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Showing results for alphax
Your search for alpax retrieved no results
Characterization of alphaX I-domain binding to Thy-1.
Choi J, Leyton L, Nham SU. Choi J, et al. Biochem Biophys Res Commun. 2005 Jun 3;331(2):557-61. doi: 10.1016/j.bbrc.2005.04.006. Biochem Biophys Res Commun. 2005. PMID: 15850796
Despite the unique characteristics on expression and regulation, alphaX-beta2 is less functionally characterized than other beta2 integrins. To understand the biological function of alphaX-beta2 more, we tested the possibility that alphaX-beta2 binds Thy-1, a …
Despite the unique characteristics on expression and regulation, alphaX-beta2 is less functionally characterized than other beta2 int …
Characterization of alphaX I-Domain Binding to Receptors for Advanced Glycation End Products (RAGE).
Buyannemekh D, Nham SU. Buyannemekh D, et al. Mol Cells. 2017 May 31;40(5):355-362. doi: 10.14348/molcells.2017.0021. Epub 2017 May 24. Mol Cells. 2017. PMID: 28535664 Free PMC article.
Furthermore, the alphaX I-domains recognize the V-domain, but not the C1 and C2-domains of RAGE. ...In conclusion, the main mechanism of alphaX I-domain binding to RAGE is a charge interaction, in which the acidic moieties of alphaX I-domains, including E244, …
Furthermore, the alphaX I-domains recognize the V-domain, but not the C1 and C2-domains of RAGE. ...In conclusion, the main mechanism …
Novel monoclonal antibody against alphaX subunit from horse CD11c/CD18 integrin.
Espino-Solis GP, Quintero-Hernandez V, Olvera-Rodriguez A, Calderon-Amador J, Pedraza-Escalona M, Licea-Navarro A, Flores-Romo L, Possani LD. Espino-Solis GP, et al. Vet Immunol Immunopathol. 2015 Apr 15;164(3-4):220-6. doi: 10.1016/j.vetimm.2015.02.002. Epub 2015 Feb 12. Vet Immunol Immunopathol. 2015. PMID: 25727181
The alphaX I-domain of the horse integrin CD11c was successfully expressed in Escherichia coli, purified, biochemically characterized and used as immunogen to generate murine monoclonal antibodies against horse CD11c, which are not yet commercially available. One monoclona …
The alphaX I-domain of the horse integrin CD11c was successfully expressed in Escherichia coli, purified, biochemically characterized …
Characterization of the residues of alphaX I-domain and ICAM-1 mediating their interactions.
Choi J, Choi J, Nham SU. Choi J, et al. Mol Cells. 2010 Sep;30(3):227-34. doi: 10.1007/s10059-010-0111-2. Epub 2010 Aug 23. Mol Cells. 2010. PMID: 20803088 Free article.
Domain 3 of ICAM-1 was identified as a primary binding site for the alphaX I-domain. Two regions of domain 3 (D(229)QRLNPTV and E(254)DEGTQRL) perform critical functions in the binding of the alphaX I-domain. Especially, the residue E(254)DEG, is most important with …
Domain 3 of ICAM-1 was identified as a primary binding site for the alphaX I-domain. Two regions of domain 3 (D(229)QRLNPTV and E(254 …
Identification of critical residues for plasminogen binding by the alphaX I-domain of the beta2 integrin, alphaXbeta2.
Gang J, Choi J, Lee JH, Nham SU. Gang J, et al. Mol Cells. 2007 Oct 31;24(2):240-6. Mol Cells. 2007. PMID: 17978577 Free article.
The betaD-alpha5 loop of the alphaX I-domain proved to be responsible for binding, and lysine residues (Lys(242), Lys(243)) in the loop were the most important for recognizing plasminogen. An excess amount of the lysine analog, 6-aminohexanoic acid, inhibited alphaX …
The betaD-alpha5 loop of the alphaX I-domain proved to be responsible for binding, and lysine residues (Lys(242), Lys(243)) in the lo …
Critical residues of alphaX I-domain recognizing fibrinogen central domain.
Lee JH, Choi J, Nham SU. Lee JH, et al. Biochem Biophys Res Commun. 2007 Apr 20;355(4):1058-63. doi: 10.1016/j.bbrc.2007.02.082. Epub 2007 Feb 26. Biochem Biophys Res Commun. 2007. PMID: 17339034
Previously we showed that two loops (alpha3-alpha4, betaD-alpha5) around a ligand-binding face of alphaX I-domain are important for the binding of the fibrinogen molecule. ...The involvement of the residues in the 3-dimensional model of the I-domain suggests that several a …
Previously we showed that two loops (alpha3-alpha4, betaD-alpha5) around a ligand-binding face of alphaX I-domain are important for t …
The structural basis of β2 integrin intra-cellular multi-protein complexes.
Bhattacharjya S. Bhattacharjya S. Biophys Rev. 2022 Sep 7;14(5):1183-1195. doi: 10.1007/s12551-022-00995-x. eCollection 2022 Oct. Biophys Rev. 2022. PMID: 36345283 Free PMC article. Review.
Among 24 different integrins, four beta2 integrins, alphaL beta2, alphaM beta2, alphaX beta2 and alphaD beta2, are specific for cell adhesion and migration of leukocytes. ...
Among 24 different integrins, four beta2 integrins, alphaL beta2, alphaM beta2, alphaX beta2 and alphaD beta2, are specific for cell …
Inhibition of subsets of G protein-coupled receptors by empty mutants of G protein alpha subunits in g(o), G(11), and G(16).
Yu B, Gu L, Simon MI. Yu B, et al. J Biol Chem. 2000 Jan 7;275(1):71-6. doi: 10.1074/jbc.275.1.71. J Biol Chem. 2000. PMID: 10617587 Free article.
These experiments demonstrated that G(11)alphaX and G(16)alphaX were xanthine nucleotide-binding proteins, similar to G(o)alphaX. ...Finally, we found that G(o)alphaX, G(11)alphaX, and G(16)alphaX all inhibited the endogenous thrombin rec …
These experiments demonstrated that G(11)alphaX and G(16)alphaX were xanthine nucleotide-binding proteins, similar to G(o)a …
Heterotropic roles of divalent cations in the establishment of allostery and affinity maturation of integrin αXβ2.
Manandhar P, Mazhar Z, Abousaway O, Aboagye C, Moussa Z, Lim D, Yu T, Byrnes J, Briggs JM, Sen M. Manandhar P, et al. Cell Rep. 2022 Aug 23;40(8):111254. doi: 10.1016/j.celrep.2022.111254. Cell Rep. 2022. PMID: 36001965 Free PMC article.
Stepwise addition of Mg(2+) reveals two mutually coupled events for the alphaXbeta2 ligand-binding domain-the alphaX I-domain-corresponding to allostery establishment and affinity maturation. Electrostatic alterations in the Mg(2+)-binding site establish long-range couplin …
Stepwise addition of Mg(2+) reveals two mutually coupled events for the alphaXbeta2 ligand-binding domain-the alphaX I-domain-corresp …
157 results