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Page 1
Role of alpha7 nicotinic receptor in the immune system and intracellular signaling pathways.
Zdanowski R, Krzyżowska M, Ujazdowska D, Lewicka A, Lewicki S. Zdanowski R, et al. Cent Eur J Immunol. 2015;40(3):373-9. doi: 10.5114/ceji.2015.54602. Epub 2015 Oct 15. Cent Eur J Immunol. 2015. PMID: 26648784 Free PMC article. Review.
In humans, this versatile molecule and its synthesizing enzyme, choline acetyltransferase, have been found in various non-neural tissues such as the epithelium, endothelium, mesothelium muscle, blood cells and immune cells. The non-neuronal acetylcholine is accompanied by …
In humans, this versatile molecule and its synthesizing enzyme, choline acetyltransferase, have been found in various non-neural tissues suc …
A new isoxazolic compound acts as alpha7 nicotinic receptor agonist in human umbilical vein endothelial cells.
Cortés MP, Alvarez R, Sepúlveda E, Jiménez-Aspee F, Astudillo L, Vallejos G, Gutiérrez M. Cortés MP, et al. Z Naturforsch C J Biosci. 2014 Jul-Aug;69(7-8):291-9. doi: 10.5560/znc.2012-0176. Z Naturforsch C J Biosci. 2014. PMID: 25265849
Recent evidence suggests that the alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs) participate in the development of angiogenesis and could be a new endothelial target for revascularization in therapeutic angiogenesis. ...In the present study w …
Recent evidence suggests that the alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs) participate in the de …
taVNS alleviates preeclampsia-induced vascular endothelial dysfunction via α7nAChR- IP3R1/GRP75/VDAC1 signal pathway.
Zhao J, Lei Y, Mu C, Wu Y, Fang R, Wu D, Xu S, Qiao H. Zhao J, et al. Inflamm Res. 2025 Sep 23;74(1):133. doi: 10.1007/s00011-025-02100-w. Inflamm Res. 2025. PMID: 40986011
In vivo, we detected blood pressure, vascular proteomics and morphology, ACh and receptor alpha7nAChR, and inflammatory factors (IL-6, IL-1beta, and TNF-alpha). In vitro, we checked cell viability, mitochondrial membrane potential, apoptosis rate, calcium levels, HUVECs mo …
In vivo, we detected blood pressure, vascular proteomics and morphology, ACh and receptor alpha7nAChR, and inflammatory factors (IL-6 …
Alpha 7-nicotinic cholinoceptor regulation of pericyte-containing retinal capillaries.
Wu K, Cheng T, Zhai Z, Jiang C, Zhou X. Wu K, et al. Br J Pharmacol. 2023 Sep;180(17):2196-2213. doi: 10.1111/bph.16067. Epub 2023 Apr 23. Br J Pharmacol. 2023. PMID: 36908011 Free article.
Pericyte relaxation and contraction are influenced by vasoactive substances and regulated by neurotransmitters. alpha7 nicotinic acetylcholine receptors (alpha7-nAChRs), involved in the regulation of vascular function and inhibitory gamma-aminobutyric …
Pericyte relaxation and contraction are influenced by vasoactive substances and regulated by neurotransmitters. alpha7 nicotinic …
The alpha7-nicotinic acetylcholine receptor and MMP-2/-9 pathway mediate the proangiogenic effect of nicotine in human retinal endothelial cells.
Dom AM, Buckley AW, Brown KC, Egleton RD, Marcelo AJ, Proper NA, Weller DE, Shah YH, Lau JK, Dasgupta P. Dom AM, et al. Invest Ophthalmol Vis Sci. 2011 Jun 22;52(7):4428-38. doi: 10.1167/iovs.10-5461. Invest Ophthalmol Vis Sci. 2011. PMID: 20554619 Free PMC article.
METHODS: Western blot analysis was performed to determine the nicotinic acetylcholine receptor (nAChR) subtypes expressed on primary human retinal microvascular endothelial cells (HRMECs). ...CONCLUSIONS: The alpha7-nAChR is vital for the proangiogenic activi …
METHODS: Western blot analysis was performed to determine the nicotinic acetylcholine receptor (nAChR) subtypes expressed on p …
Non-neuronal nicotinic alpha 7 receptor, a new endothelial target for revascularization.
Li XW, Wang H. Li XW, et al. Life Sci. 2006 Mar 13;78(16):1863-70. doi: 10.1016/j.lfs.2005.08.031. Epub 2005 Nov 8. Life Sci. 2006. PMID: 16280133
Alpha 7 nicotinic acetylcholine receptor (alpha7 nAChR) is widely expressed in the central and peripheral nervous systems, and is also found in several non-neuronal tissues, such as endothelial cells (ECs), bronchial epithelial cells, skin keratinocytes and v …
Alpha 7 nicotinic acetylcholine receptor (alpha7 nAChR) is widely expressed in the central and peripheral nervous syste …
Nicotinic acetylcholine receptor alpha7 subunit is time-dependently expressed in distinct cell types during skin wound healing in mice.
Fan YY, Yu TS, Wang T, Liu WW, Zhao R, Zhang ST, Ma WX, Zheng JL, Guan DW. Fan YY, et al. Histochem Cell Biol. 2011 Apr;135(4):375-87. doi: 10.1007/s00418-011-0798-y. Epub 2011 Mar 10. Histochem Cell Biol. 2011. PMID: 21437621
Recent studies have shown that nicotinic acetylcholine receptor alpha7 subunit (nAChRalpha7) plays an important role in regulation of inflammation, angiogenesis and keratinocyte biology, but little is known about its expression after the skin is wounded. ...I …
Recent studies have shown that nicotinic acetylcholine receptor alpha7 subunit (nAChRalpha7) plays an important role in …
Activation of nicotinic receptors can contribute to endothelium-dependent relaxations to acetylcholine in the rat aorta.
Zou Q, Leung SW, Vanhoutte PM. Zou Q, et al. J Pharmacol Exp Ther. 2012 Jun;341(3):756-63. doi: 10.1124/jpet.112.192229. Epub 2012 Mar 16. J Pharmacol Exp Ther. 2012. PMID: 22427701
Acetylcholine causes endothelium-dependent relaxations in the rat aorta. Both muscarinic acetylcholine receptors (mAChRs) and nicotinic acetylcholine receptors (nAChRs) are expressed in endothelial cells. ...Thus, when mAChRs are inhibited, nAChRs medi …
Acetylcholine causes endothelium-dependent relaxations in the rat aorta. Both muscarinic acetylcholine receptors (mAChRs) and …
Alpha7-nicotinic acetylcholine receptors on cerebral perivascular sympathetic nerves mediate choline-induced nitrergic neurogenic vasodilation.
Si ML, Lee TJ. Si ML, et al. Circ Res. 2002 Jul 12;91(1):62-9. doi: 10.1161/01.res.0000024417.79275.23. Circ Res. 2002. PMID: 12114323 Free article.
It has been suggested in isolated porcine cerebral arteries that stimulation by nicotine of alpha7-nicotinic acetylcholine receptors (alpha7-nAChRs) on sympathetic nerves, but not direct stimulation of parasympathetic nitrergic nerves, caused nitrergic …
It has been suggested in isolated porcine cerebral arteries that stimulation by nicotine of alpha7-nicotinic acetylcholine …
Methyl palmitate modulates the nicotine-induced increase in basilar arterial blood flow.
Chun-Kai H, Hsi-Hsien C, Shang-Jen C, Shei-Dei Stephen Y, Kuo-Feng H. Chun-Kai H, et al. Microcirculation. 2021 May;28(4):e12686. doi: 10.1111/micc.12686. Epub 2021 Mar 1. Microcirculation. 2021. PMID: 33595915
The choline (a selective alpha7-nicotinic acetylcholine receptor agonist)-induced increase in BABF was abolished by tetrodotoxin (a neurotoxin), N(G) -nitro-L-arginine (a nonselective NO synthase inhibitor), alpha-bungarotoxin (a selective alpha7-ni …
The choline (a selective alpha7-nicotinic acetylcholine receptor agonist)-induced increase in BABF was abolished by tet …
51 results