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Page 1
IgE, alpha-Gal and atherosclerosis.
Wilson JM, McNamara CA, Platts-Mills TAE. Wilson JM, et al. Aging (Albany NY). 2019 Apr 5;11(7):1900-1902. doi: 10.18632/aging.101894. Aging (Albany NY). 2019. PMID: 30958794 Free PMC article. No abstract available.
Immunoglobulin E Sensitization to Mammalian Oligosaccharide Galactose-alpha-1,3 (alpha-Gal) Is Associated With Noncalcified Plaque, Obstructive Coronary Artery Disease, and ST-Segment-Elevated Myocardial Infarction.
Vernon ST, Kott KA, Hansen T, Finemore M, Baumgart KW, Bhindi R, Yang J, Hansen PS, Nicholls SJ, Celermajer DS, Ward MR, van Nunen SA, Grieve SM, Figtree GA. Vernon ST, et al. Arterioscler Thromb Vasc Biol. 2022 Mar;42(3):352-361. doi: 10.1161/ATVBAHA.121.316878. Epub 2022 Jan 20. Arterioscler Thromb Vasc Biol. 2022. PMID: 35045730
BACKGROUND: Treating known risk factors for coronary artery disease (CAD) has substantially reduced CAD morbidity and mortality. However, a significant burden of CAD remains unexplained. ...CT coronary angiograms were assessed using coronary …
BACKGROUND: Treating known risk factors for coronary artery disease (CAD) has substantially reduced CAD morbidity and m …
Chemokine Receptor Activation Enhances Memory B Cell Class Switching Linked to IgE Sensitization to Alpha Gal and Cardiovascular Disease.
Pattarabanjird T, Wilson JM, Erickson LD, Workman LJ, Qiao H, Ghosheh Y, Gulati R, Durant C, Vallejo J, Saigusa R, Platts-Mills TAE, Taylor AM, Ley K, McNamara CA. Pattarabanjird T, et al. Front Cardiovasc Med. 2022 Jan 13;8:791028. doi: 10.3389/fcvm.2021.791028. eCollection 2021. Front Cardiovasc Med. 2022. PMID: 35097011 Free PMC article.
Background: Recent studies have suggested that IgE sensitization to alpha-gal is associated with coronary artery disease (CAD). However, the B cell subtype(s) responsible for production of IgE to alpha-gal and mechanisms mediating …
Background: Recent studies have suggested that IgE sensitization to alpha-gal is associated with coronary artery …
Acute Coronary Syndrome in Alpha-Gal Syndrome: A Rare Immune-Cardiac Intersection.
Zerihun W, Tewodros B, Fahed J, Mohammad A, Bekele A. Zerihun W, et al. Cureus. 2026 May 5;18(5):e108325. doi: 10.7759/cureus.108325. eCollection 2026 May. Cureus. 2026. PMID: 42255777 Free PMC article.
Alpha-gal syndrome (AGS) is an IgE-mediated hypersensitivity reaction to galactose-alpha-1,3-galactose (alpha-gal) following exposure to lone star tick bites. ...This case supports a growing body of evidence linking AGS with coronary atheroscler …
Alpha-gal syndrome (AGS) is an IgE-mediated hypersensitivity reaction to galactose-alpha-1,3-galactose (alpha-gal …
Pre-clinical strategies and emerging technologies driving advances in the alpha-gal syndrome.
Erickson LD, Wilson JM, Cramton K, Rival CM. Erickson LD, et al. Allergol Int. 2025 Jul;74(3):397-405. doi: 10.1016/j.alit.2025.03.004. Epub 2025 Apr 2. Allergol Int. 2025. PMID: 40180833 Free PMC article. Review.
Alpha-gal syndrome (AGS) is a unique allergic condition triggered by IgE antibody production against the mammalian oligosaccharide galactose-alpha-1,3-galactose (alpha-gal). ...Despite growing research, including recent findings suggesting that asympto …
Alpha-gal syndrome (AGS) is a unique allergic condition triggered by IgE antibody production against the mammalian oligosaccha …
Allergic response to medical products in patients with alpha-gal syndrome.
Kuravi KV, Sorrells LT, Nellis JR, Rahman F, Walters AH, Matheny RG, Choudhary SK, Ayares DL, Commins SP, Bianchi JR, Turek JW. Kuravi KV, et al. J Thorac Cardiovasc Surg. 2022 Dec;164(6):e411-e424. doi: 10.1016/j.jtcvs.2021.03.100. Epub 2021 Apr 9. J Thorac Cardiovasc Surg. 2022. PMID: 33933257 Free PMC article.
AGS serum did not react to tissues prepared using alpha-gal knockout pigs. CONCLUSIONS: Despite commercial decellularization processes, alpha-gal continues to be present in animal-derived medical products, including bioprosthetic valves. ...This may ha …
AGS serum did not react to tissues prepared using alpha-gal knockout pigs. CONCLUSIONS: Despite commercial decellularization p …
Alpha-Gal on bioprostheses: xenograft immune response in cardiac surgery.
Konakci KZ, Bohle B, Blumer R, Hoetzenecker W, Roth G, Moser B, Boltz-Nitulescu G, Gorlitzer M, Klepetko W, Wolner E, Ankersmit HJ. Konakci KZ, et al. Eur J Clin Invest. 2005 Jan;35(1):17-23. doi: 10.1111/j.1365-2362.2005.01441.x. Eur J Clin Invest. 2005. PMID: 15638815
ELISA was utilized to evidence whether implantation of bioprostheses elicits augmentation of pre-existing cytotoxic anti alpha-Gal IgM antibodies within 10 days of surgery. Patients who underwent coronary artery bypass grafting (CABG) or mechanical val …
ELISA was utilized to evidence whether implantation of bioprostheses elicits augmentation of pre-existing cytotoxic anti alpha-Gal …
IgE to the Mammalian Oligosaccharide Galactose-α-1,3-Galactose Is Associated With Increased Atheroma Volume and Plaques With Unstable Characteristics-Brief Report.
Wilson JM, Nguyen AT, Schuyler AJ, Commins SP, Taylor AM, Platts-Mills TAE, McNamara CA. Wilson JM, et al. Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1665-1669. doi: 10.1161/ATVBAHA.118.311222. Epub 2018 Jun 14. Arterioscler Thromb Vasc Biol. 2018. PMID: 29903734 Free PMC article.
OBJECTIVE: Emerging evidence suggests a link between coronary artery disease and type 2 immunity. We sought to test the hypothesis that IgE sensitization to the mammalian oligosaccharide galactose-alpha-1,3-galactose (alpha-Gal)-the target aller …
OBJECTIVE: Emerging evidence suggests a link between coronary artery disease and type 2 immunity. We sought to test the …
Failure to detect Fabry patients in a cohort of prematurely atherosclerotic males.
Vedder AC, Gerdes VE, Poorthuis BJ, Helmond M, Trip MD, Aerts JM, Hollak CE. Vedder AC, et al. J Inherit Metab Dis. 2007 Nov;30(6):988. doi: 10.1007/s10545-007-0721-9. Epub 2007 Sep 12. J Inherit Metab Dis. 2007. PMID: 17849232
Fabry disease, or alpha-galactosidase A (alpha-Gal A) deficiency, is a lysosomal storage disorder in which accumulation of globotriaosylceramide (Gb(3)) is thought to be responsible for the development of renal, cardiac and cerebral complications. ...Patients …
Fabry disease, or alpha-galactosidase A (alpha-Gal A) deficiency, is a lysosomal storage disorder in which accumulation …
12 results