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Page 1
Diagnosis and Management of Patients with the alpha-Gal Syndrome.
Platts-Mills TAE, Li RC, Keshavarz B, Smith AR, Wilson JM. Platts-Mills TAE, et al. J Allergy Clin Immunol Pract. 2020 Jan;8(1):15-23.e1. doi: 10.1016/j.jaip.2019.09.017. Epub 2019 Sep 28. J Allergy Clin Immunol Pract. 2020. PMID: 31568928 Free PMC article. Review.
The galactose-alpha-1,3-galactose (alpha-Gal) syndrome has many novel features that are relevant to diagnosis and management. ...In the United States, the lone star tick is the primary cause of this disease, but different ticks are responsible in other countries. Bl …
The galactose-alpha-1,3-galactose (alpha-Gal) syndrome has many novel features that are relevant to diagnosis and management. …
A retrospective review of alpha-gal syndrome complicating the management of suspected pancreatic exocrine insufficiency in one gastroenterology clinic in central Virginia.
Richards NE, Wilson JM, Platts-Mills TAE, Richards RD. Richards NE, et al. Front Gastroenterol (Lausanne). 2023 Jul 26;2:1162109. doi: 10.3389/fgstr.2023.1162109. eCollection 2023. Front Gastroenterol (Lausanne). 2023. PMID: 41821783 Free PMC article.
Pancreatic exocrine insufficiency causes similar symptoms. The pancreatic replacement enzymes, referred to here as pancreatic enzymes, used to treat pancreatic insufficiency are porcine products and contain alpha-gal. Patien …
Pancreatic exocrine insufficiency causes similar symptoms. The pancreatic replacement enzymes, referred to here as p …
Alpha-Gal Syndrome: A Review for the General Internist.
Peterson CJ, Mohankumar P, Tarbox JA, Nugent K. Peterson CJ, et al. Am J Med Sci. 2025 Mar;369(3):313-320. doi: 10.1016/j.amjms.2024.11.015. Epub 2024 Nov 28. Am J Med Sci. 2025. PMID: 39615839 Review.
Alpha-gal syndrome develops in some individuals who have had tick bites which result in IgE responses to alpha-gal, a carbohydrate not found in humans. Patients with alpha-gal syndrome develop symptoms when they ingest mammalian meat, whi …
Alpha-gal syndrome develops in some individuals who have had tick bites which result in IgE responses to alpha-gal …
Pancreatic cancer immunotherapy using a tumor lysate vaccine, engineered to express alpha-gal epitopes, targets pancreatic cancer stem cells.
Tanida T, Tanemura M, Miyoshi E, Nagano H, Furukawa K, Nonaka Y, Akita H, Hama N, Wada H, Kawamoto K, Kobayashi S, Eguchi H, Mori M, Doki Y. Tanida T, et al. Int J Oncol. 2015 Jan;46(1):78-90. doi: 10.3892/ijo.2014.2717. Epub 2014 Oct 21. Int J Oncol. 2015. PMID: 25354268
In the present study, we prepared a polyvalent tumor lysate vaccine engineered to express the alpha-gal epitopes, Galalpha1-3Galbeta1-4 GlcNAc-R (i.e., alpha-gal tumor lysate), from primary tumors. ...The results of both in vitro and in vivo experiment …
In the present study, we prepared a polyvalent tumor lysate vaccine engineered to express the alpha-gal epitopes, Galalpha1-3G …
A practical approach to pancreatic cancer immunotherapy using resected tumor lysate vaccines processed to express alpha-gal epitopes.
Furukawa K, Tanemura M, Miyoshi E, Eguchi H, Nagano H, Matsunami K, Nagaoka S, Yamada D, Asaoka T, Noda T, Wada H, Kawamoto K, Goto K, Taniyama K, Mori M, Doki Y. Furukawa K, et al. PLoS One. 2017 Oct 27;12(10):e0184901. doi: 10.1371/journal.pone.0184901. eCollection 2017. PLoS One. 2017. PMID: 29077749 Free PMC article.
METHODS: Fresh surgically resected tumors obtained from human patients were processed to enzymatically synthesize alpha-gal epitopes on the carbohydrate chains of membrane glycoproteins. Processed membranes were analyzed for the expression of alpha-gal …
METHODS: Fresh surgically resected tumors obtained from human patients were processed to enzymatically synthesize alpha-gal ep …
Distribution of, and immune response to, chicken anti-alpha Gal immunoglobulin Y antibodies in wild-type and alpha Gal knockout mice.
Walsh WE Jr, Anderson BE, Ivancic D, Zhang Z, Piccini JP, Rodgers TG, Pao W, Fryer JP. Walsh WE Jr, et al. Immunology. 2000 Dec;101(4):467-73. doi: 10.1046/j.1365-2567.2000.00136.x. Immunology. 2000. PMID: 11122450 Free PMC article.
Chicken antibodies (immunoglobulin Y; IgY) to the alpha Gal epitope (galactose alpha-1,3-galactose) bind to alpha Gal antigens of mouse and porcine tissues and endothelial cells in vitro and block human anti-alpha Gal antibody binding, co …
Chicken antibodies (immunoglobulin Y; IgY) to the alpha Gal epitope (galactose alpha-1,3-galactose) bind to alpha Ga …
Evidence that tilapia islets do not express alpha-(1,3)gal: implications for islet xenotransplantation.
Leventhal JR, Sun J, Zhang J, Galili U, Chong A, Baker M, Kaufman DB, Wright JR Jr. Leventhal JR, et al. Xenotransplantation. 2004 May;11(3):276-83. doi: 10.1111/j.1399-3089.2004.00133.x. Xenotransplantation. 2004. PMID: 15099208
METHODS AND RESULTS: Immunostaining with the alpha-(1,3)gal-specific IB4 lectin on tilapia BB, liver, heart, spleen, and head kidney was negative, as was staining with murine anti-alpha-gal-specific monoclonal antibodies. Absence of alpha-gal-specific …
METHODS AND RESULTS: Immunostaining with the alpha-(1,3)gal-specific IB4 lectin on tilapia BB, liver, heart, spleen, and head kidney was neg …
Case Report: Alpha-Gal Diagnosis in an Adolescent With Cystic Fibrosis.
Coyne S, Condren M. Coyne S, et al. Pediatr Pulmonol. 2025 Jan;60(1):e27424. doi: 10.1002/ppul.27424. Epub 2024 Nov 27. Pediatr Pulmonol. 2025. PMID: 39601456
A 17-year-old female with cystic fibrosis was diagnosed with alpha-gal syndrome after 6 months of progressively worsening abdominal pain. Alpha-gal is an acquired allergy to mammalian products that can impact what individuals are able to consume. ...Th …
A 17-year-old female with cystic fibrosis was diagnosed with alpha-gal syndrome after 6 months of progressively worsening abdo …
30 results