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Page 1
Iron absorption from supplements is greater with alternate day than with consecutive day dosing in iron-deficient anemic women.
Stoffel NU, Zeder C, Brittenham GM, Moretti D, Zimmermann MB. Stoffel NU, et al. Haematologica. 2020 May;105(5):1232-1239. doi: 10.3324/haematol.2019.220830. Epub 2019 Aug 14. Haematologica. 2020. PMID: 31413088 Free PMC article.
In iron-depleted women without anemia, oral iron supplements induce an increase in serum hepcidin (SHep) that persists for 24 hours, decreasing iron absorption from supplements given later on the same or next day. ...The primary objective of thi …
In iron-depleted women without anemia, oral iron supplements induce an increase in serum hepcidin (SHep) that persists …
Daily versus alternate day oral iron therapy in iron deficiency anemia: a systematic review.
Kamath S, Parveen RS, Hegde S, Mathias EG, Nayak V, Boloor A. Kamath S, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 May;397(5):2701-2714. doi: 10.1007/s00210-023-02817-7. Epub 2023 Nov 18. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 37979057
But adverse effects like epigastric pain, heartburn, and constipation reduce compliance to daily oral iron. There is scanty evidence regarding compliance and efficacy with alternate-day iron therapy. ...There is no significant increase in hemoglobin le …
But adverse effects like epigastric pain, heartburn, and constipation reduce compliance to daily oral iron. There is scanty evidence …
Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials.
Stoffel NU, Cercamondi CI, Brittenham G, Zeder C, Geurts-Moespot AJ, Swinkels DW, Moretti D, Zimmermann MB. Stoffel NU, et al. Lancet Haematol. 2017 Nov;4(11):e524-e533. doi: 10.1016/S2352-3026(17)30182-5. Epub 2017 Oct 9. Lancet Haematol. 2017. PMID: 29032957 Clinical Trial.
FINDINGS: For study 1, 40 women were enrolled on Oct 15-29, 2015. 21 women were assigned to the consecutive-day group and 19 to the alternate-day group. At the end of treatment (14 days for the consecutive-day group and 28 days for the alternate …
FINDINGS: For study 1, 40 women were enrolled on Oct 15-29, 2015. 21 women were assigned to the consecutive-day group and 19 to the …
Daily versus Alternate-Day Iron Supplementation for Pregnant Women with Iron Deficiency Anemia: A Randomized Controlled Trial.
Lam MC, Khandakar B, Heon I, Hussain F, Feldman K, Kaplowitz E, Overbey JR, Brustman L, Rosenn B. Lam MC, et al. Am J Perinatol. 2025 Apr;42(6):699-707. doi: 10.1055/a-2405-1381. Epub 2024 Aug 29. Am J Perinatol. 2025. PMID: 39209303 Clinical Trial.
This study aimed to evaluate the most effective regimen to raise hemoglobin (Hb) by comparing alternate-day dosing of iron to daily dosing in pregnant women with iron deficiency anemia. ...This trial suggests that there are no significant differences b …
This study aimed to evaluate the most effective regimen to raise hemoglobin (Hb) by comparing alternate-day dosing of iron …
Oral iron supplementation in iron-deficient women: How much and how often?
Stoffel NU, von Siebenthal HK, Moretti D, Zimmermann MB. Stoffel NU, et al. Mol Aspects Med. 2020 Oct;75:100865. doi: 10.1016/j.mam.2020.100865. Epub 2020 Jul 7. Mol Aspects Med. 2020. PMID: 32650997 Free article. Review.
In recent studies using serum hepcidin profiles and stable iron isotopes to quantify iron absorption in young women, we have shown that: (a) oral iron doses 60 mg in iron-deficient women, and doses 100 mg in women with IDA, stimulate an acute …
In recent studies using serum hepcidin profiles and stable iron isotopes to quantify iron absorption in young women, we …
Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women.
Moretti D, Goede JS, Zeder C, Jiskra M, Chatzinakou V, Tjalsma H, Melse-Boonstra A, Brittenham G, Swinkels DW, Zimmermann MB. Moretti D, et al. Blood. 2015 Oct 22;126(17):1981-9. doi: 10.1182/blood-2015-05-642223. Epub 2015 Aug 19. Blood. 2015. PMID: 26289639 Free article. Clinical Trial.
Iron supplements acutely increase hepcidin, but the duration and magnitude of the increase, its dose dependence, and its effects on subsequent iron absorption have not been characterized in humans. Better understanding of these phenomena might improve oral …
Iron supplements acutely increase hepcidin, but the duration and magnitude of the increase, its dose dependence, and its effec …
Alternate day versus consecutive day oral iron supplementation in iron-depleted women: a randomized double-blind placebo-controlled study.
von Siebenthal HK, Gessler S, Vallelian F, Steinwendner J, Kuenzi UM, Moretti D, Zimmermann MB, Stoffel NU. von Siebenthal HK, et al. EClinicalMedicine. 2023 Nov 3;65:102286. doi: 10.1016/j.eclinm.2023.102286. eCollection 2023 Nov. EClinicalMedicine. 2023. PMID: 38021373 Free PMC article.
Our objective was to compare consecutive-day versus alternate-day iron supplementation. METHODS: In a double-masked, randomized, placebo-controlled trial, young Swiss women (n = 150; serum ferritin 30 mug/L) were assigned to: daily 100 mg iron …
Our objective was to compare consecutive-day versus alternate-day iron supplementation. METHODS: In a double-mas …
Efficacy of alternate day versus daily oral iron therapy in children with iron deficiency anemia: a randomized controlled trial.
Grover P, S A. Grover P, et al. Int J Hematol. 2025 Dec;122(6):893-900. doi: 10.1007/s12185-025-04048-3. Epub 2025 Aug 17. Int J Hematol. 2025. PMID: 40820164 Clinical Trial.
The first group received twice-daily OIT, and the second group received alternate-day OIT. Serum hepcidin levels were measured at baseline and 48 h after starting OIT. ...Four of twenty in the alternate-day group (20%) had gastrointestinal side …
The first group received twice-daily OIT, and the second group received alternate-day OIT. Serum hepcidin levels were m …
Daily Versus Alternate Day Oral Iron Replacement for Women with Iron Deficiency Anaemia: A Randomized Controlled Trial.
Dhanush M, Vinod KV, Manivannan P, Adole PS, Govindan D. Dhanush M, et al. Indian J Hematol Blood Transfus. 2025 Apr;41(2):245-251. doi: 10.1007/s12288-024-01816-9. Epub 2024 Jun 29. Indian J Hematol Blood Transfus. 2025. PMID: 40224710 Free PMC article.
Primary outcome was the Hb change on Day-28. Secondary outcomes included Hb change on Day-56, change in serum hepcidin levels from baseline to Day-14, adverse effects (AEs) and compliance to treatment. ...However, treatment compliance was not significa …
Primary outcome was the Hb change on Day-28. Secondary outcomes included Hb change on Day-56, change in serum hepcidin …
A Prospective, Randomized, Interventional Study of Oral Iron Supplementation Comparing Daily Dose with Alternate Day Regimen Using Hepcidin as a Biomarker in Iron Deficiency Anemia.
Mehta S, Sharma BS, Gulati S, Sharma N, Goyal LK, Mehta S. Mehta S, et al. J Assoc Physicians India. 2020 May;68(5):39-41. J Assoc Physicians India. 2020. PMID: 32610864 Clinical Trial.
AIM: To assess effect of daily vis-a-vis alternate day oral iron therapy in terms of hemoglobin, reticulocyte hemoglobin equivalent (RET-He) and GI side effects using hepcidin as a biomarker. ...The study population was divided into two groups by rando …
AIM: To assess effect of daily vis-a-vis alternate day oral iron therapy in terms of hemoglobin, reticulocyte hemoglobi …
25 results