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Year Number of Results
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1939 2
1940 1
1941 1
1944 1
1945 2
1946 9
1947 6
1948 8
1949 9
1950 6
1951 17
1952 12
1953 19
1954 18
1955 17
1956 11
1957 11
1958 21
1959 17
1960 15
1961 15
1962 17
1963 21
1964 25
1965 18
1966 10
1967 6
1968 13
1969 7
1970 14
1971 21
1972 13
1973 17
1974 18
1975 46
1976 53
1977 57
1978 68
1979 104
1980 115
1981 165
1982 272
1983 328
1984 431
1985 627
1986 832
1987 880
1988 1003
1989 1385
1990 1416
1991 1517
1992 1625
1993 1723
1994 2131
1995 2172
1996 2536
1997 2755
1998 2893
1999 2942
2000 3398
2001 3495
2002 3781
2003 3853
2004 4540
2005 4878
2006 5346
2007 5490
2008 5870
2009 6353
2010 7296
2011 7779
2012 8715
2013 9320
2014 10193
2015 10745
2016 11277
2017 12064
2018 12693
2019 13527
2020 15596
2021 17405
2022 17802
2023 18488
2024 5625

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Mutations in human prion-like domains: pathogenic but not always amyloidogenic.
Bartolomé-Nafría A, García-Pardo J, Ventura S. Bartolomé-Nafría A, et al. Prion. 2024 Dec;18(1):28-39. doi: 10.1080/19336896.2024.2329186. Epub 2024 Mar 21. Prion. 2024. PMID: 38512820 Free PMC article. Review.
To date, over 60 mutations targeting the LCDs of hnRNPs have been identified and associated with a spectrum of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer's disease (AD). The cryo-EM s …
To date, over 60 mutations targeting the LCDs of hnRNPs have been identified and associated with a spectrum of neurodegenerative diseases in …
Dynamically stabilized recurrent neural network optimized with Artificial Gorilla Troops espoused Alzheimer's disorder detection using EEG signals.
Sudha G, Saravanan N, Muthalakshmi M, Birunda M. Sudha G, et al. Health Inf Sci Syst. 2024 Mar 15;12(1):25. doi: 10.1007/s13755-024-00284-9. eCollection 2024 Dec. Health Inf Sci Syst. 2024. PMID: 38495674
Alzheimer's disease is an incurable neurological disorder that damages cognitive abilities, but early identification reduces the symptoms significantly. The absence of competent healthcare professionals has made automatic identification of Alzheimer' …
Alzheimer's disease is an incurable neurological disorder that damages cognitive abilities, but early identification re …
Jointly constrained group sparse connectivity representation improves early diagnosis of Alzheimer's disease on routinely acquired T1-weighted imaging-based brain network.
Zhu C, Li H, Song Z, Jiang M, Song L, Li L, Wang X, Zheng Q. Zhu C, et al. Health Inf Sci Syst. 2024 Mar 6;12(1):19. doi: 10.1007/s13755-023-00269-0. eCollection 2024 Dec. Health Inf Sci Syst. 2024. PMID: 38464465
BACKGROUND: Radiomics-based morphological brain networks (radMBN) constructed from routinely acquired structural MRI (sMRI) data have gained attention in Alzheimer's disease (AD). However, the radMBN suffers from limited characterization of AD because sMRI on …
BACKGROUND: Radiomics-based morphological brain networks (radMBN) constructed from routinely acquired structural MRI (sMRI) data have gained …
Novel anti-neuroinflammatory pyranone-carbamate derivatives as selective butyrylcholinesterase inhibitors for treating Alzheimer's disease.
Yu C, Liu X, Ma B, Xu J, Chen Y, Dai C, Peng H, Zha D. Yu C, et al. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2313682. doi: 10.1080/14756366.2024.2313682. Epub 2024 Feb 16. J Enzyme Inhib Med Chem. 2024. PMID: 38362862 Free PMC article.
Butyrylcholinesterase (BuChE) and neuroinflammation have recently emerged as promising therapeutic directions for Alzheimer's disease (AD). Herein, we synthesised 19 novel pyranone-carbamate derivatives and evaluated their activities against cholinesterases a …
Butyrylcholinesterase (BuChE) and neuroinflammation have recently emerged as promising therapeutic directions for Alzheimer's …
Helix-to-sheet transition of the Aβ42 peptide revealed using an enhanced sampling strategy and Markov state model.
Wen H, Ouyang H, Shang H, Da C, Zhang T. Wen H, et al. Comput Struct Biotechnol J. 2023 Dec 19;23:688-699. doi: 10.1016/j.csbj.2023.12.015. eCollection 2024 Dec. Comput Struct Biotechnol J. 2023. PMID: 38292476 Free PMC article.
The self-assembly of Abeta peptides into toxic oligomers and fibrils is the primary cause of Alzheimer's disease. Moreover, the conformational transition from helix to sheet is considered a crucial step in the aggregation of Abeta peptides. ...
The self-assembly of Abeta peptides into toxic oligomers and fibrils is the primary cause of Alzheimer's disease. Moreo …
Network-based identification and mechanism exploration of active ingredients against Alzheimer's disease via targeting endoplasmic reticulum stress from traditional chinese medicine.
Dai Z, Hu T, Wei J, Wang X, Cai C, Gu Y, Hu Y, Wang W, Wu Q, Fang J. Dai Z, et al. Comput Struct Biotechnol J. 2023 Dec 20;23:506-519. doi: 10.1016/j.csbj.2023.12.017. eCollection 2024 Dec. Comput Struct Biotechnol J. 2023. PMID: 38261917 Free PMC article.
Alzheimer's disease is a neurodegenerative disease that leads to dementia and poses a serious threat to the health of the elderly. ...
Alzheimer's disease is a neurodegenerative disease that leads to dementia and poses a serious threat to the heal …
Sequence-based identification of amyloidogenic β-hairpins reveals a prostatic acid phosphatase fragment promoting semen amyloid formation.
Heid LF, Agerschou ED, Orr AA, Kupreichyk T, Schneider W, Wördehoff MM, Schwarten M, Willbold D, Tamamis P, Stoldt M, Hoyer W. Heid LF, et al. Comput Struct Biotechnol J. 2023 Dec 21;23:417-430. doi: 10.1016/j.csbj.2023.12.023. eCollection 2024 Dec. Comput Struct Biotechnol J. 2023. PMID: 38223341 Free PMC article.
beta-Structure-rich amyloid fibrils are hallmarks of several diseases, including Alzheimer's (AD), Parkinson's (PD), and type 2 diabetes (T2D). While amyloid fibrils typically consist of parallel beta-sheets, the anti-parallel beta-hairpin is a structural motif acce …
beta-Structure-rich amyloid fibrils are hallmarks of several diseases, including Alzheimer's (AD), Parkinson's (PD), and type …
Gut-brain axis interplay via STAT3 pathway: Implications of Helicobacter pylori derived secretome on inflammation and Alzheimer's disease.
Kandpal M, Baral B, Varshney N, Jain AK, Chatterji D, Meena AK, Pandey RK, Jha HC. Kandpal M, et al. Virulence. 2024 Dec;15(1):2303853. doi: 10.1080/21505594.2024.2303853. Epub 2024 Feb 4. Virulence. 2024. PMID: 38197252 Free PMC article.
The current study investigated the plausible role and its associated molecular mechanism underlying H. pylori mediated gut-brain axis disruption and neuroinflammation leading to neurological modalities like Alzheimer's disease (AD). We have chosen the antimic …
The current study investigated the plausible role and its associated molecular mechanism underlying H. pylori mediated gut-brain axis disrup …
Design and preparation of naringenin loaded functional biomimetic nano-drug delivery system for Alzheimer's disease.
Yan C, Gu J, Yin S, Wu H, Lei X, Geng F, Zhang N, Wu X. Yan C, et al. J Drug Target. 2024 Dec;32(1):80-92. doi: 10.1080/1061186X.2023.2290453. Epub 2024 Jan 12. J Drug Target. 2024. PMID: 38044844
Efficient brain drug delivery has been a challenge in the treatment of Alzheimer's Disease and other brain disorders as blood-brain barrier (BBB) impedes most drugs to reach brain. ...
Efficient brain drug delivery has been a challenge in the treatment of Alzheimer's Disease and other brain disorders as …
Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128.
Bellver-Sanchis A, Ávila-López PA, Tic I, Valle-García D, Ribalta-Vilella M, Labrador L, Banerjee DR, Guerrero A, Casadesus G, Poulard C, Pallàs M, Griñán-Ferré C. Bellver-Sanchis A, et al. Neural Regen Res. 2024 Nov 1;19(11):2532-2542. doi: 10.4103/1673-5374.393102. Epub 2024 Jan 8. Neural Regen Res. 2024. PMID: 38526289 Free article.
JOURNAL/nrgr/04.03/01300535-202419110-00033/figure1/v/2024-03-08T184507Z/r/image-tiff Dysregulation of G9a, a histone-lysine N-methyltransferase, has been observed in Alzheimer's disease and has been correlated with increased levels of chronic inflammation an …
JOURNAL/nrgr/04.03/01300535-202419110-00033/figure1/v/2024-03-08T184507Z/r/image-tiff Dysregulation of G9a, a histone-lysine N-methyltransfe …
Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer's disease.
Tang Y, Wei J, Wang XF, Long T, Xiang X, Qu L, Wang X, Yu C, Xiao X, Hu X, Zeng J, Xu Q, Wu A, Wu J, Qin D, Zhou X, Law BY. Tang Y, et al. Neural Regen Res. 2024 Nov 1;19(11):2467-2479. doi: 10.4103/NRR.NRR-D-23-00954. Epub 2024 Jan 31. Neural Regen Res. 2024. PMID: 38526283 Free article.
JOURNAL/nrgr/04.03/01300535-202419110-00027/figure1/v/2024-03-08T184507Z/r/image-tiff Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer's disease. Citri Reticulatae Semen has diverse beneficial effects on neurodegenerative …
JOURNAL/nrgr/04.03/01300535-202419110-00027/figure1/v/2024-03-08T184507Z/r/image-tiff Amyloid-beta-induced neuronal cell death contributes t …
Isoform- and cell-state-specific APOE homeostasis and function.
Lindner K, Gavin AC. Lindner K, et al. Neural Regen Res. 2024 Nov 1;19(11):2456-2466. doi: 10.4103/NRR.NRR-D-23-01470. Epub 2024 Jan 31. Neural Regen Res. 2024. PMID: 38526282 Free article.
Apolipoprotein E polymorphism, combined with environmental stresses and/or age-related alterations, influences the risk of developing late-onset Alzheimer's disease. In this review, we discuss our current knowledge of how apolipoprotein E homeostasis, i.e. it …
Apolipoprotein E polymorphism, combined with environmental stresses and/or age-related alterations, influences the risk of developing late-o …
Mechanism of Cu entry into the brain: many unanswered questions.
Roy S, Lutsenko S. Roy S, et al. Neural Regen Res. 2024 Nov 1;19(11):2421-2429. doi: 10.4103/1673-5374.393107. Epub 2024 Jan 8. Neural Regen Res. 2024. PMID: 38526278 Free article.
Cu imbalances cause or contribute to several life-threatening neurologic disorders including Menkes disease, Wilson disease, Alzheimer's disease, Parkinson's disease, and others. ...
Cu imbalances cause or contribute to several life-threatening neurologic disorders including Menkes disease, Wilson disease, …
NLRP3/1-mediated pyroptosis: beneficial clues for the development of novel therapies for Alzheimer's disease.
Hu B, Zhang J, Huang J, Luo B, Zeng X, Jia J. Hu B, et al. Neural Regen Res. 2024 Nov 1;19(11):2400-2410. doi: 10.4103/1673-5374.391311. Epub 2023 Dec 21. Neural Regen Res. 2024. PMID: 38526276 Free article.
There is accumulating evidence that nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3 (NLRP3) inflammasome-mediated microglial pyroptosis and NLRP1 inflammasome-mediated neuronal pyroptosis in the brain are closely associated with the pathogenesis of …
There is accumulating evidence that nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3 (NLRP3) inflammasome-mediate …
Unveiling DNA methylation in Alzheimer's disease: a review of array-based human brain studies.
Alves VC, Carro E, Figueiro-Silva J. Alves VC, et al. Neural Regen Res. 2024 Nov 1;19(11):2365-2376. doi: 10.4103/1673-5374.393106. Epub 2024 Jan 8. Neural Regen Res. 2024. PMID: 38526273 Free article.
The intricacies of Alzheimer's disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms, particularly DNA methylation. This review comprehensively surveys recent human-centered studies that investigate whole genome D …
The intricacies of Alzheimer's disease pathogenesis are being increasingly illuminated by the exploration of epigenetic …
Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis.
Liao W, Wei J, Liu C, Luo H, Ruan Y, Mai Y, Yu Q, Cao Z, Xu J, Zheng D, Sheng Z, Zhou X, Liu J. Liao W, et al. Neural Regen Res. 2024 Oct 1;19(10):2281-2289. doi: 10.4103/1673-5374.391310. Epub 2023 Dec 21. Neural Regen Res. 2024. PMID: 38488562 Free article.
JOURNAL/nrgr/04.03/01300535-202410000-00029/figure1/v/2024-02-06T055622Z/r/image-tiff Disturbances in the microbiota-gut-brain axis may contribute to the development of Alzheimer's disease. Magnesium-L-threonate has recently been found to have protective effe …
JOURNAL/nrgr/04.03/01300535-202410000-00029/figure1/v/2024-02-06T055622Z/r/image-tiff Disturbances in the microbiota-gut-brain axis may cont …
Efficacy of exercise rehabilitation for managing patients with Alzheimer's disease.
Li D, Jia J, Zeng H, Zhong X, Chen H, Yi C. Li D, et al. Neural Regen Res. 2024 Oct 1;19(10):2175-2188. doi: 10.4103/1673-5374.391308. Epub 2023 Dec 21. Neural Regen Res. 2024. PMID: 38488551 Free article.
Alzheimer's disease (AD) is a progressive and degenerative neurological disease characterized by the deterioration of cognitive functions. ...This review may aid the development of more effective and individualized treatment strategies to address the c …
Alzheimer's disease (AD) is a progressive and degenerative neurological disease characterized by the deteriorati …
Potential role of hippocampal neurogenesis in spinal cord injury induced post-trauma depression.
Ma Y, Qiao Y, Gao X. Ma Y, et al. Neural Regen Res. 2024 Oct 1;19(10):2144-2156. doi: 10.4103/1673-5374.392855. Epub 2024 Jan 8. Neural Regen Res. 2024. PMID: 38488549 Free article.
It has been reported both in clinic and rodent models that beyond spinal cord injury directly induced symptoms, such as paralysis, neuropathic pain, bladder/bowel dysfunction, and loss of sexual function, there are a variety of secondary complications, including memory loss, cogn …
It has been reported both in clinic and rodent models that beyond spinal cord injury directly induced symptoms, such as paralysis, neuropath …
Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice.
Aguado C, Badesso S, Martínez-Hernández J, Martín-Belmonte A, Alfaro-Ruiz R, Fernández M, Moreno-Martínez AE, Cuadrado-Tejedor M, García-Osta A, Luján R. Aguado C, et al. Neural Regen Res. 2024 Sep 1;19(9):2068-2074. doi: 10.4103/1673-5374.390963. Epub 2023 Dec 15. Neural Regen Res. 2024. PMID: 38227537 Free article.
JOURNAL/nrgr/04.03/01300535-202409000-00040/figure1/v/2024-01-16T170235Z/r/image-tiff Plaques of amyloid-beta (Abeta) and neurofibrillary tangles are the main pathological characteristics of Alzheimer's disease (AD). However, some older adult people with AD p …
JOURNAL/nrgr/04.03/01300535-202409000-00040/figure1/v/2024-01-16T170235Z/r/image-tiff Plaques of amyloid-beta (Abeta) and neurofibrillary ta …
Emerging role of galectin 3 in neuroinflammation and neurodegeneration.
Lozinski BM, Ta K, Dong Y. Lozinski BM, et al. Neural Regen Res. 2024 Sep 1;19(9):2004-2009. doi: 10.4103/1673-5374.391181. Epub 2023 Dec 21. Neural Regen Res. 2024. PMID: 38227529 Free article.
While Gal3 has previously been associated with non-CNS inflammatory and fibrotic diseases, recent studies highlight Gal3 as a prominent regulator of inflammation and neuroaxonal damage in the CNS during diseases such as multiple sclerosis, Alzheimer's disease …
While Gal3 has previously been associated with non-CNS inflammatory and fibrotic diseases, recent studies highlight Gal3 as a prominent regu …
Circadian rhythm disruption and retinal dysfunction: a bidirectional link in Alzheimer's disease?
Carrero L, Antequera D, Municio C, Carro E. Carrero L, et al. Neural Regen Res. 2024 Sep 1;19(9):1967-1972. doi: 10.4103/1673-5374.390962. Epub 2023 Dec 15. Neural Regen Res. 2024. PMID: 38227523 Free article.
Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer's disease. A predominant function of the retina is circadian synchronization, carrying information to the brain through the retinohypothalamic tract, which projects to the supr …
Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer's disease. A predominant function of …
NADPH oxidase 4 (NOX4) as a biomarker and therapeutic target in neurodegenerative diseases.
Boonpraman N, Yi SS. Boonpraman N, et al. Neural Regen Res. 2024 Sep 1;19(9):1961-1966. doi: 10.4103/1673-5374.390973. Epub 2023 Dec 15. Neural Regen Res. 2024. PMID: 38227522 Free article.
Diseases like Alzheimer's and Parkinson's diseases are defined by inflammation and the damage neurons undergo due to oxidative stress. ...Adjusting NADPH oxidase 4 activity might influence the neuroinflammatory cytokine levels, including myeloperoxidase and osteopon …
Diseases like Alzheimer's and Parkinson's diseases are defined by inflammation and the damage neurons undergo due to oxidative …
Rebuilding insight into the pathophysiology of Alzheimer's disease through new blood-brain barrier models.
Matsuo K, Nshihara H. Matsuo K, et al. Neural Regen Res. 2024 Sep 1;19(9):1954-1960. doi: 10.4103/1673-5374.390978. Epub 2023 Dec 15. Neural Regen Res. 2024. PMID: 38227521 Free article.
Blood-brain barrier breakdown is a common pathology in various neurological diseases, such as Alzheimer's disease, stroke, multiple sclerosis, and Parkinson's disease. ...In this review, we summarize recent evidence of blood-brain barrier dysfunction i …
Blood-brain barrier breakdown is a common pathology in various neurological diseases, such as Alzheimer's disease, stro …
How do neurons age? A focused review on the aging of the microtubular cytoskeleton.
Richardson B, Goedert T, Quraishe S, Deinhardt K, Mudher A. Richardson B, et al. Neural Regen Res. 2024 Sep 1;19(9):1899-1907. doi: 10.4103/1673-5374.390974. Epub 2023 Dec 15. Neural Regen Res. 2024. PMID: 38227514 Free article.
Aging is the leading risk factor for Alzheimer's disease and other neurodegenerative diseases. We now understand that a breakdown in the neuronal cytoskeleton, mainly underpinned by protein modifications leading to the destabilization of microtubules, is cent …
Aging is the leading risk factor for Alzheimer's disease and other neurodegenerative diseases. We now understand that a …
Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents.
Navarro-Lobato I, Masmudi-Martín M, López-Aranda MF, López-Téllez JF, Delgado G, Granados-Durán P, Gaona-Romero C, Carretero-Rey M, Posadas S, Quiros-Ortega ME, Khan ZU. Navarro-Lobato I, et al. Neural Regen Res. 2024 Aug 1;19(8):1835-1841. doi: 10.4103/1673-5374.389301. Epub 2023 Nov 8. Neural Regen Res. 2024. PMID: 38103251 Free PMC article.
In this study, we demonstrated that the same treatment with RGS14414 in visual area V2, which is relatively unaffected in neurodegenerative diseases such as Alzheimer's disease, produced long-lasting enhancement of ORM in young animals and prevent ORM deficit …
In this study, we demonstrated that the same treatment with RGS14414 in visual area V2, which is relatively unaffected in neurodegenerative …
Ferroptosis mechanism and Alzheimer's disease.
Feng L, Sun J, Xia L, Shi Q, Hou Y, Zhang L, Li M, Fan C, Sun B. Feng L, et al. Neural Regen Res. 2024 Aug 1;19(8):1741-1750. doi: 10.4103/1673-5374.389362. Epub 2023 Nov 8. Neural Regen Res. 2024. PMID: 38103240 Free PMC article.
Ferroptosis is a classic regulatory mode of cell death. Extensive studies of regulatory cell death in Alzheimer's disease have yielded increasing evidence that ferroptosis is closely related to the occurrence, development, and prognosis of Alzheimer' …
Ferroptosis is a classic regulatory mode of cell death. Extensive studies of regulatory cell death in Alzheimer's disease …
Interplay between microglia and environmental risk factors in Alzheimer's disease.
Zhang M, Liang C, Chen X, Cai Y, Cui L. Zhang M, et al. Neural Regen Res. 2024 Aug 1;19(8):1718-1727. doi: 10.4103/1673-5374.389745. Epub 2023 Dec 11. Neural Regen Res. 2024. PMID: 38103237 Free PMC article.
At present, the Alzheimer's disease main risk remains genetic risks, but major environmental factors are increasingly shown to impact Alzheimer's disease development and progression. ...Toward intervening and controlling these environment …
At present, the Alzheimer's disease main risk remains genetic risks, but major environmental factors are increasingly s …
Vagus nerve stimulation in cerebral stroke: biological mechanisms, therapeutic modalities, clinical applications, and future directions.
Du L, He X, Xiong X, Zhang X, Jian Z, Yang Z. Du L, et al. Neural Regen Res. 2024 Aug 1;19(8):1707-1717. doi: 10.4103/1673-5374.389365. Epub 2023 Nov 8. Neural Regen Res. 2024. PMID: 38103236 Free PMC article.
Vagus nerve stimulation is a Food and Drug Administration-approved exploratory treatment option for autism, refractory depression, epilepsy, and Alzheimer's disease. It is expected to be a novel therapeutic technique for the treatment of stroke owing to its a …
Vagus nerve stimulation is a Food and Drug Administration-approved exploratory treatment option for autism, refractory depression, epilepsy, …
Glucagon-like peptide 1 receptor activation: anti-inflammatory effects in the brain.
Diz-Chaves Y, Maastor Z, Spuch C, Lamas JA, González-Matías LC, Mallo F. Diz-Chaves Y, et al. Neural Regen Res. 2024 Aug 1;19(8):1671-1677. doi: 10.4103/1673-5374.389626. Epub 2023 Dec 11. Neural Regen Res. 2024. PMID: 38103230 Free PMC article.
This review summarizes recent advances linked to the anti-inflammatory properties of glucagon-like peptide 1 receptor activation in the brain related to multiple sclerosis, Alzheimer's disease, Parkinson's disease, vascular dementia, or chronic migrain …
This review summarizes recent advances linked to the anti-inflammatory properties of glucagon-like peptide 1 receptor activation in the brai …
Small molecular decoys in Alzheimer's disease.
Oasa S, Kouznetsova VL, Tsigelny IF, Terenius L. Oasa S, et al. Neural Regen Res. 2024 Aug 1;19(8):1658-1659. doi: 10.4103/1673-5374.389643. Epub 2023 Dec 11. Neural Regen Res. 2024. PMID: 38103228 Free PMC article. No abstract available.
Multiphoton imaging of hippocampal neural circuits: techniques and biological insights into region-, cell-type-, and pathway-specific functions.
Mizuta K, Sato M. Mizuta K, et al. Neurophotonics. 2024 Jul;11(3):033406. doi: 10.1117/1.NPh.11.3.033406. Epub 2024 Mar 8. Neurophotonics. 2024. PMID: 38464393 Free PMC article. Review.
Although many studies have focused on the dorsal CA1 pyramidal cells, studies of other local and inter-areal circuitry elements have also helped provide a more comprehensive picture of the information processing performed by the hippocampal circuits. Imaging of circuit function i …
Although many studies have focused on the dorsal CA1 pyramidal cells, studies of other local and inter-areal circuitry elements have also he …
Sorl1 knockout inhibits expression of brain-derived neurotrophic factor: involvement in the development of late-onset Alzheimer's disease.
Zhao M, Chen X, Liu J, Feng Y, Wang C, Xu T, Liu W, Liu X, Liu M, Hou D. Zhao M, et al. Neural Regen Res. 2024 Jul 1;19(7):1602-1607. doi: 10.4103/1673-5374.387975. Epub 2023 Nov 13. Neural Regen Res. 2024. PMID: 38051905 Free PMC article.
Sortilin-related receptor 1 (SORL1) is a critical gene associated with late-onset Alzheimer's disease. SORL1 contributes to the development and progression of this neurodegenerative condition by affecting the transport and metabolism of intracellular beta-amy …
Sortilin-related receptor 1 (SORL1) is a critical gene associated with late-onset Alzheimer's disease. SORL1 contribute …
Neural stem cell-derived exosomes promote mitochondrial biogenesis and restore abnormal protein distribution in a mouse model of Alzheimer's disease.
Li B, Chen Y, Zhou Y, Feng X, Gu G, Han S, Cheng N, Sun Y, Zhang Y, Cheng J, Zhang Q, Zhang W, Liu J. Li B, et al. Neural Regen Res. 2024 Jul 1;19(7):1593-1601. doi: 10.4103/1673-5374.385839. Epub 2023 Sep 22. Neural Regen Res. 2024. PMID: 38051904 Free PMC article.
Mitochondrial dysfunction is a hallmark of Alzheimer's disease. We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of APP/PS1 mice. Because Alzheimer's disease affects t …
Mitochondrial dysfunction is a hallmark of Alzheimer's disease. We previously showed that neural stem cell-derived extr …
Targeting tau in Alzheimer's disease: from mechanisms to clinical therapy.
Ye J, Wan H, Chen S, Liu GP. Ye J, et al. Neural Regen Res. 2024 Jul 1;19(7):1489-1498. doi: 10.4103/1673-5374.385847. Epub 2023 Sep 22. Neural Regen Res. 2024. PMID: 38051891 Free PMC article.
Alzheimer's disease is the most prevalent neurodegenerative disease affecting older adults. ...This review summarizes the recent findings on the underlying mechanisms of tau protein in the onset and progression of Alzheimer's disease …
Alzheimer's disease is the most prevalent neurodegenerative disease affecting older adults. ...This review summa …
Neuronal conversion from glia to replenish the lost neurons.
Liang S, Zhou J, Yu X, Lu S, Liu R. Liang S, et al. Neural Regen Res. 2024 Jul 1;19(7):1446-1453. doi: 10.4103/1673-5374.386400. Epub 2023 Oct 2. Neural Regen Res. 2024. PMID: 38051886 Free PMC article.
Neuronal injury, aging, and cerebrovascular and neurodegenerative diseases such as cerebral infarction, Alzheimer's disease, Parkinson's disease, frontotemporal dementia, amyotrophic lateral sclerosis, and Huntington's disease are characterized …
Neuronal injury, aging, and cerebrovascular and neurodegenerative diseases such as cerebral infarction, Alzheimer's disease …
Rethinking neurodegenerative diseases: neurometabolic concept linking lipid oxidation to diseases in the central nervous system.
Helgudóttir SS, Mørkholt AS, Lichota J, Bruun-Nyzell P, Andersen MC, Kristensen NMJ, Johansen AK, Zinn MR, Jensdóttir HM, Nieland JDV. Helgudóttir SS, et al. Neural Regen Res. 2024 Jul 1;19(7):1437-1445. doi: 10.4103/1673-5374.387965. Epub 2023 Nov 8. Neural Regen Res. 2024. PMID: 38051885 Free PMC article.
Currently, there is a lack of effective medicines capable of halting or reversing the progression of neurodegenerative disorders, including amyotrophic lateral sclerosis, Parkinson's disease, multiple sclerosis, or Alzheimer's disease. Given the unmet …
Currently, there is a lack of effective medicines capable of halting or reversing the progression of neurodegenerative disorders, including …
Clinical Predictors of Postmortem Amyloid and Nonamyloid Cerebral Small Vessel Disease in Middle-Aged to Older Adults.
Dallaire-Théroux C, Smith C, Duchesne S. Dallaire-Théroux C, et al. Neurol Clin Pract. 2024 Jun;14(3):e200271. doi: 10.1212/CPJ.0000000000200271. Epub 2024 Mar 21. Neurol Clin Pract. 2024. PMID: 38525067
BACKGROUND AND OBJECTIVES: Sporadic cerebral small vessel disease (CSVD) is a class of important pathologic processes known to affect the aging brain and to contribute to cognitive impairment. ...Individuals aged 40 years and older covering the spectrum of healthy aging an …
BACKGROUND AND OBJECTIVES: Sporadic cerebral small vessel disease (CSVD) is a class of important pathologic processes known to affect …
Which neuroimaging and fluid biomarkers method is better in theranostic of Alzheimer's disease? An umbrella review.
Mohammadi H, Ariaei A, Ghobadi Z, Gorgich EAC, Rustamzadeh A. Mohammadi H, et al. IBRO Neurosci Rep. 2024 Feb 29;16:403-417. doi: 10.1016/j.ibneur.2024.02.007. eCollection 2024 Jun. IBRO Neurosci Rep. 2024. PMID: 38497046 Free PMC article. Review.
Biomarkers can be classified as diagnostic, prognostic, predictor, clinical, and therapeutic. In Alzheimer's disease (AD), multiple biomarkers have been reported so far. ...Three databases, including PubMed, Web of Science, and Scopus were selected with the k …
Biomarkers can be classified as diagnostic, prognostic, predictor, clinical, and therapeutic. In Alzheimer's disease (A …
Magnetic self-assembled label-free electrochemical biosensor based on Fe3O4/α-Fe2O3 heterogeneous nanosheets for the detection of Tau proteins.
Wang J, Ouyang H, Ni Y, Zhang H, Sun L, Liu R, Li S. Wang J, et al. Bioelectrochemistry. 2024 Jun;157:108678. doi: 10.1016/j.bioelechem.2024.108678. Epub 2024 Mar 6. Bioelectrochemistry. 2024. PMID: 38452441
A type of electrochemical biosensors based on magnetic Fe(3)O(4)/alpha-Fe(2)O(3) heterogeneous nanosheets was constructed to detect Tau proteins for early diagnosis and intervention therapy of Alzheimer's disease (AD). Firstly, Fe(3)O(4)/alpha-Fe(2)O(3) heter …
A type of electrochemical biosensors based on magnetic Fe(3)O(4)/alpha-Fe(2)O(3) heterogeneous nanosheets was constructed to detect Tau prot …
Erythrocyte membrane coated with nitrogen-doped quantum dots and polydopamine composite nano-system combined with photothermal treatment of Alzheimer's disease.
Liu J, Chi M, Li L, Zhang Y, Xie M. Liu J, et al. J Colloid Interface Sci. 2024 Jun;663:856-868. doi: 10.1016/j.jcis.2024.02.219. Epub 2024 Mar 2. J Colloid Interface Sci. 2024. PMID: 38447400
Mitochondrial dysfunction and metal ion imbalance are recognized as pathological hallmarks of Alzheimer's Disease (AD), leading to deposition of beta-amyloid (Abeta) thereby and inducing neurotoxicity, activating apoptosis, eliciting oxidative stress, and ult …
Mitochondrial dysfunction and metal ion imbalance are recognized as pathological hallmarks of Alzheimer's Disease (AD), …
Brain acetylcholinesterase activity and the protective effect of Gac fruit on scopolamine-induced memory impairment in adult zebrafish.
Singsai K, Saksit N, Chaikhumwang P. Singsai K, et al. IBRO Neurosci Rep. 2024 Feb 17;16:368-372. doi: 10.1016/j.ibneur.2024.02.004. eCollection 2024 Jun. IBRO Neurosci Rep. 2024. PMID: 38435743 Free PMC article.
These findings suggest that Gac fruit extract has anti-memory impairment activity and may be beneficial for the development of health products to prevent Alzheimer's disease....
These findings suggest that Gac fruit extract has anti-memory impairment activity and may be beneficial for the development of health produc …
Melatonin-mediated calcineurin inactivation attenuates amyloid beta-induced apoptosis.
Hong JM, Munna AN, Moon JH, Seol JW, Park SY. Hong JM, et al. IBRO Neurosci Rep. 2024 Feb 10;16:336-344. doi: 10.1016/j.ibneur.2024.02.001. eCollection 2024 Jun. IBRO Neurosci Rep. 2024. PMID: 38390232 Free PMC article.
Alzheimer's disease (AD) is the most common age-related progressive neurodegenerative disorder. ...
Alzheimer's disease (AD) is the most common age-related progressive neurodegenerative disorder. ...
Characterization of dicaffeoylspermidine derivatives related glucosyltransferases during fruit development of goji berry.
Yang X, Yang M, Ye P, Li H, Li Z, Zeng S, Wang Y. Yang X, et al. Food Chem. 2024 Jun 1;442:138432. doi: 10.1016/j.foodchem.2024.138432. Epub 2024 Jan 14. Food Chem. 2024. PMID: 38241991
Among these compounds, dicaffeoylspermidine derivatives (DCSPDs) have anti-oxidant and anti-Alzheimer's Disease activity. This study employed ultra-high-performance liquid chromatography with tandem mass spectrometry to investigate metabolic changes during th …
Among these compounds, dicaffeoylspermidine derivatives (DCSPDs) have anti-oxidant and anti-Alzheimer's Disease activit …
Aluminum, a colorful gamechanger: Uptake of an aluminum-containing food color in human cells and its implications for human health.
Ganhör C, Rezk M, Doppler C, Ruthmeier T, Wechselberger C, Müller M, Kotnik M, Puh Š, Messner B, Bernhard D. Ganhör C, et al. Food Chem. 2024 Jun 1;442:138404. doi: 10.1016/j.foodchem.2024.138404. Epub 2024 Jan 11. Food Chem. 2024. PMID: 38237295 Free article.
KEGG analysis revealed that carmine-specific genes suppress oxidative phosphorylation, and showed that this suppression is associated with neurodegenerative diseases such as Alzheimer and Parkinson disease. Furthermore, carmine, but not carminic acid, increased prol …
KEGG analysis revealed that carmine-specific genes suppress oxidative phosphorylation, and showed that this suppression is associated with n …
Current biomarkers and treatment strategies in Alzheimer disease: An overview and future perspectives.
Bhole RP, Chikhale RV, Rathi KM. Bhole RP, et al. IBRO Neurosci Rep. 2023 Nov 30;16:8-42. doi: 10.1016/j.ibneur.2023.11.003. eCollection 2024 Jun. IBRO Neurosci Rep. 2023. PMID: 38169888 Free PMC article. Review.
Alzheimer's disease (AD), a progressive degenerative disorder first identified by Alois Alzheimer in 1907, poses a significant public health challenge. ...
Alzheimer's disease (AD), a progressive degenerative disorder first identified by Alois Alzheimer in 1907, poses …
Amyloid-beta and tau protein beyond Alzheimer's disease.
Abyadeh M, Gupta V, Paulo JA, Mahmoudabad AG, Shadfar S, Mirshahvaladi S, Gupta V, Nguyen CTO, Finkelstein DI, You Y, Haynes PA, Salekdeh GH, Graham SL, Mirzaei M. Abyadeh M, et al. Neural Regen Res. 2024 Jun 1;19(6):1262-1276. doi: 10.4103/1673-5374.386406. Epub 2023 Oct 2. Neural Regen Res. 2024. PMID: 37905874 Free article.
The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer's disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. ...However, under pathological co …
The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer's disea …
Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders.
Knight HM, Demirbugen Öz M, PerezGrovas-Saltijeral A. Knight HM, et al. Neural Regen Res. 2024 Jun 1;19(6):1256-1261. doi: 10.4103/1673-5374.385858. Epub 2023 Sep 22. Neural Regen Res. 2024. PMID: 37905873 Free article.
Similarly, differences in expression of the m5C writer and reader effector proteins, NSUN6, NSUN7, and ALYREF in brain tissue are indicated in individuals with Alzheimer's disease, individuals with a high neuropathological load or have suffered traumatic brai …
Similarly, differences in expression of the m5C writer and reader effector proteins, NSUN6, NSUN7, and ALYREF in brain tissue are indicated …
Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases.
Han T, Xu Y, Sun L, Hashimoto M, Wei J. Han T, et al. Neural Regen Res. 2024 Jun 1;19(6):1241-1248. doi: 10.4103/1673-5374.385845. Epub 2023 Sep 22. Neural Regen Res. 2024. PMID: 37905870 Free article.
This review describes the origin and function of microglia and focuses on the role of different states of the microglial response to aging and chronic inflammation on the occurrence and development of neurodegenerative diseases, including Alzheimer's disease, …
This review describes the origin and function of microglia and focuses on the role of different states of the microglial response to aging a …
Blood-brain barrier pathology in cerebral small vessel disease.
Jia R, Solé-Guardia G, Kiliaan AJ. Jia R, et al. Neural Regen Res. 2024 Jun 1;19(6):1233-1240. doi: 10.4103/1673-5374.385864. Epub 2023 Sep 22. Neural Regen Res. 2024. PMID: 37905869 Free article.
Cerebral small vessel disease is a neurological disease that affects the brain microvasculature and which is commonly observed among the elderly. ...The pathophysiology of these lesions has been linked to multiple processes, such as hypoperfusion, defective cerebrov …
Cerebral small vessel disease is a neurological disease that affects the brain microvasculature and which is commonly observed …
Tau truncation in the pathogenesis of Alzheimer's disease: a narrative review.
Chu D, Yang X, Wang J, Zhou Y, Gu JH, Miao J, Wu F, Liu F. Chu D, et al. Neural Regen Res. 2024 Jun 1;19(6):1221-1232. doi: 10.4103/1673-5374.385853. Epub 2023 Sep 22. Neural Regen Res. 2024. PMID: 37905868 Free article.
Alzheimer's disease is characterized by two major neuropathological hallmarks-the extracellular beta-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau protein. ...This review summarizes over 60 prot …
Alzheimer's disease is characterized by two major neuropathological hallmarks-the extracellular beta-amyloid plaques an …
Long non-coding RNAs with essential roles in neurodegenerative disorders.
Xiong W, Lu L, Li J. Xiong W, et al. Neural Regen Res. 2024 Jun 1;19(6):1212-1220. doi: 10.4103/1673-5374.385850. Epub 2023 Sep 22. Neural Regen Res. 2024. PMID: 37905867 Free article.
This review provides an overview of the current knowledge of the biology of lncRNAs and focuses on introducing the latest identified roles, regulatory mechanisms, and research status of lncRNAs in Alzheimer's disease, Parkinson's disease, Huntington's …
This review provides an overview of the current knowledge of the biology of lncRNAs and focuses on introducing the latest identified roles, …
Construction of a short version of the Montreal Cognitive Assessment (MoCA) rating scale for the Thai population using Partial Least Squares analysis.
Hemrungrojn S, Amrapala A, Maes M. Hemrungrojn S, et al. Int J Neurosci. 2024 Jun;134(1):16-27. doi: 10.1080/00207454.2022.2082966. Epub 2022 Jun 12. Int J Neurosci. 2024. PMID: 35695242
BACKGROUND: The Montreal Cognitive Assessment (MoCA) rating scale is frequently used to assess cognitive impairments in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD). OBJECTIVES: The aims of this study were to a) evaluate the construc …
BACKGROUND: The Montreal Cognitive Assessment (MoCA) rating scale is frequently used to assess cognitive impairments in amnestic mild cognit …
The potential of lumbrokinase and serratiopeptidase for the degradation of Aβ 1-42 peptide - an in vitro and in silico approach.
Metkar SK, Girigoswami A, Bondage DD, Shinde UG, Girigoswami K. Metkar SK, et al. Int J Neurosci. 2024 Jun;134(2):112-123. doi: 10.1080/00207454.2022.2089137. Epub 2022 Jun 27. Int J Neurosci. 2024. PMID: 35694981
BACKGROUND: Alzheimer's disease (AD) is diagnosed with the deposition of insoluble beta-amyloid (Abeta) peptides in the neuropil of the brain leading to dementia. ...
BACKGROUND: Alzheimer's disease (AD) is diagnosed with the deposition of insoluble beta-amyloid (Abeta) peptides in the …
Imbalanced clearance of Aβ peptide cause presynaptic plaque formation.
Fotuhi SN, Khalaj-Kondori M. Fotuhi SN, et al. Int J Neurosci. 2024 Jun;134(1):66-70. doi: 10.1080/00207454.2022.2085099. Epub 2022 Jun 5. Int J Neurosci. 2024. PMID: 35639020
Alzheimer's disease is characterized by abnormal increase of Abeta peptide which is likely as the result of imbalanced homeostasis of its production and clearance mechanisms. ...
Alzheimer's disease is characterized by abnormal increase of Abeta peptide which is likely as the result of imbalanced …
Minocycline protects against lipopolysaccharide-induced glial cells activation and oxidative stress damage in the medial prefrontal cortex (mPFC) of the rat.
Abdo Qaid EY, Abdullah Z, Zakaria R, Long I. Abdo Qaid EY, et al. Int J Neurosci. 2024 Jun;134(1):56-65. doi: 10.1080/00207454.2022.2084092. Epub 2022 Jun 15. Int J Neurosci. 2024. PMID: 35638219
PURPOSE/AIM: Neuroinflammation and oxidative stress have been encountered in neurodegenerative diseases such as Alzheimer's disease (AD). However, the neuroprotective effects of minocycline against lipopolysaccharide (LPS)-induced glial cells activation and o …
PURPOSE/AIM: Neuroinflammation and oxidative stress have been encountered in neurodegenerative diseases such as Alzheimer's …
Ginkgo biloba extract mitigates the neurotoxicity of AlCl(3) in alzheimer rat's model: role of apolipoprotein E4 and clusterin genes in stimulating ROS generation and apoptosis.
Batawi AH. Batawi AH. Int J Neurosci. 2024 Jun;134(1):34-44. doi: 10.1080/00207454.2022.2082968. Epub 2022 Jun 9. Int J Neurosci. 2024. PMID: 35634646
PURPOSE: Alzheimer's disease (AD) appears as a result of an increase in the accumulation of amyloid beta peptide (Abeta) and a decrease in neurotransmitters (acetylcholine) within the brain cells which may be due to increase in acetylcholinesterase (AchE) act …
PURPOSE: Alzheimer's disease (AD) appears as a result of an increase in the accumulation of amyloid beta peptide (Abeta …
Water extract of moschus alleviates erastin-induced ferroptosis by regulating the Keap1/Nrf2 pathway in HT22 cells.
Song C, Chu Z, Dai J, Xie D, Qin T, Xie L, Zhai Z, Huang S, Xu Y, Sun T. Song C, et al. J Ethnopharmacol. 2024 May 23;326:117937. doi: 10.1016/j.jep.2024.117937. Epub 2024 Feb 27. J Ethnopharmacol. 2024. PMID: 38423409
Modern pharmacological researches have suggested that Moschus has neuroprotective actions, and its mechanism is related to anti-inflammatory, antioxidant, and anti-apoptosis effects. Ferroptosis is one of the major pathologies of Alzheimer's disease (AD) and …
Modern pharmacological researches have suggested that Moschus has neuroprotective actions, and its mechanism is related to anti-inflammatory …
Exploring the anti-ferroptosis mechanism of Kai-Xin-San against Alzheimer's disease through integrating network pharmacology, bioinformatics, and experimental validation strategy in vivo and in vitro.
Yan C, Yang S, Shao S, Zu R, Lu H, Chen Y, Zhou Y, Ying X, Xiang S, Zhang P, Li Z, Yuan Y, Zhang Z, Wang P, Xie Z, Wang W, Ma H, Sun Y. Yan C, et al. J Ethnopharmacol. 2024 May 23;326:117915. doi: 10.1016/j.jep.2024.117915. Epub 2024 Feb 13. J Ethnopharmacol. 2024. PMID: 38360383
AIM OF THE STUDY: This study aimed to elucidate the mechanism by which KXS exerts its therapeutic effects on Alzheimer's disease (AD) by targeting ferroptosis, using a combination of network pharmacology, bioinformatics, and experimental validation strategies …
AIM OF THE STUDY: This study aimed to elucidate the mechanism by which KXS exerts its therapeutic effects on Alzheimer's di …
Saffron (Crocus sativus L.) extract attenuates chronic scopolamine-induced cognitive impairment, amyloid beta, and neurofibrillary tangles accumulation in rats.
Patel KS, Dharamsi A, Priya M, Jain S, Mandal V, Girme A, Modi SJ, Hingorani L. Patel KS, et al. J Ethnopharmacol. 2024 May 23;326:117898. doi: 10.1016/j.jep.2024.117898. Epub 2024 Feb 8. J Ethnopharmacol. 2024. PMID: 38341114
Further, the ethnopharmacological evidence indicates that saffron has shown an effect against neurodegenerative disorders namely, dementia, Alzheimer's, and Parkinson's with its bioactive constituents i.e., carotenoids and apocarotenoids. ...
Further, the ethnopharmacological evidence indicates that saffron has shown an effect against neurodegenerative disorders namely, dementia, …
Predicting the reversion from mild cognitive impairment to normal cognition based on magnetic resonance imaging, clinical, and neuropsychological examinations.
Yu HH, Tan CC, Huang SJ, Zhang XH, Tan L, Xu W; Alzheimer's Disease Neuroimaging Initiative. Yu HH, et al. J Affect Disord. 2024 May 15;353:90-98. doi: 10.1016/j.jad.2024.03.009. Epub 2024 Mar 5. J Affect Disord. 2024. PMID: 38452935
The nomogram incorporating five predictors (education, hippocampus volume, the Alzheimer's Disease Assessment Scale-Cognitive score, the Rey Auditory Verbal Learning Test-immediate score, and mean arterial pressure) achieved good C-indexes of 0.892 (95 % conf …
The nomogram incorporating five predictors (education, hippocampus volume, the Alzheimer's Disease Assessment Scale-Cog …
A dual-signal amplification strategy based on rolling circle amplification and APE1-assisted amplification for highly sensitive and specific miRNA analysis for early diagnosis of alzheimer's disease.
Xie J, Chen J, Zhang Y, Li C, Liu P, Duan WJ, Chen JX, Chen J, Dai Z, Li M. Xie J, et al. Talanta. 2024 May 15;272:125747. doi: 10.1016/j.talanta.2024.125747. Epub 2024 Feb 10. Talanta. 2024. PMID: 38364557
MicroRNA (miRNA) is involved in the progression of Alzheimer's disease (AD) and emerges as a promising AD biomarker and therapeutic target. ...
MicroRNA (miRNA) is involved in the progression of Alzheimer's disease (AD) and emerges as a promising AD biomarker and …
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants.
Jomova K, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, Valko M. Jomova K, et al. Arch Toxicol. 2024 May;98(5):1323-1367. doi: 10.1007/s00204-024-03696-4. Epub 2024 Mar 14. Arch Toxicol. 2024. PMID: 38483584 Review.
An imbalance between ROS production and elimination is termed oxidative stress, a critical factor and common denominator of many chronic diseases such as cancer, cardiovascular diseases, metabolic diseases, neurological disorders (Alzheimer's and Parkinson's disease …
An imbalance between ROS production and elimination is termed oxidative stress, a critical factor and common denominator of many chronic dis …
Systemic inflammation in relation to exceptional memory in the Long Life Family Study (LLFS).
Patel R, Cosentino S, Zheng EZ, Schupf N, Barral S, Feitosa M, Andersen SL, Sebastiani P, Ukraintseva S, Christensen K, Zmuda J, Thyagarajan B, Gu Y; Long Life Family Study (LLFS). Patel R, et al. Brain Behav Immun Health. 2024 Feb 23;37:100746. doi: 10.1016/j.bbih.2024.100746. eCollection 2024 May. Brain Behav Immun Health. 2024. PMID: 38476338 Free PMC article.
Explainable AI-based Deep-SHAP for mapping the multivariate relationships between regional neuroimaging biomarkers and cognition.
Bhattarai P, Thakuri DS, Nie Y, Chand GB. Bhattarai P, et al. Eur J Radiol. 2024 May;174:111403. doi: 10.1016/j.ejrad.2024.111403. Epub 2024 Mar 2. Eur J Radiol. 2024. PMID: 38452732
BACKGROUND: Mild cognitive impairment (MCI)/Alzheimer's disease (AD) is associated with cognitive decline beyond normal aging and linked to the alterations of brain volume quantified by magnetic resonance imaging (MRI) and amyloid-beta (Abeta) quantified by p …
BACKGROUND: Mild cognitive impairment (MCI)/Alzheimer's disease (AD) is associated with cognitive decline beyond normal …
Penthorum chinense Pursh inhibits ferroptosis in cellular and Caenorhabditis elegans models of Alzheimer's disease.
Yong YY, Yan L, Wang BD, Fan DS, Guo MS, Yu L, Wu JM, Qin DL, Law BY, Wong VK, Yu CL, Zhou XG, Wu AG. Yong YY, et al. Phytomedicine. 2024 May;127:155463. doi: 10.1016/j.phymed.2024.155463. Epub 2024 Feb 16. Phytomedicine. 2024. PMID: 38452694
BACKGROUND: Ferroptosis, a unique type of cell death triggered by iron-dependent lipid peroxidation, plays a critical role in the pathogenesis of Alzheimer's disease (AD), a debilitating condition marked by memory loss and cognitive impairment due to the accu …
BACKGROUND: Ferroptosis, a unique type of cell death triggered by iron-dependent lipid peroxidation, plays a critical role in the pathogenes …
Lower oddball event-related EEG delta and theta responses in patients with dementia due to Parkinson's and Lewy body than Alzheimer's disease.
Yıldırım E, Aktürk T, Hanoğlu L, Yener G, Babiloni C, Güntekin B. Yıldırım E, et al. Neurobiol Aging. 2024 May;137:78-93. doi: 10.1016/j.neurobiolaging.2024.02.004. Epub 2024 Feb 16. Neurobiol Aging. 2024. PMID: 38452574
Oddball task-related EEG delta and theta responses are associated with frontal executive functions, which are significantly impaired in patients with dementia due to Parkinson's disease (PDD) and Lewy bodies (DLB). The present study investigated the oddball task-related EE …
Oddball task-related EEG delta and theta responses are associated with frontal executive functions, which are significantly impaired in pati …
The association between posterior resting-state EEG alpha rhythms and functional MRI connectivity in older adults with subjective memory complaint.
Lopez S, Hampel H, Chiesa PA, Del Percio C, Noce G, Lizio R, Teipel SJ, Dyrba M, González-Escamilla G, Bakardjian H, Cavedo E, Lista S, Vergallo A, Lemercier P, Spinelli G, Grothe MJ, Potier MC, Stocchi F, Ferri R, Habert MO, Dubois B, Babiloni C; INSIGHT-preAD study group. Lopez S, et al. Neurobiol Aging. 2024 May;137:62-77. doi: 10.1016/j.neurobiolaging.2024.02.008. Epub 2024 Feb 28. Neurobiol Aging. 2024. PMID: 38431999 Free article.
Resting-state eyes-closed electroencephalographic (rsEEG) alpha rhythms are dominant in posterior cortical areas in healthy adults and are abnormal in subjective memory complaint (SMC) persons with Alzheimer's disease amyloidosis. This exploratory study in 16 …
Resting-state eyes-closed electroencephalographic (rsEEG) alpha rhythms are dominant in posterior cortical areas in healthy adults and are a …
Biophysical insight into anti-amyloidogenic nature of novel ionic Co(II)(phen)(H2O)4]+[glycinate]- chemotherapeutic drug candidate against human lysozyme aggregation.
Masroor A, Zaidi N, Nabi F, Malik S, Zehra S, Arjmand F, Naseem N, Khan RH. Masroor A, et al. Biophys Chem. 2024 May;308:107214. doi: 10.1016/j.bpc.2024.107214. Epub 2024 Feb 28. Biophys Chem. 2024. PMID: 38428228
In the recent past, there has been an ever-increasing interest in the search for metal-based therapeutic drug candidates for protein misfolding disorders (PMDs) particularly neurodegenerative disorders such as Alzheimer's, Parkinson's, Prion's diseases, and amyotrop …
In the recent past, there has been an ever-increasing interest in the search for metal-based therapeutic drug candidates for protein misfold …
Association of peripheral immunity and cerebral small vessel disease in older adults without dementia: A longitudinal study.
Xiao CY, Ma YH, Zhao YL, Liu JY, Tan L; Alzheimer’s Disease Neuroimaging Initiative. Xiao CY, et al. Neurobiol Aging. 2024 May;137:55-61. doi: 10.1016/j.neurobiolaging.2024.02.007. Epub 2024 Feb 16. Neurobiol Aging. 2024. PMID: 38422799
This study explored the associations between peripheral immunity with cerebral small vessel diseases. Older adults without dementia from the Alzheimer's Disease Neuroimaging Initiative were investigated. Peripheral blood was obtained, and magnetic resonance i …
This study explored the associations between peripheral immunity with cerebral small vessel diseases. Older adults without dementia from the …
A comparative study of structural variant calling in WGS from Alzheimer's disease families.
Malamon JS, Farrell JJ, Xia LC, Dombroski BA, Das RG, Way J, Kuzma AB, Valladares O, Leung YY, Scanlon AJ, Lopez IAB, Brehony J, Worley KC, Zhang NR, Wang LS, Farrer LA, Schellenberg GD, Lee WP, Vardarajan BN. Malamon JS, et al. Life Sci Alliance. 2024 Feb 28;7(5):e202302181. doi: 10.26508/lsa.202302181. Print 2024 May. Life Sci Alliance. 2024. PMID: 38418088 Free PMC article.
We present a protocol for variant calling, merging, genotyping, sensitivity analysis, and laboratory validation for generating a high-quality SV call set in whole-genome sequencing from the Alzheimer's Disease Sequencing Project comprising 578 individuals fro …
We present a protocol for variant calling, merging, genotyping, sensitivity analysis, and laboratory validation for generating a high-qualit …
Resting state electroencephalographic alpha rhythms are sensitive to Alzheimer's disease mild cognitive impairment progression at a 6-month follow-up.
Babiloni C, Jakhar D, Tucci F, Del Percio C, Lopez S, Soricelli A, Salvatore M, Ferri R, Catania V, Massa F, Arnaldi D, Famà F, Güntekin B, Yener G, Stocchi F, Vacca L, Marizzoni M, Giubilei F, Yıldırım E, Hanoğlu L, Hünerli D, Frisoni GB, Noce G. Babiloni C, et al. Neurobiol Aging. 2024 May;137:19-37. doi: 10.1016/j.neurobiolaging.2024.01.013. Epub 2024 Feb 1. Neurobiol Aging. 2024. PMID: 38402780 Free article.
Are posterior resting-state electroencephalographic (rsEEG) alpha rhythms sensitive to the Alzheimer's disease mild cognitive impairment (ADMCI) progression at a 6-month follow-up? ...
Are posterior resting-state electroencephalographic (rsEEG) alpha rhythms sensitive to the Alzheimer's disease mild cog …
Disintegration at the Syntax-Semantics Interface in Prodromal Alzheimer's Disease: New Evidence from Complex Sentence Anaphora in Amnestic Mild Cognitive Impairment (aMCI).
Lust B, Flynn S, Henderson C, Gair J, Sherman JC. Lust B, et al. J Neurolinguistics. 2024 May;70:101190. doi: 10.1016/j.jneuroling.2023.101190. Epub 2023 Dec 30. J Neurolinguistics. 2024. PMID: 38370310
Although diverse language deficits have been widely observed in prodromal Alzheimer's disease (AD), the underlying nature of such deficits and their explanation remains opaque. ...
Although diverse language deficits have been widely observed in prodromal Alzheimer's disease (AD), the underlying natu …
Neurosteroids: A potential target for neuropsychiatric disorders.
Wang M, Hu S, Fu X, Zhou H, Yang S, Yang C. Wang M, et al. J Steroid Biochem Mol Biol. 2024 May;239:106485. doi: 10.1016/j.jsbmb.2024.106485. Epub 2024 Feb 17. J Steroid Biochem Mol Biol. 2024. PMID: 38369032 Review.
In addition, abnormality in the synthesis and function of neurosteroids has been closely linked to neuropsychiatric disorders, such as Alzheimer's disease (AD), schizophrenia (SZ), and epilepsy. Given their important role in brain pathophysiology and disorder …
In addition, abnormality in the synthesis and function of neurosteroids has been closely linked to neuropsychiatric disorders, such as Al …
Surface-functionalized SERS platform for deep learning-assisted diagnosis of Alzheimer's disease.
Kim M, Huh S, Park HJ, Cho SH, Lee MY, Jo S, Jung YS. Kim M, et al. Biosens Bioelectron. 2024 May 1;251:116128. doi: 10.1016/j.bios.2024.116128. Epub 2024 Feb 12. Biosens Bioelectron. 2024. PMID: 38367567
Early diagnosis of Alzheimer's disease is crucial to stall the deterioration of brain function, but conventional diagnostic methods require complicated analytical procedures or inflict acute pain on the patient. ...Here, we introduce a deep learning-assisted, …
Early diagnosis of Alzheimer's disease is crucial to stall the deterioration of brain function, but conventional diagno …
DHEC mesylate attenuates pathologies and aberrant bisecting N-glycosylation in Alzheimer's disease models.
Wang Y, Cao Y, Huang H, Xue Y, Chen S, Gao X. Wang Y, et al. Neuropharmacology. 2024 May 1;248:109863. doi: 10.1016/j.neuropharm.2024.109863. Epub 2024 Feb 6. Neuropharmacology. 2024. PMID: 38325771
Tremendous progress has been made to develop the therapy of Alzheimer's disease (AD). Existing several anti-AD remedies, with certain limitations, are far from adequate. ...Herein, we characterized the pharmacological effect of DHEC mesylate in AD and found t …
Tremendous progress has been made to develop the therapy of Alzheimer's disease (AD). Existing several anti-AD remedies …
Phospho-Tau 181 quantification method for Alzheimer's disease based on an array 2D biosensor combined with surface plasmon resonance imaging.
Oldak L, Zielinska Z, Socha K, Bogdan S, Gorodkiewicz E. Oldak L, et al. Talanta. 2024 May 1;271:125736. doi: 10.1016/j.talanta.2024.125736. Epub 2024 Feb 2. Talanta. 2024. PMID: 38316077
Alzheimer's disease is among the neurodegenerative diseases for which there is a lack of rapid, effective, and non-invasive diagnostic methods. ...
Alzheimer's disease is among the neurodegenerative diseases for which there is a lack of rapid, effective, and non-inva …
Tracking mitochondrial Cu(I) fluctuations through a ratiometric fluorescent probe in AD model cells: Towards understanding how AβOs induce mitochondrial Cu(I) dyshomeostasis.
Zhao Q, Ma L, Chen S, Huang L, She G, Sun Y, Shi W, Mu L. Zhao Q, et al. Talanta. 2024 May 1;271:125716. doi: 10.1016/j.talanta.2024.125716. Epub 2024 Jan 26. Talanta. 2024. PMID: 38301373
Mitochondrial copper signaling pathway plays a role in Alzheimer's disease (AD), especially in relevant Amyloid-beta oligomers (AbetaOs) neurotoxicity and mitochondrial dysfunction. ...
Mitochondrial copper signaling pathway plays a role in Alzheimer's disease (AD), especially in relevant Amyloid-beta ol …
Genetic deletion of astrocytic calcineurin B1 prevents cognitive impairment and neuropathology development in acute and chronic mouse models of Alzheimer's disease.
Tapella L, Dematteis G, La Vitola P, Leva S, Tonelli E, Raddi M, Delconti M, Dacomo L, La Macchia A, Murari E, Talmon M, Malecka J, Chrostek G, Grilli M, Colombo L, Salmona M, Forloni G, Genazzani AA, Balducci C, Lim D. Tapella L, et al. Glia. 2024 May;72(5):899-915. doi: 10.1002/glia.24509. Epub 2024 Jan 30. Glia. 2024. PMID: 38288580
Alzheimer's disease (AD) represents an urgent yet unmet challenge for modern society, calling for exploration of innovative targets and therapeutic approaches. ...
Alzheimer's disease (AD) represents an urgent yet unmet challenge for modern society, calling for exploration of innova …
5β-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia.
Munawar Cheema M, Macakova Kotrbova Z, Hrcka Krausova B, Adla SK, Slavikova B, Chodounska H, Kratochvil M, Vondrasek J, Sedlak D, Balastik M, Kudova E. Munawar Cheema M, et al. J Steroid Biochem Mol Biol. 2024 May;239:106464. doi: 10.1016/j.jsbmb.2024.106464. Epub 2024 Jan 19. J Steroid Biochem Mol Biol. 2024. PMID: 38246201
Endogenous neurosteroids (NS) and their synthetic analogs, neuroactive steroids (NAS), are potentially useful drug-like compounds affecting the pathophysiology of miscellaneous central nervous system disorders (e.g. Alzheimers disease, epilepsy, depression, etc.). A …
Endogenous neurosteroids (NS) and their synthetic analogs, neuroactive steroids (NAS), are potentially useful drug-like compounds affecting …
Single vesicle chemistry reveals partial release happens at the mechanical stress-induced exocytosis.
Nan X, Wang M, Du J, Liu Y, Cao L, Zhou J, Liu L, Li X. Nan X, et al. Talanta. 2024 May 1;271:125637. doi: 10.1016/j.talanta.2024.125637. Epub 2024 Jan 6. Talanta. 2024. PMID: 38237284
Neuronal activity can be modulated by mechanical stress in the central nervous system (CNS) in neurodegenerative diseases, for example Alzheimer's disease. However, the impact of mechanical stress on chemical signal transmission, especially the storage and re …
Neuronal activity can be modulated by mechanical stress in the central nervous system (CNS) in neurodegenerative diseases, for example Al …
Entropy-driven catalysis-based lateral flow assay for sensitive detection of Alzheimer 's-associated MicroRNA.
Wang J, Shi L, Zhu X, Tang Q, Wu M, Li B, Liu W, Jin Y. Wang J, et al. Talanta. 2024 May 1;271:125656. doi: 10.1016/j.talanta.2024.125656. Epub 2024 Jan 11. Talanta. 2024. PMID: 38224658
Alzheimer's disease (AD) is a degenerative disease of the brain worldwide. ...
Alzheimer's disease (AD) is a degenerative disease of the brain worldwide. ...
Classification of binding property of amyloid β to lipid membranes: Membranomic research using quartz crystal microbalance combined with the immobilization of lipid planar membranes.
Shimanouchi T, Iwamura M, Sano Y, Hayashi K, Noda M, Kimura Y. Shimanouchi T, et al. Biochim Biophys Acta Proteins Proteom. 2024 May 1;1872(3):140987. doi: 10.1016/j.bbapap.2023.140987. Epub 2023 Dec 19. Biochim Biophys Acta Proteins Proteom. 2024. PMID: 38128808
A biomembrane-related fibrillogenesis of Amyloid beta from Alzheimer' disease (Abeta) is closely related to its accumulation behavior. A binding property of Abeta peptides from Alzheimer' disease to lipid membranes was then classified by a quartz cryst …
A biomembrane-related fibrillogenesis of Amyloid beta from Alzheimer' disease (Abeta) is closely related to its accumulation b …
Exploring the evolution of circular polarized light backscattered from turbid tissue-like disperse medium utilizing generalized Monte Carlo modeling approach with a combined use of Jones and Stokes-Mueller formalisms.
Lopushenko I, Sieryi O, Bykov A, Meglinski I. Lopushenko I, et al. J Biomed Opt. 2024 May;29(5):052913. doi: 10.1117/1.JBO.29.5.052913. Epub 2023 Nov 21. J Biomed Opt. 2024. PMID: 38089555 Free PMC article.
SIGNIFICANCE: Phase retardation of circularly polarized light (CPL), backscattered by biological tissue, is used extensively for quantitative evaluation of cervical intraepithelial neoplasia, presence of senile Alzheimer's plaques, and characterization of biotissues …
SIGNIFICANCE: Phase retardation of circularly polarized light (CPL), backscattered by biological tissue, is used extensively for quantitativ …
Promising use of metformin in treating neurological disorders: biomarker-guided therapies.
Loan A, Syal C, Lui M, He L, Wang J. Loan A, et al. Neural Regen Res. 2024 May;19(5):1045-1055. doi: 10.4103/1673-5374.385286. Neural Regen Res. 2024. PMID: 37862207 Free PMC article.
Neurological disorders are a diverse group of conditions that affect the nervous system and include neurodegenerative diseases (Alzheimer's disease, multiple sclerosis, Parkinson's disease, Huntington's disease), cerebrovascular conditions (stro …
Neurological disorders are a diverse group of conditions that affect the nervous system and include neurodegenerative diseases (Alzheimer …
New insights into the therapeutic approaches for the treatment of tauopathies.
Singh H, Das A, Khan MM, Pourmotabbed T. Singh H, et al. Neural Regen Res. 2024 May;19(5):1020-1026. doi: 10.4103/1673-5374.385288. Neural Regen Res. 2024. PMID: 37862204 Free PMC article.
Tauopathies are a group of neurological disorders, including Alzheimer's disease and frontotemporal dementia, which involve progressive neurodegeneration, cognitive deficits, and aberrant tau protein accumulation. ...In this review, the current therapeutic st …
Tauopathies are a group of neurological disorders, including Alzheimer's disease and frontotemporal dementia, which inv …
Mitophagy in neurodegenerative disease pathogenesis.
Yang K, Yan Y, Yu A, Zhang R, Zhang Y, Qiu Z, Li Z, Zhang Q, Wu S, Li F. Yang K, et al. Neural Regen Res. 2024 May;19(5):998-1005. doi: 10.4103/1673-5374.385281. Neural Regen Res. 2024. PMID: 37862201 Free PMC article.
Importantly, we review the critical role of mitophagy in the pathogenesis of neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. ...Together, our review may provide novel views to better und …
Importantly, we review the critical role of mitophagy in the pathogenesis of neurodegenerative diseases including Alzheimer's …
Word Fluency Test (WFT): A parallel FAS alternative.
Erickson T, Malek-Ahmadi M, Luft CA, Campbell C, Strecker HK. Erickson T, et al. Appl Neuropsychol Adult. 2024 May-Jun;31(3):282-291. doi: 10.1080/23279095.2021.2021410. Epub 2022 Jan 25. Appl Neuropsychol Adult. 2024. PMID: 35076309
The potential anti-Alzheimer's activity of Oxalis corniculata Linn. Methanolic extract in experimental rats: Role of APOE4/LRP1, TLR4/NF-kappabeta/NLRP3, Wnt 3/beta-catenin/GSK-3beta, autophagy and apoptotic cues.
Abu-Elfotuh K, Hamdan AME, Mohamed SA, Bakr RO, Ahmed AH, Atwa AM, Hamdan AM, Alanzai AG, Alnahhas RK, Gowifel AMH, Salem MA. Abu-Elfotuh K, et al. J Ethnopharmacol. 2024 Apr 24;324:117731. doi: 10.1016/j.jep.2024.117731. Epub 2024 Jan 11. J Ethnopharmacol. 2024. PMID: 38218505 Free article.
Numerous pharmacological benefits of O. corniculata are linked to its anti-inflammatory and antioxidant abilities. One of the most prevalent neurodegenerative disorders is Alzheimer's disease (AD) in which neuroinflammation and oxidative stress are its main p …
Numerous pharmacological benefits of O. corniculata are linked to its anti-inflammatory and antioxidant abilities. One of the most prevalent …
Explaining the Variability of Alzheimer Disease Fluid Biomarker Concentrations in Memory Clinic Patients Without Dementia.
Bouteloup V, Pellegrin I, Dubois B, Chene G, Planche V, Dufouil C; MEMENTO Study Group. Bouteloup V, et al. Neurology. 2024 Apr 23;102(8):e209219. doi: 10.1212/WNL.0000000000209219. Epub 2024 Mar 25. Neurology. 2024. PMID: 38527237
BACKGROUND AND OBJECTIVES: Patients' comorbidities can affect Alzheimer disease (AD) blood biomarker concentrations. Because a limited number of factors have been explored to date, our aim was to assess the proportion of the variance in fluid biomarker levels explai …
BACKGROUND AND OBJECTIVES: Patients' comorbidities can affect Alzheimer disease (AD) blood biomarker concentrations. Because a …
Lumbar puncture increases Alzheimer's disease biomarker levels in cerebrospinal fluid of rhesus monkeys.
Xu J, Li H, Hu Y, Wu S, Wu L, Lei X, Lv L, Lu Y, Wu J, Li J, Shi B, Li J, Turck CW, Wang W, Hu X. Xu J, et al. iScience. 2024 Mar 6;27(4):109436. doi: 10.1016/j.isci.2024.109436. eCollection 2024 Apr 19. iScience. 2024. PMID: 38544572 Free PMC article.
Cerebrospinal fluid (CSF) samples are commonly collected via lumbar puncture (LP) in both clinical and research settings for measurement of biomarkers of Alzheimer's disease (AD). To determine the effects of LP on CSF AD biomarkers, we collected CSF samples a …
Cerebrospinal fluid (CSF) samples are commonly collected via lumbar puncture (LP) in both clinical and research settings for measurement of …
Revealing in vivo cellular mechanisms of cerebral microbleeds on neurons and microglia across cortical layers.
Yang Q, Vazquez AL, Cui XT. Yang Q, et al. iScience. 2024 Mar 2;27(4):109371. doi: 10.1016/j.isci.2024.109371. eCollection 2024 Apr 19. iScience. 2024. PMID: 38510113 Free PMC article.
Cerebral microbleeds (CMBs) are associated with higher risk for various neurological diseases including stroke, dementia, and Alzheimer's disease. However, the understanding of cellular pathology of CMBs, particularly in deep brain regions, remains limited. . …
Cerebral microbleeds (CMBs) are associated with higher risk for various neurological diseases including stroke, dementia, and Alzheimer …
The neurotransmitter puzzle of Alzheimer's: Dissecting mechanisms and exploring therapeutic horizons.
Sharma M, Pal P, Gupta SK. Sharma M, et al. Brain Res. 2024 Apr 15;1829:148797. doi: 10.1016/j.brainres.2024.148797. Epub 2024 Feb 10. Brain Res. 2024. PMID: 38342422 Review.
Alzheimer's Disease (AD) represents a complex interplay of neurological pathways and molecular mechanisms, with significant impacts on patients' lives. ...We examine the role of microglia in AD, highlighting their contribution to the disease's inflamma …
Alzheimer's Disease (AD) represents a complex interplay of neurological pathways and molecular mechanisms, with signifi …
Could protein phosphatase 2A and glycogen synthase kinase-3 beta be targeted by natural compounds to ameliorate Alzheimer's pathologies?
Manoharan SD, Abdul Hamid H, Md Hashim NF, Cheema MS, Chiroma SM, Mustapha M, Mehat MZ. Manoharan SD, et al. Brain Res. 2024 Apr 15;1829:148793. doi: 10.1016/j.brainres.2024.148793. Epub 2024 Feb 1. Brain Res. 2024. PMID: 38309553 Review.
Alzheimer's disease (AD) is a progressive neurological disorder that impairs memory and cognitive abilities, primarily in the elderly. ...
Alzheimer's disease (AD) is a progressive neurological disorder that impairs memory and cognitive abilities, primarily …
Sex-associated microRNAs potentially implicated in sporadic Alzheimer's disease (sAD).
Tsamou M, Roggen EL. Tsamou M, et al. Brain Res. 2024 Apr 15;1829:148791. doi: 10.1016/j.brainres.2024.148791. Epub 2024 Feb 1. Brain Res. 2024. PMID: 38307153
BACKGROUND: The onset and pathology of sporadic Alzheimer's disease (sAD) seem to be affected by both sex and genetic mechanisms. ...
BACKGROUND: The onset and pathology of sporadic Alzheimer's disease (sAD) seem to be affected by both sex and genetic m …
Distinct plasma phosphorylated-tau proteins profiling for the differential diagnosis of mild cognitive impairment and Alzheimer's disease by plasmonic asymmetric nanobridge-based biosensor.
Kim S, Ma X, Jeon MJ, Song S, Lee JS, Lee JU, Lee CN, Choi SH, Sim SJ. Kim S, et al. Biosens Bioelectron. 2024 Apr 15;250:116085. doi: 10.1016/j.bios.2024.116085. Epub 2024 Jan 29. Biosens Bioelectron. 2024. PMID: 38295582
The differential diagnosis between mild cognitive impairment (MCI) and Alzheimer's disease (AD) has been highly demanded for its effectiveness in preventing and contributing to early diagnosis of AD. ...
The differential diagnosis between mild cognitive impairment (MCI) and Alzheimer's disease (AD) has been highly demande …
Clinical and cortical trajectories in non-fluent primary progressive aphasia and Alzheimer's disease: A role for emotion processing.
Landin-Romero R, Kumfor F, Ys Lee A, Leyton C, Piguet O. Landin-Romero R, et al. Brain Res. 2024 Apr 15;1829:148777. doi: 10.1016/j.brainres.2024.148777. Epub 2024 Jan 28. Brain Res. 2024. PMID: 38286395 Free article.
PARTICIPANTS: This study recruited 29 non-semantic PPA patients (15 nfvPPA and 14 lvPPA) and compared them with 15 Alzheimer's disease (AD) patients and 14 healthy controls. MEASUREMENTS: Participants completed an annual assessment (median = 2 years; range = …
PARTICIPANTS: This study recruited 29 non-semantic PPA patients (15 nfvPPA and 14 lvPPA) and compared them with 15 Alzheimer's …
Atrial fibrillation increases the risk of all-cause dementia, Alzheimer's disease, and vascular dementia: A cohort study of 373, 415 participants in the UK Biobank.
Zhai Y, Hu F, Yuan L, Ye X, Shi W, Yang R, Cao Y, Sun J, He J, Xu F. Zhai Y, et al. J Affect Disord. 2024 Apr 15;351:323-330. doi: 10.1016/j.jad.2024.01.224. Epub 2024 Jan 28. J Affect Disord. 2024. PMID: 38286227
METHODS: This current cohort study utilized data from the UK Biobank to explore the association between atrial fibrillation (AF) and all-cause dementia (ACD), encompassing its main subtypes (Alzheimer's disease (AD), and vascular dementia (VD)). Cox proportio …
METHODS: This current cohort study utilized data from the UK Biobank to explore the association between atrial fibrillation (AF) and all-cau …
Feelings of tense and risk of incident dementia: A prospective study of 482,360 individuals.
Huang X, Yuan S, Ling Y, Tan S, Xu A, Lyu J. Huang X, et al. J Affect Disord. 2024 Apr 15;351:541-550. doi: 10.1016/j.jad.2024.01.156. Epub 2024 Jan 22. J Affect Disord. 2024. PMID: 38266930
The primary outcome was all cause of dementia (ACD) and its subtypes (Alzheimer's disease (AD), vascular dementia (VD), and other dementia). ...
The primary outcome was all cause of dementia (ACD) and its subtypes (Alzheimer's disease (AD), vascular dementia (VD), …
Oxidative stress is associated with Aβ accumulation in chronic sleep deprivation model.
Beiyu Z, Rong Z, Yi Z, Shan W, Peng L, Meng W, Wei P, Ye Y, Qiumin Q. Beiyu Z, et al. Brain Res. 2024 Apr 15;1829:148776. doi: 10.1016/j.brainres.2024.148776. Epub 2024 Jan 20. Brain Res. 2024. PMID: 38253271
Amyloid-beta (Abeta) accumulation is the main pathological change in Alzheimer's disease (AD), which results from the imbalance of production and clearance of Abeta in the brain. ...
Amyloid-beta (Abeta) accumulation is the main pathological change in Alzheimer's disease (AD), which results from the i …
Altered metabolism and DAM-signatures in female brains and microglia with aging.
Cleland NRW, Potter GJ, Buck C, Quang D, Oldham D, Neal M, Saviola A, Niemeyer CS, Dobrinskikh E, Bruce KD. Cleland NRW, et al. Brain Res. 2024 Apr 15;1829:148772. doi: 10.1016/j.brainres.2024.148772. Epub 2024 Jan 18. Brain Res. 2024. PMID: 38244754
Despite Alzheimer's disease (AD) disproportionately affecting women, the mechanisms remain elusive. ...Young female brains appeared less glycolytic than male brains, but with aging, the female brain became 'male-like.' Transcriptomic analysis revealed increas …
Despite Alzheimer's disease (AD) disproportionately affecting women, the mechanisms remain elusive. ...Young female bra …
Age dependent path integration deficit in 5xFAD mice.
Mar KD, So C, Hou Y, Kim JC. Mar KD, et al. Behav Brain Res. 2024 Apr 12;463:114919. doi: 10.1016/j.bbr.2024.114919. Epub 2024 Feb 24. Behav Brain Res. 2024. PMID: 38408521 Free article.
Alzheimer's disease (AD) is a severe neurodegenerative disorder and the most common form of dementia in elderly individuals, characterized by memory deficits, cognitive decline, and neuropathology. ...
Alzheimer's disease (AD) is a severe neurodegenerative disorder and the most common form of dementia in elderly individ …
Longitudinal MRI analysis using a hybrid DenseNet-BiLSTM method for Alzheimer's disease prediction.
Jomeiri A, Navin AH, Shamsi M. Jomeiri A, et al. Behav Brain Res. 2024 Apr 12;463:114900. doi: 10.1016/j.bbr.2024.114900. Epub 2024 Feb 8. Behav Brain Res. 2024. PMID: 38341100
Alzheimer's disease is a progressive neurological disorder characterized by brain atrophy and cell death, leading to cognitive decline and impaired functioning. ...We evaluated the model on 684 longitudinal MRI images from the Alzheimer's Dis …
Alzheimer's disease is a progressive neurological disorder characterized by brain atrophy and cell death, leading to co …
Inhibitory effects of beta-asarone on lncRNA BACE1-mediated induction of autophagy in a model of Alzheimer's disease.
Wang Z, Zhou J, Zhang B, Xu Z, Wang H, Sun Q, Wang N. Wang Z, et al. Behav Brain Res. 2024 Apr 12;463:114896. doi: 10.1016/j.bbr.2024.114896. Epub 2024 Feb 4. Behav Brain Res. 2024. PMID: 38316166
Additionally, the study sought to explore potential targets of the drug in inhibiting the deposition of toxic AD-related proteins and restoring impaired mitochondrial and autophagic functions. SHY5Y cells were utilized to construct a stable Alzheimer's disease …
Additionally, the study sought to explore potential targets of the drug in inhibiting the deposition of toxic AD-related proteins and restor …
Mitophagy activation by rapamycin enhances mitochondrial function and cognition in 5×FAD mice.
Zheng W, Li K, Zhong M, Wu K, Zhou L, Huang J, Liu L, Chen Z. Zheng W, et al. Behav Brain Res. 2024 Apr 12;463:114889. doi: 10.1016/j.bbr.2024.114889. Epub 2024 Feb 1. Behav Brain Res. 2024. PMID: 38301932 Free article.
Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by severe mitochondrial dysfunction, which is an intracellular process that is significantly compromised in the early stages of AD. ...
Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by severe mitochondrial dysfunction, whi …
Glycoproteome-Wide Discovery of Cortical Glycoproteins That May Provide Cognitive Resilience in Older Adults.
Buchman AS, Yu L, Klein HU, Zammit AR, Oveisgharan S, Nag S, Tickotsky N, Levy H, Seyfried N, Morgenstern D, Levin Y, Schnaider Beeri M, Bennett DA. Buchman AS, et al. Neurology. 2024 Apr 9;102(7):e209223. doi: 10.1212/WNL.0000000000209223. Epub 2024 Mar 19. Neurology. 2024. PMID: 38502899
BACKGROUND AND OBJECTIVES: Molecular omics studies have identified proteins related to cognitive resilience but unrelated to Alzheimer disease and Alzheimer disease-related dementia (AD/ADRD) pathologies. ...
BACKGROUND AND OBJECTIVES: Molecular omics studies have identified proteins related to cognitive resilience but unrelated to Alzheimer …
Linking Type and Extent of Head Trauma to Cavum Septum Pellucidum in Older Adults With and Without Alzheimer Disease and Related Dementias.
Asken BM, Tanner JA, Vandevrede L, Apple A, Chapleau M, Gaynor LS, Lane-Donovan C, Lenio S, Yadollahikhales G, Lee S, Gontrum E, Knudtson M, Iaccarino L, La Joie R, Cobigo Y, Staffaroni AM, Casaletto KB, Gardner RC, Grinberg LT, Gorno-Tempini ML, Rosen HJ, Seeley WW, Miller BL, Kramer J, Rabinovici GD. Asken BM, et al. Neurology. 2024 Apr 9;102(7):e209183. doi: 10.1212/WNL.0000000000209183. Epub 2024 Mar 15. Neurology. 2024. PMID: 38489566
METHODS: This is an observational cohort study of University of California, San Francisco Memory and Aging Center participants (healthy controls [HCs], those with Alzheimer disease or related dementias [ADRDs], subset with traumatic encephalopathy syndrome [TES]). . …
METHODS: This is an observational cohort study of University of California, San Francisco Memory and Aging Center participants (healthy cont …
Association of β-Amyloid, Microglial Activation, Cortical Thickness, and Metabolism in Older Adults Without Dementia.
Cai Y, Shi D, Lan G, Chen L, Jiang Y, Zhou L, Guo T; Alzheimer's Disease Neuroimaging Initiative. Cai Y, et al. Neurology. 2024 Apr 9;102(7):e209205. doi: 10.1212/WNL.0000000000209205. Epub 2024 Mar 15. Neurology. 2024. PMID: 38489560
METHODS: We selected participants without dementia who had concurrent plasma Abeta(42)/Abeta(40) and Abeta-PET scans from the Alzheimer's Disease Neuroimaging Initiative cohort. Participants were categorized into Plasma/PET based on thresholds of composite (1 …
METHODS: We selected participants without dementia who had concurrent plasma Abeta(42)/Abeta(40) and Abeta-PET scans from the Alzheimer …
Lecanemab for Alzheimer Disease: Is It Worth It?
Nelson SE, Lopez OL. Nelson SE, et al. Neurology. 2024 Apr 9;102(7):e209265. doi: 10.1212/WNL.0000000000209265. Epub 2024 Mar 14. Neurology. 2024. PMID: 38484273 No abstract available.
Lecanemab Questions.
Nadeau SE. Nadeau SE. Neurology. 2024 Apr 9;102(7):e209320. doi: 10.1212/WNL.0000000000209320. Epub 2024 Mar 14. Neurology. 2024. PMID: 38484213
The recently published results of the 18-month randomized controlled trial of lecanemab, reporting the efficacy of the drug in slowing the progression of early Alzheimer disease, quickly led to approval by the FDA and widespread acceptance of lecanemab treatment. .. …
The recently published results of the 18-month randomized controlled trial of lecanemab, reporting the efficacy of the drug in slowing the p …
Cost-Effectiveness of Lecanemab for Individuals With Early-Stage Alzheimer Disease.
Nguyen HV, Mital S, Knopman DS, Alexander GC. Nguyen HV, et al. Neurology. 2024 Apr 9;102(7):e209218. doi: 10.1212/WNL.0000000000209218. Epub 2024 Mar 14. Neurology. 2024. PMID: 38484190
BACKGROUND AND OBJECTIVES: Little is known regarding the cost-effectiveness of lecanemab (Leqembi), a monoclonal antibody approved by the US Food and Drug Administration in January 2023 for the treatment of mild cognitive impairment (MCI) or mild dementia due to Alzheimer …
BACKGROUND AND OBJECTIVES: Little is known regarding the cost-effectiveness of lecanemab (Leqembi), a monoclonal antibody approved by the US …
CSF β-Amyloid and Tau Biomarker Changes in Veterans With Mild Traumatic Brain Injury.
Li G, Iliff J, Shofer J, Mayer CL, Meabon J, Cook D, Pagulayan KF, Raskind MA, Zetterberg H, Blennow K, Peskind ER. Li G, et al. Neurology. 2024 Apr 9;102(7):e209197. doi: 10.1212/WNL.0000000000209197. Epub 2024 Mar 13. Neurology. 2024. PMID: 38478804
BACKGROUND AND OBJECTIVES: Moderate-to-severe traumatic brain injuries (TBI) have been reported to increase the risk of Alzheimer disease (AD). Whether mild TBI (mTBI) in veterans confers a similar increased risk of AD is less known. ...
BACKGROUND AND OBJECTIVES: Moderate-to-severe traumatic brain injuries (TBI) have been reported to increase the risk of Alzheimer …
Association of Age-Related Neuropathologic Findings at Autopsy With a Claims-Based Epilepsy Diagnosis in Older Adults.
Oveisgharan S, Grodstein F, Evia AM Jr, James BD, Capuano AW, Chen Y, Arfanakis K, Schneider JA, Bennett DA. Oveisgharan S, et al. Neurology. 2024 Apr 9;102(7):e209172. doi: 10.1212/WNL.0000000000209172. Epub 2024 Mar 13. Neurology. 2024. PMID: 38478792
The postmortem pathologic assessment collected indices of 9 pathologies including Alzheimer disease, hippocampal sclerosis, macroinfarcts, and cerebral amyloid angiopathy. ...Cerebral amyloid angiopathy (odds ratio [OR] = 2.21, 95% CI 1.24-3.95, p = 0.007) and corti …
The postmortem pathologic assessment collected indices of 9 pathologies including Alzheimer disease, hippocampal sclerosis, ma …
Association of Neurotrophic Factors at Midlife With In Vivo Measures of β-Amyloid and Tau Burden 15 Years Later in Dementia-Free Adults.
Weinstein G, Kojis DJ, Ghosh S, Beiser AS, Seshadri S. Weinstein G, et al. Neurology. 2024 Apr 9;102(7):e209198. doi: 10.1212/WNL.0000000000209198. Epub 2024 Mar 12. Neurology. 2024. PMID: 38471064
BACKGROUND AND OBJECTIVES: Neurotrophic factors (NTFs) play an important role in Alzheimer disease (AD) pathophysiology. Brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) are important NTFs. ...
BACKGROUND AND OBJECTIVES: Neurotrophic factors (NTFs) play an important role in Alzheimer disease (AD) pathophysiology. Brain …
Nonalcoholic Fatty Liver Disease and Longitudinal Change in Imaging and Plasma Biomarkers of Alzheimer Disease and Vascular Pathology.
Lu Y, Pike JR, Hoogeveen R, Walker K, Raffield L, Selvin E, Avery C, Engel S, Mielke MM, Garcia T, Heiss G, Palta P. Lu Y, et al. Neurology. 2024 Apr 9;102(7):e209203. doi: 10.1212/WNL.0000000000209203. Epub 2024 Mar 12. Neurology. 2024. PMID: 38471046
BACKGROUND AND OBJECTIVES: Prospective measures of plasma and cerebral MRI biomarkers of Alzheimer disease (AD) and vascular neuropathology provide an opportunity to investigate possible mechanisms linking liver disease and dementia. We aimed to quantify the …
BACKGROUND AND OBJECTIVES: Prospective measures of plasma and cerebral MRI biomarkers of Alzheimer disease (AD) and vascular n …
Statin Initiation and Risk of Incident Alzheimer Disease and Cognitive Decline in Genetically Susceptible Older Adults.
Rajan KB, Mcaninch EA, Wilson RS, Dhana A, Evans-Lacko S, Evans DA. Rajan KB, et al. Neurology. 2024 Apr 9;102(7):e209168. doi: 10.1212/WNL.0000000000209168. Epub 2024 Mar 6. Neurology. 2024. PMID: 38447103
BACKGROUND AND OBJECTIVES: The association of statin initiation with incident Alzheimer disease (AD) dementia and cognitive decline by the APOE epsilon4 allele is unknown. ...CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that among those aged 65 …
BACKGROUND AND OBJECTIVES: The association of statin initiation with incident Alzheimer disease (AD) dementia and cognitive de …
Early events during the aggregation of Aβ16-22-derived switch-peptides tracked using Protein Charge Transfer Spectra.
Alom SE, Kalita S, Kawa AH, Mandal B, Swaminathan R. Alom SE, et al. Anal Chim Acta. 2024 Apr 8;1297:342374. doi: 10.1016/j.aca.2024.342374. Epub 2024 Feb 13. Anal Chim Acta. 2024. PMID: 38438229
BACKGROUND: Understanding Abeta aggregation and inhibiting it at early stages is of utmost importance in treating Alzheimer's and other related amyloidogenic diseases. However, majority of the techniques to study Abeta aggregation mainly target the late stages; whil …
BACKGROUND: Understanding Abeta aggregation and inhibiting it at early stages is of utmost importance in treating Alzheimer's …
Retromer-dependent lysosomal stress in Parkinson's disease.
Alessi DR, Cullen PJ, Cookson M, Merchant KM, Small SA. Alessi DR, et al. Philos Trans R Soc Lond B Biol Sci. 2024 Apr 8;379(1899):20220376. doi: 10.1098/rstb.2022.0376. Epub 2024 Feb 19. Philos Trans R Soc Lond B Biol Sci. 2024. PMID: 38368937 Free PMC article. Review.
While causative mutations in complex disorders are rare, they can be used to extract a biological pathway whose pathogenicity can generalize to common forms of the disease. Here we begin by relying on the biological consequences of mutations in LRRK2 and VPS35, genetic cau …
While causative mutations in complex disorders are rare, they can be used to extract a biological pathway whose pathogenicity can generalize …
Endo-lysosomal dysfunction in neurodegenerative diseases: opinion on current progress and future direction in the use of exosomes as biomarkers.
Herman M, Randall GW, Spiegel JL, Maldonado DJ, Simoes S. Herman M, et al. Philos Trans R Soc Lond B Biol Sci. 2024 Apr 8;379(1899):20220387. doi: 10.1098/rstb.2022.0387. Epub 2024 Feb 19. Philos Trans R Soc Lond B Biol Sci. 2024. PMID: 38368936 Free PMC article. Review.
Disruption of this pathway is linked to a wide range of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease and frontotemporal dementia. ...In this Opinion piece, we …
Disruption of this pathway is linked to a wide range of neurodegenerative diseases, including Alzheimer's disease, Park …
Differential effects of SORL1 deficiency on the endo-lysosomal network in human neurons and microglia.
Mishra S, Jayadev S, Young JE. Mishra S, et al. Philos Trans R Soc Lond B Biol Sci. 2024 Apr 8;379(1899):20220389. doi: 10.1098/rstb.2022.0389. Epub 2024 Feb 19. Philos Trans R Soc Lond B Biol Sci. 2024. PMID: 38368935 Free PMC article. Review.
The endosomal gene SORL1 is a strong Alzheimer's disease (AD) risk gene that harbours loss-of-function variants causative for developing AD. ...
The endosomal gene SORL1 is a strong Alzheimer's disease (AD) risk gene that harbours loss-of-function variants causati …
Cell type-specific functions of Alzheimer's disease endocytic risk genes.
Maninger JK, Nowak K, Goberdhan S, O'Donoghue R, Connor-Robson N. Maninger JK, et al. Philos Trans R Soc Lond B Biol Sci. 2024 Apr 8;379(1899):20220378. doi: 10.1098/rstb.2022.0378. Epub 2024 Feb 19. Philos Trans R Soc Lond B Biol Sci. 2024. PMID: 38368934 Free PMC article. Review.
It is also critical for the recycling of cellular components, cellular trafficking and membrane dynamics. The endocytic pathway has been consistently implicated in Alzheimer's disease (AD) through repeated genome-wide association studies and the existence of …
It is also critical for the recycling of cellular components, cellular trafficking and membrane dynamics. The endocytic pathway has been con …
Functional characterization of SORL1 variants in cell-based assays to investigate variant pathogenicity.
Fazeli E, Fazeli E, Fojtík P, Holstege H, Andersen OM. Fazeli E, et al. Philos Trans R Soc Lond B Biol Sci. 2024 Apr 8;379(1899):20220377. doi: 10.1098/rstb.2022.0377. Epub 2024 Feb 19. Philos Trans R Soc Lond B Biol Sci. 2024. PMID: 38368933 Free PMC article.
While SORLA loss-of-function variants occur almost exclusively in Alzheimer's disease cases, the majority of SORL1 variants are missense variants that are individually rare and can have individual mechanisms how they impair SORLA function as well as have indi …
While SORLA loss-of-function variants occur almost exclusively in Alzheimer's disease cases, the majority of SORL1 vari …
Understanding the endo-lysosomal network in neurodegeneration.
Cullen PJ, Holstege H, Small SA, St George-Hyslop P. Cullen PJ, et al. Philos Trans R Soc Lond B Biol Sci. 2024 Apr 8;379(1899):20220372. doi: 10.1098/rstb.2022.0372. Epub 2024 Feb 19. Philos Trans R Soc Lond B Biol Sci. 2024. PMID: 38368931 Free PMC article. No abstract available.
Protective effect of a hydromethanolic extract from Fraxinus excelsior L. bark against a rat model of aluminum chloride-induced Alzheimer's disease: Relevance to its anti-inflammatory and antioxidant effects.
Iranpanah A, Fakhri S, Bahrami G, Majnooni MB, Gravandi MM, Taghavi S, Badrbani MA, Amirian R, Farzaei MH. Iranpanah A, et al. J Ethnopharmacol. 2024 Apr 6;323:117708. doi: 10.1016/j.jep.2024.117708. Epub 2024 Jan 4. J Ethnopharmacol. 2024. PMID: 38181932
Moreover, FE bark and leaves have been used to treat neurological disorders, aging, neuropathic pain, urinary complaints, and articular pain in traditional and ethnomedicine. Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder resulting fr …
Moreover, FE bark and leaves have been used to treat neurological disorders, aging, neuropathic pain, urinary complaints, and articular pain …
SuanZaoRen decoction alleviates neuronal loss, synaptic damage and ferroptosis of AD via activating DJ-1/Nrf2 signaling pathway.
Long Q, Li T, Zhu Q, He L, Zhao B. Long Q, et al. J Ethnopharmacol. 2024 Apr 6;323:117679. doi: 10.1016/j.jep.2023.117679. Epub 2023 Dec 29. J Ethnopharmacol. 2024. PMID: 38160863 Free article.
ETHNOPHARMACOLOGICAL RELEVANCE: SuanZaoRen Decoction (SZRD), a famous herbal prescription, and has been widely proven to have positive therapeutic effects on insomnia, depression and Alzheimer's disease (AD). However, the anti-AD molecular mechanism of SZRD r …
ETHNOPHARMACOLOGICAL RELEVANCE: SuanZaoRen Decoction (SZRD), a famous herbal prescription, and has been widely proven to have positive thera …
Effect of Cerebralcare Granule combined with memantine on Alzheimer's disease.
Yang M, Zhang X, Qiao O, Zhang J, Li X, Ma X, Zhou S, Gao W. Yang M, et al. J Ethnopharmacol. 2024 Apr 6;323:117609. doi: 10.1016/j.jep.2023.117609. Epub 2023 Dec 23. J Ethnopharmacol. 2024. PMID: 38142875
ETHNOPHARMACOLOGICAL RELEVANCE: In elderly people, Alzheimer's disease (AD) is the most common form of dementia. It has been shown that traditional Chinese medicine (TCM) based on phytomedicines enhances the therapeutic effects of modern medicine when taken i …
ETHNOPHARMACOLOGICAL RELEVANCE: In elderly people, Alzheimer's disease (AD) is the most common form of dementia. It has …
Inhibition of Alzheimer's disease by 4-octyl itaconate revealed by RNA-seq transcriptome analysis.
Liu Y, Xia P, Zong S, Zheng N, Cui X, Wang C, Wang M, Wang X, Yu S, Zhao H, Lu Z. Liu Y, et al. Eur J Pharmacol. 2024 Apr 5;968:176432. doi: 10.1016/j.ejphar.2024.176432. Epub 2024 Feb 16. Eur J Pharmacol. 2024. PMID: 38369275
AIMS: This study aimed to examine the therapeutic effects and response mechanisms of 4-OI in Alzheimer's disease (AD). METHODS: In this study, network pharmacology was employed to analyze potential targets for AD drug therapy. ...
AIMS: This study aimed to examine the therapeutic effects and response mechanisms of 4-OI in Alzheimer's disease (AD). …
Risk of Dementia During Antihypertensive Drug Therapy in the Elderly.
Rea F, Corrao G, Mancia G. Rea F, et al. J Am Coll Cardiol. 2024 Apr 2;83(13):1194-1203. doi: 10.1016/j.jacc.2024.01.030. Epub 2024 Mar 25. J Am Coll Cardiol. 2024. PMID: 38538198
Cases were the 13,812 patients (age 77.5 6.6 years; 40% men) who developed dementia or Alzheimer's disease during follow-up (up to 2019). For each case, 5 control subjects were selected to be matched for sex, age, and clinical status. ...
Cases were the 13,812 patients (age 77.5 6.6 years; 40% men) who developed dementia or Alzheimer's disease during follo …
Analysis of gait characteristics and related factors in patients with Parkinson's disease based on wearable devices.
Tang H, Liao X, Yao J, Xing Y, Zhao X, Cheng W, Gu T, Huang Y, Xu G, Luan P, Tian J, Li G. Tang H, et al. Brain Behav. 2024 Apr;14(4):e3440. doi: 10.1002/brb3.3440. Brain Behav. 2024. PMID: 38538928
BACKGROUND: Postural instability and gait disorder dominant (PIGD) is one of the most common disabling symptoms of Parkinson's disease (PD), which seriously affects patients' quality of life. Therefore, it is essential to identify PIGD and develop targeted interventions to …
BACKGROUND: Postural instability and gait disorder dominant (PIGD) is one of the most common disabling symptoms of Parkinson's disease …
Soluble Biomarkers of Cerebrovascular Pathologies.
Foley KE, Wilcock DM. Foley KE, et al. Stroke. 2024 Apr;55(4):801-811. doi: 10.1161/STROKEAHA.123.044172. Epub 2024 Mar 25. Stroke. 2024. PMID: 38527143 Review.
With the advancement of imaging and pathological studies, we now understand that VCID is often comorbid with Alzheimer disease. While researchers in the Alzheimer disease field have been working for years to establish and test blood-based biomarkers fo …
With the advancement of imaging and pathological studies, we now understand that VCID is often comorbid with Alzheimer disease …
Tobacco use and risk of acute stroke in 32 countries in the INTERSTROKE study: a case-control study.
Wang X, Liu X, O'Donnell MJ, McQueen M, Sniderman A, Pare G, Hankey GJ, Rangarajan S, Chin SL, Rao-Melacini P, Ferguson J, Xavier D, Zhang H, Liu L, Pais P, Lopez-Jaramillo P, Damasceno A, Langhorne P, Rosengren A, Dans AL, Elsayed A, Avezum A, Mondo C, Judge C, Diener HC, Ryglewicz D, Czlonkowska A, Pogosova N, Weimar C, Iqbal R, Diaz R, Yusoff K, Yusufali A, Oguz A, Penaherrera E, Lanas F, Ogah OS, Ogunniyi A, Iversen HK, Malaga G, Rumboldt Z, Oveisgharan S, Al Hussain F, Nilanont Y, Yusuf S; INTERSTROKE Investigators. Wang X, et al. EClinicalMedicine. 2024 Mar 14;70:102515. doi: 10.1016/j.eclinm.2024.102515. eCollection 2024 Apr. EClinicalMedicine. 2024. PMID: 38516107 Free PMC article.
Effect of Dietary Habits on Alzheimer's Disease Progression.
Ahn SH, Jeong JH, Park KW, Kim EJ, Yoon SJ, Yoon B, Jang JW, Minn Y, Choi SH. Ahn SH, et al. Yonsei Med J. 2024 Apr;65(4):217-226. doi: 10.3349/ymj.2023.0119. Yonsei Med J. 2024. PMID: 38515359 Free article.
This study investigated the association between dietary habits and dementia progression over 3 years in patients with Alzheimer's disease dementia (ADD). MATERIALS AND METHODS: This study included 705 patients with mild-to-moderate ADD. ...
This study investigated the association between dietary habits and dementia progression over 3 years in patients with Alzheimer's …
The expectations and experiences of patients regarding the diagnostic workup at a specialized memory clinic: An interview study.
Aspö M, Sundell M, Protsiv M, Wiggenraad F, Rydén M, Mangialasche F, Kivipelto M, Visser LNC. Aspö M, et al. Health Expect. 2024 Apr;27(2):e14021. doi: 10.1111/hex.14021. Health Expect. 2024. PMID: 38515262 Free PMC article.
BACKGROUND: Because of the shift towards earlier diagnosis of dementia and/or Alzheimer's disease (AD), increasing numbers of individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI) are seen in memory clinics. ...
BACKGROUND: Because of the shift towards earlier diagnosis of dementia and/or Alzheimer's disease (AD), increasing numb …
Epigenetics and the neurodegenerative process.
Słowikowski B, Owecki W, Jeske J, Jezierski M, Draguła M, Goutor U, Jagodziński PP, Kozubski W, Dorszewska J. Słowikowski B, et al. Epigenomics. 2024 Apr;16(7):473-491. doi: 10.2217/epi-2023-0416. Epub 2024 Mar 21. Epigenomics. 2024. PMID: 38511224 Review.
This review summarizes current knowledge about neurological disorders caused by epigenetic changes in diseases such as Alzheimer's disease, Parkinson's disease, stroke and epilepsy. Advances in epigenetic techniques may be key to understanding the epig …
This review summarizes current knowledge about neurological disorders caused by epigenetic changes in diseases such as Alzheimer's …
Towards an ion-channel-centric approach to ultrasound neuromodulation.
Prieto ML, Maduke M. Prieto ML, et al. Curr Opin Behav Sci. 2024 Apr;56:101355. doi: 10.1016/j.cobeha.2024.101355. Epub 2024 Feb 15. Curr Opin Behav Sci. 2024. PMID: 38505510
Ultrasound neuromodulation is a promising technology that could revolutionize study and treatment of brain conditions ranging from mood disorders to Alzheimer's disease and stroke. An understanding of how ultrasound directly modulates specific ion channels co …
Ultrasound neuromodulation is a promising technology that could revolutionize study and treatment of brain conditions ranging from mood diso …
Efficacy of Sailuotong on neurovascular unit in amyloid precursor protein/presenilin-1 transgenic mice with Alzheimer's disease.
Linjuan S, Chengfu LI, Jiangang L, Nannan LI, Fuhua H, Dandan Q, Zhuang T, Min Z, Wenjie C, Xiaohui Z, Chenguang T, Dong C, Jiangxia Q, Yang L, Xiao L, Xiaoying Z, Yunling Z. Linjuan S, et al. J Tradit Chin Med. 2024 Apr;44(2):289-302. doi: 10.19852/j.cnki.jtcm.20240203.007. J Tradit Chin Med. 2024. PMID: 38504535
OBJECTIVE: To discuss the influence of Sailuotong (, SLT) on the Neurovascular Unit (NVUs) of amyloid precursor protein (APP)/presenilin-1(PS1) mice and evaluate the role of gas supplementation in activating blood circulation during the progression of Alzheimer's …
OBJECTIVE: To discuss the influence of Sailuotong (, SLT) on the Neurovascular Unit (NVUs) of amyloid precursor protein (APP)/presenilin-1(P …
Emotion in public involvement: A conceptual review.
Liabo K, Asare L, Ruthen P, Burton J, Staunton P, Day J. Liabo K, et al. Health Expect. 2024 Apr;27(2):e14020. doi: 10.1111/hex.14020. Health Expect. 2024. PMID: 38504467 Free PMC article. Review.
Simple ammonium salt and sigma-1 receptor ligand dipentylammonium provides neuroprotective effects in cell culture and Caenorhabditis elegans models of Alzheimer's disease.
Prasanth MI, Verma K, Brimson S, Tencomnao T, Brimson JM. Prasanth MI, et al. Biomed Pharmacother. 2024 Apr;173:116455. doi: 10.1016/j.biopha.2024.116455. Epub 2024 Mar 18. Biomed Pharmacother. 2024. PMID: 38503234 Free article.
The sigma-1 receptor (sigma-1R), a chaperone protein located at the mitochondria-associated membrane (MAM) of the endoplasmic reticulum, can interact with and modify the signaling pathways of various proteins, thereby modulating many disease pathologies, including Alzhe …
The sigma-1 receptor (sigma-1R), a chaperone protein located at the mitochondria-associated membrane (MAM) of the endoplasmic reticulum, can …
Chronic traumatic encephalopathy neuropathologic change in former Australian rugby players.
Shepherd CE, McCann H, McLean CA, Iverson GL, Gardner AJ. Shepherd CE, et al. Neuropathol Appl Neurobiol. 2024 Apr;50(2):e12972. doi: 10.1111/nan.12972. Neuropathol Appl Neurobiol. 2024. PMID: 38502287
However, coexisting neuropathologies were common, with limbic-predominant age-related TDP-43 encephalopathy and ageing-related tau astrogliopathy seen in all cases, intermediate or high Alzheimer's disease neuropathological change seen in four cases and hippo …
However, coexisting neuropathologies were common, with limbic-predominant age-related TDP-43 encephalopathy and ageing-related tau astroglio …
Resveratrol prevents cognitive deficits induced by sleep deprivation via modulating sirtuin 1 associated pathways in the hippocampus.
Zhang YM, Wei RM, Zhang JY, Liu S, Zhang KX, Kong XY, Ge YJ, Li XY, Chen GH. Zhang YM, et al. J Biochem Mol Toxicol. 2024 Apr;38(4):e23698. doi: 10.1002/jbt.23698. J Biochem Mol Toxicol. 2024. PMID: 38501767
Resveratrol, an agonist of the Sirt1, has demonstrated anti-inflammation and neuroprotective effects in models of Alzheimer's disease, Parkinson's disease, and schizophrenia. However, the beneficial effects of resveratrol on sleep deprivation-induced c …
Resveratrol, an agonist of the Sirt1, has demonstrated anti-inflammation and neuroprotective effects in models of Alzheimer's …
"Relationships, Very Quickly, Turn to Nothing": Loneliness, Social Isolation, and Adaptation to Changing Social Lives Among Persons Living With Dementia and Care Partners.
Kotwal AA, Allison TA, Halim M, Garrett SB, Perissinotto CM, Ritchie CS, Smith AK, Harrison KL. Kotwal AA, et al. Gerontologist. 2024 Apr 1;64(4):gnae014. doi: 10.1093/geront/gnae014. Gerontologist. 2024. PMID: 38499400
BACKGROUND AND OBJECTIVES: Persons with dementia and their care partners have known risks for loneliness and social isolation throughout the disease trajectory, yet little is described about social lives in a population heterogeneous for disease stage, syndrome type …
BACKGROUND AND OBJECTIVES: Persons with dementia and their care partners have known risks for loneliness and social isolation throughout the …
Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
GBD 2021 Nervous System Disorders Collaborators. GBD 2021 Nervous System Disorders Collaborators. Lancet Neurol. 2024 Apr;23(4):344-381. doi: 10.1016/S1474-4422(24)00038-3. Epub 2024 Mar 14. Lancet Neurol. 2024. PMID: 38493795 Free article.
The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spec …
The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's …
Kallistatin leads to cognition impairment via downregulating glutamine synthetase.
Long Y, Zhao Z, Xie W, Shi J, Yang F, Zhu D, Jiang P, Tang Q, Ti Z, Jiang B, Yang X, Gao G, Qi W. Long Y, et al. Pharmacol Res. 2024 Apr;202:107145. doi: 10.1016/j.phrs.2024.107145. Epub 2024 Mar 14. Pharmacol Res. 2024. PMID: 38492829 Free article.
In many neurodegenerative disorders, such as Alzheimer's disease (AD), glutamate-mediated neuronal excitotoxicity is considered the basis for cognitive impairment. ...
In many neurodegenerative disorders, such as Alzheimer's disease (AD), glutamate-mediated neuronal excitotoxicity is co …
Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease.
Mezeiova E, Prchal L, Hrabinova M, Muckova L, Pulkrabkova L, Soukup O, Misiachna A, Janousek J, Fibigar J, Kucera T, Horak M, Makhaeva GF, Korabecny J. Mezeiova E, et al. Biomed Pharmacother. 2024 Apr;173:116399. doi: 10.1016/j.biopha.2024.116399. Epub 2024 Mar 15. Biomed Pharmacother. 2024. PMID: 38492439 Free article.
The search for novel drugs to address the medical needs of Alzheimer's disease (AD) is an ongoing process relying on the discovery of disease-modifying agents. Given the complexity of the disease, such an aim can be pursued by developing so-call …
The search for novel drugs to address the medical needs of Alzheimer's disease (AD) is an ongoing process relying on th …
National plans and awareness campaigns as priorities for achieving global brain health.
Winter SF, Walsh D, Catsman-Berrevoets C, Feigin V, Destrebecq F, Dickson SL, Leonardi M, Hoemberg V, Tassorelli C, Ferretti MT, Dé A, Chadha AS, Lynch C, Bakhtadze S, Saylor D, Hwang S, Rostasy K, Kluger BM, Wright C, Zee PC, Dodick DW, Jaarsma J, Owolabi MO, Zaletel J, Albreht T, Dhamija RK, Helme A, Laurson-Doube J, Amos A, Baingana FK, Baker GA, Sofia F, Galvin O, Hawrot T. Winter SF, et al. Lancet Glob Health. 2024 Apr;12(4):e697-e706. doi: 10.1016/S2214-109X(23)00598-3. Lancet Glob Health. 2024. PMID: 38485433 Free PMC article. Review.
Gut instincts: Unveiling the connection between gut microbiota and Alzheimer's disease.
Peddinti V, Avaghade MM, Suthar SU, Rout B, Gomte SS, Agnihotri TG, Jain A. Peddinti V, et al. Clin Nutr ESPEN. 2024 Apr;60:266-280. doi: 10.1016/j.clnesp.2024.02.019. Epub 2024 Feb 19. Clin Nutr ESPEN. 2024. PMID: 38479921 Review.
Alzheimer's disease (AD) is a neurodegenerative disorder marked by neuroinflammation and gradual cognitive decline. ...
Alzheimer's disease (AD) is a neurodegenerative disorder marked by neuroinflammation and gradual cognitive decline. ...
Tetramethylpyrazine Nitrone alleviates D-galactose-induced murine skeletal muscle aging and motor deficits by activating the AMPK signaling pathway.
Nie L, He K, Qiu C, Li Q, Xiong B, Gao C, Zhang X, Jing M, Wu W, Liu J, Zhang G, Zhang Z, Yang X, Sun Y, Wang Y. Nie L, et al. Biomed Pharmacother. 2024 Apr;173:116415. doi: 10.1016/j.biopha.2024.116415. Epub 2024 Mar 12. Biomed Pharmacother. 2024. PMID: 38479182 Free article.
Tetramethylpyrazine nitrone (TBN), a novel derivative of tetramethylpyrazine (TMP) designed and synthesized by our group, possesses multi-functional mechanisms of action and displays broad protective effects in vitro and in animal models of age-related brain disorders such as str …
Tetramethylpyrazine nitrone (TBN), a novel derivative of tetramethylpyrazine (TMP) designed and synthesized by our group, possesses multi-fu …
Modulation of secretory factors by lipofundin contributes to its anti‑neuroinflammatory effects.
Chen MS, Hu CL, Jiang SK, Chong ZY, Chen JC. Chen MS, et al. Exp Ther Med. 2024 Feb 27;27(4):169. doi: 10.3892/etm.2024.12456. eCollection 2024 Apr. Exp Ther Med. 2024. PMID: 38476917 Free PMC article.
As the global population ages, the prevalence of neuroinflammatory diseases such as Alzheimer's disease, Parkinson's disease and stroke continues to increase. ...
As the global population ages, the prevalence of neuroinflammatory diseases such as Alzheimer's disease, Parkinson's …
Reducing brain Abeta burden ameliorates high-fat diet-induced fatty liver disease in APP/PS1 mice.
Tsay HJ, Gan YL, Su YH, Sun YY, Yao HH, Chen HW, Hsu YT, Hsu JT, Wang HD, Shie FS. Tsay HJ, et al. Biomed Pharmacother. 2024 Apr;173:116404. doi: 10.1016/j.biopha.2024.116404. Epub 2024 Mar 11. Biomed Pharmacother. 2024. PMID: 38471275 Free article.
High-fat diet (HFD)-induced fatty liver disease is a deteriorating risk factor for Alzheimer's disease (AD). Mitigating fatty liver disease has been shown to attenuate AD-like pathology in animal models. ...
High-fat diet (HFD)-induced fatty liver disease is a deteriorating risk factor for Alzheimer's disease (AD). Mit …
Synthesis and molecular docking studies of 5-trifluoromethoxy-2-indolinones as cholinesterase dual inhibitors.
Soylu-Eter Ö, Özsoy N, Karalı N. Soylu-Eter Ö, et al. Future Med Chem. 2024 Apr;16(7):623-645. doi: 10.4155/fmc-2023-0281. Epub 2024 Mar 5. Future Med Chem. 2024. PMID: 38470247
Background: In Alzheimer's disease, butyrylcholinesterase (BuChE) activity gradually increases, while acetylcholinesterase (AChE) activity decreases or remains unchanged. Dual inhibitors have important roles in regulation of synaptic acetylcholine levels and …
Background: In Alzheimer's disease, butyrylcholinesterase (BuChE) activity gradually increases, while acetylcholinester …
An inside job: New roles for ApoE at the lipid droplet.
Feringa FM, van der Kant R. Feringa FM, et al. J Cell Biol. 2024 Apr 1;223(4):e202402171. doi: 10.1083/jcb.202402171. Epub 2024 Mar 11. J Cell Biol. 2024. PMID: 38466168 Free article.
Blood-based biomarkers for Alzheimer's disease.
[No authors listed] [No authors listed] Neuroscientist. 2024 Apr;30(2):155. doi: 10.1177/10738584241236157. Neuroscientist. 2024. PMID: 38465455 No abstract available.
A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer's mice.
Abd-Elrahman KS, Colson TL, Sarasija S, Ferguson SSG. Abd-Elrahman KS, et al. Biomed Pharmacother. 2024 Apr;173:116388. doi: 10.1016/j.biopha.2024.116388. Epub 2024 Mar 9. Biomed Pharmacother. 2024. PMID: 38460371 Free article.
Alzheimer's disease (AD) is the most prevalent type of dementia, disproportionately affecting females, who make up nearly 60% of diagnosed cases. ...This study sheds light on an additional mechanism through which novel M1 mAChR PAMs exhibit disease-mod …
Alzheimer's disease (AD) is the most prevalent type of dementia, disproportionately affecting females, who make up near …
Targeting aberrant glycosylation to modulate microglial response and improve cognition in models of Alzheimer's disease.
Wang Y, Du Y, Huang H, Cao Y, Pan K, Zhou Y, He J, Yao W, Chen S, Gao X. Wang Y, et al. Pharmacol Res. 2024 Apr;202:107133. doi: 10.1016/j.phrs.2024.107133. Epub 2024 Mar 6. Pharmacol Res. 2024. PMID: 38458367 Free article.
Altered glycosylation profiles have been correlated with potential drug targets in various diseases, including Alzheimer's disease (AD). In this area, the linkage between bisecting N-acetylglucosamine (GlcNAc), a product of N-acetylglucosaminyltransferase III …
Altered glycosylation profiles have been correlated with potential drug targets in various diseases, including Alzheimer's …
A network approach to subjective cognitive decline: Exploring multivariate relationships in neuropsychological test performance across Alzheimer's disease risk states.
Grunden N, Phillips NA; Consortium for the Early Identification of Alzheimer's Disease-Quebec (CIMA-Q); COMPASS-ND group. Grunden N, et al. Cortex. 2024 Apr;173:313-332. doi: 10.1016/j.cortex.2024.02.005. Epub 2024 Feb 21. Cortex. 2024. PMID: 38458017
Following previous network studies of mild cognitive impairment (MCI) and Alzheimer's dementia (AD), the current study centered upon the novel visualization and analysis of the SCD cognitive network compared to cognitively normal (CN) older adult, MCI, and AD group …
Following previous network studies of mild cognitive impairment (MCI) and Alzheimer's dementia (AD), the current study centere …
Thematic Analysis of Alzheimer's Medication Management Discussion in a Non-Moderated Online Forum.
Liu J, Meyer K, Glassner A, Gonzales M, Bartlett Ellis RJ, Park H, Song L, Patel N, Wang J. Liu J, et al. West J Nurs Res. 2024 Apr;46(4):307-314. doi: 10.1177/01939459241237671. Epub 2024 Mar 8. West J Nurs Res. 2024. PMID: 38456477 Free PMC article.
BACKGROUND: Managing medications for Alzheimer's disease and related dementias is challenging for caregivers. ...CONCLUSIONS: The experiences shared on a non-moderated, unstructured online forum indicate that medication management is challenging and overwhelm …
BACKGROUND: Managing medications for Alzheimer's disease and related dementias is challenging for caregivers. ...CONCLU …
Molecular hybridization: a powerful tool for multitarget drug discovery.
de Sena Murteira Pinheiro P, Franco LS, Montagnoli TL, Fraga CAM. de Sena Murteira Pinheiro P, et al. Expert Opin Drug Discov. 2024 Apr;19(4):451-470. doi: 10.1080/17460441.2024.2322990. Epub 2024 Mar 8. Expert Opin Drug Discov. 2024. PMID: 38456452 Review.
The article discusses the design strategies and target selection for a multitarget polypharmacology approach to treat various diseases, including cancer, Alzheimer's disease, cardiac arrhythmia, endometriosis, and inflammatory diseases. ...
The article discusses the design strategies and target selection for a multitarget polypharmacology approach to treat various diseases, incl …
Free water in gray matter linked to gut microbiota changes with decreased butyrate producers in Alzheimer's disease and mild cognitive impairment.
Yamashiro K, Takabayashi K, Kamagata K, Nishimoto Y, Togashi Y, Yamauchi Y, Ogaki K, Li Y, Hatano T, Motoi Y, Suzuki M, Miyakawa K, Ishikawa D, Aoki S, Urabe T, Hattori N. Yamashiro K, et al. Neurobiol Dis. 2024 Apr;193:106464. doi: 10.1016/j.nbd.2024.106464. Epub 2024 Mar 5. Neurobiol Dis. 2024. PMID: 38452948 Free article.
Neuroinflammation contributes to the pathology and progression of Alzheimer's disease (AD), and it can be observed even with mild cognitive impairment (MCI), a prodromal phase of AD. ...
Neuroinflammation contributes to the pathology and progression of Alzheimer's disease (AD), and it can be observed even …
Imaging Biomarkers of VCI: A Focused Update.
Clancy U, Kancheva AK, Valdés Hernández MDC, Jochems ACC, Muñoz Maniega S, Quinn TJ, Wardlaw JM. Clancy U, et al. Stroke. 2024 Apr;55(4):791-800. doi: 10.1161/STROKEAHA.123.044171. Epub 2024 Mar 6. Stroke. 2024. PMID: 38445496 Review.
Vascular cognitive impairment is common after stroke, in memory clinics, medicine for the elderly services, and undiagnosed in the community. Vascular disease is said to be the second most common cause of dementia after Alzheimer disease, yet vascular dysfunc …
Vascular cognitive impairment is common after stroke, in memory clinics, medicine for the elderly services, and undiagnosed in the community …
Efficacy and safety of repetitive Transcranial Magnetic Stimulation and transcranial Direct Current Stimulation in memory deficits in patients with Alzheimer's disease: Meta-analysis and systematic review.
Fernandes SM, Mendes AJ, Rodrigues PFS, Conde A, Rocha M, Leite J. Fernandes SM, et al. Int J Clin Health Psychol. 2024 Apr-Jun;24(2):100452. doi: 10.1016/j.ijchp.2024.100452. Epub 2024 Mar 1. Int J Clin Health Psychol. 2024. PMID: 38444886 Free PMC article.
Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are two of the most used non-pharmacological interventions for Alzheimer's Disease (AD). However, most of the clinical trials have focused on evaluating the …
Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are two of the most used non-pharmaco …
Phytochemicals targeting Alzheimer's disease via the AMP-activated protein kinase pathway, effects, and mechanisms of action.
Zhao Z, Yan J, Huang L, Yang X. Zhao Z, et al. Biomed Pharmacother. 2024 Apr;173:116373. doi: 10.1016/j.biopha.2024.116373. Epub 2024 Mar 4. Biomed Pharmacother. 2024. PMID: 38442672 Free article. Review.
Alzheimer's disease (AD), characterized by cognitive dysfunction and other behavioral abnormalities, is a progressive neurodegenerative disease that occurs due to aging. ...
Alzheimer's disease (AD), characterized by cognitive dysfunction and other behavioral abnormalities, is a progressive n …
Predicting amyloid positivity from FDG-PET images using radiomics: A parsimonious model.
Rasi R, Guvenis A; Alzheimer's Disease Neuroimaging Initiative. Rasi R, et al. Comput Methods Programs Biomed. 2024 Apr;247:108098. doi: 10.1016/j.cmpb.2024.108098. Epub 2024 Feb 22. Comput Methods Programs Biomed. 2024. PMID: 38442621
BACKGROUND AND OBJECTIVE: Amyloid plaques are one of the physical hallmarks of Alzheimer's disease. The objective of this study is to predict amyloid positivity non-invasively from FDG-PET images using a radiomics approach. METHODS: We obtained FDG-PET images …
BACKGROUND AND OBJECTIVE: Amyloid plaques are one of the physical hallmarks of Alzheimer's disease. The objective of th …
Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy.
Toral-Rios D, Long JM, Ulrich JD, Yu J, Strickland MR, Han X, Holtzman DM, Cashikar AG, Paul SM. Toral-Rios D, et al. J Exp Med. 2024 Apr 1;221(4):e20232000. doi: 10.1084/jem.20232000. Epub 2024 Mar 1. J Exp Med. 2024. PMID: 38442267
Alzheimer's disease (AD) is characterized by amyloid plaques and neurofibrillary tangles, in addition to neuroinflammation and changes in brain lipid metabolism. 25-Hydroxycholesterol (25-HC), a known modulator of both inflammation and lipid metabolism, is pr …
Alzheimer's disease (AD) is characterized by amyloid plaques and neurofibrillary tangles, in addition to neuroinflammat …
T cell infiltration mediates neurodegeneration and cognitive decline in Alzheimer's disease.
Zeng J, Liao Z, Yang H, Wang Q, Wu Z, Hua F, Zhou Z. Zeng J, et al. Neurobiol Dis. 2024 Apr;193:106461. doi: 10.1016/j.nbd.2024.106461. Epub 2024 Mar 2. Neurobiol Dis. 2024. PMID: 38437992 Free article. Review.
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder with pathological features of beta-amyloid (Abeta) and hyperphosphorylated tau protein accumulation in the brain, often accompanied by cognitive decline. ...
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder with pathological features of beta-amyloid (Abeta) a …
Generation of an induced pluripotent stem cell line (PNUYHi002-A) from a patient with Alzheimer's disease carrying PRNP M232R variant.
Kim MK, Kim Y, Lee N, Moon HJ, Lee JH, Kim EJ, Kim YJ, Kim JH, Jung NY. Kim MK, et al. Stem Cell Res. 2024 Apr;76:103361. doi: 10.1016/j.scr.2024.103361. Epub 2024 Feb 28. Stem Cell Res. 2024. PMID: 38437769 Free article.
We generated a human induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells isolated from a 59-year-old male patient with Alzheimer's disease (AD). The iPSC line was meticulously characterized to confirm its pluripotency, absenc …
We generated a human induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells isolated from a 59-year-old male …
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