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Oral iron supplementation in iron-deficient women: How much and how often?
Stoffel NU, von Siebenthal HK, Moretti D, Zimmermann MB. Stoffel NU, et al. Mol Aspects Med. 2020 Oct;75:100865. doi: 10.1016/j.mam.2020.100865. Epub 2020 Jul 7. Mol Aspects Med. 2020. PMID: 32650997 Free article. Review.
In recent studies using serum hepcidin profiles and stable iron isotopes to quantify iron absorption in young women, we have shown that: (a) oral iron doses 60 mg in iron-deficient women, and doses 100 mg in women with IDA, stimulate an acute …
In recent studies using serum hepcidin profiles and stable iron isotopes to quantify iron absorption in young women, we …
Daily versus Alternate-Day Iron Supplementation for Pregnant Women with Iron Deficiency Anemia: A Randomized Controlled Trial.
Lam MC, Khandakar B, Heon I, Hussain F, Feldman K, Kaplowitz E, Overbey JR, Brustman L, Rosenn B. Lam MC, et al. Am J Perinatol. 2025 Apr;42(6):699-707. doi: 10.1055/a-2405-1381. Epub 2024 Aug 29. Am J Perinatol. 2025. PMID: 39209303 Clinical Trial.
This study aimed to evaluate the most effective regimen to raise hemoglobin (Hb) by comparing alternate-day dosing of iron to daily dosing in pregnant women with iron deficiency anemia. ...This trial suggests that there are no significant differences b …
This study aimed to evaluate the most effective regimen to raise hemoglobin (Hb) by comparing alternate-day dosing of iron …
Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials.
Stoffel NU, Cercamondi CI, Brittenham G, Zeder C, Geurts-Moespot AJ, Swinkels DW, Moretti D, Zimmermann MB. Stoffel NU, et al. Lancet Haematol. 2017 Nov;4(11):e524-e533. doi: 10.1016/S2352-3026(17)30182-5. Epub 2017 Oct 9. Lancet Haematol. 2017. PMID: 29032957 Clinical Trial.
FINDINGS: For study 1, 40 women were enrolled on Oct 15-29, 2015. 21 women were assigned to the consecutive-day group and 19 to the alternate-day group. At the end of treatment (14 days for the consecutive-day group and 28 days for the alternate …
FINDINGS: For study 1, 40 women were enrolled on Oct 15-29, 2015. 21 women were assigned to the consecutive-day group and 19 to the …
Alternate day versus consecutive day oral iron supplementation in iron-depleted women: a randomized double-blind placebo-controlled study.
von Siebenthal HK, Gessler S, Vallelian F, Steinwendner J, Kuenzi UM, Moretti D, Zimmermann MB, Stoffel NU. von Siebenthal HK, et al. EClinicalMedicine. 2023 Nov 3;65:102286. doi: 10.1016/j.eclinm.2023.102286. eCollection 2023 Nov. EClinicalMedicine. 2023. PMID: 38021373 Free PMC article.
Our objective was to compare consecutive-day versus alternate-day iron supplementation. METHODS: In a double-masked, randomized, placebo-controlled trial, young Swiss women (n = 150; serum ferritin 30 mug/L) were assigned to: daily 100 mg ir …
Our objective was to compare consecutive-day versus alternate-day iron supplementation. METHODS: In a dou …
Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women.
Moretti D, Goede JS, Zeder C, Jiskra M, Chatzinakou V, Tjalsma H, Melse-Boonstra A, Brittenham G, Swinkels DW, Zimmermann MB. Moretti D, et al. Blood. 2015 Oct 22;126(17):1981-9. doi: 10.1182/blood-2015-05-642223. Epub 2015 Aug 19. Blood. 2015. PMID: 26289639 Free article. Clinical Trial.
Better understanding of these phenomena might improve oral iron dosing schedules. We investigated whether the acute iron-induced increase in hepcidin influences iron absorption of successive daily iron doses and twice-daily iron doses. .. …
Better understanding of these phenomena might improve oral iron dosing schedules. We investigated whether the acute iron-induc …
Simple sugar supplementation abrogates exercise-induced increase in hepcidin in young men.
Tomczyk M, Kortas J, Flis D, Skrobot W, Camilleri R, Antosiewicz J. Tomczyk M, et al. J Int Soc Sports Nutr. 2017 Apr 20;14:10. doi: 10.1186/s12970-017-0169-8. eCollection 2017. J Int Soc Sports Nutr. 2017. PMID: 28428736 Free PMC article. Clinical Trial.
This investigation assessed the effects of a diet rich in simple sugars (glucose or fructose) on exercise-induced hepcidin which is hormone regulating iron metabolism. METHODS: A group of physically active young men completed an incremental exercise test before and …
This investigation assessed the effects of a diet rich in simple sugars (glucose or fructose) on exercise-induced hepcidin which is h …
Improving Iron Status Without Iron: Clinical Insights From Recombinant Human Lactoferrin Supplementation.
Evans C, Peterson R, Antonio J, Clark A. Evans C, et al. Cureus. 2026 Apr 21;18(4):e107451. doi: 10.7759/cureus.107451. eCollection 2026 Apr. Cureus. 2026. PMID: 42022247 Free PMC article.
Helaina human lactoferrin (LF) (effera ) is a potential, well-tolerated alternative for improving iron status in women who present with chronic iron deficiency. ...While limited to case reports, these observations support further controlled trials of effera …
Helaina human lactoferrin (LF) (effera ) is a potential, well-tolerated alternative for improving iron status in women who pre …
Impact of Oral Iron Dosing Regimens on Iron Biomarkers in Pregnancy: Insights from the PANDA Trial.
Haynes S, Armitage AE, Roy N, Morovat A, Drakesmith H, Churchill D, Stanworth SJ. Haynes S, et al. Blood Adv. 2026 Apr 23:bloodadvances.2026019740. doi: 10.1182/bloodadvances.2026019740. Online ahead of print. Blood Adv. 2026. PMID: 42024457
Non-daily dosing may improve tolerability but provides less iron. This study aimed to evaluate how daily, alternate-day, and three-times-weekly oral iron supplementation affects iron status biomarkers in non-anaemic pregnant participants. …
Non-daily dosing may improve tolerability but provides less iron. This study aimed to evaluate how daily, alternate-day …
A Prospective, Randomized, Interventional Study of Oral Iron Supplementation Comparing Daily Dose with Alternate Day Regimen Using Hepcidin as a Biomarker in Iron Deficiency Anemia.
Mehta S, Sharma BS, Gulati S, Sharma N, Goyal LK, Mehta S. Mehta S, et al. J Assoc Physicians India. 2020 May;68(5):39-41. J Assoc Physicians India. 2020. PMID: 32610864 Clinical Trial.
AIM: To assess effect of daily vis-a-vis alternate day oral iron therapy in terms of hemoglobin, reticulocyte hemoglobin equivalent (RET-He) and GI side effects using hepcidin as a biomarker. ...The study population was divided into two groups by rando …
AIM: To assess effect of daily vis-a-vis alternate day oral iron therapy in terms of hemoglobin, reticulocyte hemoglobi …