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The Immunology of Alpha-Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat.
Platts-Mills TAE, Gangwar RS, Workman L, Wilson JM. Platts-Mills TAE, et al. Immunol Rev. 2025 Jul;332(1):e70035. doi: 10.1111/imr.70035. Immunol Rev. 2025. PMID: 40515672 Free PMC article. Review.
The primary features of the alpha-gal syndrome (AGS) are (i) The IgE ab that are causally related to anaphylaxis with infusions of Cetuximab are specific for galactose alpha-1,3-galactose. ...A further important fact is that all humans make a "natural" …
The primary features of the alpha-gal syndrome (AGS) are (i) The IgE ab that are causally related to anaphylaxis with i …
'Doc, will I ever eat steak again?': diagnosis and management of alpha-gal syndrome.
Patel C, Iweala OI. Patel C, et al. Curr Opin Pediatr. 2020 Dec;32(6):816-824. doi: 10.1097/MOP.0000000000000955. Curr Opin Pediatr. 2020. PMID: 33009122 Free PMC article. Review.
PURPOSE OF REVIEW: Alpha-gal syndrome encompasses a constellation of symptoms associated with immune-mediated hypersensitivity responses to galactose-alpha-1,3-galactose (alpha-gal). The purpose of this review is to discuss our current understanding of the et …
PURPOSE OF REVIEW: Alpha-gal syndrome encompasses a constellation of symptoms associated with immune-mediated hypersens …
The epidemiology of food allergy in adults.
Warren C, Nimmagadda SR, Gupta R, Levin M. Warren C, et al. Ann Allergy Asthma Immunol. 2023 Mar;130(3):276-287. doi: 10.1016/j.anai.2022.11.026. Epub 2022 Dec 9. Ann Allergy Asthma Immunol. 2023. PMID: 36509408 Review.
The prevalence and awareness of food allergy (FA) among US adults is arguably at a historical high, both with respect to primary immunoglobulin E-mediated food hypersensitivity and other food-triggered conditions that operate through a variety of immunologic mechanisms (eg, polle …
The prevalence and awareness of food allergy (FA) among US adults is arguably at a historical high, both with respect to primary immunoglobu …
Recently Evolved Francisella-Like Endosymbiont Outcompetes an Ancient and Evolutionarily Associated Coxiella-Like Endosymbiont in the Lone Star Tick (Amblyomma americanum) Linked to the Alpha-Gal Syndrome.
Kumar D, Sharma SR, Adegoke A, Kennedy A, Tuten HC, Li AY, Karim S. Kumar D, et al. Front Cell Infect Microbiol. 2022 Apr 12;12:787209. doi: 10.3389/fcimb.2022.787209. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35493735 Free PMC article.
While ongoing studies have attempted to investigate the contribution of different tick-inherent factors to the induction of alpha-gal syndrome, an otherwise understudied aspect is the contribution of the tick microbiome and specifically obligate endosymbionts …
While ongoing studies have attempted to investigate the contribution of different tick-inherent factors to the induction of alpha- …
A case of alpha-gal syndrome: Recall urticaria and 10 years of measurements of IgE to galactose-alpha-1,3-galactose.
Leth-Møller KB, van Hage M, Linneberg A, Kårhus LL. Leth-Møller KB, et al. J Allergy Clin Immunol Glob. 2024 May 16;3(3):100280. doi: 10.1016/j.jacig.2024.100280. eCollection 2024 Aug. J Allergy Clin Immunol Glob. 2024. PMID: 38881738 Free PMC article.
Pruritus related to the site of a previous tick bite strengthens the diagnosis of alpha-gal syndrome....
Pruritus related to the site of a previous tick bite strengthens the diagnosis of alpha-gal syndrome....
Knowledge, attitudes, and practices of Illinois medical professionals related to ticks and tick-borne disease.
Carson DA, Kopsco H, Gronemeyer P, Mateus-Pinilla N, Smith GS, Sandstrom EN, Smith RL. Carson DA, et al. One Health. 2022 Jul 31;15:100424. doi: 10.1016/j.onehlt.2022.100424. eCollection 2022 Dec. One Health. 2022. PMID: 36277108 Free PMC article.
Only 32% of physicians knew the cause of Alpha-gal syndrome and fewer than 18% were aware of available diagnostic testing. Tick or TBD-related education within the past two years was the most significant predictor of higher scores, increasing overall knowledg …
Only 32% of physicians knew the cause of Alpha-gal syndrome and fewer than 18% were aware of available diagnostic testi …
Assessing the potential risk of lone star tick, Amblyomma americanum, establishment in California.
Foley J, Rubino F, Kam D, Lozano K. Foley J, et al. Ticks Tick Borne Dis. 2025 Nov;16(6):102566. doi: 10.1016/j.ttbdis.2025.102566. Epub 2025 Nov 11. Ticks Tick Borne Dis. 2025. PMID: 41223718 Free article.
We sought data on LSTs and LST risk from 30 different entities including companies that identify and test ticks, natural history and entomology museums and collections, experts, and large databases. These queries and published records yielded records of 76 LSTs from …
We sought data on LSTs and LST risk from 30 different entities including companies that identify and test ticks, natural history …