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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1982 3
1983 3
1984 1
1986 7
1987 3
1988 2
1989 1
1990 2
1991 5
1992 4
1993 1
1994 3
1995 2
1996 6
1997 12
1998 9
1999 6
2000 1
2001 14
2002 7
2003 4
2004 16
2005 13
2006 13
2007 9
2008 12
2009 9
2010 11
2011 17
2012 14
2013 10
2014 16
2015 17
2016 13
2017 12
2018 16
2019 23
2020 26
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316 results
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Page 1
Herpes simplex virus type 1 and Alzheimer's disease: possible mechanisms and signposts.
Itzhaki RF. Itzhaki RF. FASEB J. 2017 Aug;31(8):3216-3226. doi: 10.1096/fj.201700360. FASEB J. 2017. PMID: 28765170 Review.
Support for the concept that herpes simplex virus type 1 (HSV1), when present in the brains of apolipoprotein E-ε4 carriers, is a major risk for Alzheimer's disease (AD) is increasing steadily, with over 120 publications providing direct or indi …
Support for the concept that herpes simplex virus type 1 (HSV1), when present in the brains of apolipoprotein E-ε4 carriers, i …
Herpes Simplex Virus Type 1 and Other Pathogens are Key Causative Factors in Sporadic Alzheimer's Disease.
Harris SA, Harris EA. Harris SA, et al. J Alzheimers Dis. 2015;48(2):319-53. doi: 10.3233/JAD-142853. J Alzheimers Dis. 2015. PMID: 26401998 Free PMC article. Review.
This review focuses on research in epidemiology, neuropathology, molecular biology, and genetics regarding the hypothesis that pathogens interact with susceptibility genes and are causative in sporadic Alzheimer's disease (AD). ...There are significant associ …
This review focuses on research in epidemiology, neuropathology, molecular biology, and genetics regarding the hypothesis that pathogens int …
Herpes simplex virus type 1 and Alzheimer's disease: link and potential impact on treatment.
Mancuso R, Sicurella M, Agostini S, Marconi P, Clerici M. Mancuso R, et al. Expert Rev Anti Infect Ther. 2019 Sep;17(9):715-731. doi: 10.1080/14787210.2019.1656064. Epub 2019 Aug 23. Expert Rev Anti Infect Ther. 2019. PMID: 31414935 Review.
Introduction: Alzheimer's disease (AD), the most common form of dementia worldwide, is a multifactorial disease with a still unknown etiology. Herpes simplex virus 1 (HSV-1) has long been suspected to be one of the factors involved in the …
Introduction: Alzheimer's disease (AD), the most common form of dementia worldwide, is a multifactorial disease …
Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer's Disease.
Harris SA, Harris EA. Harris SA, et al. Front Aging Neurosci. 2018 Mar 6;10:48. doi: 10.3389/fnagi.2018.00048. eCollection 2018. Front Aging Neurosci. 2018. PMID: 29559905 Free PMC article. Review.
This review focuses on research in the areas of epidemiology, neuropathology, molecular biology and genetics that implicates herpes simplex virus type 1 (HSV-1) as a causative agent in the pathogenesis of sporadic Alzheimer's disease (AD). ...
This review focuses on research in the areas of epidemiology, neuropathology, molecular biology and genetics that implicates herpes …
Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer's Disease.
Itzhaki RF. Itzhaki RF. Front Aging Neurosci. 2018 Oct 19;10:324. doi: 10.3389/fnagi.2018.00324. eCollection 2018. Front Aging Neurosci. 2018. PMID: 30405395 Free PMC article. Review.
Strong evidence has emerged recently for the concept that herpes simplex virus type 1 (HSV1) is a major risk for Alzheimer's disease (AD). ...Studies on the link between epilepsy, AD and herpes simplex encephalitis (HSE) are descri …
Strong evidence has emerged recently for the concept that herpes simplex virus type 1 (HSV1) is a major risk for Alzheimer …
Herpes Simplex Virus, Alzheimer's Disease and a Possible Role for Rab GTPases.
Bearer EL, Wu C. Bearer EL, et al. Front Cell Dev Biol. 2019 Aug 7;7:134. doi: 10.3389/fcell.2019.00134. eCollection 2019. Front Cell Dev Biol. 2019. PMID: 31448273 Free PMC article.
Herpes simplex virus (HSV) is a common pathogen, infecting 85% of adults in the United States. After reaching the nucleus of the long-lived neuron, HSV may enter latency to persist throughout the life span. Re-activation of latent herpesviruses is associated with pr …
Herpes simplex virus (HSV) is a common pathogen, infecting 85% of adults in the United States. After reaching the nucleus of t …
Time to test antibacterial therapy in Alzheimer's disease.
Panza F, Lozupone M, Solfrizzi V, Watling M, Imbimbo BP. Panza F, et al. Brain. 2019 Oct 1;142(10):2905-2929. doi: 10.1093/brain/awz244. Brain. 2019. PMID: 31532495 Review.
Infiltration of the brain by pathogens may act as a trigger or co-factor for Alzheimer's disease, with Herpes simplex virus type 1, Chlamydia pneumoniae, and Porphyromonas gingivalis being most frequently implicated. ...One is that patients with …
Infiltration of the brain by pathogens may act as a trigger or co-factor for Alzheimer's disease, with Herpes …
Viral Hypothesis and Antiviral Treatment in Alzheimer's Disease.
Devanand DP. Devanand DP. Curr Neurol Neurosci Rep. 2018 Jul 14;18(9):55. doi: 10.1007/s11910-018-0863-1. Curr Neurol Neurosci Rep. 2018. PMID: 30008124 Free PMC article. Review.
PURPOSE OF REVIEW: Viruses, particularly herpes simplex virus (HSV), may be a cause of Alzheimer's disease (AD). The evidence supporting the viral hypothesis suggests that antiviral treatment trials, which have not been conducted, are warranted. …
PURPOSE OF REVIEW: Viruses, particularly herpes simplex virus (HSV), may be a cause of Alzheimer's disease …
Interaction between Cytomegalovirus and Herpes Simplex Virus Type 1 Associated with the Risk of Alzheimer's Disease Development.
Lövheim H, Olsson J, Weidung B, Johansson A, Eriksson S, Hallmans G, Elgh F. Lövheim H, et al. J Alzheimers Dis. 2018;61(3):939-945. doi: 10.3233/JAD-161305. J Alzheimers Dis. 2018. PMID: 29254081
BACKGROUND: Several environmental factors, including infectious agents, have been suggested to cause Alzheimer's disease (AD). ...OBJECTIVE: To investigate whether carriage of CMV, alone or in combination with Herpes simplex virus (HSV), increas …
BACKGROUND: Several environmental factors, including infectious agents, have been suggested to cause Alzheimer's disease …
Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection.
Eimer WA, Vijaya Kumar DK, Navalpur Shanmugam NK, Rodriguez AS, Mitchell T, Washicosky KJ, György B, Breakefield XO, Tanzi RE, Moir RD. Eimer WA, et al. Neuron. 2018 Jul 11;99(1):56-63.e3. doi: 10.1016/j.neuron.2018.06.030. Neuron. 2018. PMID: 30001512 Free PMC article.
Amyloid-β peptide (Aβ) fibrilization and deposition as β-amyloid are hallmarks of Alzheimer's disease (AD) pathology. We recently reported Aβ is an innate immune protein that protects against fungal and bacterial infections. ...Here, we show Aβ oligomers bind …
Amyloid-β peptide (Aβ) fibrilization and deposition as β-amyloid are hallmarks of Alzheimer's disease (AD) pathology. W …
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