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Alpha-Gal-containing biologics and anaphylaxis.
Chinuki Y, Morita E. Chinuki Y, et al. Allergol Int. 2019 Jul;68(3):296-300. doi: 10.1016/j.alit.2019.04.001. Epub 2019 Apr 30. Allergol Int. 2019. PMID: 31053502 Free article. Review.
The alpha-Gal-specific IgE test (bovine thyroglobulin-conjugated ImmunoCAP) or CD63-expression-based basophil activation test may be useful to identify patients with IgE to alpha-Gal in order to predict risk for cetuximab-induced anaphylactic shock. .. …
The alpha-Gal-specific IgE test (bovine thyroglobulin-conjugated ImmunoCAP) or CD63-expression-based basophil activation test …
alpha-Gal and other recent findings that have informed our understanding of anaphylaxis.
Wilson JM, Platts-Mills TAE. Wilson JM, et al. Ann Allergy Asthma Immunol. 2020 Feb;124(2):135-142. doi: 10.1016/j.anai.2019.11.024. Epub 2019 Nov 28. Ann Allergy Asthma Immunol. 2020. PMID: 31785367 Free PMC article. Review.
Induction of allergen-specific IgG4 is often part of the allergic response and is associated with protection against anaphylaxis. The recognition of the alpha-Gal syndrome suggests that carbohydrates can be epitopes that are relevant to anaphylaxis and …
Induction of allergen-specific IgG4 is often part of the allergic response and is associated with protection against anaphylaxis. The …
Diagnosis & management of alpha-gal syndrome: lessons from 2,500 patients.
Commins SP. Commins SP. Expert Rev Clin Immunol. 2020 Jul;16(7):667-677. doi: 10.1080/1744666X.2020.1782745. Epub 2020 Jul 8. Expert Rev Clin Immunol. 2020. PMID: 32571129 Free PMC article. Review.
INTRODUCTION: Alpha-gal Syndrome (AGS) is a unique allergy to non-primate mammalian meat (and derived-products) that is associated with tick bites and is due to a specific IgE antibody to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal). . …
INTRODUCTION: Alpha-gal Syndrome (AGS) is a unique allergy to non-primate mammalian meat (and derived-products) that is associ …
The Immunology of Alpha-Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat.
Platts-Mills TAE, Gangwar RS, Workman L, Wilson JM. Platts-Mills TAE, et al. Immunol Rev. 2025 Jul;332(1):e70035. doi: 10.1111/imr.70035. Immunol Rev. 2025. PMID: 40515672 Free PMC article. Review.
The primary features of the alpha-gal syndrome (AGS) are (i) The IgE ab that are causally related to anaphylaxis with infusions of Cetuximab are specific for galactose alpha-1,3-galactose. ...A further important fact is that all humans make a "natural" respon …
The primary features of the alpha-gal syndrome (AGS) are (i) The IgE ab that are causally related to anaphylaxis with i …
Alpha-Gal Syndrome: A Novel and Increasingly Common Cause of Anaphylaxis.
Edlow JA. Edlow JA. Ann Emerg Med. 2024 Apr;83(4):380-384. doi: 10.1016/j.annemergmed.2023.08.491. Epub 2023 Oct 11. Ann Emerg Med. 2024. PMID: 37831041 Review.
The alpha-gal syndrome is a recently described cause of anaphylaxis to red meat that has been increasing in frequency over time. ...As many as 10% of patients diagnosed with idiopathic anaphylaxis have alpha-gal syndrome in some parts of …
The alpha-gal syndrome is a recently described cause of anaphylaxis to red meat that has been increasing in frequency o …
Diagnosis and Management of Patients with the alpha-Gal Syndrome.
Platts-Mills TAE, Li RC, Keshavarz B, Smith AR, Wilson JM. Platts-Mills TAE, et al. J Allergy Clin Immunol Pract. 2020 Jan;8(1):15-23.e1. doi: 10.1016/j.jaip.2019.09.017. Epub 2019 Sep 28. J Allergy Clin Immunol Pract. 2020. PMID: 31568928 Free PMC article. Review.
The galactose-alpha-1,3-galactose (alpha-Gal) syndrome has many novel features that are relevant to diagnosis and management. ...In the United States, the lone star tick is the primary cause of this disease, but different ticks are responsible in other countries. Bl …
The galactose-alpha-1,3-galactose (alpha-Gal) syndrome has many novel features that are relevant to diagnosis and management. …
Tick bites, IgE to galactose-alpha-1,3-galactose and urticarial or anaphylactic reactions to mammalian meat: The alpha-gal syndrome.
Wilson JM, Erickson L, Levin M, Ailsworth SM, Commins SP, Platts-Mills TAE. Wilson JM, et al. Allergy. 2024 Jun;79(6):1440-1454. doi: 10.1111/all.16003. Epub 2024 Jan 9. Allergy. 2024. PMID: 38193233 Free PMC article. Review.
The syndrome, mediated by IgE antibodies against the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal), can also involve reactions to visceral organs, dairy, gelatin and other products, including medications sourced from non-primate mammals. ...In addition t …
The syndrome, mediated by IgE antibodies against the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal), can also invol …
Anaphylaxis triggered by alpha-gal allergy.
Rørvik SD, Alnæs MB, Vikenes BC, Kristiansen T. Rørvik SD, et al. Tidsskr Nor Laegeforen. 2024 Jun 5;144(8). doi: 10.4045/tidsskr.24.0122. Print 2024 Jun 25. Tidsskr Nor Laegeforen. 2024. PMID: 38934309 Free article. English, Norwegian.
BACKGROUND: Alpha-gal allergy or red meat allergy is a rare yet potentially severe allergy. Sensitisation usually occurs when alpha-gal present in the tick's saliva is transferred to humans during a tick bite, prompting the production of IgE antibodies …
BACKGROUND: Alpha-gal allergy or red meat allergy is a rare yet potentially severe allergy. Sensitisation usually occurs when …
Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat.
Commins SP, Jerath MR, Cox K, Erickson LD, Platts-Mills T. Commins SP, et al. Allergol Int. 2016 Jan;65(1):16-20. doi: 10.1016/j.alit.2015.10.001. Epub 2015 Nov 21. Allergol Int. 2016. PMID: 26666477 Free PMC article. Review.
As the number of known exposures associated with anaphylaxis is limited, discovery of novel causative agents is crucial to evaluation and management of patients with idiopathic anaphylaxis. ...Our recent work has identified these responses as being due to a novel Ig …
As the number of known exposures associated with anaphylaxis is limited, discovery of novel causative agents is crucial to evaluation …
Anaphylaxis to the carbohydrate side chain alpha-gal.
Platts-Mills TA, Schuyler AJ, Tripathi A, Commins SP. Platts-Mills TA, et al. Immunol Allergy Clin North Am. 2015 May;35(2):247-60. doi: 10.1016/j.iac.2015.01.009. Epub 2015 Mar 6. Immunol Allergy Clin North Am. 2015. PMID: 25841549 Free PMC article. Review.
Investigation of pretreatment sera established that they contained immunoglobulin (Ig) E against the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal), which is present on the Fab of cetuximab. Alpha-gal is a blood group substance of nonprimate …
Investigation of pretreatment sera established that they contained immunoglobulin (Ig) E against the oligosaccharide galactose-alpha-1,3-gal …
274 results