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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1982 1
1989 1
1992 2
1993 1
1994 2
1995 3
1996 3
1997 3
1998 6
1999 5
2000 6
2001 5
2002 8
2003 5
2004 11
2005 12
2006 10
2007 8
2008 16
2009 8
2010 12
2011 5
2012 9
2013 14
2014 15
2015 21
2016 14
2017 20
2018 14
2019 18
2020 17
2021 26
2022 9
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276 results
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Page 1
The essential elements of Alzheimer's disease.
Lei P, Ayton S, Bush AI. Lei P, et al. J Biol Chem. 2021 Jan-Jun;296:100105. doi: 10.1074/jbc.REV120.008207. Epub 2020 Nov 27. J Biol Chem. 2021. PMID: 33219130 Free PMC article. Review.
Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque neuropathology are yet to be proved effective despite many phase 3 clinical trials. ...Here, we review these essential elements of AD for their broad potential to con …
Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque neuropathology are yet to be prov …
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.
Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD. Stockwell BR, et al. Cell. 2017 Oct 5;171(2):273-285. doi: 10.1016/j.cell.2017.09.021. Cell. 2017. PMID: 28985560 Free PMC article. Review.
The sensitivity to ferroptosis is tightly linked to numerous biological processes, including amino acid, iron, and polyunsaturated fatty acid metabolism, and the biosynthesis of glutathione, phospholipids, NADPH, and coenzyme Q(10). Ferroptosis has been implicated in the p …
The sensitivity to ferroptosis is tightly linked to numerous biological processes, including amino acid, iron, and polyunsaturated fatty aci …
Posttranslational Modifications in Ferroptosis.
Wei X, Yi X, Zhu XH, Jiang DS. Wei X, et al. Oxid Med Cell Longev. 2020 Nov 26;2020:8832043. doi: 10.1155/2020/8832043. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 33294126 Free PMC article. Review.
To date, ferroptosis has been implicated in many diseases, such as carcinogenesis, degenerative diseases (e.g., Huntington's, Alzheimer's, and Parkinson's diseases), ischemia-reperfusion injury, and cardiovascular diseases. ...At least three major path …
To date, ferroptosis has been implicated in many diseases, such as carcinogenesis, degenerative diseases (e.g., Huntington's, Alzh …
Glutathione in the Brain.
Aoyama K. Aoyama K. Int J Mol Sci. 2021 May 9;22(9):5010. doi: 10.3390/ijms22095010. Int J Mol Sci. 2021. PMID: 34065042 Free PMC article. Review.
Glutathione (GSH) is the most abundant non-protein thiol, and plays crucial roles in the antioxidant defense system and the maintenance of redox homeostasis in neurons. GSH depletion in the brain is a common finding in patients with neurodegenerative diseases, such as A …
Glutathione (GSH) is the most abundant non-protein thiol, and plays crucial roles in the antioxidant defense system and the maintenan …
The Application of Ferroptosis in Diseases.
Qiu Y, Cao Y, Cao W, Jia Y, Lu N. Qiu Y, et al. Pharmacol Res. 2020 Sep;159:104919. doi: 10.1016/j.phrs.2020.104919. Epub 2020 May 25. Pharmacol Res. 2020. PMID: 32464324 Review.
Ferroptosis involves various biology processes, such as iron metabolism, lipid metabolism, oxidative stress and biosynthesis of nicotinamide adenine dinucleotide phosphate (NADPH), glutathione (GSH) and coenzyme Q10 (CoQ10). A growing body of evidence suggests that ferropt …
Ferroptosis involves various biology processes, such as iron metabolism, lipid metabolism, oxidative stress and biosynthesis of nicotinamide …
Ferroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer's disease.
Lane DJR, Metselaar B, Greenough M, Bush AI, Ayton SJ. Lane DJR, et al. Essays Biochem. 2021 Dec 22;65(7):925-940. doi: 10.1042/EBC20210017. Essays Biochem. 2021. PMID: 34623415 Review.
Ferroptosis is an iron- and lipid peroxidation-dependent cell death modality and emerging evidence indicates that ferroptosis has great explanatory potential for neuronal loss and associated CNS dysfunction in a range of neurodegenerative diseases (e.g., Alzheimer's …
Ferroptosis is an iron- and lipid peroxidation-dependent cell death modality and emerging evidence indicates that ferroptosis has great expl …
Free radicals and antioxidants in normal physiological functions and human disease.
Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Valko M, et al. Int J Biochem Cell Biol. 2007;39(1):44-84. doi: 10.1016/j.biocel.2006.07.001. Epub 2006 Aug 4. Int J Biochem Cell Biol. 2007. PMID: 16978905 Review.
For example, a growing body of evidence shows that ROS within cells act as secondary messengers in intracellular signalling cascades which induce and maintain the oncogenic phenotype of cancer cells, however, ROS can also induce cellular senescence and apoptosis and can therefore …
For example, a growing body of evidence shows that ROS within cells act as secondary messengers in intracellular signalling cascades which i …
Ferroptosis Mechanisms Involved in Neurodegenerative Diseases.
Reichert CO, de Freitas FA, Sampaio-Silva J, Rokita-Rosa L, Barros PL, Levy D, Bydlowski SP. Reichert CO, et al. Int J Mol Sci. 2020 Nov 20;21(22):8765. doi: 10.3390/ijms21228765. Int J Mol Sci. 2020. PMID: 33233496 Free PMC article. Review.
Since the 1960s, increased concentration of iron in the central nervous system has been associated with oxidative stress, oxidation of proteins and lipids, and cell death. Here, we review the main mechanisms involved in the process of ferroptosis such as lipid peroxidation …
Since the 1960s, increased concentration of iron in the central nervous system has been associated with oxidative stress, oxidation of prote …
A Hypothesis and Evidence That Mercury May be an Etiological Factor in Alzheimer's Disease.
Siblerud R, Mutter J, Moore E, Naumann J, Walach H. Siblerud R, et al. Int J Environ Res Public Health. 2019 Dec 17;16(24):5152. doi: 10.3390/ijerph16245152. Int J Environ Res Public Health. 2019. PMID: 31861093 Free PMC article.
Genetic factors in patients with Alzheimer's disease are also associated with mercury. Apolipoprotein E 4 allele increases the toxicity of mercury. ...The greatest exogenous sources of brain mercury come from dental amalgams. Conclusion: This review of …
Genetic factors in patients with Alzheimer's disease are also associated with mercury. Apolipoprotein E 4 allele increa …
Glutathione metabolism and its implications for health.
Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Wu G, et al. J Nutr. 2004 Mar;134(3):489-92. doi: 10.1093/jn/134.3.489. J Nutr. 2004. PMID: 14988435 Review.
Glutathione (gamma-glutamyl-cysteinyl-glycine; GSH) is the most abundant low-molecular-weight thiol, and GSH/glutathione disulfide is the major redox couple in animal cells. ...Glutathione deficiency contributes to oxidative stress, which plays a key role in …
Glutathione (gamma-glutamyl-cysteinyl-glycine; GSH) is the most abundant low-molecular-weight thiol, and GSH/glutathione disul …
276 results