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A C. elegans screening platform for the rapid assessment of chemical disruption of germline function.
Allard P, Kleinstreuer NC, Knudsen TB, Colaiácovo MP. Allard P, et al. Environ Health Perspect. 2013 Jun;121(6):717-24. doi: 10.1289/ehp.1206301. Epub 2013 Apr 19. Environ Health Perspect. 2013. PMID: 23603051 Free PMC article.
OBJECTIVES: We developed an assay in Caenorhabditis elegans that fluorescently marks aneuploid embryos after chemical exposure. METHODS: We qualified the predictive value of the assay against chemotherapeutic agents as well as environmental compounds from the ToxCast Phase …
OBJECTIVES: We developed an assay in Caenorhabditis elegans that fluorescently marks aneuploid embryos after chemical exposure. METHO …
Single-nucleus resolution mapping of the adult C. elegans and its application to elucidate inter- and trans-generational response to alcohol.
Truong L, Chen YW, Barrere-Cain R, Levenson MT, Shuck K, Xiao W, da Veiga Beltrame E, Panter B, Reich E, Sternberg PW, Yang X, Allard P. Truong L, et al. Cell Rep. 2023 Jun 27;42(6):112535. doi: 10.1016/j.celrep.2023.112535. Epub 2023 May 23. Cell Rep. 2023. PMID: 37227821 Free PMC article.
Single-cell transcriptomic platforms provide an opportunity to map an organism's response to environmental cues with high resolution. Here, we applied single-nucleus RNA sequencing (snRNA-seq) to establish the tissue and cell type-resolved transcriptome of the adult C. …
Single-cell transcriptomic platforms provide an opportunity to map an organism's response to environmental cues with high resolution. …
Analyzing high-throughput assay data to advance the rapid screening of environmental chemicals for human reproductive toxicity.
Varshavsky JR, Lam J, Cooper C, Allard P, Fung J, Oke A, Kumar R, Robinson JF, Woodruff TJ. Varshavsky JR, et al. bioRxiv [Preprint]. 2024 May 22:2024.05.21.595187. doi: 10.1101/2024.05.21.595187. bioRxiv. 2024. Update in: Reprod Toxicol. 2025 Jan;131:108725. doi: 10.1016/j.reprotox.2024.108725. PMID: 38826231 Free PMC article. Updated. Preprint.
While high-throughput (HTP) assays have been proposed as platforms to rapidly assess reproductive toxicity, there is currently a lack of established assays that specifically address germline development/function and fertility. We assessed the applicability domains of yeast …
While high-throughput (HTP) assays have been proposed as platforms to rapidly assess reproductive toxicity, there is currently a lack …
Analyzing high-throughput assay data to advance the rapid screening of environmental chemicals for human reproductive toxicity.
Varshavsky JR, Lam J, Cooper C, Allard P, Fung J, Oke A, Kumar R, Robinson JF, Woodruff TJ. Varshavsky JR, et al. Reprod Toxicol. 2025 Jan;131:108725. doi: 10.1016/j.reprotox.2024.108725. Epub 2024 Oct 16. Reprod Toxicol. 2025. PMID: 39419704 Free article.
While high-throughput (HTP) assays have been proposed as platforms to rapidly assess reproductive toxicity, there is currently a lack of established assays that specifically address germline development/function and fertility. We assessed the applicability domains of yeast …
While high-throughput (HTP) assays have been proposed as platforms to rapidly assess reproductive toxicity, there is currently a lack …
Comparative genomic analysis and virulence differences in closely related salmonella enterica serotype heidelberg isolates from humans, retail meats, and animals.
Hoffmann M, Zhao S, Pettengill J, Luo Y, Monday SR, Abbott J, Ayers SL, Cinar HN, Muruvanda T, Li C, Allard MW, Whichard J, Meng J, Brown EW, McDermott PF. Hoffmann M, et al. Genome Biol Evol. 2014 May;6(5):1046-68. doi: 10.1093/gbe/evu079. Genome Biol Evol. 2014. PMID: 24732280 Free PMC article.
Heidelberg isolates using whole-genome sequencing (WGS) generated by the 454 GS FLX (Roche) platform. The isolates, including 30 with nearly indistinguishable (one band difference) Xbal pulsed-field gel electrophoresis patterns (JF6X01.0032, JF6X01.0058), were collected fr …
Heidelberg isolates using whole-genome sequencing (WGS) generated by the 454 GS FLX (Roche) platform. The isolates, including 30 with …