causes. This diversity is refle …
These disorders have diverse clinical characteristics and aetiologies, with Alzheimer disease, cerebrovascular disease, Lewy body disease, f …
ACG Clinical Guideline: Alcoholic Liver Disease.
Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH. Singal AK, et al. Am J Gastroenterol. 2018 Feb;113(2):175-194. doi: 10.1038/ajg.2017.469. Epub 2018 Jan 16. Am J Gastroenterol. 2018. PMID: 29336434 Free PMC article.
Alcoholic liver disease (ALD) comprises a clinical-histologic spectrum including fatty liver, alcoholic hepatitis (AH), and cirrhosis with its complications. ...Corticosteroids provide short-term survival benefit in about half of treated patients with severe AH and
Alcoholic liver disease (ALD) comprises a clinical-histologic spectrum including fatty liver, alcoholic hepatitis (AH), and ci
Liver fibrosis assessment: MR and US elastography.
Ozturk A, Olson MC, Samir AE, Venkatesh SK. Ozturk A, et al. Abdom Radiol (NY). 2022 Sep;47(9):3037-3050. doi: 10.1007/s00261-021-03269-4. Epub 2021 Oct 23. Abdom Radiol (NY). 2022. PMID: 34687329 Free PMC article. Review.
Other clinical applications of elastography include liver decompensation prediction, and differentiation of non-alcoholic steatohepatitis (NASH) from simple steatosis (SS). In this review, we briefly describe the different elastography methods, discuss current clinical app …
Other clinical applications of elastography include liver decompensation prediction, and differentiation of non-alcoholic steatohepat …
Management of alcohol use disorder: a gastroenterology and hepatology-focused perspective.
Díaz LA, König D, Weber S, Ayares G, Fuentealba JM, Vázquez V, Bataller R, Kamath PS, Winder GS, Leggio L, Arab JP. Díaz LA, et al. Lancet Gastroenterol Hepatol. 2025 May;10(5):475-490. doi: 10.1016/S2468-1253(24)00380-7. Epub 2025 Feb 13. Lancet Gastroenterol Hepatol. 2025. PMID: 39956128 Review.
Alcohol use disorder is a prevalent and major but preventable cause of morbidity and mortality worldwide, causing several important health consequences, including chronic liver disease. ...The management of patients with alcohol use disorder
Alcohol use disorder is a prevalent and major but preventable cause of morbidity and mortality worldwide, causing sever
The knowns and unknowns of treatment for alcoholic hepatitis.
Sehrawat TS, Liu M, Shah VH. Sehrawat TS, et al. Lancet Gastroenterol Hepatol. 2020 May;5(5):494-506. doi: 10.1016/S2468-1253(19)30326-7. Lancet Gastroenterol Hepatol. 2020. PMID: 32277902 Free PMC article. Review.
Medical therapy for severe alcoholic hepatitis relies on corticosteroids, which have modest effectiveness. Abstinence from alcohol is critically important in patients with alcoholic hepatitis, but recidivism is high. Because of the absence of effective medica …
Medical therapy for severe alcoholic hepatitis relies on corticosteroids, which have modest effectiveness. Abstinence from alcohol
HILPDA promotes NASH-driven HCC development by restraining intracellular fatty acid flux in hypoxia.
Povero D, Chen Y, Johnson SM, McMahon CE, Pan M, Bao H, Petterson XT, Blake E, Lauer KP, O'Brien DR, Yu Y, Graham RP, Taner T, Han X, Razidlo GL, Liu J. Povero D, et al. J Hepatol. 2023 Aug;79(2):378-393. doi: 10.1016/j.jhep.2023.03.041. Epub 2023 Apr 13. J Hepatol. 2023. PMID: 37061197 Free PMC article.
BACKGROUND & AIMS: The prevalence of non-alcoholic steatohepatitis (NASH)-driven hepatocellular carcinoma (HCC) is rising rapidly, yet its underlying mechanisms remain unclear. ...CONCLUSIONS: Hepatic HILPDA is a pivotal oncometabolic factor in the NASH liver microenvi …
BACKGROUND & AIMS: The prevalence of non-alcoholic steatohepatitis (NASH)-driven hepatocellular carcinoma (HCC) is rising rapidly …
Acute-on-chronic liver failure in cirrhosis.
Arroyo V, Moreau R, Kamath PS, Jalan R, Ginès P, Nevens F, Fernández J, To U, García-Tsao G, Schnabl B. Arroyo V, et al. Nat Rev Dis Primers. 2016 Jun 9;2:16041. doi: 10.1038/nrdp.2016.41. Nat Rev Dis Primers. 2016. PMID: 27277335 Free article. Review.
ACLF frequently occurs in a closed temporal relationship to a precipitating event, such as bacterial infection or acute alcoholic, drug-induced or viral hepatitis. However, no precipitating event can be identified in approximately 40% of patients. ...
ACLF frequently occurs in a closed temporal relationship to a precipitating event, such as bacterial infection or acute alcoholic, dr …
Guidelines for Reasonable and Appropriate Care in the Emergency Department (GRACE-4): Alcohol use disorder and cannabinoid hyperemesis syndrome management in the emergency department.
Borgundvaag B, Bellolio F, Miles I, Schwarz ES, Sharif S, Su MK, Baumgartner K, Liss DB, Sheikh H, Vogel J, Austin EB, Upadhye S, Klaiman M, Vellend R, Munkley A, Carpenter CR. Borgundvaag B, et al. Acad Emerg Med. 2024 May;31(5):425-455. doi: 10.1111/acem.14911. Acad Emerg Med. 2024. PMID: 38747203 Free article.
The fourth Society for Academic Emergency Medicine (SAEM) Guidelines for Reasonable and Appropriate Care in the Emergency Department (GRACE-4) is on the topic of the emergency department (ED) management of nonopioid use disorders and focuses on alcohol withdrawal syndrome …
The fourth Society for Academic Emergency Medicine (SAEM) Guidelines for Reasonable and Appropriate Care in the Emergency Department (GRACE- …
1,320 results