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Showing results for alphahl c
Your search for alphadol-c retrieved no results
Arresting and releasing Staphylococcal alpha-hemolysin at intermediate stages of pore formation by engineered disulfide bonds.
Kawate T, Gouaux E. Kawate T, et al. Protein Sci. 2003 May;12(5):997-1006. doi: 10.1110/ps.0231203. Protein Sci. 2003. PMID: 12717022 Free PMC article.
To accomplish this, we created four double cysteine mutants, D108C/K154C (alphaHL-A), M113C/K147C (alphaHL-B), H48C/ N121C (alphaHL-C), I5C/G130C (alphaHL-D), in which disulfide bonds may form between the pre-stem domain and the beta-sandwich do …
To accomplish this, we created four double cysteine mutants, D108C/K154C (alphaHL-A), M113C/K147C (alphaHL-B), H48C/ N121C ( …
Ion Mobility-Mass Spectrometry Reveals That α-Hemolysin from Staphylococcus aureus Simultaneously Forms Hexameric and Heptameric Complexes in Detergent Micelle Solutions.
Wilson JW, Rolland AD, Klausen GM, Prell JS. Wilson JW, et al. Anal Chem. 2019 Aug 6;91(15):10204-10211. doi: 10.1021/acs.analchem.9b02243. Epub 2019 Jul 18. Anal Chem. 2019. PMID: 31282652 Free PMC article.
The stable pore structure of alphaHL has also been exploited in vitro as a nanopore tool. Early structural experiments suggested alphaHL forms a hexameric pore, while more recent X-ray crystal structure and solution studies have identified a heptameric pore structur …
The stable pore structure of alphaHL has also been exploited in vitro as a nanopore tool. Early structural experiments suggested a
Nucleobase Recognition by Truncated α-Hemolysin Pores.
Ayub M, Stoddart D, Bayley H. Ayub M, et al. ACS Nano. 2015 Aug 25;9(8):7895-903. doi: 10.1021/nn5060317. Epub 2015 Jul 28. ACS Nano. 2015. PMID: 26114210 Free PMC article.
The alpha-hemolysin (alphaHL) protein nanopore has been investigated previously as a base detector for the strand sequencing of DNA and RNA. ...New work has also shown that truncated-barrel mutants (TBM) of alphaHL form functional pores in lipid bilayers. Therefore, …
The alpha-hemolysin (alphaHL) protein nanopore has been investigated previously as a base detector for the strand sequencing of DNA a …
Bacteria-based cascade in situ near-infrared nano-optogenetically induced photothermal tumor therapy.
Hu X, Chen J, Qiu Y, Chen S, Liu Y, Yu X, Liu Y, Yang X, Zhang Y, Zhu Y. Hu X, et al. Theranostics. 2024 Aug 12;14(13):4933-4947. doi: 10.7150/thno.98097. eCollection 2024. Theranostics. 2024. PMID: 39267783 Free PMC article.
Herein, we construct a bacteria-based cascade near-infrared optogentical-photothermal system (EcN(alphaHL)-UCNPs) for enhanced tumor therapy. Methods: EcN(alphaHL)-UCNPs consists of an optogenetically engineered Escherichia coli Nissle 1917 (EcN) conjugated with lan …
Herein, we construct a bacteria-based cascade near-infrared optogentical-photothermal system (EcN(alphaHL)-UCNPs) for enhanced tumor …
Recent advances in biological nanopores for nanopore sequencing, sensing and comparison of functional variations in MspA mutants.
Bhatti H, Jawed R, Ali I, Iqbal K, Han Y, Lu Z, Liu Q. Bhatti H, et al. RSC Adv. 2021 Aug 31;11(46):28996-29014. doi: 10.1039/d1ra02364k. eCollection 2021 Aug 23. RSC Adv. 2021. PMID: 35478559 Free PMC article. Review.
Additionally, high throughput and label-free detection of target analytes instigated the exploration of new bacterial channel proteins such as Fragaceatoxin C (FraC), Cytolysin A (ClyA), Ferric hydroxamate uptake component A (FhuA) and Curli specific gene G (CsgG) along wi …
Additionally, high throughput and label-free detection of target analytes instigated the exploration of new bacterial channel proteins such …
Electrostatic Control of Polymer Translocation Speed through α‑Hemolysin Protein Pore.
Jeon BJ, Muthukumar M. Jeon BJ, et al. Macromolecules. 2016 Dec 13;49(23):9132-9138. doi: 10.1021/acs.macromol.6b01663. Epub 2016 Nov 22. Macromolecules. 2016. PMID: 29706665 Free PMC article.
At both pH 4.5 and pH 7.5, decreasing the cis salt concentration, c(s,cis) , results in faster polymer translocations. On the other hand, a decrease in trans salt concentration, c(s,trans) , retards the polymer transport process at pH 4.5, while at pH 7.5 the transl …
At both pH 4.5 and pH 7.5, decreasing the cis salt concentration, c(s,cis) , results in faster polymer translocations. On the other h …
Modulation of factor VIII pharmacokinetics by genetic components in factor VIII receptors.
Lunghi B, Morfini M, Martinelli N, Branchini A, Linari S, Castaman G, Bernardi F. Lunghi B, et al. Haemophilia. 2023 Mar;29(2):479-487. doi: 10.1111/hae.14722. Epub 2022 Dec 19. Haemophilia. 2023. PMID: 36533781
RESULTS: In the initial FVIII distribution phase, the STAB2 rs4981022 AA, ASGR2 rs2289645 TT and LDLR rs688 TT genotypes may contribute to increase C(max) , and prolong or shorten AlphaHL. In the elimination phase, a shorter BetaHL was associated with the CLEC4M rs8 …
RESULTS: In the initial FVIII distribution phase, the STAB2 rs4981022 AA, ASGR2 rs2289645 TT and LDLR rs688 TT genotypes may contribute to i …
Long-term memory in Staphylococcus aureus α-hemolysin ion channel kinetics.
Silva MP, Rodrigues CG, Machado DC, Nogueira RA. Silva MP, et al. Eur Biophys J. 2023 Nov;52(8):661-671. doi: 10.1007/s00249-023-01675-8. Epub 2023 Aug 5. Eur Biophys J. 2023. PMID: 37542583
All experiments were carried out under the following conditions: 1 M NaCl solution, pH 4.5; transmembrane potential of + 40 mV and temperature 25 1 C. Single-channel currents were recorded in real-time in the memory of a microcomputer coupled to an A/D converter and a patc …
All experiments were carried out under the following conditions: 1 M NaCl solution, pH 4.5; transmembrane potential of + 40 mV and temperatu …
Single-Molecule Titration in a Protein Nanoreactor Reveals the Protonation/Deprotonation Mechanism of a C:C Mismatch in DNA.
Ren H, Cheyne CG, Fleming AM, Burrows CJ, White HS. Ren H, et al. J Am Chem Soc. 2018 Apr 18;140(15):5153-5160. doi: 10.1021/jacs.8b00593. Epub 2018 Apr 3. J Am Chem Soc. 2018. PMID: 29562130 Free PMC article.
Modulation between two states in the current-time trace for duplexes containing the C:C mismatch in proximity to the latch constriction of alpha-HL is attributed to the base flipping of the C:C mismatch. As the pH is lowered, the rate for the C: …
Modulation between two states in the current-time trace for duplexes containing the C:C mismatch in proximity to the latch con …
Differentiation of G:C vs A:T and G:C vs G:mC Base Pairs in the Latch Zone of alpha-Hemolysin.
Ding Y, Fleming AM, White HS, Burrows CJ. Ding Y, et al. ACS Nano. 2015 Nov 24;9(11):11325-32. doi: 10.1021/acsnano.5b05055. Epub 2015 Oct 27. ACS Nano. 2015. PMID: 26506108 Free PMC article.
Our laboratories previously demonstrated that trapping duplex DNA in the vestibule of wild-type alpha-HL under force could distinguish the presence of an abasic site compared to a G:C base pair positioned in the latch zone at the top of the vestibule. Herein, a series of d …
Our laboratories previously demonstrated that trapping duplex DNA in the vestibule of wild-type alpha-HL under force could distinguish the p …
31 results