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Guideline for allergological diagnosis of drug hypersensitivity reactions: S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI) in cooperation with the German Dermatological Society (DDG), the Association of German Allergologists (ÄDA), the German Society for Pediatric Allergology (GPA), the German Contact Dermatitis Research Group (DKG), the German Society for Pneumology (DGP), the German Society of Otorhinolaryngology, Head and Neck Surgery, the Austrian Society of Allergology and Immunology (ÖGAI), the Austrian Society of Dermatology and Venereology (ÖGDV), the German Academy of Allergology and Environmental Medicine (DAAU), and the German Documentation Center for Severe Skin Reactions (dZh).
Brockow K, Wurpts G, Trautmann A, Pfützner W, Treudler R, Bircher AJ, Brehler R, Buhl T, Dickel H, Fuchs T, Jakob T, Kurz J, Kreft B, Lange L, Merk HF, Mockenhaupt M, Mülleneisen N, Ott H, Ring J, Ruëff F, Sachs B, Sitter H, Wedi B, Wöhrl S, Worm M, Zuberbier T. Brockow K, et al. Allergol Select. 2023 Aug 9;7:122-139. doi: 10.5414/ALX02422E. eCollection 2023. Allergol Select. 2023. PMID: 37705676 Free PMC article.
Safety of Intravenous Heparin for Cardiac Surgery in Patients With Alpha-Gal Syndrome.
Hawkins RB, Wilson JM, Mehaffey JH, Platts-Mills TAE, Ailawadi G. Hawkins RB, et al. Ann Thorac Surg. 2021 Jun;111(6):1991-1997. doi: 10.1016/j.athoracsur.2020.07.050. Epub 2020 Oct 5. Ann Thorac Surg. 2021. PMID: 33031779 Free PMC article.
As heparin is porcine-derived, we hypothesized that patients with alpha-gal syndrome who received high-dose heparin for cardiac surgery would have increased risk of anaphylaxis. ...Higher preoperative alpha-gal titers may confer a …
As heparin is porcine-derived, we hypothesized that patients with alpha-gal syndrome who received high-dose heparin …
Perioperative implications of patients with alpha gal allergies.
Nourian MM, Stone CA Jr, Siegrist KK, Riess ML. Nourian MM, et al. J Clin Anesth. 2023 Jun;86:111056. doi: 10.1016/j.jclinane.2023.111056. Epub 2023 Jan 20. J Clin Anesth. 2023. PMID: 36682226 Free PMC article. Review.
Alpha Gal Syndrome (AGS) is an emerging immune response to mammalian products (MP) containing the oligosaccharide galactose-alpha-1,3 galactose (alpha-Gal) which includes meats and inactive ingredients in certain medications. This becomes clinically im …
Alpha Gal Syndrome (AGS) is an emerging immune response to mammalian products (MP) containing the oligosaccharide galactose-al …
Alpha-Gal Syndrome: A Review for the General Internist.
Peterson CJ, Mohankumar P, Tarbox JA, Nugent K. Peterson CJ, et al. Am J Med Sci. 2025 Mar;369(3):313-320. doi: 10.1016/j.amjms.2024.11.015. Epub 2024 Nov 28. Am J Med Sci. 2025. PMID: 39615839 Review.
Alpha-gal syndrome develops in some individuals who have had tick bites which result in IgE responses to alpha-gal, a carbohydrate not found in humans. Patients with alpha-gal syndrome develop symptoms when they ingest mammalian meat, whi …
Alpha-gal syndrome develops in some individuals who have had tick bites which result in IgE responses to alpha-gal …
The Alpha-Gal Syndrome and Hypersensitivity to Biomaterials: Understanding Xenoimmunity.
Sami N, Parikh MA, Mihatov N, Frishman WH, Peterson SJ. Sami N, et al. Cardiol Rev. 2026 Feb 18. doi: 10.1097/CRD.0000000000001200. Online ahead of print. Cardiol Rev. 2026. PMID: 41703677
Patients face risk when exposed to porcine heparin, gelatin-based hemostatic agents, or bioprosthetic heart valves, with reactions ranging from delayed urticaria to immediate anaphylaxis. ...Cardiovascular hypersensitivity extends beyond alpha-gal synd …
Patients face risk when exposed to porcine heparin, gelatin-based hemostatic agents, or bioprosthetic heart valves, with reactions ra …
Alpha-Gal Syndrome Managed With Omalizumab for Perioperative Optimization of Total Hip Arthroplasty: A Case Report.
Kohli-Pamnani A, Rodenas M, Duah BA, Ansah-Twum J, Blessing M, Mansour E. Kohli-Pamnani A, et al. JBJS Case Connect. 2026 Mar 5;16(1). doi: 10.2106/JBJS.CC.25.00691. eCollection 2026 Jan 1. JBJS Case Connect. 2026. PMID: 41785334
CASE: A 65-year-old woman with alpha-gal syndrome (AGS) required total hip arthroplasty. Laboratories revealed galactose-alpha-1,3-galactose immunoglobulin E 0.4 kU/L (abnormal 0.1 kU/L). ...She tolerated hip arthroplasty without perioperative anaphylaxis o …
CASE: A 65-year-old woman with alpha-gal syndrome (AGS) required total hip arthroplasty. Laboratories revealed galactose-alpha …
Intraoperative Anaphylaxis in the Setting of Undiagnosed Alpha-Gal Syndrome: A Heart Team Clinical Conundrum.
Henderson JJ, Saleem D, George E, Still S. Henderson JJ, et al. JACC Case Rep. 2026 Jan 7;31(1):106033. doi: 10.1016/j.jaccas.2025.106033. Epub 2025 Nov 8. JACC Case Rep. 2026. PMID: 41504355 Free PMC article.
BACKGROUND: Alpha-gal syndrome (AGS) is a delayed allergic reaction to galactose-alpha-1,3-galactose, a carbohydrate in nonprimate mammalian tissue. ...DISCUSSION AND TAKE-HOME MESSAGES: In addition to anaphylaxis, AGS may also have long-term cardiovascular e …
BACKGROUND: Alpha-gal syndrome (AGS) is a delayed allergic reaction to galactose-alpha-1,3-galactose, a carbohydrate in nonpri …