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The Immunology of Alpha-Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat.
Platts-Mills TAE, Gangwar RS, Workman L, Wilson JM. Platts-Mills TAE, et al. Immunol Rev. 2025 Jul;332(1):e70035. doi: 10.1111/imr.70035. Immunol Rev. 2025. PMID: 40515672 Free PMC article. Review.
The primary features of the alpha-gal syndrome (AGS) are (i) The IgE ab that are causally related to anaphylaxis with infusions of Cetuximab are specific for galactose alpha-1,3-galactose. ...A further important fact is that all humans make a "natural" respon …
The primary features of the alpha-gal syndrome (AGS) are (i) The IgE ab that are causally related to anaphylaxis with infusion …
Idiopathic Anaphylaxis.
Ben-Shoshan M, Cem A, Cook VE, Khalaf R, Freigeh G. Ben-Shoshan M, et al. J Allergy Clin Immunol Pract. 2025 Dec;13(12):3165-3178.e1. doi: 10.1016/j.jaip.2025.08.019. Epub 2025 Aug 27. J Allergy Clin Immunol Pract. 2025. PMID: 40882893 Free article. Review.
Evaluation revealed elevated acute tryptase levels with a normal baseline, negative skin testing results, and negative galactose-alpha-1,3-galactose (alpha-gal) and KIT mutation analysis. The patient improved on daily cetirizine with no further reactions. ...Future …
Evaluation revealed elevated acute tryptase levels with a normal baseline, negative skin testing results, and negative galactose-alpha-1,3-g …
Guideline for allergological diagnosis of drug hypersensitivity reactions: S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI) in cooperation with the German Dermatological Society (DDG), the Association of German Allergologists (ÄDA), the German Society for Pediatric Allergology (GPA), the German Contact Dermatitis Research Group (DKG), the German Society for Pneumology (DGP), the German Society of Otorhinolaryngology, Head and Neck Surgery, the Austrian Society of Allergology and Immunology (ÖGAI), the Austrian Society of Dermatology and Venereology (ÖGDV), the German Academy of Allergology and Environmental Medicine (DAAU), and the German Documentation Center for Severe Skin Reactions (dZh).
Brockow K, Wurpts G, Trautmann A, Pfützner W, Treudler R, Bircher AJ, Brehler R, Buhl T, Dickel H, Fuchs T, Jakob T, Kurz J, Kreft B, Lange L, Merk HF, Mockenhaupt M, Mülleneisen N, Ott H, Ring J, Ruëff F, Sachs B, Sitter H, Wedi B, Wöhrl S, Worm M, Zuberbier T. Brockow K, et al. Allergol Select. 2023 Aug 9;7:122-139. doi: 10.5414/ALX02422E. eCollection 2023. Allergol Select. 2023. PMID: 37705676 Free PMC article.
'Doc, will I ever eat steak again?': diagnosis and management of alpha-gal syndrome.
Patel C, Iweala OI. Patel C, et al. Curr Opin Pediatr. 2020 Dec;32(6):816-824. doi: 10.1097/MOP.0000000000000955. Curr Opin Pediatr. 2020. PMID: 33009122 Free PMC article. Review.
PURPOSE OF REVIEW: Alpha-gal syndrome encompasses a constellation of symptoms associated with immune-mediated hypersensitivity responses to galactose-alpha-1,3-galactose (alpha-gal). The purpose of this review is to discuss our current understanding of …
PURPOSE OF REVIEW: Alpha-gal syndrome encompasses a constellation of symptoms associated with immune-mediated hypersensitivity …
The epidemiology of food allergy in adults.
Warren C, Nimmagadda SR, Gupta R, Levin M. Warren C, et al. Ann Allergy Asthma Immunol. 2023 Mar;130(3):276-287. doi: 10.1016/j.anai.2022.11.026. Epub 2022 Dec 9. Ann Allergy Asthma Immunol. 2023. PMID: 36509408 Review.
The prevalence and awareness of food allergy (FA) among US adults is arguably at a historical high, both with respect to primary immunoglobulin E-mediated food hypersensitivity and other food-triggered conditions that operate through a variety of immunologic mechanisms (eg, polle …
The prevalence and awareness of food allergy (FA) among US adults is arguably at a historical high, both with respect to primary immunoglobu …
Anderson-Fabry disease: a multiorgan disease.
Tuttolomondo A, Pecoraro R, Simonetta I, Miceli S, Pinto A, Licata G. Tuttolomondo A, et al. Curr Pharm Des. 2013;19(33):5974-96. doi: 10.2174/13816128113199990352. Curr Pharm Des. 2013. PMID: 23448451 Review.
The abnormal neuronal accumulation of glycosphingolipid appears to have little clinical effect on the natural history of Fabry disease, with the possible exception of some reported mild cognitive abnormalities. ...Since heterozygous women show angiokeratomas in only …
The abnormal neuronal accumulation of glycosphingolipid appears to have little clinical effect on the natural history of Fabry …
A case of alpha-gal syndrome: Recall urticaria and 10 years of measurements of IgE to galactose-alpha-1,3-galactose.
Leth-Møller KB, van Hage M, Linneberg A, Kårhus LL. Leth-Møller KB, et al. J Allergy Clin Immunol Glob. 2024 May 16;3(3):100280. doi: 10.1016/j.jacig.2024.100280. eCollection 2024 Aug. J Allergy Clin Immunol Glob. 2024. PMID: 38881738 Free PMC article.
Alpha-gal IgE level can change rapidly. Reassessment of a patient's alpha-gal IgE level may be helpful in the patient's clinical follow-up. Pruritus related to the site of a previous tick bite strengthens the diagnosis of alpha-gal syndro …
Alpha-gal IgE level can change rapidly. Reassessment of a patient's alpha-gal IgE level may be helpful in the pa …
Fabry Disease: Recognition, Diagnosis, and Treatment of Neurological Features.
Ranieri M, Bedini G, Parati EA, Bersano A. Ranieri M, et al. Curr Treat Options Neurol. 2016 Jul;18(7):33. doi: 10.1007/s11940-016-0414-5. Curr Treat Options Neurol. 2016. PMID: 27225543 Review.
Fabry disease is an X-linked, lysosomal storage disorder caused by a mutation in the GLA gene leading to a deficiency in alpha-galactosidase A enzyme (alpha-Gal A) activity, which in turn results in accumulation of globotriaosylceramide in the vascular endothelium a …
Fabry disease is an X-linked, lysosomal storage disorder caused by a mutation in the GLA gene leading to a deficiency in alpha-galactosidase …
Food Allergy: Our Evolving Understanding of Its Pathogenesis, Prevention, and Treatment.
Iweala OI, Burks AW. Iweala OI, et al. Curr Allergy Asthma Rep. 2016 May;16(5):37. doi: 10.1007/s11882-016-0616-7. Curr Allergy Asthma Rep. 2016. PMID: 27041704 Review.
We review current understanding of the pathogenesis, epidemiology, and natural history of food allergy, including the unconventional IgE-mediated food allergy to mammalian meat known as alpha-gal food allergy. ...
We review current understanding of the pathogenesis, epidemiology, and natural history of food allergy, including the unconven …
Recently Evolved Francisella-Like Endosymbiont Outcompetes an Ancient and Evolutionarily Associated Coxiella-Like Endosymbiont in the Lone Star Tick (Amblyomma americanum) Linked to the Alpha-Gal Syndrome.
Kumar D, Sharma SR, Adegoke A, Kennedy A, Tuten HC, Li AY, Karim S. Kumar D, et al. Front Cell Infect Microbiol. 2022 Apr 12;12:787209. doi: 10.3389/fcimb.2022.787209. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35493735 Free PMC article.
While ongoing studies have attempted to investigate the contribution of different tick-inherent factors to the induction of alpha-gal syndrome, an otherwise understudied aspect is the contribution of the tick microbiome and specifically obligate endosymbionts to the …
While ongoing studies have attempted to investigate the contribution of different tick-inherent factors to the induction of alpha- …
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