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127 results

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Page 1
The Immunology of Alpha-Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat.
Platts-Mills TAE, Gangwar RS, Workman L, Wilson JM. Platts-Mills TAE, et al. Immunol Rev. 2025 Jul;332(1):e70035. doi: 10.1111/imr.70035. Immunol Rev. 2025. PMID: 40515672 Free PMC article. Review.
The primary features of the alpha-gal syndrome (AGS) are (i) The IgE ab that are causally related to anaphylaxis with infusions of Cetuximab are specific for galactose alpha-1,3-galactose. ...(iii) The anaphylactic reactions to food derived from non-primate m …
The primary features of the alpha-gal syndrome (AGS) are (i) The IgE ab that are causally related to anaphylaxis with i …
Diagnosis & management of alpha-gal syndrome: lessons from 2,500 patients.
Commins SP. Commins SP. Expert Rev Clin Immunol. 2020 Jul;16(7):667-677. doi: 10.1080/1744666X.2020.1782745. Epub 2020 Jul 8. Expert Rev Clin Immunol. 2020. PMID: 32571129 Free PMC article. Review.
INTRODUCTION: Alpha-gal Syndrome (AGS) is a unique allergy to non-primate mammalian meat (and derived-products) that is associated with tick bites and is due to a specific IgE antibody to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal). A …
INTRODUCTION: Alpha-gal Syndrome (AGS) is a unique allergy to non-primate mammalian meat (and derived-products) that is associ …
Diagnosis and Management of Patients with the alpha-Gal Syndrome.
Platts-Mills TAE, Li RC, Keshavarz B, Smith AR, Wilson JM. Platts-Mills TAE, et al. J Allergy Clin Immunol Pract. 2020 Jan;8(1):15-23.e1. doi: 10.1016/j.jaip.2019.09.017. Epub 2019 Sep 28. J Allergy Clin Immunol Pract. 2020. PMID: 31568928 Free PMC article. Review.
The galactose-alpha-1,3-galactose (alpha-Gal) syndrome has many novel features that are relevant to diagnosis and management. In most cases, the diagnosis can be made on a history of delayed allergic reactions to mammalian meat and the blood test for IgE to t …
The galactose-alpha-1,3-galactose (alpha-Gal) syndrome has many novel features that are relevant to diagnosis and management. …
Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat.
Commins SP, Jerath MR, Cox K, Erickson LD, Platts-Mills T. Commins SP, et al. Allergol Int. 2016 Jan;65(1):16-20. doi: 10.1016/j.alit.2015.10.001. Epub 2015 Nov 21. Allergol Int. 2016. PMID: 26666477 Free PMC article. Review.
As the number of known exposures associated with anaphylaxis is limited, discovery of novel causative agents is crucial to evaluation and management of patients with idiopathic anaphylaxis. ...Our recent work has identified these responses as being due to a novel Ig …
As the number of known exposures associated with anaphylaxis is limited, discovery of novel causative agents is crucial to evaluation …
Tick bites, IgE to galactose-alpha-1,3-galactose and urticarial or anaphylactic reactions to mammalian meat: The alpha-gal syndrome.
Wilson JM, Erickson L, Levin M, Ailsworth SM, Commins SP, Platts-Mills TAE. Wilson JM, et al. Allergy. 2024 Jun;79(6):1440-1454. doi: 10.1111/all.16003. Epub 2024 Jan 9. Allergy. 2024. PMID: 38193233 Free PMC article. Review.
The syndrome, mediated by IgE antibodies against the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal), can also involve reactions to visceral organs, dairy, gelatin and other products, including medications sourced from non-primate mammals. ...Reactions in …
The syndrome, mediated by IgE antibodies against the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal), can also invol …
Management of Food Allergies and Food-Related Anaphylaxis.
Iglesia EGA, Kwan M, Virkud YV, Iweala OI. Iglesia EGA, et al. JAMA. 2024 Feb 13;331(6):510-521. doi: 10.1001/jama.2023.26857. JAMA. 2024. PMID: 38349368 Free PMC article.
Alpha-gal syndrome, which is associated with tick bites, is a rising cause of IgE-mediated food anaphylaxis. ...CONCLUSIONS AND RELEVANCE: IgE-mediated food allergies, including delayed IgE-mediated allergic responses to red meat in alpha-gal …
Alpha-gal syndrome, which is associated with tick bites, is a rising cause of IgE-mediated food anaphylaxis. ...CONCLUS …
Delayed anaphylaxis due to Alpha-gal allergy: A modified desensitization protocol with red meat in an adult patient.
Tepetam FM, Yegin Katran Z, Bayraktar Barın R, Çakmak Uğurlu B. Tepetam FM, et al. Tuberk Toraks. 2023 Sep;71(3):318-324. doi: 10.5578/tt.20239714. Tuberk Toraks. 2023. PMID: 37740636 Free PMC article.
Alpha-gal allergy is the sensitization to Alpha-gal present in saliva when a tick bites and the development of an IgE-mediated reaction to Alpha-gal also present in red meat by cross-reactivity. ...In addition, the high level of Alpha …
Alpha-gal allergy is the sensitization to Alpha-gal present in saliva when a tick bites and the development of a …
Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment.
Sicherer SH, Sampson HA. Sicherer SH, et al. J Allergy Clin Immunol. 2014 Feb;133(2):291-307; quiz 308. doi: 10.1016/j.jaci.2013.11.020. Epub 2013 Dec 31. J Allergy Clin Immunol. 2014. PMID: 24388012 Review.
Interesting clinical insights into pathogenesis include discoveries regarding gene-environment interactions and an increasing understanding of the role of nonoral sensitizing exposures causing food allergy, such as delayed allergic reactions to carbohydrate moieties in mam …
Interesting clinical insights into pathogenesis include discoveries regarding gene-environment interactions and an increasing understanding …
Alpha-Gal Syndrome: A Novel and Increasingly Common Cause of Anaphylaxis.
Edlow JA. Edlow JA. Ann Emerg Med. 2024 Apr;83(4):380-384. doi: 10.1016/j.annemergmed.2023.08.491. Epub 2023 Oct 11. Ann Emerg Med. 2024. PMID: 37831041 Review.
The alpha-gal syndrome is a recently described cause of anaphylaxis to red meat that has been increasing in frequency over time. ...As many as 10% of patients diagnosed with idiopathic anaphylaxis have alpha-gal syndrome in some parts of …
The alpha-gal syndrome is a recently described cause of anaphylaxis to red meat that has been increasing in frequency o …
Delayed anaphylaxis to red meat in patients with IgE specific for galactose alpha-1,3-galactose (alpha-gal).
Commins SP, Platts-Mills TA. Commins SP, et al. Curr Allergy Asthma Rep. 2013 Feb;13(1):72-7. doi: 10.1007/s11882-012-0315-y. Curr Allergy Asthma Rep. 2013. PMID: 23054628 Free PMC article. Review.
Our recent work has identified a novel IgE antibody (Ab) response to a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal), that has been associated with two distinct forms of anaphylaxis: (1) immediate onset anaphylaxis during …
Our recent work has identified a novel IgE antibody (Ab) response to a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose ( …
127 results