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Year Number of Results
1971 1
1972 6
1973 5
1974 16
1975 65
1976 48
1977 54
1978 68
1979 60
1980 80
1981 82
1982 80
1983 95
1984 94
1985 86
1986 103
1987 97
1988 93
1989 116
1990 120
1991 106
1992 147
1993 162
1994 161
1995 170
1996 155
1997 191
1998 202
1999 218
2000 235
2001 216
2002 257
2003 260
2004 303
2005 317
2006 320
2007 348
2008 392
2009 400
2010 417
2011 400
2012 442
2013 447
2014 474
2015 456
2016 447
2017 439
2018 433
2019 466
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2021 448
2022 383
2023 356
2024 330
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2026 240

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11,891 results

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Page 1
alpha-tubulin detyrosination fine-tunes kinetochore-microtubule attachments.
Girão H, Macário-Monteiro J, Figueiredo AC, Silva E Sousa R, Doria E, Demidov V, Osório H, Jacome A, Meraldi P, Grishchuk EL, Maiato H. Girão H, et al. Nat Commun. 2024 Nov 9;15(1):9720. doi: 10.1038/s41467-024-54155-8. Nat Commun. 2024. PMID: 39521805 Free PMC article.
Post-translational cycles of alpha-tubulin detyrosination and tyrosination generate microtubule diversity, the cellular functions of which remain largely unknown. ...Remarkably, detyrosinated alpha-tubulin levels near kinetochore microtubule plus-ends …
Post-translational cycles of alpha-tubulin detyrosination and tyrosination generate microtubule diversity, the cellular functi …
Structural basis for alpha-tubulin-specific and modification state-dependent glutamylation.
Mahalingan KK, Grotjahn DA, Li Y, Lander GC, Zehr EA, Roll-Mecak A. Mahalingan KK, et al. Nat Chem Biol. 2024 Nov;20(11):1493-1504. doi: 10.1038/s41589-024-01599-0. Epub 2024 Apr 24. Nat Chem Biol. 2024. PMID: 38658656 Free PMC article.
Microtubules have spatiotemporally complex posttranslational modification patterns. Tubulin tyrosine ligase-like (TTLL) enzymes introduce the most prevalent modifications on alpha-tubulin and beta-tubulin. ...By binding to a beta-tubulin …
Microtubules have spatiotemporally complex posttranslational modification patterns. Tubulin tyrosine ligase-like (TTLL) enzymes intro …
A tubulin-binding protein that preferentially binds to GDP-tubulin and promotes GTP exchange.
Yon WJ, Ha T, Zheng Y, Pedersen RTA. Yon WJ, et al. J Biol Chem. 2025 Aug;301(8):110401. doi: 10.1016/j.jbc.2025.110401. Epub 2025 Jun 19. J Biol Chem. 2025. PMID: 40543590 Free PMC article.
In the dimer, alpha-tubulin is constitutively bound to GTP, while beta-tubulin can bind to either GDP (GDP-tubulin) or GTP (GTP-tubulin). ...Here, we use quantitative binding assays to show that BuGZ, a spindle assembly factor, binds …
In the dimer, alpha-tubulin is constitutively bound to GTP, while beta-tubulin can bind to either GDP (GDP-tubulin …
Cryo-EM structures of the tubulin cofactors reveal the molecular basis of alpha/beta-tubulin biogenesis.
Taheri A, Wang Z, Singal B, Guo F, Al-Bassam J. Taheri A, et al. Nat Commun. 2025 Dec 29;17(1):1405. doi: 10.1038/s41467-025-68142-0. Nat Commun. 2025. PMID: 41461644 Free PMC article.
The TBC-DEG-alphabeta-tubulin structures show that TBC-DEG wraps around beta-tubulin while TBCE extends along alpha-tubulin. ...TBCC engages the GTP-bound Arl2, multiple sites of TBCD, and the native alphabeta-tubulin intradimer interface near t …
The TBC-DEG-alphabeta-tubulin structures show that TBC-DEG wraps around beta-tubulin while TBCE extends along alpha- …
The Game of Tubulins.
Kristensson MA. Kristensson MA. Cells. 2021 Mar 28;10(4):745. doi: 10.3390/cells10040745. Cells. 2021. PMID: 33800665 Free PMC article. Review.
Members of the tubulin superfamily are GTPases; the activities of GTPases are necessary for life. The members of the tubulin superfamily are the constituents of the microtubules and the gamma-tubulin meshwork. ...The intricate functions (game) of tubulins dep …
Members of the tubulin superfamily are GTPases; the activities of GTPases are necessary for life. The members of the tubulin s …
Molecular basis of Toxoplasma gondii oryzalin resistance from a novel alpha-tubulin binding site model.
Flores-León CD, Dominguez L, Aguayo-Ortiz R. Flores-León CD, et al. Arch Biochem Biophys. 2022 Nov 15;730:109398. doi: 10.1016/j.abb.2022.109398. Epub 2022 Sep 15. Arch Biochem Biophys. 2022. PMID: 36116504
Oryzalin (ORY) is a dinitroaniline derivative that inhibits the microtubule polymerization in plants and parasitic protozoa by selectively binding to the alpha-tubulin subunit. This herbicidal agent exhibits good antiprotozoal activity against major human par …
Oryzalin (ORY) is a dinitroaniline derivative that inhibits the microtubule polymerization in plants and parasitic protozoa by selectively …
Localization of the ATP binding site on alpha-tubulin.
Zabrecky JR, Cole RD. Zabrecky JR, et al. Arch Biochem Biophys. 1983 Sep;225(2):475-81. doi: 10.1016/0003-9861(83)90056-5. Arch Biochem Biophys. 1983. PMID: 6688710
The binding site for ATP to tubulin was established by use of the photoaffinity label [gamma-32P]N3ATP. ...Radioactivity was found predominantly in one peptide band from the alpha subunit. The location of the [gamma-32P]N3ATP binding site on the alp …
The binding site for ATP to tubulin was established by use of the photoaffinity label [gamma-32P]N3ATP. ...Radioactivity was f …
Podophyllotoxin derivatives-tubulin complex reveals a potential binding site of tubulin polymerization inhibitors in alpha-tubulin adjacent to colchicine site.
Zhao W, Shen R, Li HM, Zhong JJ, Tang YJ. Zhao W, et al. Int J Biol Macromol. 2024 Sep;276(Pt 1):133678. doi: 10.1016/j.ijbiomac.2024.133678. Epub 2024 Jul 4. Int J Biol Macromol. 2024. PMID: 38971286
Recent studies implied that GTP pocket of alpha-tubulin adjacent to colchicine sites is a potential binding site for developing tubulin polymerization inhibitors. ...This work provided a structural basis of the potential binding sites for extend …
Recent studies implied that GTP pocket of alpha-tubulin adjacent to colchicine sites is a potential binding site for de …
Identification of alpha-tubulin as an hsp105alpha-binding protein by the yeast two-hybrid system.
Saito Y, Yamagishi N, Ishihara K, Hatayama T. Saito Y, et al. Exp Cell Res. 2003 Jun 10;286(2):233-40. doi: 10.1016/s0014-4827(03)00054-5. Exp Cell Res. 2003. PMID: 12749852
Hsp105alpha prevents stress-induced apoptosis in neuronal cells and binds to Hsp70/Hsc70 and suppresses the Hsp70 chaperone activity in vitro. In this study, to further elucidate the function of Hsp105alpha, we searched for Hsp105alpha-binding proteins by screening …
Hsp105alpha prevents stress-induced apoptosis in neuronal cells and binds to Hsp70/Hsc70 and suppresses the Hsp70 chaperone activity …
Sulforaphane-cysteine inhibits alpha-tubulin/PD-L1/PFKFB4 axis leading to apoptosis in human glioblastoma.
Li J, Wu D, Zhang S, Wu Y, Bi X, Zhou Y, Wu W. Li J, et al. Med Oncol. 2025 Jul 14;42(8):333. doi: 10.1007/s12032-025-02901-3. Med Oncol. 2025. PMID: 40659958
PD-L1 expression was downregulated after knockdown of alpha-tubulin. SFN-Cys promoted 26S proteasome-mediated degradation of alpha-tubulin and PD-L1, and reduced the binding of alpha-tubulin to PD-L1 causing apoptosis. ...Therefore …
PD-L1 expression was downregulated after knockdown of alpha-tubulin. SFN-Cys promoted 26S proteasome-mediated degradation of …
11,891 results
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