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Page 1
Alpha-Gal Syndrome and Aortic Valve Replacement.
Sami N, Ravishankar B, Worku B, Khatib D, McGintee E, Sacchi T, Dogan O, Perk G, Reisman M, Mihatov N. Sami N, et al. JACC Case Rep. 2025 Oct 15;30(32):105478. doi: 10.1016/j.jaccas.2025.105478. JACC Case Rep. 2025. PMID: 41106900 Free PMC article.
BACKGROUND: Alpha-gal syndrome (AGS) is an IgE-mediated hypersensitivity response to galactose-alpha-1,3-galactose (alpha-gal), an oligosaccharide present in beef and pork. This complicates bioprosthetic heart valve selection, as both …
BACKGROUND: Alpha-gal syndrome (AGS) is an IgE-mediated hypersensitivity response to galactose-alpha-1,3-galactose (alpha …
First quantification of alpha-Gal epitope in current glutaraldehyde-fixed heart valve bioprostheses.
Naso F, Gandaglia A, Bottio T, Tarzia V, Nottle MB, d'Apice AJ, Cowan PJ, Cozzi E, Galli C, Lagutina I, Lazzari G, Iop L, Spina M, Gerosa G. Naso F, et al. Xenotransplantation. 2013 Jul-Aug;20(4):252-61. doi: 10.1111/xen.12044. Epub 2013 Jul 19. Xenotransplantation. 2013. PMID: 23865597
BACKGROUND: Glutaraldehyde fixation does not guarantee complete tissue biocompatibility in current clinical bioprosthetic heart valves (BHVs). Particularly, circulating anti-alphaGal human antibodies increase significantly from just 10 days after a BHV implantation. …
BACKGROUND: Glutaraldehyde fixation does not guarantee complete tissue biocompatibility in current clinical bioprosthetic heart va …
Alpha gal syndrome, a relative not absolute contraindication to the use of bovine pericardium to close an intracardiac septal defect: a case report.
Taira K, Kanade R, Yammine M, Tannous H, Kumar S. Taira K, et al. J Cardiothorac Surg. 2024 Apr 16;19(1):221. doi: 10.1186/s13019-024-02763-2. J Cardiothorac Surg. 2024. PMID: 38627833 Free PMC article.
CASE PRESENTATION: We present the case of a 31-year-old male who underwent cardiac surgery in the setting of alpha-gal syndrome for a large atrial septal defect (ASD) and mitral valve prolapse (MVP). ...CONCLUSIONS: This case highlights that the use of bov …
CASE PRESENTATION: We present the case of a 31-year-old male who underwent cardiac surgery in the setting of alpha-gal syndrom …
Safe Implantation of a Bovine Bioprosthetic Aortic Valve in a Patient With Galactose-alpha-1,3-Galactose Allergy.
Chen S, Zeigler S. Chen S, et al. Ann Thorac Surg. 2024 Oct;118(4):950-952. doi: 10.1016/j.athoracsur.2024.06.033. Epub 2024 Jul 11. Ann Thorac Surg. 2024. PMID: 38996861
Allergy to galactose-alpha-1,3-galactose (alpha-gal) is associated with immediate allergic manifestations and premature degeneration of the prosthesis in patients who receive bovine- or porcine-derived bioprosthetic valves. Here, we report a 72-year-ol …
Allergy to galactose-alpha-1,3-galactose (alpha-gal) is associated with immediate allergic manifestations and premature degene …
Next-generation transcatheter aortic valve implantation.
Lim HG, Jeong S, Kim GB, Lee W, Son KH, Kim YJ. Lim HG, et al. JTCVS Open. 2020 Jun 24;3:14-24. doi: 10.1016/j.xjon.2020.06.008. eCollection 2020 Sep. JTCVS Open. 2020. PMID: 36003870 Free PMC article.
Echocardiography and cardiac catheterization demonstrated good hemodynamic status and function of the aortic valve. The xenografts were well preserved without alpha-Gal immune reaction or calcification based on the immunological, radiographic, microscopic, an …
Echocardiography and cardiac catheterization demonstrated good hemodynamic status and function of the aortic valve. The xenografts we …
Changes of the Structural and Biomechanical Properties of the Bovine Pericardium after the Removal of alpha-Gal Epitopes by Decellularization and alpha-Galactosidase Treatment.
Nam J, Choi SY, Sung SC, Lim HG, Park SS, Kim SH, Kim YJ. Nam J, et al. Korean J Thorac Cardiovasc Surg. 2012 Dec;45(6):380-9. doi: 10.5090/kjtcs.2012.45.6.380. Epub 2012 Dec 7. Korean J Thorac Cardiovasc Surg. 2012. PMID: 23275920 Free PMC article.
BACKGROUND: Bovine pericardium is one of the most widely used materials in bioprosthetic heart valves. ...RESULTS: Recombinant B. thetaiotaomicron alpha-gal could effectively remove alpha-gal from bovine pericardium B. theta …
BACKGROUND: Bovine pericardium is one of the most widely used materials in bioprosthetic heart valves. ...RESULTS: Reco …
Quantification of Alpha-Gal Expression in Commercial BioProsthetic Heart Valves and Its Potential Mitigation.
Colli A, Zilla P, Calafiore AM, Padalino M, Naso F, George I. Colli A, et al. Struct Heart. 2025 Oct 13;10(3):100739. doi: 10.1016/j.shj.2025.100739. eCollection 2026 Mar. Struct Heart. 2025. PMID: 41646629 Free PMC article.
BACKGROUND AND AIMS: Bioprosthetic heart valves (BHVs) are inherently susceptible to structural degeneration, driven by a combination of mechanical stress, lipid infiltration, glutaraldehyde-induced crosslinking instability, and progressive calcification. ...RESULTS …
BACKGROUND AND AIMS: Bioprosthetic heart valves (BHVs) are inherently susceptible to structural degeneration, driven by a comb …
Calcification of decellularized and alpha-galactosidase-treated bovine pericardial tissue in an alpha-Gal knock-out mouse implantation model: comparison with primate pericardial tissue.
Kim MS, Lim HG, Kim YJ. Kim MS, et al. Eur J Cardiothorac Surg. 2016 Mar;49(3):894-900. doi: 10.1093/ejcts/ezv189. Epub 2015 May 20. Eur J Cardiothorac Surg. 2016. PMID: 25994817 Free article.
The genetically manipulated alpha-Gal knock-out (KO) mice lacking the alpha-Gal epitope and containing anti-alpha-Gal antibodies may simulate an immune response against xenoantigens in primates including humans. ...METHODS: Four types of …
The genetically manipulated alpha-Gal knock-out (KO) mice lacking the alpha-Gal epitope and containing anti-a …
Correlations between the alpha-Gal antigen, antibody response and calcification of cardiac valve bioprostheses: experimental evidence obtained using an alpha-Gal knockout mouse animal model.
Naso F, Colli A, Zilla P, Calafiore AM, Lotan C, Padalino MA, Sturaro G, Gandaglia A, Spina M. Naso F, et al. Front Immunol. 2023 Jun 21;14:1210098. doi: 10.3389/fimmu.2023.1210098. eCollection 2023. Front Immunol. 2023. PMID: 37426661 Free PMC article.
INTRODUCTION: Preformed antibodies against alphaGal in the human and the presence of alphaGal antigens on the tissue constituting the commercial bioprosthetic heart valves (BHVs, mainly bovine or porcine pericardium), lead to opsonization of the implanted BHV …
INTRODUCTION: Preformed antibodies against alphaGal in the human and the presence of alphaGal antigens on the tissue constituting the commer …
Alpha-Gal specific IgG immune response after implantation of bioprostheses.
Mangold A, Szerafin T, Hoetzenecker K, Hacker S, Lichtenauer M, Niederpold T, Nickl S, Dworschak M, Blumer R, Auer J, Ankersmit HJ. Mangold A, et al. Thorac Cardiovasc Surg. 2009 Jun;57(4):191-5. doi: 10.1055/s-0029-1185395. Epub 2009 May 20. Thorac Cardiovasc Surg. 2009. PMID: 19670109
BACKGROUND: We have previously shown that the alpha-Gal (Galalpha1.3-Galbeta1-4GlcNAc-R) epitope is a relevant xenoantigen present on bioprostheses utilized in cardiac surgery and elicits an alpha-Gal specific IgM immune response. ...We utilized confoc …
BACKGROUND: We have previously shown that the alpha-Gal (Galalpha1.3-Galbeta1-4GlcNAc-R) epitope is a relevant xenoantigen pre …
28 results