Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 3
1983 2
1984 3
1985 10
1986 18
1987 21
1988 13
1989 24
1990 11
1991 31
1992 23
1993 20
1994 22
1995 23
1996 28
1997 34
1998 25
1999 26
2000 15
2001 15
2002 14
2003 15
2004 20
2005 21
2006 14
2007 11
2008 16
2009 13
2010 13
2011 14
2012 7
2013 12
2014 8
2015 13
2016 18
2017 13
2018 20
2019 6
2020 8
2021 12
2022 7
2023 2

Text availability

Article attribute

Article type

Publication date

Search Results

614 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Effect of Alprostadil on the Prevention of Contrast-Induced Nephropathy: A Meta-Analysis of 36 Randomized Controlled Trials.
Xie J, Jiang M, Lin Y, Deng H, Li L. Xie J, et al. Angiology. 2019 Aug;70(7):594-612. doi: 10.1177/0003319719825597. Epub 2019 Jan 22. Angiology. 2019. PMID: 30669852 Review.
Contrast-induced nephropathy (CIN) is the third leading cause of acquired acute renal injury in hospitalized patients. Alprostadil plays a role in the maintenance and redistribution of intrarenal blood flow and the excretion of electrolytes and water. However, the effectiv …
Contrast-induced nephropathy (CIN) is the third leading cause of acquired acute renal injury in hospitalized patients. Alprostadil pl …
Efficacy of Alprostadil in Preventing Contrast-Induced Nephropathy: A Systematic Review and Meta-Analysis.
Xu H, Wang H, Zhang C, Xiao J, Hua N, Tang X, Xie J, Zhang Z. Xu H, et al. Angiology. 2021 Oct;72(9):878-888. doi: 10.1177/00033197211004412. Epub 2021 Apr 15. Angiology. 2021. PMID: 33853365
We included 29 studies with 5623 patients. Compared with hydration, 10 g/d alprostadil or 20 g/d alprostadil plus hydration significantly decreased the incidence of CIN. ...Alprostadil plus hydration significantly decreased urine macroglobulin versus hydratio …
We included 29 studies with 5623 patients. Compared with hydration, 10 g/d alprostadil or 20 g/d alprostadil plus hydration si …
Alprostadil for hypertensive nephropathy: A systematic review and meta-analysis of randomized controlled trials.
Fu H, Hou W, Zhang Y, Hu X. Fu H, et al. PLoS One. 2022 May 26;17(5):e0269111. doi: 10.1371/journal.pone.0269111. eCollection 2022. PLoS One. 2022. PMID: 35617324 Free PMC article.
Compared to conventional treatment alone, alprostadil combined with conventional treatment can improve renal function in patients with hypertensive nephropathy more effectively. ...This is the first meta-analysis to evaluate the efficacy of alprostadil for hypertens …
Compared to conventional treatment alone, alprostadil combined with conventional treatment can improve renal function in patients wit …
The Preventive Effect of Alprostadil on the Contrast-Induced Nephropathy of Coronary Heart Disease Treated by Percutaneous Coronary Intervention in Moderate and High-Risk Population Stratified by Mehran Score.
Liu X, Zhang P, Zhang J, Zhang X, Yang S, Fu N. Liu X, et al. Angiology. 2022 Jan;73(1):33-41. doi: 10.1177/00033197211015540. Epub 2021 Jun 8. Angiology. 2022. PMID: 34098771 Clinical Trial.
Alprostadil can be used as a preventive treatment for moderate- and high-risk CIN patients classified by the MRS. The reduction of CIN by alprostadil may be related to an anti-inflammatory effect....
Alprostadil can be used as a preventive treatment for moderate- and high-risk CIN patients classified by the MRS. The reduction of CI
Alprostadil protects type 2 diabetes mellitus patients treated with metformin from contrast-induced nephropathy.
Wang J, Ai X, Li L, Gao Y, Sun N, Li C, Sun W. Wang J, et al. Int Urol Nephrol. 2017 Nov;49(11):2019-2026. doi: 10.1007/s11255-017-1639-2. Epub 2017 Jun 27. Int Urol Nephrol. 2017. PMID: 28656510 Clinical Trial.
METHODS: In this single-institution, single-blind, superiority trial, we randomly assigned 451 T2DM patients taking metformin and underwent emergency contrast-enhanced CT examination to either the alprostadil group (227 patients) receiving alprostadil or the control …
METHODS: In this single-institution, single-blind, superiority trial, we randomly assigned 451 T2DM patients taking metformin and underwent …
The effect of alprostadil on preventing contrast-induced nephropathy for percutaneous coronary intervention in diabetic patients: A systematic review and meta-analysis.
Ye Z, Lu H, Guo W, Dai W, Li H, Yang H, Li L. Ye Z, et al. Medicine (Baltimore). 2016 Nov;95(46):e5306. doi: 10.1097/MD.0000000000005306. Medicine (Baltimore). 2016. PMID: 27861357 Free PMC article. Review.
METHODS: An electronic database search was conducted in MEDLINE, Embase, Cochrane library, CBM, CNKI, VIP, and WanFang to retrieve randomized controlled trial (RCT) comparing Alprostadil versus hydration on preventing CIN for PCI in diabetic patients. ...CONCLUSION: Our re …
METHODS: An electronic database search was conducted in MEDLINE, Embase, Cochrane library, CBM, CNKI, VIP, and WanFang to retrieve randomize …
Is topical alprostadil an usable and reliable alternative to intracavernous injection for penile dynamic duplex ultrasonography?
Arcaniolo D, Bellastella G, Manfredi C, Terribile M, Giordano DR, Quattrone C, La Rocca R, De Sio M, Verze P, Mirone V. Arcaniolo D, et al. Andrologia. 2020 Mar;52(2):e13480. doi: 10.1111/and.13480. Epub 2019 Nov 11. Andrologia. 2020. PMID: 31710398 Clinical Trial.
The main aim of our study was to evaluate the usability and reliability of topical alprostadil for PDDU compared with standard intracavernous injection. ...Patients reported less pain/discomfort during the procedure in case of topical alprostadil use and an overall …
The main aim of our study was to evaluate the usability and reliability of topical alprostadil for PDDU compared with standard intrac …
Efficacy of alprostadil for preventing of contrast-induced nephropathy: A meta-analysis.
Zhang JZ, Kang XJ, Gao Y, Zheng YY, Wu TT, Li L, Liu F, Yang YN, Li XM, Ma YT, Xie X. Zhang JZ, et al. Sci Rep. 2017 Apr 21;7(1):1045. doi: 10.1038/s41598-017-01160-1. Sci Rep. 2017. PMID: 28432310 Free PMC article.

Compared to the control group, the CIN risk decreased significantly in the alprostadil group (P < 0.00001, OR = 0.29, 95% CI = 0.21-0.39). In the subgroup of coronary angiography patients, the use of alprostadil also decreased the risk of CIN (P < 0.00001, OR

Compared to the control group, the CIN risk decreased significantly in the alprostadil group (P < 0.00001, OR = 0.29, 95% CI = 0.2

Effects of alprostadil combined with tanshinone IIa injection on microcirculation disorder, outcomes, and cardiac function in AMI patients after PCI.
Lu Y, Yan Y, Liu X. Lu Y, et al. Ann Palliat Med. 2021 Jan;10(1):97-103. doi: 10.21037/apm-20-2147. Ann Palliat Med. 2021. PMID: 33545751 Free article. Clinical Trial.
BACKGROUND: Alprostadil can effectively dilate blood vessels, improve cardiac microcirculation, and reduce cardiac load. ...METHODS: A total of 300 AMI patients who underwent PCI in our hospital from January 2013 to June 2018 were randomly selected and divided into group A …
BACKGROUND: Alprostadil can effectively dilate blood vessels, improve cardiac microcirculation, and reduce cardiac load. ...METHODS: …
Alprostadil infusion in patients with dry age related macular degeneration: a randomized controlled clinical trial.
Augustin AJ, Diehm C, Grieger F, Bentz J. Augustin AJ, et al. Expert Opin Investig Drugs. 2013 Jul;22(7):803-12. doi: 10.1517/13543784.2013.794782. Epub 2013 Apr 30. Expert Opin Investig Drugs. 2013. PMID: 23627650 Clinical Trial.
Safety results were in line with the good safety profile of alprostadil. CONCLUSION: A numerical treatment effect in favor of alprostadil was visible, which lasted until the end of follow up. These results provide further evidence that alprostadil probably ha …
Safety results were in line with the good safety profile of alprostadil. CONCLUSION: A numerical treatment effect in favor of alpr
614 results