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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 2
1989 1
1993 1
1998 1
2000 1
2002 2
2004 1
2006 7
2007 2
2008 1
2011 4
2012 1
2014 3
2015 6
2016 2
2017 5
2018 3
2019 1
2020 4
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44 results
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Polymicrobial Infections In Brain Tissue From Alzheimer's Disease Patients.
Pisa D, Alonso R, Fernández-Fernández AM, Rábano A, Carrasco L. Pisa D, et al. Sci Rep. 2017 Jul 17;7(1):5559. doi: 10.1038/s41598-017-05903-y. Sci Rep. 2017. PMID: 28717130 Free PMC article.
Several studies have advanced the idea that the etiology of Alzheimer's disease (AD) could be microbial in origin. In the present study, we tested the possibility that polymicrobial infections exist in tissue from the entorhinal cortex/hippocampus region of p …
Several studies have advanced the idea that the etiology of Alzheimer's disease (AD) could be microbial in origin. In t …
[Alzheimer's disease: the infectious hypothesis].
Roubaud Baudron C, Varon C, Mégraud F, Salles N. Roubaud Baudron C, et al. Geriatr Psychol Neuropsychiatr Vieil. 2015 Dec;13(4):418-24. doi: 10.1684/pnv.2015.0574. Geriatr Psychol Neuropsychiatr Vieil. 2015. PMID: 26707559 Review. French.
Several hypotheses are proposed for understanding the Alzheimer's disease (AD) pathological mechanisms, mainly the amyloid theory, but the process inducing Aß peptide deposit, tau protein degeneration, and ultimately neuronal loss, is still to be elucidated. …
Several hypotheses are proposed for understanding the Alzheimer's disease (AD) pathological mechanisms, mainly the amyl …
RNA Sequencing Reveals Small and Variable Contributions of Infectious Agents to Transcriptomes of Postmortem Nervous Tissues From Amyotrophic Lateral Sclerosis, Alzheimer's Disease and Parkinson's Disease Subjects, and Increased Expression of Genes From Disease-Activated Microglia.
Bennett JP Jr, Keeney PM, Brohawn DG. Bennett JP Jr, et al. Front Neurosci. 2019 Mar 28;13:235. doi: 10.3389/fnins.2019.00235. eCollection 2019. Front Neurosci. 2019. PMID: 30983949 Free PMC article.
Nervous tissues from both humans with neurodegenerative diseases (NDD) and animals with genetic models of human NDD, such as rare monogenic causes of Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease (AD), and Parkinson's disease (PD), sh …
Nervous tissues from both humans with neurodegenerative diseases (NDD) and animals with genetic models of human NDD, such as rare monogenic …
Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer's Disease.
Carter CJ. Carter CJ. J Alzheimers Dis Rep. 2017 Sep 28;1(1):125-157. doi: 10.3233/ADR-170017. J Alzheimers Dis Rep. 2017. PMID: 30480234 Free PMC article.
Diverse pathogens are detected in Alzheimer's disease (AD) brains. A bioinformatics survey showed that AD genome-wide association study (GWAS) genes (localized in bone marrow, immune locations and microglia) relate to multiple host/pathogen interactomes (Cand …
Diverse pathogens are detected in Alzheimer's disease (AD) brains. A bioinformatics survey showed that AD genome-wide a …
Do infections have a role in the pathogenesis of Alzheimer disease?
Itzhaki RF, Golde TE, Heneka MT, Readhead B. Itzhaki RF, et al. Nat Rev Neurol. 2020 Apr;16(4):193-197. doi: 10.1038/s41582-020-0323-9. Epub 2020 Mar 9. Nat Rev Neurol. 2020. PMID: 32152461 Review.
The idea that infectious agents in the brain have a role in the pathogenesis of Alzheimer disease (AD) was proposed nearly 30 years ago. ...Several recent discoveries have reignited interest in the infectious theory of AD, culminating in a debate on the topic at the …
The idea that infectious agents in the brain have a role in the pathogenesis of Alzheimer disease (AD) was proposed nearly 30 …
Plaques of Alzheimer's disease originate from cysts of Borrelia burgdorferi, the Lyme disease spirochete.
MacDonald AB. MacDonald AB. Med Hypotheses. 2006;67(3):592-600. doi: 10.1016/j.mehy.2006.02.035. Epub 2006 May 3. Med Hypotheses. 2006. PMID: 16675154
Rounded "plaques' in high density in brain tissue are emblematic of Alzheimer's disease (AD). Plaques may be conceptualized as rounded "pock mark-like" areas of brain tissue injury. ...Furthermore, there is "plaque diversity" in Alzheimer's; sma …
Rounded "plaques' in high density in brain tissue are emblematic of Alzheimer's disease (AD). Plaques may be conceptual …
Infectious Agents and Neurodegenerative Diseases: Exploring the Links.
Alam MZ, Alam Q, Kamal MA, Jiman-Fatani AA, Azhar EI, Khan MA, Haque A. Alam MZ, et al. Curr Top Med Chem. 2017;17(12):1390-1399. doi: 10.2174/1568026617666170103164040. Curr Top Med Chem. 2017. PMID: 28049398 Review.
Recent studies have shown that bacterial and viral infections are risk factors for various neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS), Multiple Sclerosis (MS), Alzheimer's disease (AD), and Lyme disease (LD). ...We will focu …
Recent studies have shown that bacterial and viral infections are risk factors for various neurodegenerative diseases such as Amyotrophic la …
Identification of Essential Oils with Strong Activity against Stationary Phase Borrelia burgdorferi.
Feng J, Shi W, Miklossy J, Tauxe GM, McMeniman CJ, Zhang Y. Feng J, et al. Antibiotics (Basel). 2018 Oct 16;7(4):89. doi: 10.3390/antibiotics7040089. Antibiotics (Basel). 2018. PMID: 30332754 Free PMC article.
Lyme disease is the most common vector borne-disease in the United States (US). While the majority of the Lyme disease patients can be cured with 2⁻4 weeks antibiotic treatment, about 10⁻20% of patients continue to suffer from persisting symptoms. ...
Lyme disease is the most common vector borne-disease in the United States (US). While the majority of the Lyme disease
Alzheimer's neuroborreliosis with trans-synaptic spread of infection and neurofibrillary tangles derived from intraneuronal spirochetes.
MacDonald AB. MacDonald AB. Med Hypotheses. 2007;68(4):822-5. doi: 10.1016/j.mehy.2006.08.043. Epub 2006 Oct 20. Med Hypotheses. 2007. PMID: 17055667
But the mere suggestion that infection might be a cause of Alzheimer's disease confounds the establishment. If a good case is to be made for infection in Alzheimer's disease, an excellent nerve cell infection model is needed. ...If Bor
But the mere suggestion that infection might be a cause of Alzheimer's disease confounds the establishment. If a good c …
Alzheimer's disease Braak Stage progressions: reexamined and redefined as Borrelia infection transmission through neural circuits.
MacDonald AB. MacDonald AB. Med Hypotheses. 2007;68(5):1059-64. doi: 10.1016/j.mehy.2006.09.054. Epub 2006 Nov 17. Med Hypotheses. 2007. PMID: 17113237
In Alzheimer's disease, there are progressive losses in all of these components. Brain structure crumbles. The deterioration in Alzheimer's is ordered, reproducible, and stepwise. ...Amalgamation of Zoster with Rabies models produces a hybrid mo …
In Alzheimer's disease, there are progressive losses in all of these components. Brain structure crumbles. The deterior …
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