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125 results

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Page 1
B cell-derived acetylcholine promotes liver regeneration by regulating Kupffer cell and hepatic CD8(+) T cell function.
Modares NF, Hendrikse LD, Smith LK, Paul MS, Haight J, Luo P, Liu S, Fortin J, Tong FK, Wakeham AC, Jafari SM, Zheng C, Buckland M, Flick R, Silvester J, Berger T, Ketela T, Helke S, Foffi E, Niavarani R, Mcwilliam R, Saunders ME, Colonna I, David BA, Rastogi T, Lee WY, Kubes P, Mak TW. Modares NF, et al. Immunity. 2025 May 13;58(5):1201-1216.e7. doi: 10.1016/j.immuni.2025.04.002. Epub 2025 Apr 25. Immunity. 2025. PMID: 40286791 Free article.
Kupffer cells and hepatic CD8(+) T cells expressed the alpha7 nicotinic ACh receptor (nAChR), and LR was disrupted in mice lacking alpha7 nAChR. Mechanistically, B cell-derived ACh signaled through alpha7 nAChR to positively regulate the function of re …
Kupffer cells and hepatic CD8(+) T cells expressed the alpha7 nicotinic ACh receptor (nAChR), and LR was disrupted in mice lac …
Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit.
Rosas-Ballina M, Olofsson PS, Ochani M, Valdés-Ferrer SI, Levine YA, Reardon C, Tusche MW, Pavlov VA, Andersson U, Chavan S, Mak TW, Tracey KJ. Rosas-Ballina M, et al. Science. 2011 Oct 7;334(6052):98-101. doi: 10.1126/science.1209985. Epub 2011 Sep 15. Science. 2011. PMID: 21921156 Free PMC article.
A prototypical vagus nerve circuit, the inflammatory reflex, inhibits tumor necrosis factor-alpha production in spleen by a mechanism requiring acetylcholine signaling through the alpha7 nicotinic acetylcholine receptor expressed on cytokine-producing macrophages. N …
A prototypical vagus nerve circuit, the inflammatory reflex, inhibits tumor necrosis factor-alpha production in spleen by a mechanism requir …
Minireview: Divergent roles of alpha7 nicotinic acetylcholine receptors expressed on antigen-presenting cells and CD4(+) T cells in the regulation of T cell differentiation.
Mashimo M, Fujii T, Ono S, Moriwaki Y, Misawa H, Kawashima K. Mashimo M, et al. Int Immunopharmacol. 2020 May;82:106306. doi: 10.1016/j.intimp.2020.106306. Epub 2020 Feb 18. Int Immunopharmacol. 2020. PMID: 32086096 Review.
Using spleen cells from ovalbumin (OVA)-specific T cell receptor transgenic DO11.10 mice and the alpha7 nAChR agonist GTS-21, investigation of (1) antigen processing-dependent and (2) -independent, antigen presenting cell (APC)-dependent, naive CD4(+) T …
Using spleen cells from ovalbumin (OVA)-specific T cell receptor transgenic DO11.10 mice and the alpha7 nAChR agonist G …
[Dual Roles of alpha7 Nicotinic Acetylcholine Receptors Expressed in Immune Cells in T Cell Differentiation -alpha7 nAChRs Exert Different Actions between Antigen-presenting Cells and CD4(+) T Cells].
Mashimo M. Mashimo M. Yakugaku Zasshi. 2020;140(12):1421-1425. doi: 10.1248/yakushi.20-00151. Yakugaku Zasshi. 2020. PMID: 33268683 Free article. Review. Japanese.
The cholinergic system which these components comprise has important effects on the regulation of immune and inflammatory responses. alpha7 nAChR is a neuronal-type nAChR composed of a homopentamer of the alpha7 subunit and is characterized by high permeability to C …
The cholinergic system which these components comprise has important effects on the regulation of immune and inflammatory responses. alph …
Vagal Stimulation Rescues HFpEF by Altering Cardiac Resident Macrophage Function.
Venkatesan T, Toumpourleka M, Niewiadomska M, Farhat K, Morris L, Elkholey K, Maryam B, Cordova A, Darby IG, Whyte S, Miller SJ, Yashchenko A, Anguiano AC, Gipson J, Reel JM, Cox MA, Zimmerman KA, Stavrakis S. Venkatesan T, et al. Circ Res. 2025 Aug 15;137(5):664-681. doi: 10.1161/CIRCRESAHA.125.326236. Epub 2025 Jul 15. Circ Res. 2025. PMID: 40662221
Furthermore, treatment with tVNS reduced the number of CCR2(+) CRM and the expression of Spp1 while also inducing the expression of Igf1 in TLF(+) (Timd4(+) [T-cell immunoglobulin and mucin domain containing 4(+)]/Lyve1(+) [Lymphatic vessel endothelial hyaluronan re …
Furthermore, treatment with tVNS reduced the number of CCR2(+) CRM and the expression of Spp1 while also inducing the expression of Igf1 in …
Unprecedented effect of vitamin D3 on T-cell receptor beta subunit and alpha7 nicotinic acetylcholine receptor expression in a 3-nitropropionic acid induced mouse model of Huntington's disease.
Manjari S, Abraham SM, Poornima R, Chaturvedi RK, Maity S, Komal P. Manjari S, et al. IBRO Neurosci Rep. 2023 Jul 14;15:116-125. doi: 10.1016/j.ibneur.2023.07.001. eCollection 2023 Dec. IBRO Neurosci Rep. 2023. PMID: 38204575 Free PMC article.
However, it remains unclear whether, under such a neurotoxic condition, characterized by neuroinflammation and oxidative stress, the gene expression of the immune resident protein, T-cell receptor beta subunit (TCR-beta), alpha7 nicotinic acetylcholine …
However, it remains unclear whether, under such a neurotoxic condition, characterized by neuroinflammation and oxidative stress, the gene ex …
T-cell receptor activation decreases excitability of cortical interneurons by inhibiting alpha7 nicotinic receptors.
Komal P, Gudavicius G, Nelson CJ, Nashmi R. Komal P, et al. J Neurosci. 2014 Jan 1;34(1):22-35. doi: 10.1523/JNEUROSCI.2093-13.2014. J Neurosci. 2014. PMID: 24381265 Free PMC article.
Many proteins in the immune system are also expressed in the brain. One such class of immune proteins are T-cell receptors (TCRs), whose functions in T lymphocytes in adaptive immunity are well characterized. ...In mouse layer 1 neocortical neurons, TC …
Many proteins in the immune system are also expressed in the brain. One such class of immune proteins are T-cell receptors (TC …
Alpha7 nicotinic acetylcholine receptor participates in the effect of dexmedetomidine on Treg cell differentiation.
Wang Y, Yang X, Kong X, Gong H, Lei Y, Ji F. Wang Y, et al. Immunopharmacol Immunotoxicol. 2026 Apr;48(2):282-291. doi: 10.1080/08923973.2026.2640188. Epub 2026 Mar 11. Immunopharmacol Immunotoxicol. 2026. PMID: 41787693
BACKGROUND: The anti-inflammatory effect of dexmedetomidine can be mediated through alpha7 nicotinic acetylcholine receptor (alpha7nAChR). However, it remains unknown whether alpha7nAChR is involved in mediating the effects of dexmedetomidine on CD4(+)T ce …
BACKGROUND: The anti-inflammatory effect of dexmedetomidine can be mediated through alpha7 nicotinic acetylcholine receptor (a …
Contributions of Non-Neuronal Cholinergic Systems to the Regulation of Immune Cell Function, Highlighting the Role of alpha7 Nicotinic Acetylcholine Receptors.
Kawashima K, Mashimo M, Nomura A, Fujii T. Kawashima K, et al. Int J Mol Sci. 2024 Apr 22;25(8):4564. doi: 10.3390/ijms25084564. Int J Mol Sci. 2024. PMID: 38674149 Free PMC article. Review.
A current focus of much research on non-neuronal cholinergic systems in immune cells is alpha7 nAChRs, as these receptors expressed on macrophages and T cells are involved in regulating inflammatory and immune responses. This makes alpha7 nAChRs an attractive potent …
A current focus of much research on non-neuronal cholinergic systems in immune cells is alpha7 nAChRs, as these receptors expressed o …
Activation of alpha7 nicotinic acetylcholine receptor promotes HIV-1 transcription.
Wen J, Zhao C, Chen J, Song S, Lin Z, Xie S, Qi H, Wang J, Su X. Wen J, et al. Cell Insight. 2022 Apr 27;1(3):100028. doi: 10.1016/j.cellin.2022.100028. eCollection 2022 Jun. Cell Insight. 2022. PMID: 37193048 Free PMC article.
Alpha7 nicotinic acetylcholine receptor (alpha7 nAChR), a hub of the cholinergic anti-inflammatory pathway (CAP), is required for the treatment of inflammatory diseases. HIV-1 infection can upregulate the expression of alpha7 nAChR in T lymph …
Alpha7 nicotinic acetylcholine receptor (alpha7 nAChR), a hub of the cholinergic anti-inflammatory pathway (CAP), is re …
125 results