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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1913 1
1936 1
1939 2
1940 1
1941 1
1944 1
1945 2
1946 9
1947 6
1948 8
1949 9
1950 6
1951 17
1952 12
1953 19
1954 18
1955 17
1956 11
1957 11
1958 21
1959 17
1960 15
1961 15
1962 17
1963 21
1964 25
1965 18
1966 10
1967 6
1968 13
1969 7
1970 14
1971 21
1972 13
1973 17
1974 18
1975 46
1976 53
1977 57
1978 68
1979 104
1980 115
1981 165
1982 272
1983 328
1984 431
1985 627
1986 832
1987 880
1988 1003
1989 1385
1990 1416
1991 1517
1992 1625
1993 1723
1994 2134
1995 2172
1996 2536
1997 2755
1998 2894
1999 2942
2000 3398
2001 3495
2002 3781
2003 3853
2004 4540
2005 4879
2006 5346
2007 5490
2008 5870
2009 6353
2010 7296
2011 7779
2012 8716
2013 9320
2014 10193
2015 10745
2016 11277
2017 12064
2018 12692
2019 13527
2020 15596
2021 17406
2022 17803
2023 18495
2024 6699

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EM-COGLOAD: An investigation into age and cognitive load detection using eye tracking and deep learning.
Miles G, Smith M, Zook N, Zhang W. Miles G, et al. Comput Struct Biotechnol J. 2024 Mar 27;24:264-280. doi: 10.1016/j.csbj.2024.03.014. eCollection 2024 Dec. Comput Struct Biotechnol J. 2024. PMID: 38638116 Free PMC article.
Alzheimer's Disease is the most prevalent neurodegenerative disease, and is a leading cause of disability among the elderly. Eye movement behaviour demonstrates potential as a non-invasive biomarker for Alzheimer's Disease, with ch …
Alzheimer's Disease is the most prevalent neurodegenerative disease, and is a leading cause of disability among …
MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons.
Sharma B, Torres MM, Rodriguez S, Gangwani L, Kumar S. Sharma B, et al. Neural Regen Res. 2024 Dec 1;19(12):2698-2707. doi: 10.4103/NRR.NRR-D-23-01064. Epub 2024 Mar 1. Neural Regen Res. 2024. PMID: 38595288 Free article.
JOURNAL/nrgr/04.03/01300535-202412000-00026/figure1/v/2024-04-08T165401Z/r/image-tiff Gamma-aminobutyric acid (GABA)ergic neurons, the most abundant inhibitory neurons in the human brain, have been found to be reduced in many neurological disorders, including Alzheimer' …
JOURNAL/nrgr/04.03/01300535-202412000-00026/figure1/v/2024-04-08T165401Z/r/image-tiff Gamma-aminobutyric acid (GABA)ergic neurons, the most …
On the functions of astrocyte-mediated neuronal slow inward currents.
Pál B. Pál B. Neural Regen Res. 2024 Dec 1;19(12):2602-2612. doi: 10.4103/NRR.NRR-D-23-01723. Epub 2024 Mar 1. Neural Regen Res. 2024. PMID: 38595279 Free article.
Slow inward currents are significant contributors to paroxysmal depolarizational shifts/interictal spikes. These events are related to epilepsy, but also found in Alzheimer's disease, Parkinson's disease, and stroke, leading to the decline of cognitive …
Slow inward currents are significant contributors to paroxysmal depolarizational shifts/interictal spikes. These events are related to epile …
Critical evaluation of the reliability of DNA methylation probes on the Illumina MethylationEPIC v1.0 BeadChip microarrays.
Zhang W, Young JI, Gomez L, Schmidt MA, Lukacsovich D, Varma A, Chen XS, Kunkle B, Martin ER, Wang L. Zhang W, et al. Epigenetics. 2024 Dec;19(1):2333660. doi: 10.1080/15592294.2024.2333660. Epub 2024 Apr 2. Epigenetics. 2024. PMID: 38564759 Free PMC article.
We conducted a comprehensive assessment of the EPIC v1.0 array probe reliability using 69 blood DNA samples, each measured twice, generated by the Alzheimer's Disease Neuroimaging Initiative study. We observed higher reliability in probes with average methyla …
We conducted a comprehensive assessment of the EPIC v1.0 array probe reliability using 69 blood DNA samples, each measured twice, generated …
Mutations in human prion-like domains: pathogenic but not always amyloidogenic.
Bartolomé-Nafría A, García-Pardo J, Ventura S. Bartolomé-Nafría A, et al. Prion. 2024 Dec;18(1):28-39. doi: 10.1080/19336896.2024.2329186. Epub 2024 Mar 21. Prion. 2024. PMID: 38512820 Free PMC article. Review.
To date, over 60 mutations targeting the LCDs of hnRNPs have been identified and associated with a spectrum of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer's disease (AD). The cryo-EM s …
To date, over 60 mutations targeting the LCDs of hnRNPs have been identified and associated with a spectrum of neurodegenerative diseases in …
Dynamically stabilized recurrent neural network optimized with Artificial Gorilla Troops espoused Alzheimer's disorder detection using EEG signals.
Sudha G, Saravanan N, Muthalakshmi M, Birunda M. Sudha G, et al. Health Inf Sci Syst. 2024 Mar 15;12(1):25. doi: 10.1007/s13755-024-00284-9. eCollection 2024 Dec. Health Inf Sci Syst. 2024. PMID: 38495674
Alzheimer's disease is an incurable neurological disorder that damages cognitive abilities, but early identification reduces the symptoms significantly. The absence of competent healthcare professionals has made automatic identification of Alzheimer' …
Alzheimer's disease is an incurable neurological disorder that damages cognitive abilities, but early identification re …
Jointly constrained group sparse connectivity representation improves early diagnosis of Alzheimer's disease on routinely acquired T1-weighted imaging-based brain network.
Zhu C, Li H, Song Z, Jiang M, Song L, Li L, Wang X, Zheng Q. Zhu C, et al. Health Inf Sci Syst. 2024 Mar 6;12(1):19. doi: 10.1007/s13755-023-00269-0. eCollection 2024 Dec. Health Inf Sci Syst. 2024. PMID: 38464465
BACKGROUND: Radiomics-based morphological brain networks (radMBN) constructed from routinely acquired structural MRI (sMRI) data have gained attention in Alzheimer's disease (AD). However, the radMBN suffers from limited characterization of AD because sMRI on …
BACKGROUND: Radiomics-based morphological brain networks (radMBN) constructed from routinely acquired structural MRI (sMRI) data have gained …
Novel anti-neuroinflammatory pyranone-carbamate derivatives as selective butyrylcholinesterase inhibitors for treating Alzheimer's disease.
Yu C, Liu X, Ma B, Xu J, Chen Y, Dai C, Peng H, Zha D. Yu C, et al. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2313682. doi: 10.1080/14756366.2024.2313682. Epub 2024 Feb 16. J Enzyme Inhib Med Chem. 2024. PMID: 38362862 Free PMC article.
Butyrylcholinesterase (BuChE) and neuroinflammation have recently emerged as promising therapeutic directions for Alzheimer's disease (AD). Herein, we synthesised 19 novel pyranone-carbamate derivatives and evaluated their activities against cholinesterases a …
Butyrylcholinesterase (BuChE) and neuroinflammation have recently emerged as promising therapeutic directions for Alzheimer's …
Helix-to-sheet transition of the Aβ42 peptide revealed using an enhanced sampling strategy and Markov state model.
Wen H, Ouyang H, Shang H, Da C, Zhang T. Wen H, et al. Comput Struct Biotechnol J. 2023 Dec 19;23:688-699. doi: 10.1016/j.csbj.2023.12.015. eCollection 2024 Dec. Comput Struct Biotechnol J. 2023. PMID: 38292476 Free PMC article.
The self-assembly of Abeta peptides into toxic oligomers and fibrils is the primary cause of Alzheimer's disease. Moreover, the conformational transition from helix to sheet is considered a crucial step in the aggregation of Abeta peptides. ...
The self-assembly of Abeta peptides into toxic oligomers and fibrils is the primary cause of Alzheimer's disease. Moreo …
Network-based identification and mechanism exploration of active ingredients against Alzheimer's disease via targeting endoplasmic reticulum stress from traditional chinese medicine.
Dai Z, Hu T, Wei J, Wang X, Cai C, Gu Y, Hu Y, Wang W, Wu Q, Fang J. Dai Z, et al. Comput Struct Biotechnol J. 2023 Dec 20;23:506-519. doi: 10.1016/j.csbj.2023.12.017. eCollection 2024 Dec. Comput Struct Biotechnol J. 2023. PMID: 38261917 Free PMC article.
Alzheimer's disease is a neurodegenerative disease that leads to dementia and poses a serious threat to the health of the elderly. ...
Alzheimer's disease is a neurodegenerative disease that leads to dementia and poses a serious threat to the heal …
Sequence-based identification of amyloidogenic β-hairpins reveals a prostatic acid phosphatase fragment promoting semen amyloid formation.
Heid LF, Agerschou ED, Orr AA, Kupreichyk T, Schneider W, Wördehoff MM, Schwarten M, Willbold D, Tamamis P, Stoldt M, Hoyer W. Heid LF, et al. Comput Struct Biotechnol J. 2023 Dec 21;23:417-430. doi: 10.1016/j.csbj.2023.12.023. eCollection 2024 Dec. Comput Struct Biotechnol J. 2023. PMID: 38223341 Free PMC article.
beta-Structure-rich amyloid fibrils are hallmarks of several diseases, including Alzheimer's (AD), Parkinson's (PD), and type 2 diabetes (T2D). While amyloid fibrils typically consist of parallel beta-sheets, the anti-parallel beta-hairpin is a structural motif acce …
beta-Structure-rich amyloid fibrils are hallmarks of several diseases, including Alzheimer's (AD), Parkinson's (PD), and type …
Gut-brain axis interplay via STAT3 pathway: Implications of Helicobacter pylori derived secretome on inflammation and Alzheimer's disease.
Kandpal M, Baral B, Varshney N, Jain AK, Chatterji D, Meena AK, Pandey RK, Jha HC. Kandpal M, et al. Virulence. 2024 Dec;15(1):2303853. doi: 10.1080/21505594.2024.2303853. Epub 2024 Feb 4. Virulence. 2024. PMID: 38197252 Free PMC article.
The current study investigated the plausible role and its associated molecular mechanism underlying H. pylori mediated gut-brain axis disruption and neuroinflammation leading to neurological modalities like Alzheimer's disease (AD). We have chosen the antimic …
The current study investigated the plausible role and its associated molecular mechanism underlying H. pylori mediated gut-brain axis disrup …
Design and preparation of naringenin loaded functional biomimetic nano-drug delivery system for Alzheimer's disease.
Yan C, Gu J, Yin S, Wu H, Lei X, Geng F, Zhang N, Wu X. Yan C, et al. J Drug Target. 2024 Dec;32(1):80-92. doi: 10.1080/1061186X.2023.2290453. Epub 2024 Jan 12. J Drug Target. 2024. PMID: 38044844
Efficient brain drug delivery has been a challenge in the treatment of Alzheimer's Disease and other brain disorders as blood-brain barrier (BBB) impedes most drugs to reach brain. ...
Efficient brain drug delivery has been a challenge in the treatment of Alzheimer's Disease and other brain disorders as …
Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128.
Bellver-Sanchis A, Ávila-López PA, Tic I, Valle-García D, Ribalta-Vilella M, Labrador L, Banerjee DR, Guerrero A, Casadesus G, Poulard C, Pallàs M, Griñán-Ferré C. Bellver-Sanchis A, et al. Neural Regen Res. 2024 Nov 1;19(11):2532-2542. doi: 10.4103/1673-5374.393102. Epub 2024 Jan 8. Neural Regen Res. 2024. PMID: 38526289 Free article.
JOURNAL/nrgr/04.03/01300535-202419110-00033/figure1/v/2024-03-08T184507Z/r/image-tiff Dysregulation of G9a, a histone-lysine N-methyltransferase, has been observed in Alzheimer's disease and has been correlated with increased levels of chronic inflammation an …
JOURNAL/nrgr/04.03/01300535-202419110-00033/figure1/v/2024-03-08T184507Z/r/image-tiff Dysregulation of G9a, a histone-lysine N-methyltransfe …
Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer's disease.
Tang Y, Wei J, Wang XF, Long T, Xiang X, Qu L, Wang X, Yu C, Xiao X, Hu X, Zeng J, Xu Q, Wu A, Wu J, Qin D, Zhou X, Law BY. Tang Y, et al. Neural Regen Res. 2024 Nov 1;19(11):2467-2479. doi: 10.4103/NRR.NRR-D-23-00954. Epub 2024 Jan 31. Neural Regen Res. 2024. PMID: 38526283 Free article.
JOURNAL/nrgr/04.03/01300535-202419110-00027/figure1/v/2024-03-08T184507Z/r/image-tiff Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer's disease. Citri Reticulatae Semen has diverse beneficial effects on neurodegenerative …
JOURNAL/nrgr/04.03/01300535-202419110-00027/figure1/v/2024-03-08T184507Z/r/image-tiff Amyloid-beta-induced neuronal cell death contributes t …
Isoform- and cell-state-specific APOE homeostasis and function.
Lindner K, Gavin AC. Lindner K, et al. Neural Regen Res. 2024 Nov 1;19(11):2456-2466. doi: 10.4103/NRR.NRR-D-23-01470. Epub 2024 Jan 31. Neural Regen Res. 2024. PMID: 38526282 Free article.
Apolipoprotein E polymorphism, combined with environmental stresses and/or age-related alterations, influences the risk of developing late-onset Alzheimer's disease. In this review, we discuss our current knowledge of how apolipoprotein E homeostasis, i.e. it …
Apolipoprotein E polymorphism, combined with environmental stresses and/or age-related alterations, influences the risk of developing late-o …
Mechanism of Cu entry into the brain: many unanswered questions.
Roy S, Lutsenko S. Roy S, et al. Neural Regen Res. 2024 Nov 1;19(11):2421-2429. doi: 10.4103/1673-5374.393107. Epub 2024 Jan 8. Neural Regen Res. 2024. PMID: 38526278 Free article.
Cu imbalances cause or contribute to several life-threatening neurologic disorders including Menkes disease, Wilson disease, Alzheimer's disease, Parkinson's disease, and others. ...
Cu imbalances cause or contribute to several life-threatening neurologic disorders including Menkes disease, Wilson disease, …
NLRP3/1-mediated pyroptosis: beneficial clues for the development of novel therapies for Alzheimer's disease.
Hu B, Zhang J, Huang J, Luo B, Zeng X, Jia J. Hu B, et al. Neural Regen Res. 2024 Nov 1;19(11):2400-2410. doi: 10.4103/1673-5374.391311. Epub 2023 Dec 21. Neural Regen Res. 2024. PMID: 38526276 Free article.
There is accumulating evidence that nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3 (NLRP3) inflammasome-mediated microglial pyroptosis and NLRP1 inflammasome-mediated neuronal pyroptosis in the brain are closely associated with the pathogenesis of …
There is accumulating evidence that nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3 (NLRP3) inflammasome-mediate …
Unveiling DNA methylation in Alzheimer's disease: a review of array-based human brain studies.
Alves VC, Carro E, Figueiro-Silva J. Alves VC, et al. Neural Regen Res. 2024 Nov 1;19(11):2365-2376. doi: 10.4103/1673-5374.393106. Epub 2024 Jan 8. Neural Regen Res. 2024. PMID: 38526273 Free article.
The intricacies of Alzheimer's disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms, particularly DNA methylation. This review comprehensively surveys recent human-centered studies that investigate whole genome D …
The intricacies of Alzheimer's disease pathogenesis are being increasingly illuminated by the exploration of epigenetic …
Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis.
Liao W, Wei J, Liu C, Luo H, Ruan Y, Mai Y, Yu Q, Cao Z, Xu J, Zheng D, Sheng Z, Zhou X, Liu J. Liao W, et al. Neural Regen Res. 2024 Oct 1;19(10):2281-2289. doi: 10.4103/1673-5374.391310. Epub 2023 Dec 21. Neural Regen Res. 2024. PMID: 38488562 Free article.
JOURNAL/nrgr/04.03/01300535-202410000-00029/figure1/v/2024-02-06T055622Z/r/image-tiff Disturbances in the microbiota-gut-brain axis may contribute to the development of Alzheimer's disease. Magnesium-L-threonate has recently been found to have protective effe …
JOURNAL/nrgr/04.03/01300535-202410000-00029/figure1/v/2024-02-06T055622Z/r/image-tiff Disturbances in the microbiota-gut-brain axis may cont …
Efficacy of exercise rehabilitation for managing patients with Alzheimer's disease.
Li D, Jia J, Zeng H, Zhong X, Chen H, Yi C. Li D, et al. Neural Regen Res. 2024 Oct 1;19(10):2175-2188. doi: 10.4103/1673-5374.391308. Epub 2023 Dec 21. Neural Regen Res. 2024. PMID: 38488551 Free article.
Alzheimer's disease (AD) is a progressive and degenerative neurological disease characterized by the deterioration of cognitive functions. ...This review may aid the development of more effective and individualized treatment strategies to address the c …
Alzheimer's disease (AD) is a progressive and degenerative neurological disease characterized by the deteriorati …
Potential role of hippocampal neurogenesis in spinal cord injury induced post-trauma depression.
Ma Y, Qiao Y, Gao X. Ma Y, et al. Neural Regen Res. 2024 Oct 1;19(10):2144-2156. doi: 10.4103/1673-5374.392855. Epub 2024 Jan 8. Neural Regen Res. 2024. PMID: 38488549 Free article.
It has been reported both in clinic and rodent models that beyond spinal cord injury directly induced symptoms, such as paralysis, neuropathic pain, bladder/bowel dysfunction, and loss of sexual function, there are a variety of secondary complications, including memory loss, cogn …
It has been reported both in clinic and rodent models that beyond spinal cord injury directly induced symptoms, such as paralysis, neuropath …
The roles of long non-coding RNAs in Alzheimer's disease diagnosis, treatment, and their involvement in Alzheimer's disease immune responses.
Wu X, Xia P, Yang L, Lu C, Lu Z. Wu X, et al. Noncoding RNA Res. 2024 Mar 16;9(3):659-666. doi: 10.1016/j.ncrna.2024.03.008. eCollection 2024 Sep. Noncoding RNA Res. 2024. PMID: 38577023 Free PMC article. Review.
Alzheimer's disease (AD) is the most frequent type of dementia, presenting a substantial danger to the health and well-being of the aged population. ...Unfortunately, no effective treatments or diagnostic tools are available for Alzheimer's d …
Alzheimer's disease (AD) is the most frequent type of dementia, presenting a substantial danger to the health and well- …
Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice.
Aguado C, Badesso S, Martínez-Hernández J, Martín-Belmonte A, Alfaro-Ruiz R, Fernández M, Moreno-Martínez AE, Cuadrado-Tejedor M, García-Osta A, Luján R. Aguado C, et al. Neural Regen Res. 2024 Sep 1;19(9):2068-2074. doi: 10.4103/1673-5374.390963. Epub 2023 Dec 15. Neural Regen Res. 2024. PMID: 38227537 Free article.
JOURNAL/nrgr/04.03/01300535-202409000-00040/figure1/v/2024-01-16T170235Z/r/image-tiff Plaques of amyloid-beta (Abeta) and neurofibrillary tangles are the main pathological characteristics of Alzheimer's disease (AD). However, some older adult people with AD p …
JOURNAL/nrgr/04.03/01300535-202409000-00040/figure1/v/2024-01-16T170235Z/r/image-tiff Plaques of amyloid-beta (Abeta) and neurofibrillary ta …
Emerging role of galectin 3 in neuroinflammation and neurodegeneration.
Lozinski BM, Ta K, Dong Y. Lozinski BM, et al. Neural Regen Res. 2024 Sep 1;19(9):2004-2009. doi: 10.4103/1673-5374.391181. Epub 2023 Dec 21. Neural Regen Res. 2024. PMID: 38227529 Free article.
While Gal3 has previously been associated with non-CNS inflammatory and fibrotic diseases, recent studies highlight Gal3 as a prominent regulator of inflammation and neuroaxonal damage in the CNS during diseases such as multiple sclerosis, Alzheimer's disease …
While Gal3 has previously been associated with non-CNS inflammatory and fibrotic diseases, recent studies highlight Gal3 as a prominent regu …
Circadian rhythm disruption and retinal dysfunction: a bidirectional link in Alzheimer's disease?
Carrero L, Antequera D, Municio C, Carro E. Carrero L, et al. Neural Regen Res. 2024 Sep 1;19(9):1967-1972. doi: 10.4103/1673-5374.390962. Epub 2023 Dec 15. Neural Regen Res. 2024. PMID: 38227523 Free article.
Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer's disease. A predominant function of the retina is circadian synchronization, carrying information to the brain through the retinohypothalamic tract, which projects to the supr …
Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer's disease. A predominant function of …
NADPH oxidase 4 (NOX4) as a biomarker and therapeutic target in neurodegenerative diseases.
Boonpraman N, Yi SS. Boonpraman N, et al. Neural Regen Res. 2024 Sep 1;19(9):1961-1966. doi: 10.4103/1673-5374.390973. Epub 2023 Dec 15. Neural Regen Res. 2024. PMID: 38227522 Free article.
Diseases like Alzheimer's and Parkinson's diseases are defined by inflammation and the damage neurons undergo due to oxidative stress. ...Adjusting NADPH oxidase 4 activity might influence the neuroinflammatory cytokine levels, including myeloperoxidase and osteopon …
Diseases like Alzheimer's and Parkinson's diseases are defined by inflammation and the damage neurons undergo due to oxidative …
Rebuilding insight into the pathophysiology of Alzheimer's disease through new blood-brain barrier models.
Matsuo K, Nshihara H. Matsuo K, et al. Neural Regen Res. 2024 Sep 1;19(9):1954-1960. doi: 10.4103/1673-5374.390978. Epub 2023 Dec 15. Neural Regen Res. 2024. PMID: 38227521 Free article.
Blood-brain barrier breakdown is a common pathology in various neurological diseases, such as Alzheimer's disease, stroke, multiple sclerosis, and Parkinson's disease. ...In this review, we summarize recent evidence of blood-brain barrier dysfunction i …
Blood-brain barrier breakdown is a common pathology in various neurological diseases, such as Alzheimer's disease, stro …
How do neurons age? A focused review on the aging of the microtubular cytoskeleton.
Richardson B, Goedert T, Quraishe S, Deinhardt K, Mudher A. Richardson B, et al. Neural Regen Res. 2024 Sep 1;19(9):1899-1907. doi: 10.4103/1673-5374.390974. Epub 2023 Dec 15. Neural Regen Res. 2024. PMID: 38227514 Free article.
Aging is the leading risk factor for Alzheimer's disease and other neurodegenerative diseases. We now understand that a breakdown in the neuronal cytoskeleton, mainly underpinned by protein modifications leading to the destabilization of microtubules, is cent …
Aging is the leading risk factor for Alzheimer's disease and other neurodegenerative diseases. We now understand that a …
Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents.
Navarro-Lobato I, Masmudi-Martín M, López-Aranda MF, López-Téllez JF, Delgado G, Granados-Durán P, Gaona-Romero C, Carretero-Rey M, Posadas S, Quiros-Ortega ME, Khan ZU. Navarro-Lobato I, et al. Neural Regen Res. 2024 Aug 1;19(8):1835-1841. doi: 10.4103/1673-5374.389301. Epub 2023 Nov 8. Neural Regen Res. 2024. PMID: 38103251 Free PMC article.
In this study, we demonstrated that the same treatment with RGS14414 in visual area V2, which is relatively unaffected in neurodegenerative diseases such as Alzheimer's disease, produced long-lasting enhancement of ORM in young animals and prevent ORM deficit …
In this study, we demonstrated that the same treatment with RGS14414 in visual area V2, which is relatively unaffected in neurodegenerative …
Ferroptosis mechanism and Alzheimer's disease.
Feng L, Sun J, Xia L, Shi Q, Hou Y, Zhang L, Li M, Fan C, Sun B. Feng L, et al. Neural Regen Res. 2024 Aug 1;19(8):1741-1750. doi: 10.4103/1673-5374.389362. Epub 2023 Nov 8. Neural Regen Res. 2024. PMID: 38103240 Free PMC article.
Ferroptosis is a classic regulatory mode of cell death. Extensive studies of regulatory cell death in Alzheimer's disease have yielded increasing evidence that ferroptosis is closely related to the occurrence, development, and prognosis of Alzheimer' …
Ferroptosis is a classic regulatory mode of cell death. Extensive studies of regulatory cell death in Alzheimer's disease …
Interplay between microglia and environmental risk factors in Alzheimer's disease.
Zhang M, Liang C, Chen X, Cai Y, Cui L. Zhang M, et al. Neural Regen Res. 2024 Aug 1;19(8):1718-1727. doi: 10.4103/1673-5374.389745. Epub 2023 Dec 11. Neural Regen Res. 2024. PMID: 38103237 Free PMC article.
At present, the Alzheimer's disease main risk remains genetic risks, but major environmental factors are increasingly shown to impact Alzheimer's disease development and progression. ...Toward intervening and controlling these environment …
At present, the Alzheimer's disease main risk remains genetic risks, but major environmental factors are increasingly s …
Vagus nerve stimulation in cerebral stroke: biological mechanisms, therapeutic modalities, clinical applications, and future directions.
Du L, He X, Xiong X, Zhang X, Jian Z, Yang Z. Du L, et al. Neural Regen Res. 2024 Aug 1;19(8):1707-1717. doi: 10.4103/1673-5374.389365. Epub 2023 Nov 8. Neural Regen Res. 2024. PMID: 38103236 Free PMC article.
Vagus nerve stimulation is a Food and Drug Administration-approved exploratory treatment option for autism, refractory depression, epilepsy, and Alzheimer's disease. It is expected to be a novel therapeutic technique for the treatment of stroke owing to its a …
Vagus nerve stimulation is a Food and Drug Administration-approved exploratory treatment option for autism, refractory depression, epilepsy, …
Glucagon-like peptide 1 receptor activation: anti-inflammatory effects in the brain.
Diz-Chaves Y, Maastor Z, Spuch C, Lamas JA, González-Matías LC, Mallo F. Diz-Chaves Y, et al. Neural Regen Res. 2024 Aug 1;19(8):1671-1677. doi: 10.4103/1673-5374.389626. Epub 2023 Dec 11. Neural Regen Res. 2024. PMID: 38103230 Free PMC article.
This review summarizes recent advances linked to the anti-inflammatory properties of glucagon-like peptide 1 receptor activation in the brain related to multiple sclerosis, Alzheimer's disease, Parkinson's disease, vascular dementia, or chronic migrain …
This review summarizes recent advances linked to the anti-inflammatory properties of glucagon-like peptide 1 receptor activation in the brai …
Small molecular decoys in Alzheimer's disease.
Oasa S, Kouznetsova VL, Tsigelny IF, Terenius L. Oasa S, et al. Neural Regen Res. 2024 Aug 1;19(8):1658-1659. doi: 10.4103/1673-5374.389643. Epub 2023 Dec 11. Neural Regen Res. 2024. PMID: 38103228 Free PMC article. No abstract available.
Strong cathode electroluminescence biosensor based on CeO2 functionalized PCN-222@Ag NPs for sensitive detection of p-Tau-181 protein.
Jiang YQ, Wei YP, Liu XP, Chen JS, Mao CJ, Jin BK. Jiang YQ, et al. J Colloid Interface Sci. 2024 Jul;665:144-151. doi: 10.1016/j.jcis.2024.03.125. Epub 2024 Mar 20. J Colloid Interface Sci. 2024. PMID: 38520931
Electrochemiluminescence (ECL) biosensors provide a convenient and high sensitivity method for early disease diagnosis. However, creating luminophore arrays relying on powerful ECL signals remains a daunting task. ...This work provides new ideas for developing sensitive EC …
Electrochemiluminescence (ECL) biosensors provide a convenient and high sensitivity method for early disease diagnosis. However, crea …
Multiphoton imaging of hippocampal neural circuits: techniques and biological insights into region-, cell-type-, and pathway-specific functions.
Mizuta K, Sato M. Mizuta K, et al. Neurophotonics. 2024 Jul;11(3):033406. doi: 10.1117/1.NPh.11.3.033406. Epub 2024 Mar 8. Neurophotonics. 2024. PMID: 38464393 Free PMC article. Review.
Although many studies have focused on the dorsal CA1 pyramidal cells, studies of other local and inter-areal circuitry elements have also helped provide a more comprehensive picture of the information processing performed by the hippocampal circuits. Imaging of circuit function i …
Although many studies have focused on the dorsal CA1 pyramidal cells, studies of other local and inter-areal circuitry elements have also he …
Sorl1 knockout inhibits expression of brain-derived neurotrophic factor: involvement in the development of late-onset Alzheimer's disease.
Zhao M, Chen X, Liu J, Feng Y, Wang C, Xu T, Liu W, Liu X, Liu M, Hou D. Zhao M, et al. Neural Regen Res. 2024 Jul 1;19(7):1602-1607. doi: 10.4103/1673-5374.387975. Epub 2023 Nov 13. Neural Regen Res. 2024. PMID: 38051905 Free PMC article.
Sortilin-related receptor 1 (SORL1) is a critical gene associated with late-onset Alzheimer's disease. SORL1 contributes to the development and progression of this neurodegenerative condition by affecting the transport and metabolism of intracellular beta-amy …
Sortilin-related receptor 1 (SORL1) is a critical gene associated with late-onset Alzheimer's disease. SORL1 contribute …
Neural stem cell-derived exosomes promote mitochondrial biogenesis and restore abnormal protein distribution in a mouse model of Alzheimer's disease.
Li B, Chen Y, Zhou Y, Feng X, Gu G, Han S, Cheng N, Sun Y, Zhang Y, Cheng J, Zhang Q, Zhang W, Liu J. Li B, et al. Neural Regen Res. 2024 Jul 1;19(7):1593-1601. doi: 10.4103/1673-5374.385839. Epub 2023 Sep 22. Neural Regen Res. 2024. PMID: 38051904 Free PMC article.
Mitochondrial dysfunction is a hallmark of Alzheimer's disease. We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of APP/PS1 mice. Because Alzheimer's disease affects t …
Mitochondrial dysfunction is a hallmark of Alzheimer's disease. We previously showed that neural stem cell-derived extr …
Targeting tau in Alzheimer's disease: from mechanisms to clinical therapy.
Ye J, Wan H, Chen S, Liu GP. Ye J, et al. Neural Regen Res. 2024 Jul 1;19(7):1489-1498. doi: 10.4103/1673-5374.385847. Epub 2023 Sep 22. Neural Regen Res. 2024. PMID: 38051891 Free PMC article.
Alzheimer's disease is the most prevalent neurodegenerative disease affecting older adults. ...This review summarizes the recent findings on the underlying mechanisms of tau protein in the onset and progression of Alzheimer's disease …
Alzheimer's disease is the most prevalent neurodegenerative disease affecting older adults. ...This review summa …
Neuronal conversion from glia to replenish the lost neurons.
Liang S, Zhou J, Yu X, Lu S, Liu R. Liang S, et al. Neural Regen Res. 2024 Jul 1;19(7):1446-1453. doi: 10.4103/1673-5374.386400. Epub 2023 Oct 2. Neural Regen Res. 2024. PMID: 38051886 Free PMC article.
Neuronal injury, aging, and cerebrovascular and neurodegenerative diseases such as cerebral infarction, Alzheimer's disease, Parkinson's disease, frontotemporal dementia, amyotrophic lateral sclerosis, and Huntington's disease are characterized …
Neuronal injury, aging, and cerebrovascular and neurodegenerative diseases such as cerebral infarction, Alzheimer's disease …
Rethinking neurodegenerative diseases: neurometabolic concept linking lipid oxidation to diseases in the central nervous system.
Helgudóttir SS, Mørkholt AS, Lichota J, Bruun-Nyzell P, Andersen MC, Kristensen NMJ, Johansen AK, Zinn MR, Jensdóttir HM, Nieland JDV. Helgudóttir SS, et al. Neural Regen Res. 2024 Jul 1;19(7):1437-1445. doi: 10.4103/1673-5374.387965. Epub 2023 Nov 8. Neural Regen Res. 2024. PMID: 38051885 Free PMC article.
Currently, there is a lack of effective medicines capable of halting or reversing the progression of neurodegenerative disorders, including amyotrophic lateral sclerosis, Parkinson's disease, multiple sclerosis, or Alzheimer's disease. Given the unmet …
Currently, there is a lack of effective medicines capable of halting or reversing the progression of neurodegenerative disorders, including …
Tianma-Gouteng pair ameliorates the cognitive deficits on two transgenic mouse models of Alzheimer's disease.
Zhong M, Xu QQ, Hu Z, Yang W, Lin ZX, Xian YF. Zhong M, et al. J Ethnopharmacol. 2024 Jun 28;328:118113. doi: 10.1016/j.jep.2024.118113. Epub 2024 Mar 26. J Ethnopharmacol. 2024. PMID: 38548119
ETHNOPHARMACOLOGICAL RELEVANCE: Alzheimer's disease (AD) is a progressive neurodegenerative disease. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Alzheimer's disease (AD) is a progressive neurodegenerative disease. ...
A systematic review on polysaccharides from Morinda officinalis How: Advances in the preparation, structural characterization and pharmacological activities.
Liu M, Wang C, Zhang H, Guo H, Kang L, Li H, Li K. Liu M, et al. J Ethnopharmacol. 2024 Jun 28;328:118090. doi: 10.1016/j.jep.2024.118090. Epub 2024 Mar 21. J Ethnopharmacol. 2024. PMID: 38521432 Review.
RESULTS: Morinda officinalis has been widely used in tonifying the kidney yang since ancient times, and is famous for one of the "Four Southern Medicines" in China for the treatment of depression, osteoporosis, rheumatoid arthritis, infertility, fatigue and Alzheimer's …
RESULTS: Morinda officinalis has been widely used in tonifying the kidney yang since ancient times, and is famous for one of the "Four South …
Mechanism interpretation of Guhan Yangshengjing for protection against Alzheimer's disease by network pharmacology and molecular docking.
Cheung S, Zhong Y, Wu L, Jia X, He MQ, Ai Y, Jiao Q, Liang Q. Cheung S, et al. J Ethnopharmacol. 2024 Jun 28;328:117976. doi: 10.1016/j.jep.2024.117976. Epub 2024 Mar 16. J Ethnopharmacol. 2024. PMID: 38492794
ETHNOPHARMACOLOGICAL RELEVANCE: Guhan Yangshengjing (GHYSJ) is an effective prescription for delaying progression of Alzheimer's disease (AD) based on the ancient Chinese medical classics excavated from Mawangdui Han Tomb. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Guhan Yangshengjing (GHYSJ) is an effective prescription for delaying progression of Alzheimer's …
Neuroprotective effects of Shenghui decoction via inhibition of the JNK/p38 MAPK signaling pathway in an AlCl(3)-induced zebrafish (Danio rerio) model of Alzheimer's disease.
Lu H, Tan A, Zhang Y, Chen Y, Ran S, Wang P. Lu H, et al. J Ethnopharmacol. 2024 Jun 28;328:117993. doi: 10.1016/j.jep.2024.117993. Epub 2024 Feb 27. J Ethnopharmacol. 2024. PMID: 38423408
ETHNOPHARMACOLOGICAL RELEVANCE: Alzheimer's disease (AD) is a multi-factorial degenerative disease, and multi-targeted therapies targeting multiple pathogenic mechanisms should be explored. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Alzheimer's disease (AD) is a multi-factorial degenerative disease, and multi-ta …
A review of the advances, insights, and prospects of gene therapy for Alzheimer's disease: A novel target for therapeutic medicine.
Ataei B, Hokmabadi M, Asadi S, Asadifard E, Aghaei Zarch SM, Najafi S, Bagheri-Mohammadi S. Ataei B, et al. Gene. 2024 Jun 20;912:148368. doi: 10.1016/j.gene.2024.148368. Epub 2024 Mar 12. Gene. 2024. PMID: 38485038 Review.
Neurodegenerative diseases such as Alzheimer's disease (AD) are still an important issue for scientists because it is difficult to cure with the available molecular medications and conventional treatments. ...
Neurodegenerative diseases such as Alzheimer's disease (AD) are still an important issue for scientists because it is d …
Structural characterization of a galactoglucomannan with anti-neuroinflammatory activity from Ganoderma lucidum.
Cao C, Liao Y, Yu Q, Zhang D, Huang J, Su Y, Yan C. Cao C, et al. Carbohydr Polym. 2024 Jun 15;334:122030. doi: 10.1016/j.carbpol.2024.122030. Epub 2024 Mar 6. Carbohydr Polym. 2024. PMID: 38553228
In this work, the crude polysaccharide GL70 exhibited a remarkable impact on enhancing the spatial learning and memory function, as well as reducing the anxiety symptoms of the lipopolysaccharide (LPS)-induced rat model of Alzheimer's disease (AD). A galactog …
In this work, the crude polysaccharide GL70 exhibited a remarkable impact on enhancing the spatial learning and memory function, as well as …
Ultrathin Parylene C-based sensitivity-gain nanoplasmonic sensor integrated on VCSEL for Aβ42 detection.
Lv X, Ma Z, Jiang W, Huang C, Deng J, Zhang H, Chang P, Xie Y. Lv X, et al. Biosens Bioelectron. 2024 Jun 15;254:116220. doi: 10.1016/j.bios.2024.116220. Epub 2024 Mar 16. Biosens Bioelectron. 2024. PMID: 38518564
As Alzheimer's disease prevalence continues to rise, there is an increasing demand for efficient on-chip biosensors capable of early biomarker detection. ...These findings underscore the reusability and reliability of the ultrathin Parylene C-based VCSEL bios …
As Alzheimer's disease prevalence continues to rise, there is an increasing demand for efficient on-chip biosensors cap …
Cannabidiol improves the cognitive function of SAMP8 AD model mice involving the microbiota-gut-brain axis.
Ma BQ, Jia JX, Wang H, Li SJ, Yang ZJ, Wang XX, Yan XS. Ma BQ, et al. J Toxicol Environ Health A. 2024 Jun 2;87(11):471-479. doi: 10.1080/15287394.2024.2338914. Epub 2024 Apr 9. J Toxicol Environ Health A. 2024. PMID: 38590254
Cannabidiol (CBD), a natural component extracted from Cannabis sativa L. exerts neuroprotective, antioxidant, and anti-inflammatory effects in Alzheimer's disease (AD), a disease characterized by impaired cognition and accumulation of amyloid-B peptide …
Cannabidiol (CBD), a natural component extracted from Cannabis sativa L. exerts neuroprotective, antioxidant, and anti-inflammatory effects …
Caregiver Experiences and Burden in Moderate-Advanced Dementia With Lewy Bodies.
Armstrong MJ, Dai Y, Sovich K, LaBarre B, Paulson HL, Maixner SM, Fields JA, Lunde AM, Forsberg LK, Boeve BF, Manning CA, Galvin JE, Taylor AS, Li Z. Armstrong MJ, et al. Neurol Clin Pract. 2024 Jun;14(3):e200292. doi: 10.1212/CPJ.0000000000200292. Epub 2024 Apr 10. Neurol Clin Pract. 2024. PMID: 38617555 Free PMC article.
METHODS: Dyads of individuals with moderate-advanced DLB and their primary informal caregivers were recruited from specialty clinics, advocacy organizations, and research registries. The study collected demographics, disease-related measures, and measures of the caregiver …
METHODS: Dyads of individuals with moderate-advanced DLB and their primary informal caregivers were recruited from specialty clinics, advoca …
The impact of the COVID-19 pandemic on non-COVID-associated mortality: A descriptive longitudinal study of UK data.
Makanjuola S, Shantikumar S. Makanjuola S, et al. Public Health Pract (Oxf). 2024 Mar 11;7:100489. doi: 10.1016/j.puhip.2024.100489. eCollection 2024 Jun. Public Health Pract (Oxf). 2024. PMID: 38562991 Free PMC article.
Age-stratified analyses also revealed significant increases in the 20-64 age-group in: 'Cerebrovascular Disorders', 'Dementia and Alzheimer's Disease', and 'Ischaemic Heart Diseases'. CONCLUSION: Trends in non-COVID condition-specific mortality rates from 201 …
Age-stratified analyses also revealed significant increases in the 20-64 age-group in: 'Cerebrovascular Disorders', 'Dementia and Alzheim …
Pathways explaining racial/ethnic and socio-economic disparities in brain white matter integrity outcomes in the UK Biobank study.
Weiss J, Beydoun MA, Beydoun HA, Georgescu MF, Hu YH, Noren Hooten N, Banerjee S, Launer LJ, Evans MK, Zonderman AB. Weiss J, et al. SSM Popul Health. 2024 Mar 20;26:101655. doi: 10.1016/j.ssmph.2024.101655. eCollection 2024 Jun. SSM Popul Health. 2024. PMID: 38562403 Free PMC article.
Multiple linear regression models were conducted, testing independent associations of race/ethnicity, socio-economic and other downstream factors in relation to global mean FA, while stratifying by Alzheimer's Disease polygenic Risk Score (AD PRS) tertiles. R …
Multiple linear regression models were conducted, testing independent associations of race/ethnicity, socio-economic and other downstream fa …
Associations between multidomain modifiable dementia risk factors with AD biomarkers and cognition in middle-aged and older adults.
Bransby L, Yassi N, Rosenich E, Buckley R, Li QX, Maruff P, Pase M, Lim YY. Bransby L, et al. Neurobiol Aging. 2024 Jun;138:63-71. doi: 10.1016/j.neurobiolaging.2024.02.015. Epub 2024 Mar 2. Neurobiol Aging. 2024. PMID: 38537555 Free article.
Compared to the no/single domain risk group, the multidomain risk group performed worse on the Preclinical Alzheimer's Cognitive Composite (d=0.63, p=.005), and Executive Function (d=0.50, p=.016), and had increased p-tau(181) (d=0.47, p=.042) and t-tau (d=0.54, p=. …
Compared to the no/single domain risk group, the multidomain risk group performed worse on the Preclinical Alzheimer's Cogniti …
Clinical Predictors of Postmortem Amyloid and Nonamyloid Cerebral Small Vessel Disease in Middle-Aged to Older Adults.
Dallaire-Théroux C, Smith C, Duchesne S. Dallaire-Théroux C, et al. Neurol Clin Pract. 2024 Jun;14(3):e200271. doi: 10.1212/CPJ.0000000000200271. Epub 2024 Mar 21. Neurol Clin Pract. 2024. PMID: 38525067
BACKGROUND AND OBJECTIVES: Sporadic cerebral small vessel disease (CSVD) is a class of important pathologic processes known to affect the aging brain and to contribute to cognitive impairment. ...Individuals aged 40 years and older covering the spectrum of healthy aging an …
BACKGROUND AND OBJECTIVES: Sporadic cerebral small vessel disease (CSVD) is a class of important pathologic processes known to affect …
Electrochemical detection of manganese ions using aptamer-based layers.
Jarczewska M, Borowska M, Olszewski M, Malinowska E. Jarczewska M, et al. Talanta. 2024 Jun 1;273:125926. doi: 10.1016/j.talanta.2024.125926. Epub 2024 Mar 20. Talanta. 2024. PMID: 38522191
Even though, Mn is necessary for proper development of central nervous system, its elevated concentration might lead to certain diseases such as epilepsies, cell death in focal cerebral ischemia as well as neurodegenerative diseases such as Huntington and Alzheimer. Hence, …
Even though, Mn is necessary for proper development of central nervous system, its elevated concentration might lead to certain diseases suc …
Multi-shell diffusion MRI of the fornix as a biomarker for cognition in Alzheimer's disease.
Sakaie K, Koenig K, Lerner A, Appleby B, Ogrocki P, Pillai JA, Rao S, Leverenz JB, Lowe MJ. Sakaie K, et al. Magn Reson Imaging. 2024 Jun;109:221-226. doi: 10.1016/j.mri.2024.03.030. Epub 2024 Mar 21. Magn Reson Imaging. 2024. PMID: 38521367 Free article.
BACKGROUND AND PURPOSE: A substantial fraction of those who had Alzheimer's Disease (AD) pathology on autopsy did not have dementia in life. ...The purpose of this work is to leverage multi-shell dMRI to correct for PVA and to evaluate PVA-corrected dMRI meas …
BACKGROUND AND PURPOSE: A substantial fraction of those who had Alzheimer's Disease (AD) pathology on autopsy did not h …
Increased extra-neurite conductivity of brain in patients with Alzheimer's disease: A pilot study.
Hong S, Choi Y, Lee MB, Rhee HY, Park S, Ryu CW, Cho AR, Kwon OI, Jahng GH. Hong S, et al. Psychiatry Res Neuroimaging. 2024 Jun;340:111807. doi: 10.1016/j.pscychresns.2024.111807. Epub 2024 Mar 5. Psychiatry Res Neuroimaging. 2024. PMID: 38520873 Free article.
The objectives of this study were to investigate how the extra-neurite conductivity (EC) and intra-neurite conductivity (IC) were reflected in Alzheimer's disease (AD) patients compared with old cognitively normal (CN) people and patients with amnestic mild c …
The objectives of this study were to investigate how the extra-neurite conductivity (EC) and intra-neurite conductivity (IC) were reflected …
ER-stress response in retinal Muller glia occurs significantly earlier than amyloid pathology in the Alzheimer's mouse brain and retina.
Palko SI, Benoit MR, Yao AY, Mohan R, Yan R. Palko SI, et al. Glia. 2024 Jun;72(6):1067-1081. doi: 10.1002/glia.24514. Epub 2024 Mar 18. Glia. 2024. PMID: 38497356
Alzheimer's Disease (AD) pathogenesis is thought to begin up to 20 years before cognitive symptoms appear, suggesting the need for more sensitive diagnostic biomarkers of AD. ...
Alzheimer's Disease (AD) pathogenesis is thought to begin up to 20 years before cognitive symptoms appear, suggesting t …
Which neuroimaging and fluid biomarkers method is better in theranostic of Alzheimer's disease? An umbrella review.
Mohammadi H, Ariaei A, Ghobadi Z, Gorgich EAC, Rustamzadeh A. Mohammadi H, et al. IBRO Neurosci Rep. 2024 Feb 29;16:403-417. doi: 10.1016/j.ibneur.2024.02.007. eCollection 2024 Jun. IBRO Neurosci Rep. 2024. PMID: 38497046 Free PMC article. Review.
Biomarkers can be classified as diagnostic, prognostic, predictor, clinical, and therapeutic. In Alzheimer's disease (AD), multiple biomarkers have been reported so far. ...Three databases, including PubMed, Web of Science, and Scopus were selected with the k …
Biomarkers can be classified as diagnostic, prognostic, predictor, clinical, and therapeutic. In Alzheimer's disease (A …
Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment.
Naude J, Wang M, Leon R, Smith E, Ismail Z. Naude J, et al. Neurobiol Aging. 2024 Jun;138:19-27. doi: 10.1016/j.neurobiolaging.2024.02.006. Epub 2024 Feb 16. Neurobiol Aging. 2024. PMID: 38490074
Phosphorylated tau (p-tau) is a hallmark biological manifestation of Alzheimer disease (AD). We investigated associations between MBI and tau accumulation in early-stage AD cortical regions. In 442 Alzheimer's Disease Neuroimaging Initiative par …
Phosphorylated tau (p-tau) is a hallmark biological manifestation of Alzheimer disease (AD). We investigated associations betw …
Microvascular burden and long-term risk of stroke and dementia in type 2 diabetes mellitus.
Liu YJ, Zhao JY, Han WW, Yang HH, Wu XB, Xie F, Wang HP, Wang J, Zhao X, Wan ZX, Chen GC, Qin LQ, Li FR. Liu YJ, et al. J Affect Disord. 2024 Jun 1;354:68-74. doi: 10.1016/j.jad.2024.03.053. Epub 2024 Mar 11. J Affect Disord. 2024. PMID: 38479499
RESULTS: During a median follow-up of 11.5 years, 1103 incident stroke (964 ischemic and 269 hemorrhagic stroke) and 813 incident dementia (312 Alzheimer's disease and 304 vascular dementia) cases were identified. ...The corresponding estimates were 4.28 (2.3 …
RESULTS: During a median follow-up of 11.5 years, 1103 incident stroke (964 ischemic and 269 hemorrhagic stroke) and 813 incident dementia ( …
Psychosis in Alzheimer's disease is associated with specific changes in brain MRI volume, cognition and neuropathology.
Almeida FC, Jesus T, Coelho A, Quintas-Neves M, Gauthreaux K, Teylan MA, Mock CN, Kukull WA, Crary JF, Oliveira TG. Almeida FC, et al. Neurobiol Aging. 2024 Jun;138:10-18. doi: 10.1016/j.neurobiolaging.2024.02.013. Epub 2024 Mar 2. Neurobiol Aging. 2024. PMID: 38471417
Psychosis in Alzheimer's Disease (AD) is prevalent and indicates poor prognosis. ...
Psychosis in Alzheimer's Disease (AD) is prevalent and indicates poor prognosis. ...
Mitochondrial disorders leading to Alzheimer's disease-perspectives of diagnosis and treatment.
Pszczołowska M, Walczak K, Miśków W, Mroziak M, Chojdak-Łukasiewicz J, Leszek J. Pszczołowska M, et al. Geroscience. 2024 Jun;46(3):2977-2988. doi: 10.1007/s11357-024-01118-y. Epub 2024 Mar 8. Geroscience. 2024. PMID: 38457008 Free PMC article. Review.
Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia globally. ...
Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia globally. ...
Magnetic self-assembled label-free electrochemical biosensor based on Fe3O4/α-Fe2O3 heterogeneous nanosheets for the detection of Tau proteins.
Wang J, Ouyang H, Ni Y, Zhang H, Sun L, Liu R, Li S. Wang J, et al. Bioelectrochemistry. 2024 Jun;157:108678. doi: 10.1016/j.bioelechem.2024.108678. Epub 2024 Mar 6. Bioelectrochemistry. 2024. PMID: 38452441
A type of electrochemical biosensors based on magnetic Fe(3)O(4)/alpha-Fe(2)O(3) heterogeneous nanosheets was constructed to detect Tau proteins for early diagnosis and intervention therapy of Alzheimer's disease (AD). Firstly, Fe(3)O(4)/alpha-Fe(2)O(3) heter …
A type of electrochemical biosensors based on magnetic Fe(3)O(4)/alpha-Fe(2)O(3) heterogeneous nanosheets was constructed to detect Tau prot …
Erythrocyte membrane coated with nitrogen-doped quantum dots and polydopamine composite nano-system combined with photothermal treatment of Alzheimer's disease.
Liu J, Chi M, Li L, Zhang Y, Xie M. Liu J, et al. J Colloid Interface Sci. 2024 Jun;663:856-868. doi: 10.1016/j.jcis.2024.02.219. Epub 2024 Mar 2. J Colloid Interface Sci. 2024. PMID: 38447400
Mitochondrial dysfunction and metal ion imbalance are recognized as pathological hallmarks of Alzheimer's Disease (AD), leading to deposition of beta-amyloid (Abeta) thereby and inducing neurotoxicity, activating apoptosis, eliciting oxidative stress, and ult …
Mitochondrial dysfunction and metal ion imbalance are recognized as pathological hallmarks of Alzheimer's Disease (AD), …
Brain acetylcholinesterase activity and the protective effect of Gac fruit on scopolamine-induced memory impairment in adult zebrafish.
Singsai K, Saksit N, Chaikhumwang P. Singsai K, et al. IBRO Neurosci Rep. 2024 Feb 17;16:368-372. doi: 10.1016/j.ibneur.2024.02.004. eCollection 2024 Jun. IBRO Neurosci Rep. 2024. PMID: 38435743 Free PMC article.
These findings suggest that Gac fruit extract has anti-memory impairment activity and may be beneficial for the development of health products to prevent Alzheimer's disease....
These findings suggest that Gac fruit extract has anti-memory impairment activity and may be beneficial for the development of health produc …
Effects of anthocyanidins on the conformational transition of Aβ(1-42) peptide: Insights from molecular docking and molecular dynamics simulations.
Zakaria N, Wan Harun WMRS, Mohammad Latif MA, Azaman SNA, Abdul Rahman MB, Faujan NH. Zakaria N, et al. J Mol Graph Model. 2024 Jun;129:108732. doi: 10.1016/j.jmgm.2024.108732. Epub 2024 Feb 15. J Mol Graph Model. 2024. PMID: 38412813
Recent evidence from in vitro and in vivo studies has shown that anthocyanins and anthocyanidins can reduce and inhibit the amyloid beta (Abeta) species, one of the hallmarks of Alzheimer's disease (AD). However, their inhibition mechanisms on Abeta species a …
Recent evidence from in vitro and in vivo studies has shown that anthocyanins and anthocyanidins can reduce and inhibit the amyloid beta (Ab …
Machine learning based on functional and structural connectivity in mild cognitive impairment.
Li Y, Shao Y, Wang J, Liu Y, Yang Y, Wang Z, Xi Q. Li Y, et al. Magn Reson Imaging. 2024 Jun;109:10-17. doi: 10.1016/j.mri.2024.02.013. Epub 2024 Feb 24. Magn Reson Imaging. 2024. PMID: 38408690
OBJECTIVE: Alzheimer's disease (AD) is a chronic, degenerative neurological disorder characterized by progressive cognitive decline and mental behavioral abnormalities. ...
OBJECTIVE: Alzheimer's disease (AD) is a chronic, degenerative neurological disorder characterized by progressive cogni …
Binding interactions and in silico ADME prediction of isoconessimine derivatives as potent acetylcholinesterase inhibitors.
Tue-Ngeun P, Rakitikul W, Thinkumrob N, Hannongbua S, Meelua W, Jitonnom J. Tue-Ngeun P, et al. J Mol Graph Model. 2024 Jun;129:108746. doi: 10.1016/j.jmgm.2024.108746. Epub 2024 Feb 21. J Mol Graph Model. 2024. PMID: 38401250
In pursuit of new acetylcholinesterase (AChE) inhibitors for treating Alzheimer's disease (AD), a series of ten previously synthesized isoconessimine compounds (7a-7j) was in silico investigated for their binding interactions with AChE and pharmacokinetics ba …
In pursuit of new acetylcholinesterase (AChE) inhibitors for treating Alzheimer's disease (AD), a series of ten previou …
Molecular cross-talk between long COVID-19 and Alzheimer's disease.
Pszczołowska M, Walczak K, Misków W, Antosz K, Batko J, Karska J, Leszek J. Pszczołowska M, et al. Geroscience. 2024 Jun;46(3):2885-2899. doi: 10.1007/s11357-024-01096-1. Epub 2024 Feb 23. Geroscience. 2024. PMID: 38393535 Free PMC article. Review.
Some of its symptoms affect the nervous system and resemble symptoms of Alzheimer's disease (AD)-a neurodegenerative condition caused by the accumulation of amyloid beta and hyperphosphorylation of tau proteins. Multiple studies have found dependence between …
Some of its symptoms affect the nervous system and resemble symptoms of Alzheimer's disease (AD)-a neurodegenerative co …
Melatonin-mediated calcineurin inactivation attenuates amyloid beta-induced apoptosis.
Hong JM, Munna AN, Moon JH, Seol JW, Park SY. Hong JM, et al. IBRO Neurosci Rep. 2024 Feb 10;16:336-344. doi: 10.1016/j.ibneur.2024.02.001. eCollection 2024 Jun. IBRO Neurosci Rep. 2024. PMID: 38390232 Free PMC article.
Alzheimer's disease (AD) is the most common age-related progressive neurodegenerative disorder. ...
Alzheimer's disease (AD) is the most common age-related progressive neurodegenerative disorder. ...
Percutaneous biopsies of skeletal muscle and adipose tissue in individuals older than 70: methods and outcomes in the Study of Muscle, Mobility and Aging (SOMMA).
Zamora Z, Lui LY, Sparks LM, Justice J, Lyles M, Gentle L, Gregory H, Yeo RX, Kershaw EE, Stefanovic-Racic M, Newman AB, Kritchevsky S, Toledo FGS. Zamora Z, et al. Geroscience. 2024 Jun;46(3):3419-3428. doi: 10.1007/s11357-024-01087-2. Epub 2024 Feb 5. Geroscience. 2024. PMID: 38315316 Free PMC article.
The impact of a tDCS and cognitive training intervention on task-based functional connectivity.
Kraft JN, Indahlastari A, Boutzoukas EM, Hausman HK, Hardcastle C, Albizu A, O'Shea A, Evangelista ND, Van Etten EJ, Bharadwaj PK, Song H, Smith SG, DeKosky ST, Hishaw GA, Wu S, Marsiske M, Cohen R, Alexander GE, Porges E, Woods AJ. Kraft JN, et al. Geroscience. 2024 Jun;46(3):3325-3339. doi: 10.1007/s11357-024-01077-4. Epub 2024 Jan 24. Geroscience. 2024. PMID: 38265579 Free PMC article.
The influence of APOE status on rate of cognitive decline.
Morrison C, Oliver MD, Berry V, Kamal F, Dadar M. Morrison C, et al. Geroscience. 2024 Jun;46(3):3263-3274. doi: 10.1007/s11357-024-01069-4. Epub 2024 Jan 22. Geroscience. 2024. PMID: 38253819 Free PMC article.
BACKGROUND: Apolipoprotein (APOE) e4 positivity and subjective cognitive decline (SCD) both increase risk of Alzheimer's disease (AD) development. However, few studies have examined the relationship between SCD and APOE status, especially using longitudinal d …
BACKGROUND: Apolipoprotein (APOE) e4 positivity and subjective cognitive decline (SCD) both increase risk of Alzheimer's di …
Characterization of dicaffeoylspermidine derivatives related glucosyltransferases during fruit development of goji berry.
Yang X, Yang M, Ye P, Li H, Li Z, Zeng S, Wang Y. Yang X, et al. Food Chem. 2024 Jun 1;442:138432. doi: 10.1016/j.foodchem.2024.138432. Epub 2024 Jan 14. Food Chem. 2024. PMID: 38241991
Among these compounds, dicaffeoylspermidine derivatives (DCSPDs) have anti-oxidant and anti-Alzheimer's Disease activity. This study employed ultra-high-performance liquid chromatography with tandem mass spectrometry to investigate metabolic changes during th …
Among these compounds, dicaffeoylspermidine derivatives (DCSPDs) have anti-oxidant and anti-Alzheimer's Disease activit …
Quantum dipole interactions and transient hydrogen bond orientation order in cells, cellular membranes and myelin sheath: Implications for MRI signal relaxation, anisotropy, and T1 magnetic field dependence.
Yablonskiy DA, Sukstanskii AL. Yablonskiy DA, et al. Magn Reson Med. 2024 Jun;91(6):2597-2611. doi: 10.1002/mrm.29996. Epub 2024 Jan 19. Magn Reson Med. 2024. PMID: 38241135
CONCLUSION: By incorporating quantum proton interactions involved in brain imaging, the THB approach introduces new insights on the complex relationship between brain tissue cellular structure and MRI measurements, thus offering a promising new tool for better understanding of br …
CONCLUSION: By incorporating quantum proton interactions involved in brain imaging, the THB approach introduces new insights on the complex …
Aluminum, a colorful gamechanger: Uptake of an aluminum-containing food color in human cells and its implications for human health.
Ganhör C, Rezk M, Doppler C, Ruthmeier T, Wechselberger C, Müller M, Kotnik M, Puh Š, Messner B, Bernhard D. Ganhör C, et al. Food Chem. 2024 Jun 1;442:138404. doi: 10.1016/j.foodchem.2024.138404. Epub 2024 Jan 11. Food Chem. 2024. PMID: 38237295 Free article.
KEGG analysis revealed that carmine-specific genes suppress oxidative phosphorylation, and showed that this suppression is associated with neurodegenerative diseases such as Alzheimer and Parkinson disease. Furthermore, carmine, but not carminic acid, increased prol …
KEGG analysis revealed that carmine-specific genes suppress oxidative phosphorylation, and showed that this suppression is associated with n …
Frontal-temporal regional differences in brain energy metabolism and mitochondrial function using 31P MRS in older adults.
Lopez FV, O'Shea A, Huo Z, DeKosky ST, Trouard TP, Alexander GE, Woods AJ, Bowers D. Lopez FV, et al. Geroscience. 2024 Jun;46(3):3185-3195. doi: 10.1007/s11357-023-01046-3. Epub 2024 Jan 16. Geroscience. 2024. PMID: 38225480 Free PMC article.
Damaged or dysfunctional mitochondria have been implicated in the pathogenesis of age-related neurodegenerative conditions like Alzheimer's disease (AD). The aim of the current study was to investigate mitochondrial function over frontal and temporal regions …
Damaged or dysfunctional mitochondria have been implicated in the pathogenesis of age-related neurodegenerative conditions like Alzheimer …
Longitudinal changes in the functional connectivity of individuals at risk of Alzheimer's disease.
García-Colomo A, Nebreda A, Carrasco-Gómez M, de Frutos-Lucas J, Ramirez-Toraño F, Spuch C, Comis-Tuche M, Bruña R, Alfonsín S, Maestú F. García-Colomo A, et al. Geroscience. 2024 Jun;46(3):2989-3003. doi: 10.1007/s11357-023-01036-5. Epub 2024 Jan 4. Geroscience. 2024. PMID: 38172488 Free PMC article.
First-degree relatives of Alzheimer's disease patients constitute a key population in the search for early markers. ...This study consolidates the use of electrophysiology, in combination with plasma biomarkers, to monitor healthy individuals at risk of Al …
First-degree relatives of Alzheimer's disease patients constitute a key population in the search for early markers. ... …
Current biomarkers and treatment strategies in Alzheimer disease: An overview and future perspectives.
Bhole RP, Chikhale RV, Rathi KM. Bhole RP, et al. IBRO Neurosci Rep. 2023 Nov 30;16:8-42. doi: 10.1016/j.ibneur.2023.11.003. eCollection 2024 Jun. IBRO Neurosci Rep. 2023. PMID: 38169888 Free PMC article. Review.
Alzheimer's disease (AD), a progressive degenerative disorder first identified by Alois Alzheimer in 1907, poses a significant public health challenge. ...
Alzheimer's disease (AD), a progressive degenerative disorder first identified by Alois Alzheimer in 1907, poses …
Amyloid-beta and tau protein beyond Alzheimer's disease.
Abyadeh M, Gupta V, Paulo JA, Mahmoudabad AG, Shadfar S, Mirshahvaladi S, Gupta V, Nguyen CTO, Finkelstein DI, You Y, Haynes PA, Salekdeh GH, Graham SL, Mirzaei M. Abyadeh M, et al. Neural Regen Res. 2024 Jun 1;19(6):1262-1276. doi: 10.4103/1673-5374.386406. Epub 2023 Oct 2. Neural Regen Res. 2024. PMID: 37905874 Free article.
The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer's disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. ...However, under pathological co …
The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer's disea …
Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders.
Knight HM, Demirbugen Öz M, PerezGrovas-Saltijeral A. Knight HM, et al. Neural Regen Res. 2024 Jun 1;19(6):1256-1261. doi: 10.4103/1673-5374.385858. Epub 2023 Sep 22. Neural Regen Res. 2024. PMID: 37905873 Free article.
Similarly, differences in expression of the m5C writer and reader effector proteins, NSUN6, NSUN7, and ALYREF in brain tissue are indicated in individuals with Alzheimer's disease, individuals with a high neuropathological load or have suffered traumatic brai …
Similarly, differences in expression of the m5C writer and reader effector proteins, NSUN6, NSUN7, and ALYREF in brain tissue are indicated …
Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases.
Han T, Xu Y, Sun L, Hashimoto M, Wei J. Han T, et al. Neural Regen Res. 2024 Jun 1;19(6):1241-1248. doi: 10.4103/1673-5374.385845. Epub 2023 Sep 22. Neural Regen Res. 2024. PMID: 37905870 Free article.
This review describes the origin and function of microglia and focuses on the role of different states of the microglial response to aging and chronic inflammation on the occurrence and development of neurodegenerative diseases, including Alzheimer's disease, …
This review describes the origin and function of microglia and focuses on the role of different states of the microglial response to aging a …
Blood-brain barrier pathology in cerebral small vessel disease.
Jia R, Solé-Guardia G, Kiliaan AJ. Jia R, et al. Neural Regen Res. 2024 Jun 1;19(6):1233-1240. doi: 10.4103/1673-5374.385864. Epub 2023 Sep 22. Neural Regen Res. 2024. PMID: 37905869 Free article.
Cerebral small vessel disease is a neurological disease that affects the brain microvasculature and which is commonly observed among the elderly. ...The pathophysiology of these lesions has been linked to multiple processes, such as hypoperfusion, defective cerebrov …
Cerebral small vessel disease is a neurological disease that affects the brain microvasculature and which is commonly observed …
Tau truncation in the pathogenesis of Alzheimer's disease: a narrative review.
Chu D, Yang X, Wang J, Zhou Y, Gu JH, Miao J, Wu F, Liu F. Chu D, et al. Neural Regen Res. 2024 Jun 1;19(6):1221-1232. doi: 10.4103/1673-5374.385853. Epub 2023 Sep 22. Neural Regen Res. 2024. PMID: 37905868 Free article.
Alzheimer's disease is characterized by two major neuropathological hallmarks-the extracellular beta-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau protein. ...This review summarizes over 60 prot …
Alzheimer's disease is characterized by two major neuropathological hallmarks-the extracellular beta-amyloid plaques an …
Long non-coding RNAs with essential roles in neurodegenerative disorders.
Xiong W, Lu L, Li J. Xiong W, et al. Neural Regen Res. 2024 Jun 1;19(6):1212-1220. doi: 10.4103/1673-5374.385850. Epub 2023 Sep 22. Neural Regen Res. 2024. PMID: 37905867 Free article.
This review provides an overview of the current knowledge of the biology of lncRNAs and focuses on introducing the latest identified roles, regulatory mechanisms, and research status of lncRNAs in Alzheimer's disease, Parkinson's disease, Huntington's …
This review provides an overview of the current knowledge of the biology of lncRNAs and focuses on introducing the latest identified roles, …
A variant in the 5'UTR of ERBB4 is associated with lifespan in Golden Retrievers.
Rebhun RB, York D, De Graaf FMD, Yoon P, Batcher KL, Luker ME, Ryan S, Peyton J, Kent MS, Stern JA, Bannasch DL. Rebhun RB, et al. Geroscience. 2024 Jun;46(3):2849-2862. doi: 10.1007/s11357-023-00968-2. Epub 2023 Oct 19. Geroscience. 2024. PMID: 37855863 Free PMC article.
Genome-wide association studies (GWAS) in long-lived human populations have led to identification of variants associated with Alzheimer's disease and cardiovascular disease, the latter being the most common cause of mortality in people worldwide. ...Ta …
Genome-wide association studies (GWAS) in long-lived human populations have led to identification of variants associated with Alzheimer …
Racial Differences in Nursing Home Quality of Life Among Residents Living With Alzheimer's Disease and Related Dementias.
Shippee TP, Parikh RR, Baker ZG, Bucy TI, Ng W, Jarosek S, Qin X, Woodhouse M, Nkimbeng M, McCarthy T. Shippee TP, et al. J Aging Health. 2024 Jun;36(5-6):379-389. doi: 10.1177/08982643231191164. Epub 2023 Jul 26. J Aging Health. 2024. PMID: 37493607
ObjectivesAmong nursing home (NH) residents with Alzheimer's disease (AD) and AD-related dementias (AD/ADRD), racial/ethnic disparities in quality of care exist. ...
ObjectivesAmong nursing home (NH) residents with Alzheimer's disease (AD) and AD-related dementias (AD/ADRD), racial/et …
Construction of a short version of the Montreal Cognitive Assessment (MoCA) rating scale for the Thai population using Partial Least Squares analysis.
Hemrungrojn S, Amrapala A, Maes M. Hemrungrojn S, et al. Int J Neurosci. 2024 Jun;134(1):16-27. doi: 10.1080/00207454.2022.2082966. Epub 2022 Jun 12. Int J Neurosci. 2024. PMID: 35695242
BACKGROUND: The Montreal Cognitive Assessment (MoCA) rating scale is frequently used to assess cognitive impairments in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD). OBJECTIVES: The aims of this study were to a) evaluate the construc …
BACKGROUND: The Montreal Cognitive Assessment (MoCA) rating scale is frequently used to assess cognitive impairments in amnestic mild cognit …
The potential of lumbrokinase and serratiopeptidase for the degradation of Aβ 1-42 peptide - an in vitro and in silico approach.
Metkar SK, Girigoswami A, Bondage DD, Shinde UG, Girigoswami K. Metkar SK, et al. Int J Neurosci. 2024 Jun;134(2):112-123. doi: 10.1080/00207454.2022.2089137. Epub 2022 Jun 27. Int J Neurosci. 2024. PMID: 35694981
BACKGROUND: Alzheimer's disease (AD) is diagnosed with the deposition of insoluble beta-amyloid (Abeta) peptides in the neuropil of the brain leading to dementia. ...
BACKGROUND: Alzheimer's disease (AD) is diagnosed with the deposition of insoluble beta-amyloid (Abeta) peptides in the …
Imbalanced clearance of Aβ peptide cause presynaptic plaque formation.
Fotuhi SN, Khalaj-Kondori M. Fotuhi SN, et al. Int J Neurosci. 2024 Jun;134(1):66-70. doi: 10.1080/00207454.2022.2085099. Epub 2022 Jun 5. Int J Neurosci. 2024. PMID: 35639020
Alzheimer's disease is characterized by abnormal increase of Abeta peptide which is likely as the result of imbalanced homeostasis of its production and clearance mechanisms. ...
Alzheimer's disease is characterized by abnormal increase of Abeta peptide which is likely as the result of imbalanced …
Minocycline protects against lipopolysaccharide-induced glial cells activation and oxidative stress damage in the medial prefrontal cortex (mPFC) of the rat.
Abdo Qaid EY, Abdullah Z, Zakaria R, Long I. Abdo Qaid EY, et al. Int J Neurosci. 2024 Jun;134(1):56-65. doi: 10.1080/00207454.2022.2084092. Epub 2022 Jun 15. Int J Neurosci. 2024. PMID: 35638219
PURPOSE/AIM: Neuroinflammation and oxidative stress have been encountered in neurodegenerative diseases such as Alzheimer's disease (AD). However, the neuroprotective effects of minocycline against lipopolysaccharide (LPS)-induced glial cells activation and o …
PURPOSE/AIM: Neuroinflammation and oxidative stress have been encountered in neurodegenerative diseases such as Alzheimer's …
Ginkgo biloba extract mitigates the neurotoxicity of AlCl(3) in alzheimer rat's model: role of apolipoprotein E4 and clusterin genes in stimulating ROS generation and apoptosis.
Batawi AH. Batawi AH. Int J Neurosci. 2024 Jun;134(1):34-44. doi: 10.1080/00207454.2022.2082968. Epub 2022 Jun 9. Int J Neurosci. 2024. PMID: 35634646
PURPOSE: Alzheimer's disease (AD) appears as a result of an increase in the accumulation of amyloid beta peptide (Abeta) and a decrease in neurotransmitters (acetylcholine) within the brain cells which may be due to increase in acetylcholinesterase (AchE) act …
PURPOSE: Alzheimer's disease (AD) appears as a result of an increase in the accumulation of amyloid beta peptide (Abeta …
Water extract of moschus alleviates erastin-induced ferroptosis by regulating the Keap1/Nrf2 pathway in HT22 cells.
Song C, Chu Z, Dai J, Xie D, Qin T, Xie L, Zhai Z, Huang S, Xu Y, Sun T. Song C, et al. J Ethnopharmacol. 2024 May 23;326:117937. doi: 10.1016/j.jep.2024.117937. Epub 2024 Feb 27. J Ethnopharmacol. 2024. PMID: 38423409
Modern pharmacological researches have suggested that Moschus has neuroprotective actions, and its mechanism is related to anti-inflammatory, antioxidant, and anti-apoptosis effects. Ferroptosis is one of the major pathologies of Alzheimer's disease (AD) and …
Modern pharmacological researches have suggested that Moschus has neuroprotective actions, and its mechanism is related to anti-inflammatory …
Exploring the anti-ferroptosis mechanism of Kai-Xin-San against Alzheimer's disease through integrating network pharmacology, bioinformatics, and experimental validation strategy in vivo and in vitro.
Yan C, Yang S, Shao S, Zu R, Lu H, Chen Y, Zhou Y, Ying X, Xiang S, Zhang P, Li Z, Yuan Y, Zhang Z, Wang P, Xie Z, Wang W, Ma H, Sun Y. Yan C, et al. J Ethnopharmacol. 2024 May 23;326:117915. doi: 10.1016/j.jep.2024.117915. Epub 2024 Feb 13. J Ethnopharmacol. 2024. PMID: 38360383
AIM OF THE STUDY: This study aimed to elucidate the mechanism by which KXS exerts its therapeutic effects on Alzheimer's disease (AD) by targeting ferroptosis, using a combination of network pharmacology, bioinformatics, and experimental validation strategies …
AIM OF THE STUDY: This study aimed to elucidate the mechanism by which KXS exerts its therapeutic effects on Alzheimer's di …
Saffron (Crocus sativus L.) extract attenuates chronic scopolamine-induced cognitive impairment, amyloid beta, and neurofibrillary tangles accumulation in rats.
Patel KS, Dharamsi A, Priya M, Jain S, Mandal V, Girme A, Modi SJ, Hingorani L. Patel KS, et al. J Ethnopharmacol. 2024 May 23;326:117898. doi: 10.1016/j.jep.2024.117898. Epub 2024 Feb 8. J Ethnopharmacol. 2024. PMID: 38341114
Further, the ethnopharmacological evidence indicates that saffron has shown an effect against neurodegenerative disorders namely, dementia, Alzheimer's, and Parkinson's with its bioactive constituents i.e., carotenoids and apocarotenoids. ...
Further, the ethnopharmacological evidence indicates that saffron has shown an effect against neurodegenerative disorders namely, dementia, …
Differential scanning calorimetry in drug-membrane interactions.
Zambrano P, Manrique-Moreno M, Petit K, Colina JR, Jemiola-Rzeminska M, Suwalsky M, Strzalka K. Zambrano P, et al. Biochem Biophys Res Commun. 2024 May 21;709:149806. doi: 10.1016/j.bbrc.2024.149806. Epub 2024 Mar 19. Biochem Biophys Res Commun. 2024. PMID: 38579619 Free article. Review.
It further explores the interactions of specific classes of drugs with phospholipid membranes, including non-steroidal anti-inflammatory drugs, anticancer agents, natural products with antioxidant properties, and Alzheimer's disease therapeutics. The manuscri …
It further explores the interactions of specific classes of drugs with phospholipid membranes, including non-steroidal anti-inflammatory dru …
Amyloid precursor protein combinatorial phosphorylation code regulates AMPA receptor removal during distinct forms of synaptic plasticity.
Lee J, Pak DTS. Lee J, et al. Biochem Biophys Res Commun. 2024 May 21;709:149803. doi: 10.1016/j.bbrc.2024.149803. Epub 2024 Mar 26. Biochem Biophys Res Commun. 2024. PMID: 38552556
Plasticity is impaired in neurodegenerative conditions including Alzheimer disease (AD). A central factor in AD is amyloid precursor protein (APP). ...
Plasticity is impaired in neurodegenerative conditions including Alzheimer disease (AD). A central factor in AD is amyloid pre …
Effect of total flavonoids of Dracocephalum moldavica L. On neuroinflammation in Alzheimer's disease model amyloid-beta (Abeta1-42)-peptide-induced astrocyte activation.
Ren W, Yan XS, Fan JC, Huo DS, Wang XX, Jia JX, Yang ZJ. Ren W, et al. J Toxicol Environ Health A. 2024 May 18;87(10):436-447. doi: 10.1080/15287394.2024.2336570. Epub 2024 Apr 1. J Toxicol Environ Health A. 2024. PMID: 38557424
One of the main pathological features noted in Alzheimer's disease (AD) is the presence of plagues of aggregated beta-amyloid (Abeta1-42)-peptides. ...
One of the main pathological features noted in Alzheimer's disease (AD) is the presence of plagues of aggregated beta-a …
Effects of schisandrin B on hypoxia-related cognitive function and protein expression in vascular dementia rats.
He JB, Zhang H, Zheng HX, Jia JX, Zhang YC, Yan XS, Li XX, Wei KW, Mao J, Chen H, Li J, Wang H, Zhang M, Zhao ZY. He JB, et al. J Toxicol Environ Health A. 2024 May 18;87(10):421-427. doi: 10.1080/15287394.2024.2334247. Epub 2024 Mar 29. J Toxicol Environ Health A. 2024. PMID: 38551405
Vascular dementia (VD) a heterogenous group of brain disorders in which cognitive impairment is attributable to vascular risk factors and cerebrovascular disease. A common phenomenon in VD is a dysfunctional cerebral regulatory mechanism associated with insufficient cerebr …
Vascular dementia (VD) a heterogenous group of brain disorders in which cognitive impairment is attributable to vascular risk factors and ce …
Mechanisms underlying LncRNA SNHG1 regulation of Alzheimer's disease involve DNA methylation.
Chen H, Zhang CJ, Zhao ZY, Gao YY, Zhao JT, Li XX, Zhang M, Wang H. Chen H, et al. J Toxicol Environ Health A. 2024 May 18;87(10):428-435. doi: 10.1080/15287394.2024.2334248. Epub 2024 Mar 29. J Toxicol Environ Health A. 2024. PMID: 38551404
Alzheimer's disease (AD) is a neurodegenerative disease associated with long non-coding RNAs and DNA methylation; however, the mechanisms underlying the role of lncRNA small nucleolar RNA host gene 1 (lncRNA SNHG1) and subsequent involvement of DNA met …
Alzheimer's disease (AD) is a neurodegenerative disease associated with long non-coding RNAs and DNA methylation …
Ergosterol promotes neurite outgrowth, inhibits amyloid-beta synthesis, and extends longevity: In vitro neuroblastoma and in vivo Caenorhabditis elegans evidence.
Sillapachaiyaporn C, Wongwan C, Mongkolpobsin K, Nilkhet S, Isidoro C, Chuchawankul S, Tencomnao T. Sillapachaiyaporn C, et al. Life Sci. 2024 May 15;345:122606. doi: 10.1016/j.lfs.2024.122606. Epub 2024 Apr 3. Life Sci. 2024. PMID: 38574884
AIMS: Alzheimer's disease (AD), the most common neurodegenerative disorder associated with aging, is characterized by amyloid-beta (Abeta) plaques in the hippocampus. ...
AIMS: Alzheimer's disease (AD), the most common neurodegenerative disorder associated with aging, is characterized by a …
Phosphoproteomic analysis of APP/PS1 mice of Alzheimer's disease by DIA based mass spectrometry analysis with PRM verification.
Gao Y, Li J, Hu K, Wang S, Yang S, Ai Q, Yan J. Gao Y, et al. J Proteomics. 2024 May 15;299:105157. doi: 10.1016/j.jprot.2024.105157. Epub 2024 Mar 9. J Proteomics. 2024. PMID: 38462170
Traditional Chinese medicine has been utilized in China for approximately thousands of years in clinical settings to prevent Alzheimer's disease (AD) and enhance memory, despite the lack of a systematic exploration of its biological underpinnings. ...
Traditional Chinese medicine has been utilized in China for approximately thousands of years in clinical settings to prevent Alzheimer …
Exploring the potential anti-thyroid activity of Acetyl-L-carnitine: Lactoperoxidase inhibition profile, iodine complexation and scavenging power against H2O2. Experimental and theoretical studies.
Caro-Ramírez JY, Franca CA, Lavecchia M, Naso LG, Williams PAM, Ferrer EG. Caro-Ramírez JY, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2024 May 15;313:124098. doi: 10.1016/j.saa.2024.124098. Epub 2024 Feb 29. Spectrochim Acta A Mol Biomol Spectrosc. 2024. PMID: 38460232
L-Acetylcarnitine (ALC), a versatile compound, has demonstrated beneficial effects in depression, Alzheimer's disease, cognitive impairment, and other conditions. This study focuses on its antithyroid activity. ...
L-Acetylcarnitine (ALC), a versatile compound, has demonstrated beneficial effects in depression, Alzheimer's disease, …
Predicting the reversion from mild cognitive impairment to normal cognition based on magnetic resonance imaging, clinical, and neuropsychological examinations.
Yu HH, Tan CC, Huang SJ, Zhang XH, Tan L, Xu W; Alzheimer's Disease Neuroimaging Initiative. Yu HH, et al. J Affect Disord. 2024 May 15;353:90-98. doi: 10.1016/j.jad.2024.03.009. Epub 2024 Mar 5. J Affect Disord. 2024. PMID: 38452935
The nomogram incorporating five predictors (education, hippocampus volume, the Alzheimer's Disease Assessment Scale-Cognitive score, the Rey Auditory Verbal Learning Test-immediate score, and mean arterial pressure) achieved good C-indexes of 0.892 (95 % conf …
The nomogram incorporating five predictors (education, hippocampus volume, the Alzheimer's Disease Assessment Scale-Cog …
Investigating the binding interaction of quinoline yellow with bovine serum albumin and anti-amyloidogenic behavior of ferulic acid on QY-induced BSA fibrils.
Fatima M, Nabi F, Khan RH, Naeem A. Fatima M, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2024 May 15;313:124076. doi: 10.1016/j.saa.2024.124076. Epub 2024 Feb 25. Spectrochim Acta A Mol Biomol Spectrosc. 2024. PMID: 38442614
Protein aggregation induces profound changes in the structure along with the conformation of the protein, and is responsible for the pathogenesis of a number of neurodegenerative conditions such as Huntington's, Creutzfeldt-Jacob, Type II diabetes mellitus, Alzheimer's …
Protein aggregation induces profound changes in the structure along with the conformation of the protein, and is responsible for the pathoge …
Amylovis-201 enhances physiological memory formation and rescues memory and hippocampal cell loss in a streptozotocin-induced Alzheimer's disease animal model.
Mercerón-Martínez D, Alacán Ricardo L, Bejerano Pina A, Orama Rojo N, Expósito Seco A, Vega Hurtado Y, Estupiñán Días B, Fernández I, García Pupo L, Sablón Carrazana M, Rodríguez-Tanty C, Menéndez Soto Del Valle R, Almaguer-Melian W. Mercerón-Martínez D, et al. Brain Res. 2024 May 15;1831:148848. doi: 10.1016/j.brainres.2024.148848. Epub 2024 Mar 2. Brain Res. 2024. PMID: 38432261
Alzheimer's disease is the most common neurodegenerative disease, and its treatment is lacking. ...
Alzheimer's disease is the most common neurodegenerative disease, and its treatment is lacking. ...
Propofol-induced hippocampal Neurotoxicity: A mitochondrial perspective.
Ebrahimi M, Dabbagh A, Madadi F. Ebrahimi M, et al. Brain Res. 2024 May 15;1831:148841. doi: 10.1016/j.brainres.2024.148841. Epub 2024 Feb 29. Brain Res. 2024. PMID: 38428475 Review.
It can, however, become permanent in vulnerable populations, such as the elderly, who are more susceptible to Alzheimer's disease, and neonates and children, whose brains are still developing and require neurogenesis. ...
It can, however, become permanent in vulnerable populations, such as the elderly, who are more susceptible to Alzheimer's d …
Low-frequency rTMS modulated the excitability and high-frequency firing in hippocampal neurons of the Alzheimer's disease mouse model.
Zhang Z, Ding C, Fu R, Wang J, Zhao J, Zhu H. Zhang Z, et al. Brain Res. 2024 May 15;1831:148822. doi: 10.1016/j.brainres.2024.148822. Epub 2024 Feb 24. Brain Res. 2024. PMID: 38408558
Repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, holds potential for applications in the treatment of Alzheimer's disease (AD). This study aims to compare the therapeutic effects of rTMS at different frequencies …
Repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, holds potential for applications in the tre …
The changes of neurogenesis in the hippocampal dentate gyrus of SAMP8 mice and the effects of acupuncture and moxibustion.
Liu X, Chen J, Du Y, Tian Q, Wang L, Li W, Liu G, Tan Q, Wang J, Deng X. Liu X, et al. Brain Res. 2024 May 15;1831:148814. doi: 10.1016/j.brainres.2024.148814. Epub 2024 Feb 21. Brain Res. 2024. PMID: 38395250
BACKGROUND: Influenced by the global aging population, the incidence of Alzheimer's disease (AD) has increased sharply. In addition to increasing beta-amyloid plaque deposition and tau tangle formation, neurogenesis dysfunction has recently been observed in A …
BACKGROUND: Influenced by the global aging population, the incidence of Alzheimer's disease (AD) has increased sharply. …
A dual-signal amplification strategy based on rolling circle amplification and APE1-assisted amplification for highly sensitive and specific miRNA analysis for early diagnosis of alzheimer's disease.
Xie J, Chen J, Zhang Y, Li C, Liu P, Duan WJ, Chen JX, Chen J, Dai Z, Li M. Xie J, et al. Talanta. 2024 May 15;272:125747. doi: 10.1016/j.talanta.2024.125747. Epub 2024 Feb 10. Talanta. 2024. PMID: 38364557
MicroRNA (miRNA) is involved in the progression of Alzheimer's disease (AD) and emerges as a promising AD biomarker and therapeutic target. ...
MicroRNA (miRNA) is involved in the progression of Alzheimer's disease (AD) and emerges as a promising AD biomarker and …
Electroacupuncture improves cognitive function in APP/PS1 mice by inhibiting oxidative stress related hippocampal neuronal ferroptosis.
Chen Y, Li Y, Wu M, Li Z. Chen Y, et al. Brain Res. 2024 May 15;1831:148744. doi: 10.1016/j.brainres.2023.148744. Epub 2023 Dec 30. Brain Res. 2024. PMID: 38163562
BACKGROUND: Electroacupuncture, recognized as a crucial non-pharmacological therapeutic approach, has demonstrated notable efficacy in enhancing cognitive function among Alzheimer's disease (AD) patients. This study aimed to investigate the neuroprotective pr …
BACKGROUND: Electroacupuncture, recognized as a crucial non-pharmacological therapeutic approach, has demonstrated notable efficacy in enhan …
Proportion of Community-Dwelling Individuals Older Than 70 Years Eligible for Lecanemab Initiation: The Gothenburg H70 Birth Cohort Study.
Dittrich A, Westman E, Shams S, Skillbäck T, Zetterberg H, Blennow K, Zettergren A, Skoog I, Kern S. Dittrich A, et al. Neurology. 2024 May 14;102(9):e209402. doi: 10.1212/WNL.0000000000209402. Epub 2024 Apr 9. Neurology. 2024. PMID: 38593394
OBJECTIVES: To determine the prevalence of individuals with Alzheimer disease (AD) eligible for treatment with the recently FDA-approved lecanemab based on data from a population-based sample of 70-year-olds and extrapolate an estimation of individuals eligible in E …
OBJECTIVES: To determine the prevalence of individuals with Alzheimer disease (AD) eligible for treatment with the recently FD …
Age-related changes in species-typical behaviours in the 5xFAD mouse model of Alzheimer's disease from 4 to 16 months of age.
O'Leary TP, Brown RE. O'Leary TP, et al. Behav Brain Res. 2024 May 8;465:114970. doi: 10.1016/j.bbr.2024.114970. Epub 2024 Mar 24. Behav Brain Res. 2024. PMID: 38531510 Free article.
Alzheimer's disease (AD) patients show age-related decreases in the ability to perform activities of daily living and the decline in these activities is related to the severity of neurobiological deterioration underlying the disease. ...
Alzheimer's disease (AD) patients show age-related decreases in the ability to perform activities of daily living and t …
CK2 negatively regulates the extinction of remote fear memory.
Yang J, Lin L, Zou GJ, Wang LF, Li F, Li CQ, Cui YH, Huang FL. Yang J, et al. Behav Brain Res. 2024 May 8;465:114960. doi: 10.1016/j.bbr.2024.114960. Epub 2024 Mar 15. Behav Brain Res. 2024. PMID: 38494129
Casein kinase 2 (CK2), which regulates neuroplasticity via phosphorylation of its substrates, has a significant influence in various neurological disorders, such as Alzheimer's disease and Parkinson's disease, as well as in the process of learning and …
Casein kinase 2 (CK2), which regulates neuroplasticity via phosphorylation of its substrates, has a significant influence in various neurolo …
Quercetin-3-O-glc-1-3-rham-1-6-glucoside decreases Aβ production, inhibits Aβ aggregation and neurotoxicity, and prohibits the production of inflammatory cytokines.
Tan S, Wu L, Liu J, Wu Z, Cheng Q, Qu Q, Zhu L, Yan Y, Wu H, Ling TJ, Liu RT, Yang S. Tan S, et al. Eur J Pharmacol. 2024 May 5;970:176491. doi: 10.1016/j.ejphar.2024.176491. Epub 2024 Mar 19. Eur J Pharmacol. 2024. PMID: 38503399
Alzheimer's disease (AD) is a progressive neurodegenerative disease with the hallmark of aggregation of beta-amyloid (Abeta) into extracellular fibrillar deposition. ...
Alzheimer's disease (AD) is a progressive neurodegenerative disease with the hallmark of aggregation of beta-amy …
Sex differences in luteinizing hormone aggravates Abeta deposition in APP/PS1 and Abeta(1-42)-induced mouse models of Alzheimer's disease.
Jia Y, Du X, Wang Y, Song Q, He L. Jia Y, et al. Eur J Pharmacol. 2024 May 5;970:176485. doi: 10.1016/j.ejphar.2024.176485. Epub 2024 Mar 15. Eur J Pharmacol. 2024. PMID: 38492878
Alzheimer's disease (AD) exhibits a higher incidence rate among older women, and dysregulation of the hypothalamic-pituitary-gonadal (HPG) axis during aging is associated with cognitive impairments and the development of dementia. luteinizing hormone (LH) has …
Alzheimer's disease (AD) exhibits a higher incidence rate among older women, and dysregulation of the hypothalamic-pitu …
Learning to live with Lewy.
Guttmacher LB. Guttmacher LB. Lancet Psychiatry. 2024 May;11(5):328-329. doi: 10.1016/S2215-0366(24)00103-2. Lancet Psychiatry. 2024. PMID: 38631784 No abstract available.
Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study.
Wisch JK, McKay NS, Boerwinkle AH, Kennedy J, Flores S, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O'Bryant SE, Price JC, Laymon CM, Krinsky-McHale SJ, Lai F, Rosas HD, Hartley SL, Zaman S, Lott IT, Tudorascu D, Zammit M, Brickman AM, Lee JH, Bird TD, Cohen A, Chrem P, Daniels A, Chhatwal JP, Cruchaga C, Ibanez L, Jucker M, Karch CM, Day GS, Lee JH, Levin J, Llibre-Guerra J, Li Y, Lopera F, Roh JH, Ringman JM, Supnet-Bell C, van Dyck CH, Xiong C, Wang G, Morris JC, McDade E, Bateman RJ, Benzinger TLS, Gordon BA, Ances BM; Alzheimer's Biomarker Consortium-Down syndrome; Dominantly Inherited Alzheimer Network. Wisch JK, et al. Lancet Neurol. 2024 May;23(5):500-510. doi: 10.1016/S1474-4422(24)00084-X. Lancet Neurol. 2024. PMID: 38631766
BACKGROUND: In people with genetic forms of Alzheimer's disease, such as in Down syndrome and autosomal-dominant Alzheimer's disease, pathological changes specific to Alzheimer's disease (ie, accumulation of amyloid a …
BACKGROUND: In people with genetic forms of Alzheimer's disease, such as in Down syndrome and autosomal-dominant Alz …
MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study.
Valentino RR, Scotton WJ, Roemer SF, Lashley T, Heckman MG, Shoai M, Martinez-Carrasco A, Tamvaka N, Walton RL, Baker MC, Macpherson HL, Real R, Soto-Beasley AI, Mok K, Revesz T, Christopher EA, DeTure M, Seeley WW, Lee EB, Frosch MP, Molina-Porcel L, Gefen T, Redding-Ochoa J, Ghetti B, Robinson AC, Kobylecki C, Rowe JB, Beach TG, Teich AF, Keith JL, Bodi I, Halliday GM, Gearing M, Arzberger T, Morris CM, White CL 3rd, Mechawar N, Boluda S, MacKenzie IR, McLean C, Cykowski MD, Wang SJ, Graff C, Nagra RM, Kovacs GG, Giaccone G, Neumann M, Ang LC, Carvalho A, Morris HR, Rademakers R, Hardy JA, Dickson DW, Rohrer JD, Ross OA; Pick's disease International Consortium. Valentino RR, et al. Lancet Neurol. 2024 May;23(5):487-499. doi: 10.1016/S1474-4422(24)00083-8. Lancet Neurol. 2024. PMID: 38631765
The primary aim of this study was to evaluate the association of MAPT H2 with Pick's disease risk, age at onset, and disease duration. METHODS: In this genetic association study, we used data from the Pick's disease International Consortium, which we establis …
The primary aim of this study was to evaluate the association of MAPT H2 with Pick's disease risk, age at onset, and disease d …
Synthesis and investigation of the cholinesterase inhibitory and antioxidant capacities of some novel N'-(quinolin-4-ylmethylene)propanehydrazides against Alzheimer's disease.
Kilic B, Dogruer DS. Kilic B, et al. Drug Dev Res. 2024 May;85(3):e22183. doi: 10.1002/ddr.22183. Drug Dev Res. 2024. PMID: 38628078
One of the worst long-term health issues of the past few decades is Alzheimer's disease (AD). Unfortunately, there are currently insufficient choices for treating and caring for AD, which makes it a popular subject for drug development research. ...
One of the worst long-term health issues of the past few decades is Alzheimer's disease (AD). Unfortunately, there are …
Associations Between Blood-Based Biomarkers and Cognitive and Functional Trajectories Among Participants of the MEMENTO Cohort.
Grasset L, Bouteloup V, Cacciamani F, Pellegrin I, Planche V, Chêne G, Dufouil C; MEMENTO study group. Grasset L, et al. Neurology. 2024 May;102(9):e209307. doi: 10.1212/WNL.0000000000209307. Epub 2024 Apr 16. Neurology. 2024. PMID: 38626384
BACKGROUND AND OBJECTIVES: Elevated levels of Alzheimer disease (AD) blood-based biomarkers are associated with accelerated cognitive decline. ...
BACKGROUND AND OBJECTIVES: Elevated levels of Alzheimer disease (AD) blood-based biomarkers are associated with accelerated co …
Perivascular Spaces, Diffusivity Along Perivascular Spaces, and Free Water in Cerebral Small Vessel Disease.
Li H, Jacob MA, Cai M, Kessels RPC, Norris DG, Duering M, De Leeuw FE, Tuladhar AM. Li H, et al. Neurology. 2024 May;102(9):e209306. doi: 10.1212/WNL.0000000000209306. Epub 2024 Apr 16. Neurology. 2024. PMID: 38626373
BACKGROUND AND OBJECTIVES: Previous studies have linked the MRI measures of perivascular spaces (PVSs), diffusivity along the perivascular spaces (DTI-ALPS), and free water (FW) to cerebral small vessel disease (SVD) and SVD-related cognitive impairments. However, studies …
BACKGROUND AND OBJECTIVES: Previous studies have linked the MRI measures of perivascular spaces (PVSs), diffusivity along the perivascular s …
Preliminary translation of 'Reducing Disability in Alzheimer's Disease' among individuals with intellectual disabilities and caregiver dyads.
Ptomey LT, Barton K, Swinford E, Bodde A, George A, Gorczyca AM, Niedens CM, Sprague SC, Yeager A, Helsel B, Teri L, Vidoni ED, Perales-Puchalt J. Ptomey LT, et al. J Appl Res Intellect Disabil. 2024 May;37(3):e13239. doi: 10.1111/jar.13239. J Appl Res Intellect Disabil. 2024. PMID: 38621995
BACKGROUND: The Reducing Disability in Alzheimer's Disease in Kansas City (RDAD-KC) intervention has been shown to improve the health of individuals with dementia and caregiver dyads. ...
BACKGROUND: The Reducing Disability in Alzheimer's Disease in Kansas City (RDAD-KC) intervention has been shown to impr …
Nanostructure and dynamics of N-truncated copper amyloid-β peptides from advanced X-ray absorption fine structure.
Ekanayake RSK, Streltsov VA, Best SP, Chantler CT. Ekanayake RSK, et al. IUCrJ. 2024 May 1. doi: 10.1107/S2052252524001830. Online ahead of print. IUCrJ. 2024. PMID: 38602752
N-truncated Cu:Abeta peptide complexes contribute to oxidative stress and neurotoxicity in Alzheimer's patients' brains. However, the redox properties of copper in different Abeta peptide sequences are inconsistent. ...
N-truncated Cu:Abeta peptide complexes contribute to oxidative stress and neurotoxicity in Alzheimer's patients' brains. Howev …
Pharmacological interventions to improve sleep in people with Alzheimer's disease: a meta-analysis of randomized controlled trials.
Bedward A, Kaur J, Seedat S, Donohue H, Kow CS, Rasheed MK, Javed A, Hasan SS. Bedward A, et al. Expert Rev Neurother. 2024 May;24(5):527-539. doi: 10.1080/14737175.2024.2341004. Epub 2024 Apr 10. Expert Rev Neurother. 2024. PMID: 38597219 Review.
INTRODUCTION: This systematic review and meta-analysis evaluates the evidence from randomized controlled trials (RCTs) involving pharmacological interventions for improving sleep in people with Alzheimer's disease (AD). METHODS: A systematic literature search …
INTRODUCTION: This systematic review and meta-analysis evaluates the evidence from randomized controlled trials (RCTs) involving pharmacolog …
Formulation and characterization of polymeric nanoparticle of Rivastigmine for effective management of Alzheimer's disease.
Imam F, Mukhopadhyay S, Kothiyal P, Alshehri S, Saad Alharbi K, Afzal M, Iqbal M, Rashid Khan M, Khalid Anwer M, Ahmed Hattab Alanazi A, Ghanem Alqahtani A, Abdullah Alhamamah M. Imam F, et al. Saudi Pharm J. 2024 May;32(5):102048. doi: 10.1016/j.jsps.2024.102048. Epub 2024 Mar 22. Saudi Pharm J. 2024. PMID: 38585197 Free PMC article.
Memory loss or dementia is a progressive disorder, and one of its common forms is Alzheimer's disease (AD), effecting mostly middle aged and older adults. ...This formulation (F1) was further assessed for in vivo studies on animal model. A pharmacological scr …
Memory loss or dementia is a progressive disorder, and one of its common forms is Alzheimer's disease (AD), effecting m …
The impact of COVID-19 on deaths from dementia and Alzheimer's disease in Chile: an analysis of panel data for 16 regions, 2017-2022.
Barría-Sandoval C, Ferreira G, Navarrete JP, Farhang M. Barría-Sandoval C, et al. Lancet Reg Health Am. 2024 Apr 2;33:100726. doi: 10.1016/j.lana.2024.100726. eCollection 2024 May. Lancet Reg Health Am. 2024. PMID: 38584874 Free PMC article.
BACKGROUND: Although several studies have documented the detrimental impacts of global COVID-19 containment measures on individuals with Alzheimer's disease and dementia, a comprehensive analysis of mortality rates for these conditions within the Chilean popu …
BACKGROUND: Although several studies have documented the detrimental impacts of global COVID-19 containment measures on individuals with …
Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review).
Qin P, Sun Y, Li L. Qin P, et al. Int J Mol Med. 2024 May;53(5):47. doi: 10.3892/ijmm.2024.5371. Epub 2024 Apr 5. Int J Mol Med. 2024. PMID: 38577947 Free PMC article. Review.
In addition to providing energy to cells, mitochondria also participate in the immunoinflammatory response of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis and epilepsy, by regulating processes such …
In addition to providing energy to cells, mitochondria also participate in the immunoinflammatory response of neurodegenerative disorders in …
Discovery of novel quinolin-2-one derivatives as potential GSK-3beta inhibitors for treatment of Alzheimer's disease: Pharmacophore-based design, preliminary SAR, in vitro and in vivo biological evaluation.
Abdo Moustafa E, Abdelrasheed Allam H, Fouad MA, El Kerdawy AM, Nasser Eid El-Sayed N, Wagner C, Abdel-Aziz HA, Abdel Fattah Ezzat M. Abdo Moustafa E, et al. Bioorg Chem. 2024 May;146:107324. doi: 10.1016/j.bioorg.2024.107324. Epub 2024 Mar 30. Bioorg Chem. 2024. PMID: 38569322
Recently, glycogen synthase kinase-3beta (GSK-3beta) has been considered as a critical factor implicated in Alzheimer's disease (AD). In a previous work, a 3D pharmacophore model for GSK-3beta inhibitors was created and the results suggested that derivative Z …
Recently, glycogen synthase kinase-3beta (GSK-3beta) has been considered as a critical factor implicated in Alzheimer's dis …
Associations Between Age at Menopause, Vascular Risk, and 3-Year Cognitive Change in the Canadian Longitudinal Study on Aging.
Wood Alexander M, Wu CY, Coughlan GT, Puri T, Buckley RF, Palta P, Swardfager W, Masellis M, Galea LAM, Einstein G, Black SE, Rabin JS. Wood Alexander M, et al. Neurology. 2024 May;102(9):e209298. doi: 10.1212/WNL.0000000000209298. Epub 2024 Apr 3. Neurology. 2024. PMID: 38569140
BACKGROUND AND OBJECTIVES: Mounting evidence supports sex differences in Alzheimer disease (AD) risk. Vascular and hormonal factors may together contribute to AD risk in female adults. ...
BACKGROUND AND OBJECTIVES: Mounting evidence supports sex differences in Alzheimer disease (AD) risk. Vascular and hormonal fa …
Profiling lecanemab as a treatment option for Alzheimer's disease.
Schiller ER, Silverglate BD, Grossberg GT. Schiller ER, et al. Expert Rev Neurother. 2024 May;24(5):433-441. doi: 10.1080/14737175.2024.2333970. Epub 2024 Apr 3. Expert Rev Neurother. 2024. PMID: 38566584 Review.
Food and Drug Administration (FDA) granted full approval to lecanemab for the treatment of mild cognitive impairment (MCI) due to Alzheimer's disease (AD) and mild AD dementia. Considering the limited treatment options for AD, the approval of lecanemab offers …
Food and Drug Administration (FDA) granted full approval to lecanemab for the treatment of mild cognitive impairment (MCI) due to Alzheim …
Detection of individual brain tau deposition in Alzheimer's disease based on latent feature-enhanced generative adversarial network.
Jiang J, Shi R, Lu J, Wang M, Zhang Q, Zhang S, Wang L, Alberts I, Rominger A, Zuo C, Shi K; Alzheimer's Disease Neuroimaging Initiative. Jiang J, et al. Neuroimage. 2024 May 1;291:120593. doi: 10.1016/j.neuroimage.2024.120593. Epub 2024 Mar 28. Neuroimage. 2024. PMID: 38554780 Free article.
OBJECTIVE: The conventional methods for interpreting tau PET imaging in Alzheimer's disease (AD), including visual assessment and semi-quantitative analysis of fixed hallmark regions, are insensitive to detect individual small lesions because of the spatiotem …
OBJECTIVE: The conventional methods for interpreting tau PET imaging in Alzheimer's disease (AD), including visual asse …
A SERS nanocellulose-paper-based analytical device for ultrasensitive detection of Alzheimer's disease.
Yuan W, Yuan H, Li R, Yong R, Mitrovic I, Lim EG, Duan S, Song P. Yuan W, et al. Anal Chim Acta. 2024 May 1;1301:342447. doi: 10.1016/j.aca.2024.342447. Epub 2024 Mar 4. Anal Chim Acta. 2024. PMID: 38553119
BACKGROUND: Alzheimer's disease (AD), one of the most prevalent neurodegenerative diseases, results in severe cognitive decline and irreversible memory loss. Early detection of AD is significant to patients for personalized intervention since effective cure a …
BACKGROUND: Alzheimer's disease (AD), one of the most prevalent neurodegenerative diseases, results in severe cognitive …
Mitochondria-tau association promotes cognitive decline and hippocampal bioenergetic deficits during the aging.
Olesen MA, Pradenas E, Villavicencio-Tejo F, Porter GA, Johnson GVW, Quintanilla RA. Olesen MA, et al. Free Radic Biol Med. 2024 May 1;217:141-156. doi: 10.1016/j.freeradbiomed.2024.03.017. Epub 2024 Mar 27. Free Radic Biol Med. 2024. PMID: 38552927
We previously showed that caspase-3 cleaved tau, a relevant tau form in Alzheimer's disease (AD), affects mitochondrial bioenergetics, dynamics and synaptic plasticity by the opening of mitochondrial permeability transition pore (mPTP). ...
We previously showed that caspase-3 cleaved tau, a relevant tau form in Alzheimer's disease (AD), affects mitochondrial …
Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia.
López-Molina L, Sancho-Balsells A, Al-Massadi O, Montalban E, Alberch J, Arranz B, Girault JA, Giralt A. López-Molina L, et al. Neurobiol Dis. 2024 May;194:106487. doi: 10.1016/j.nbd.2024.106487. Epub 2024 Mar 27. Neurobiol Dis. 2024. PMID: 38552722 Free article.
Pyk2 has been shown previously to be involved in several psychological and cognitive alterations related to stress, Huntington's disease, and Alzheimer's disease. All these disorders are accompanied by different types of impairments in sociability, whi …
Pyk2 has been shown previously to be involved in several psychological and cognitive alterations related to stress, Huntington's disease …
Synthesis, in silico ADMET prediction analysis, and pharmacological evaluation of sulfonamide derivatives tethered with pyrazole or pyridine as anti-diabetic and anti-Alzheimer's agents.
Abdelazeem NM, Aboulthana WM, Hassan AS, Almehizia AA, Naglah AM, Alkahtani HM. Abdelazeem NM, et al. Saudi Pharm J. 2024 May;32(5):102025. doi: 10.1016/j.jsps.2024.102025. Epub 2024 Mar 12. Saudi Pharm J. 2024. PMID: 38550332 Free PMC article.
Based on previous developments of our research programs in trying to find new compounds with multiple biological targets such as antioxidant, anti-diabetic, anti-Alzheimer's, and anti-arthritic agents. In the context, a novel series of sulfonamide derivatives based …
Based on previous developments of our research programs in trying to find new compounds with multiple biological targets such as antioxidant …
Association between cytomegalovirus infection and neurological disorders: A systematic review.
Sanami S, Shamsabadi S, Dayhimi A, Pirhayati M, Ahmad S, Pirhayati A, Ajami M, Hemati S, Shirvani M, Alagha A, Abbarin D, Alizadeh A, Pazoki-Toroudi H. Sanami S, et al. Rev Med Virol. 2024 May;34(3):e2532. doi: 10.1002/rmv.2532. Rev Med Virol. 2024. PMID: 38549138 Review.
This virus has been linked to several neurological disorders, including Alzheimer's disease, Parkinson's disease, Autism spectrum disorder, Huntington's disease (HD), ataxia, Bell's palsy (BP), and brain tumours, which can cause a wide range of …
This virus has been linked to several neurological disorders, including Alzheimer's disease, Parkinson's disease …
Impaired olfactory identification in dementia-free individuals is associated with the functional abnormality of the precuneus.
Xie B, Yang S, Hao Y, Sun Y, Li L, Guo C, Yang Y. Xie B, et al. Neurobiol Dis. 2024 May;194:106483. doi: 10.1016/j.nbd.2024.106483. Epub 2024 Mar 26. Neurobiol Dis. 2024. PMID: 38527709 Free article.
METHODS: A total of 236 participants were enrolled, including 45 Alzheimer's disease (AD) individuals and 191dementia-free individuals. ...
METHODS: A total of 236 participants were enrolled, including 45 Alzheimer's disease (AD) individuals and 191dementia-f …
Chuanzhitongluo capsule improves cognitive impairment in mice with chronic cerebral hypoperfusion via the cholinergic anti-inflammatory pathway.
Wang Z, Han B, Qi J, Cao X, Gu H, Sun J. Wang Z, et al. Exp Gerontol. 2024 May;189:112407. doi: 10.1016/j.exger.2024.112407. Epub 2024 Mar 23. Exp Gerontol. 2024. PMID: 38522309 Free article.
Vascular cognitive impairment (VCI) has become a common disease-causing cognitive deficit in humans, second only to Alzheimer's Disease (AD). ...
Vascular cognitive impairment (VCI) has become a common disease-causing cognitive deficit in humans, second only to Alzheimer' …
Efficacy and safety of tofacitinib for chronic plaque psoriasis and psoriatic arthritis: a systematic review and meta-analysis of randomized controlled trials.
Dai Q, Zhang Y, Liu Q, Zhang C. Dai Q, et al. Clin Rheumatol. 2024 May;43(5):1605-1613. doi: 10.1007/s10067-024-06940-5. Epub 2024 Mar 22. Clin Rheumatol. 2024. PMID: 38517652
Tofacitinib has efficacy in comorbid psychiatric disorders (depression, anxiety, or Alzheimer's disease) and inflammatory bowel disease (ulcerative colitis), but patients with comorbid renal insufficiency, hepatic dysfunction, osteoporosis, cardiovascu …
Tofacitinib has efficacy in comorbid psychiatric disorders (depression, anxiety, or Alzheimer's disease) and inflammato …
Hybrid molecules synergistically mitigate ferroptosis and amyloid-associated toxicities in Alzheimer's disease.
Padhi D, Baruah P, Ramesh M, Moorthy H, Govindaraju T. Padhi D, et al. Redox Biol. 2024 May;71:103119. doi: 10.1016/j.redox.2024.103119. Epub 2024 Mar 11. Redox Biol. 2024. PMID: 38507972 Free PMC article.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the build-up of extracellular amyloid beta (Abeta) plaques and intracellular neurofibrillary tangles (NFTs). ...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the build-up of extracellular amyloid beta (A …
Diurnal cortisol, neuroinflammation, and neuroimaging visual rating scales in memory clinic patients.
Holleman J, Daniilidou M, Kåreholt I, Aspö M, Hagman G, Udeh-Momoh CT, Spulber G, Kivipelto M, Solomon A, Matton A, Sindi S. Holleman J, et al. Brain Behav Immun. 2024 May;118:499-509. doi: 10.1016/j.bbi.2024.03.024. Epub 2024 Mar 17. Brain Behav Immun. 2024. PMID: 38503394
BACKGROUND: Neuroinflammation is a hallmark of the Alzheimer's disease (AD) pathogenic process. Cortisol dysregulation may increase AD risk and is related to brain atrophy. ...
BACKGROUND: Neuroinflammation is a hallmark of the Alzheimer's disease (AD) pathogenic process. Cortisol dysregulation …
A nonlinear meccano for Alzheimer's emergence by amyloid beta-mediated glutamatergic hyperactivity.
Bonifazi G, Luchena C, Gaminde-Blasco A, Ortiz-Sanz C, Capetillo-Zarate E, Matute C, Alberdi E, De Pittà M. Bonifazi G, et al. Neurobiol Dis. 2024 May;194:106473. doi: 10.1016/j.nbd.2024.106473. Epub 2024 Mar 15. Neurobiol Dis. 2024. PMID: 38493903 Free article.
The pathophysiological process of Alzheimer's disease (AD) is believed to begin many years before the formal diagnosis of AD dementia. ...
The pathophysiological process of Alzheimer's disease (AD) is believed to begin many years before the formal diagnosis …
Role of GABAB receptors in cognition and EEG activity in aged APP and PS1 transgenic mice.
Yuan D, Zhou Z, Song M, Zhang Y, Zhang Y, Ren P, Chen Z, Fu Y. Yuan D, et al. Neurochem Int. 2024 May;175:105718. doi: 10.1016/j.neuint.2024.105718. Epub 2024 Mar 13. Neurochem Int. 2024. PMID: 38490487
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. ...
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. ...
Targeting terminal pathway reduces brain complement activation, amyloid load and synapse loss, and improves cognition in a mouse model of dementia.
Zelek WM, Bevan RJ, Morgan BP. Zelek WM, et al. Brain Behav Immun. 2024 May;118:355-363. doi: 10.1016/j.bbi.2024.03.017. Epub 2024 Mar 12. Brain Behav Immun. 2024. PMID: 38485063 Free article.
Complement is dysregulated in the brain in Alzheimer's Disease and in mouse models of Alzheimer's disease. Each of the complement derived effectors, opsonins, anaphylatoxins and membrane attack complex (MAC), have been implicated as drive …
Complement is dysregulated in the brain in Alzheimer's Disease and in mouse models of Alzheimer's dise …
Effect of outer membrane vesicles of Lactobacillus pentosus on Tau phosphorylation and CDK5-Calpain pathway in mice.
Shao Z, Lu Y, Xing A, He X, Xie H, Hu M. Shao Z, et al. Exp Gerontol. 2024 May;189:112400. doi: 10.1016/j.exger.2024.112400. Epub 2024 Mar 15. Exp Gerontol. 2024. PMID: 38484904 Free article.
Alzheimer's disease (AD) stands as a neurodegenerative disorder causing cognitive decline, posing a significant health concern for the elderly population in China. ...
Alzheimer's disease (AD) stands as a neurodegenerative disorder causing cognitive decline, posing a significant health …
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants.
Jomova K, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, Valko M. Jomova K, et al. Arch Toxicol. 2024 May;98(5):1323-1367. doi: 10.1007/s00204-024-03696-4. Epub 2024 Mar 14. Arch Toxicol. 2024. PMID: 38483584 Review.
An imbalance between ROS production and elimination is termed oxidative stress, a critical factor and common denominator of many chronic diseases such as cancer, cardiovascular diseases, metabolic diseases, neurological disorders (Alzheimer's and Parkinson's disease …
An imbalance between ROS production and elimination is termed oxidative stress, a critical factor and common denominator of many chronic dis …
A review on the new age methodologies for early detection of Alzheimer's and Parkinson's disease.
Ghosh N, Sinha K, Sil PC. Ghosh N, et al. Basic Clin Pharmacol Toxicol. 2024 May;134(5):602-613. doi: 10.1111/bcpt.14003. Epub 2024 Mar 14. Basic Clin Pharmacol Toxicol. 2024. PMID: 38482977 Review.
BACKGROUNDS: Neurodegenerative diseases (NDDs) such as Alzheimer's (AD) and Parkinson's (PD) are often diagnosed late, impeding effective treatment; therefore, early detection is imperative. ...
BACKGROUNDS: Neurodegenerative diseases (NDDs) such as Alzheimer's (AD) and Parkinson's (PD) are often diagnosed late, impedin …
Systemic inflammation in relation to exceptional memory in the Long Life Family Study (LLFS).
Patel R, Cosentino S, Zheng EZ, Schupf N, Barral S, Feitosa M, Andersen SL, Sebastiani P, Ukraintseva S, Christensen K, Zmuda J, Thyagarajan B, Gu Y; Long Life Family Study (LLFS). Patel R, et al. Brain Behav Immun Health. 2024 Feb 23;37:100746. doi: 10.1016/j.bbih.2024.100746. eCollection 2024 May. Brain Behav Immun Health. 2024. PMID: 38476338 Free PMC article.
STCGRU: A hybrid model based on CNN and BiGRU for mild cognitive impairment diagnosis.
Zhou H, Yin L, Su R, Zhang Y, Yuan Y, Xie P, Li X. Zhou H, et al. Comput Methods Programs Biomed. 2024 May;248:108123. doi: 10.1016/j.cmpb.2024.108123. Epub 2024 Mar 8. Comput Methods Programs Biomed. 2024. PMID: 38471292
BACKGROUND AND OBJECTIVE: Early diagnosis of mild cognitive impairment (MCI) is one of the essential measures to prevent its further development into Alzheimer's disease (AD). In this paper, we propose a hybrid deep learning model for early diagnosis of MCI, …
BACKGROUND AND OBJECTIVE: Early diagnosis of mild cognitive impairment (MCI) is one of the essential measures to prevent its further develop …
Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease.
Balakrishnan R, Jannat K, Choi DK. Balakrishnan R, et al. Redox Biol. 2024 May;71:103105. doi: 10.1016/j.redox.2024.103105. Epub 2024 Mar 4. Redox Biol. 2024. PMID: 38471283 Free PMC article. Review.
Cognitive dysfunction can occur both in normal aging and age-related neurological disorders, such as mild cognitive impairment and Alzheimer's disease (AD). These disorders have few treatment options due to side effects and limited efficacy. ...
Cognitive dysfunction can occur both in normal aging and age-related neurological disorders, such as mild cognitive impairment and Alzhei …
Ad-derived bone marrow transplant induces proinflammatory immune peripheral mechanisms accompanied by decreased neuroplasticity and reduced gut microbiome diversity affecting AD-like phenotype in the absence of Aβ neuropathology.
Iban-Arias R, Yang EJ, Griggs E, Soares Dias Portela A, Osman A, Trageser KJ, Shahed M, Maria Pasinetti G. Iban-Arias R, et al. Brain Behav Immun. 2024 May;118:252-272. doi: 10.1016/j.bbi.2024.03.012. Epub 2024 Mar 8. Brain Behav Immun. 2024. PMID: 38461954
Immune system dysfunction is increasingly recognized as a significant feature that contributes to Alzheimer's disease (AD) pathogenesis, reflected by alterations in central and peripheral responses leading to detrimental mechanisms that can contribute to the …
Immune system dysfunction is increasingly recognized as a significant feature that contributes to Alzheimer's disease ( …
Hybrid representation learning for cognitive diagnosis in late-life depression over 5 years with structural MRI.
Zhang L, Wang L, Yu M, Wu R, Steffens DC, Potter GG, Liu M. Zhang L, et al. Med Image Anal. 2024 May;94:103135. doi: 10.1016/j.media.2024.103135. Epub 2024 Mar 6. Med Image Anal. 2024. PMID: 38461654
Late-life depression (LLD) is a highly prevalent mood disorder occurring in older adults and is frequently accompanied by cognitive impairment (CI). Studies have shown that LLD may increase the risk of Alzheimer's disease (AD). However, the heterogeneity of p …
Late-life depression (LLD) is a highly prevalent mood disorder occurring in older adults and is frequently accompanied by cognitive impairme …
Unraveling brain diseases: The promise of brain-on-a-chip models.
Cerutti L, Brofiga M. Cerutti L, et al. J Neurosci Methods. 2024 May;405:110105. doi: 10.1016/j.jneumeth.2024.110105. Epub 2024 Mar 7. J Neurosci Methods. 2024. PMID: 38460796 Free article. Review.
This technology offers a promising test-bed for studying brain disorders at the cellular and network levels, providing insights into disease mechanisms, drug screening, and, in perspective, the development of personalized therapeutic strategies. In this review, we provide …
This technology offers a promising test-bed for studying brain disorders at the cellular and network levels, providing insights into dise …
Dementia and depression: Biological connections with amyloid β protein.
Dos Santos HM, Bertollo AG, Mingoti MED, Grolli RE, Kreuz KM, Ignácio ZM. Dos Santos HM, et al. Basic Clin Pharmacol Toxicol. 2024 May;134(5):563-573. doi: 10.1111/bcpt.13996. Epub 2024 Mar 8. Basic Clin Pharmacol Toxicol. 2024. PMID: 38459754 Review.
It is estimated that dementia affects 50 million people worldwide and that Alzheimer's disease (AD) is responsible for up to 75% of cases. Small extracellular senile plaques composed of filamentous aggregates of amyloid beta (Abeta) protein tend to bind to ne …
It is estimated that dementia affects 50 million people worldwide and that Alzheimer's disease (AD) is responsible for …
Inferring brain causal and temporal-lag networks for recognizing abnormal patterns of dementia.
Xia Z, Zhou T, Mamoon S, Lu J. Xia Z, et al. Med Image Anal. 2024 May;94:103133. doi: 10.1016/j.media.2024.103133. Epub 2024 Mar 6. Med Image Anal. 2024. PMID: 38458094
To verify the effectiveness of the proposed estimation method, we perform experiments on the Alzheimer's Disease Neuroimaging Initiative (ADNI) database by comparing the proposed model with several existing methods, including correlation-based and causality-b …
To verify the effectiveness of the proposed estimation method, we perform experiments on the Alzheimer's Disease Neuroi …
Loss and microglia phagocytosis of synaptic proteins in frontotemporal lobar degeneration with TDP-43 proteinopathy.
Ayala I, Bahrami A, Pan Y, Spencer C, Flanagan ME, Mesulam MM, Gefen T, Geula C. Ayala I, et al. Neurochem Int. 2024 May;175:105719. doi: 10.1016/j.neuint.2024.105719. Epub 2024 Mar 5. Neurochem Int. 2024. PMID: 38452814
Cortical synaptic loss has emerged as an early abnormality in Alzheimer's disease (AD) with a strong relationship to cognitive performance. ...
Cortical synaptic loss has emerged as an early abnormality in Alzheimer's disease (AD) with a strong relationship to co …
Explainable AI-based Deep-SHAP for mapping the multivariate relationships between regional neuroimaging biomarkers and cognition.
Bhattarai P, Thakuri DS, Nie Y, Chand GB. Bhattarai P, et al. Eur J Radiol. 2024 May;174:111403. doi: 10.1016/j.ejrad.2024.111403. Epub 2024 Mar 2. Eur J Radiol. 2024. PMID: 38452732
BACKGROUND: Mild cognitive impairment (MCI)/Alzheimer's disease (AD) is associated with cognitive decline beyond normal aging and linked to the alterations of brain volume quantified by magnetic resonance imaging (MRI) and amyloid-beta (Abeta) quantified by p …
BACKGROUND: Mild cognitive impairment (MCI)/Alzheimer's disease (AD) is associated with cognitive decline beyond normal …
Penthorum chinense Pursh inhibits ferroptosis in cellular and Caenorhabditis elegans models of Alzheimer's disease.
Yong YY, Yan L, Wang BD, Fan DS, Guo MS, Yu L, Wu JM, Qin DL, Law BY, Wong VK, Yu CL, Zhou XG, Wu AG. Yong YY, et al. Phytomedicine. 2024 May;127:155463. doi: 10.1016/j.phymed.2024.155463. Epub 2024 Feb 16. Phytomedicine. 2024. PMID: 38452694
BACKGROUND: Ferroptosis, a unique type of cell death triggered by iron-dependent lipid peroxidation, plays a critical role in the pathogenesis of Alzheimer's disease (AD), a debilitating condition marked by memory loss and cognitive impairment due to the accu …
BACKGROUND: Ferroptosis, a unique type of cell death triggered by iron-dependent lipid peroxidation, plays a critical role in the pathogenes …
Lower oddball event-related EEG delta and theta responses in patients with dementia due to Parkinson's and Lewy body than Alzheimer's disease.
Yıldırım E, Aktürk T, Hanoğlu L, Yener G, Babiloni C, Güntekin B. Yıldırım E, et al. Neurobiol Aging. 2024 May;137:78-93. doi: 10.1016/j.neurobiolaging.2024.02.004. Epub 2024 Feb 16. Neurobiol Aging. 2024. PMID: 38452574
Oddball task-related EEG delta and theta responses are associated with frontal executive functions, which are significantly impaired in patients with dementia due to Parkinson's disease (PDD) and Lewy bodies (DLB). The present study investigated the oddball task-related EE …
Oddball task-related EEG delta and theta responses are associated with frontal executive functions, which are significantly impaired in pati …
Integrative Multimodal Metabolomics to Early Predict Cognitive Decline Among Amyloid Positive Community-Dwelling Older Adults.
Tremblay-Franco M, Canlet C, Carriere A, Nakhle J, Galinier A, Portais JC, Yart A, Dray C, Lu WH, Bertrand Michel J, Guyonnet S, Rolland Y, Vellas B, Delrieu J, Barreto PS, Pénicaud L, Casteilla L, Ader I; MAPT/DSA Group. Tremblay-Franco M, et al. J Gerontol A Biol Sci Med Sci. 2024 May 1;79(5):glae077. doi: 10.1093/gerona/glae077. J Gerontol A Biol Sci Med Sci. 2024. PMID: 38452244 Free PMC article.
Alzheimer's disease is strongly linked to metabolic abnormalities. ...
Alzheimer's disease is strongly linked to metabolic abnormalities. ...
The association between posterior resting-state EEG alpha rhythms and functional MRI connectivity in older adults with subjective memory complaint.
Lopez S, Hampel H, Chiesa PA, Del Percio C, Noce G, Lizio R, Teipel SJ, Dyrba M, González-Escamilla G, Bakardjian H, Cavedo E, Lista S, Vergallo A, Lemercier P, Spinelli G, Grothe MJ, Potier MC, Stocchi F, Ferri R, Habert MO, Dubois B, Babiloni C; INSIGHT-preAD study group. Lopez S, et al. Neurobiol Aging. 2024 May;137:62-77. doi: 10.1016/j.neurobiolaging.2024.02.008. Epub 2024 Feb 28. Neurobiol Aging. 2024. PMID: 38431999 Free article.
Resting-state eyes-closed electroencephalographic (rsEEG) alpha rhythms are dominant in posterior cortical areas in healthy adults and are abnormal in subjective memory complaint (SMC) persons with Alzheimer's disease amyloidosis. This exploratory study in 16 …
Resting-state eyes-closed electroencephalographic (rsEEG) alpha rhythms are dominant in posterior cortical areas in healthy adults and are a …
Purpose in Life and Its Association to Parkinsonism.
Koga HK, Grodstein F, Williams DR, Buchman AS, Kubzansky LD. Koga HK, et al. J Gerontol B Psychol Sci Soc Sci. 2024 May 1;79(5):gbae026. doi: 10.1093/geronb/gbae026. J Gerontol B Psychol Sci Soc Sci. 2024. PMID: 38430551
., parkinsonian gait, rigidity, bradykinesia, and tremor) were assessed using the United Parkinson's Disease Rating Scale. We examined purpose with risk of developing incident parkinsonism using Cox proportional hazards models. ...
., parkinsonian gait, rigidity, bradykinesia, and tremor) were assessed using the United Parkinson's Disease Rating Scale. We examine …
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