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The delaying effect of alpha-glycerophosphocholine on senescence, transthyretin deposition, and osteoarthritis in senescence-accelerated mouse prone 8 mice.
Matsubara K, Okuda M, Shibata S, Miyaki S, Ohkubo T, Izu H, Fujii T. Matsubara K, et al. Biosci Biotechnol Biochem. 2018 Apr;82(4):647-653. doi: 10.1080/09168451.2017.1403883. Epub 2017 Dec 1. Biosci Biotechnol Biochem. 2018. PMID: 29191088
Administration of alpha-glycerophosphocholine (GPC), a choline compound in food, is expected to contribute to human health. In this study, we evaluated its effect on aging in senescence-accelerated mouse prone 8 (SAMP8) mice. ...
Administration of alpha-glycerophosphocholine (GPC), a choline compound in food, is expected to contribute to human health. In …
Anti-diabetic effect of S-adenosylmethionine and α-glycerophosphocholine in KK-A(y) mice.
Izu H, Okuda M, Shibata S, Fujii T, Matsubara K. Izu H, et al. Biosci Biotechnol Biochem. 2019 Apr;83(4):747-750. doi: 10.1080/09168451.2018.1559721. Epub 2018 Dec 22. Biosci Biotechnol Biochem. 2019. PMID: 30582404
Six-week-old male KK-A(y) mice received drinking water with S-adenosylmethionine (SAM), α-glycerophosphocholine (GPC), or SAM+GPC for 10 weeks. ...Abbreviations: SAM: S-adenosylmethionine; GPC: α-glycerophosphocholine....
Six-week-old male KK-A(y) mice received drinking water with S-adenosylmethionine (SAM), α-glycerophosphocholine (GPC), or SAM+GPC for …
L-alpha-glycerophosphocholine contributes to meat's enhancement of nonheme iron absorption.
Armah CN, Sharp P, Mellon FA, Pariagh S, Lund EK, Dainty JR, Teucher B, Fairweather-Tait SJ. Armah CN, et al. J Nutr. 2008 May;138(5):873-7. doi: 10.1093/jn/138.5.873. J Nutr. 2008. PMID: 18424594 Clinical Trial.
Tandem mass spectrometry was used to identify the compound as L-alpha-glycerophosphocholine (L-alpha) by comparing the spectra against authentic material. ...Nonheme iron absorption from lasagna was increased by the addition of either ascorbic acid (P = 0.010 …
Tandem mass spectrometry was used to identify the compound as L-alpha-glycerophosphocholine (L-alpha) by comparing the …
Choline and choline-related nutrients in regular and preterm infant growth.
Bernhard W, Poets CF, Franz AR. Bernhard W, et al. Eur J Nutr. 2019 Apr;58(3):931-945. doi: 10.1007/s00394-018-1834-7. Epub 2018 Oct 8. Eur J Nutr. 2019. PMID: 30298207 Review.
Supply via breast milk, with phosphocholine and α-glycerophosphocholine as its major choline components, does not prevent such postnatal decrease. ...
Supply via breast milk, with phosphocholine and α-glycerophosphocholine as its major choline components, does not prevent such postna …
alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks. An Italian multicenter clinical trial.
Barbagallo Sangiorgi G, Barbagallo M, Giordano M, Meli M, Panzarasa R. Barbagallo Sangiorgi G, et al. Ann N Y Acad Sci. 1994 Jun 30;717:253-69. doi: 10.1111/j.1749-6632.1994.tb12095.x. Ann N Y Acad Sci. 1994. PMID: 8030842 Clinical Trial.
The clinical efficacy and the tolerability of alpha-glycerophosphocholine (alpha-GPC), a drug able to provide high levels of choline for the nervous cells of the brain and to protect their cell walls, have been tested in a clinical open multicenter trial on 2 …
The clinical efficacy and the tolerability of alpha-glycerophosphocholine (alpha-GPC), a drug able to provide high leve …
Plasma Metabolites From Choline Pathway and Risk of Cardiovascular Disease in the PREDIMED (Prevention With Mediterranean Diet) Study.
Guasch-Ferré M, Hu FB, Ruiz-Canela M, Bulló M, Toledo E, Wang DD, Corella D, Gómez-Gracia E, Fiol M, Estruch R, Lapetra J, Fitó M, Arós F, Serra-Majem L, Ros E, Dennis C, Liang L, Clish CB, Martínez-González MA, Salas-Salvadó J. Guasch-Ferré M, et al. J Am Heart Assoc. 2017 Oct 28;6(11):e006524. doi: 10.1161/JAHA.117.006524. J Am Heart Assoc. 2017. PMID: 29080862 Free PMC article. Clinical Trial.
We used liquid chromatography-tandem mass spectrometry to measure, at baseline and at 1 year of follow-up, plasma concentrations of 5 metabolites in the choline pathway: trimethylamine N-oxide, betaine, choline, phosphocholine, and α-glycerophosphocholine. ...The multivari …
We used liquid chromatography-tandem mass spectrometry to measure, at baseline and at 1 year of follow-up, plasma concentrations of 5 metabo …
Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults.
Kawamura T, Okubo T, Sato K, Fujita S, Goto K, Hamaoka T, Iemitsu M. Kawamura T, et al. Nutrition. 2012 Nov-Dec;28(11-12):1122-6. doi: 10.1016/j.nut.2012.02.011. Epub 2012 Jun 5. Nutrition. 2012. PMID: 22673596 Clinical Trial.
OBJECTIVE: α-Glycerophosphocholine (GPC) is a putative acetylcholine precursor that potentially increases growth hormone secretion through the action of acetylcholine-stimulated catecholamine. ...
OBJECTIVE: α-Glycerophosphocholine (GPC) is a putative acetylcholine precursor that potentially increases growth hormone secretion th …
Plasma trimethylamine-N-oxide and related metabolites are associated with type 2 diabetes risk in the Prevención con Dieta Mediterránea (PREDIMED) trial.
Papandreou C, Bulló M, Zheng Y, Ruiz-Canela M, Yu E, Guasch-Ferré M, Toledo E, Clish C, Corella D, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Lapetra J, Serra-Majem L, Gómez-Gracia E, Liang L, Fragkiadakis GA, Razquin C, Hu FB, Salas-Salvadó J. Papandreou C, et al. Am J Clin Nutr. 2018 Jul 1;108(1):163-173. doi: 10.1093/ajcn/nqy058. Am J Clin Nutr. 2018. PMID: 29982310 Free PMC article.
We used liquid chromatography-tandem mass spectrometry to measure plasma TMAO, l-carnitine, betaine, lyso-phosphatidylcholine (LPC) and lyso-phosphatidylethanolamine (LPE) species, phosphocholine, α-glycerophosphocholine, and choline at baseline and after 1 y. ...RESULTS: …
We used liquid chromatography-tandem mass spectrometry to measure plasma TMAO, l-carnitine, betaine, lyso-phosphatidylcholine (LPC) and lyso …
An effective method for the determination of the enantio-purity of L-α-glycerophosphocholine (L-α-GPC).
de Ferra L, Massa A, Di Mola A, Diehl B. de Ferra L, et al. J Pharm Biomed Anal. 2020 May 10;183:113152. doi: 10.1016/j.jpba.2020.113152. Epub 2020 Feb 8. J Pharm Biomed Anal. 2020. PMID: 32088520
Herein we describe for the first time a practical analytical method for determining the enantio-purity of L-α-glycerophosphocholine (L-α-GPC) by chiral derivatization. ...
Herein we describe for the first time a practical analytical method for determining the enantio-purity of L-α-glycerophosphocholine ( …
Acute ingestion of neuromuscular enhancement supplements do not improve power output, work capacity, and cognition.
Bunn JA, Crossley A, Timiney MD. Bunn JA, et al. J Sports Med Phys Fitness. 2018 Jul-Aug;58(7-8):974-979. doi: 10.23736/S0022-4707.17.07022-0. Epub 2017 Feb 21. J Sports Med Phys Fitness. 2018. PMID: 28222577 Clinical Trial.
METHODS: Twenty college-aged trained males (21.2±1.4 years, 181.2±6.1 cm, 94.4±20.5 kg, and 15.9±6.6% body fat) received the supplements (SUPP: 500 mg alpha glycerophosphocholine [AGPC], 250 mg uridine-5'-monophosphate, and 1500 mg DHA) or a placebo (PLA) in a rando …
METHODS: Twenty college-aged trained males (21.2±1.4 years, 181.2±6.1 cm, 94.4±20.5 kg, and 15.9±6.6% body fat) received the supplements (SU …
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