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Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes) Ameliorates Spatial Learning and Memory Deficits in Rats with Hypercholesterolemia and Alzheimer's Disease.
Rahman MA, Hossain S, Abdullah N, Aminudin N. Rahman MA, et al. Int J Med Mushrooms. 2020;22(1):93-103. doi: 10.1615/IntJMedMushrooms.2020033383. Int J Med Mushrooms. 2020. PMID: 32464001
Hypercholesterolemia has been implicated as one of the pathomechanistic factors of Alzheimer's disease (AD), the most common neurodegenerative disorder affecting memory and learning abilities. ...Thus, usage of G. lucidum seems promising in withstandin …
Hypercholesterolemia has been implicated as one of the pathomechanistic factors of Alzheimer's disease (AD), the most c …
Ganoderma lucidum Triterpenoids (GLTs) Reduce Neuronal Apoptosis via Inhibition of ROCK Signal Pathway in APP/PS1 Transgenic Alzheimer's Disease Mice.
Yu N, Huang Y, Jiang Y, Zou L, Liu X, Liu S, Chen F, Luo J, Zhu Y. Yu N, et al. Oxid Med Cell Longev. 2020 Jan 28;2020:9894037. doi: 10.1155/2020/9894037. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 32089787 Free PMC article.
Alzheimer's disease (AD) is the most common cause of dementia among senior citizen. Ganoderma lucidum triterpenoids (GLTs) have nutritional health benefits and has been shown to promote health and longevity, but a protective effect of GLTs on AD
Alzheimer's disease (AD) is the most common cause of dementia among senior citizen. Ganoderma lucidum tri
Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Ameliorates Nonspatial Learning and Memory Deficits in Rats with Hypercholesterolemia and Alzheimer's Disease.
Rahman MA, Hossain S, Abdullah N, Aminudin N. Rahman MA, et al. Int J Med Mushrooms. 2020;22(11):1067-1078. doi: 10.1615/IntJMedMushrooms.2020036354. Int J Med Mushrooms. 2020. PMID: 33426838
Alzheimer's disease (AD) is the leading neurodegenerative disorder affecting memory and learning of aged people. ...Recent AD control guidelines have suggested lifestyle modification to slow down the progression of AD. In this regard, medicinal mushroom Ga
Alzheimer's disease (AD) is the leading neurodegenerative disorder affecting memory and learning of aged people. ...Rec
Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Brain Injury.
Quan Y, Ma A, Yang B. Quan Y, et al. Adv Exp Med Biol. 2019;1182:159-180. doi: 10.1007/978-981-32-9421-9_6. Adv Exp Med Biol. 2019. PMID: 31777018 Review.
Ganoderma lucidum (G. lucidum, Lingzhi), one of highly nutritious and significantly effective medicinal herbs, has been used for clinical applications for thousands of years. ...This chapter reviews the neuroprotective effects of G. lucidum and
Ganoderma lucidum (G. lucidum, Lingzhi), one of highly nutritious and significantly effective medicinal herbs, h
Therapeutic potential of the medicinal mushroom Ganoderma lucidum against Alzheimer's disease.
Chen XJ, Deng Z, Zhang LL, Pan Y, Fu J, Zou L, Bai Z, Xiao X, Sheng F. Chen XJ, et al. Biomed Pharmacother. 2024 Mar;172:116222. doi: 10.1016/j.biopha.2024.116222. Epub 2024 Feb 3. Biomed Pharmacother. 2024. PMID: 38310653 Free article. Review.
Alzheimer's disease (AD) is a high-incidence neurodegenerative disorder, characterized by cognitive impairment, memory loss, and psychiatric abnormalities. Ganoderma lucidum is a famous medicinal fungus with a long history of dietary intake, con
Alzheimer's disease (AD) is a high-incidence neurodegenerative disorder, characterized by cognitive impairment, memory
Spore powder of Ganoderma lucidum for Alzheimer's disease: A protocol for systematic review.
Qin LH, Wang C, Qin LW, Liang YF, Wang GH. Qin LH, et al. Medicine (Baltimore). 2019 Feb;98(5):e14382. doi: 10.1097/MD.0000000000014382. Medicine (Baltimore). 2019. PMID: 30702632 Free PMC article.
BACKGROUND: Previous studies have reported that spore powder of Ganoderma lucidum (SPGL) may be effective for the treatment of Alzheimer's disease (AD). ...
BACKGROUND: Previous studies have reported that spore powder of Ganoderma lucidum (SPGL) may be effective for the treatment of …
Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease.
Huang S, Mao J, Ding K, Zhou Y, Zeng X, Yang W, Wang P, Zhao C, Yao J, Xia P, Pei G. Huang S, et al. Stem Cell Reports. 2017 Jan 10;8(1):84-94. doi: 10.1016/j.stemcr.2016.12.007. Stem Cell Reports. 2017. PMID: 28076758 Free PMC article.
Promoting neurogenesis is a promising strategy for the treatment of cognition impairment associated with Alzheimer's disease (AD). Ganoderma lucidum is a revered medicinal mushroom for health-promoting benefits in the Orient. ...G. lucidum
Promoting neurogenesis is a promising strategy for the treatment of cognition impairment associated with Alzheimer's diseas
Identification of potential neuroprotective compound from Ganoderma lucidum extract targeting microtubule affinity regulation kinase 4 involved in Alzheimer's disease through molecular dynamics simulation and MMGBSA.
Ahmad F, Singh G, Soni H, Tandon S. Ahmad F, et al. Aging Med (Milton). 2022 Dec 12;6(2):144-154. doi: 10.1002/agm2.12232. eCollection 2023 Jun. Aging Med (Milton). 2022. PMID: 37287673 Free PMC article.
OBJECTIVE: Alzheimer's disease (AD) is one of the most prevalent neurological ailments, affecting around 50 million individuals globally. ...Compounds from Ganoderma lucidum (Reishi mushroom) extracts were selected to be used as ligands f …
OBJECTIVE: Alzheimer's disease (AD) is one of the most prevalent neurological ailments, affecting around 50 million ind …
Effect of Ganoderma Lucidum Preparation on the Behavior,Biochemistry,and Autoimmune Parameters of Mouse Models of APP/PS1 Double Transgenic Alzheimer's Disease.
Qin C, Wu S, Chen B, Wu X, Qu K, Liu J, Zhang G, Xu Y, Shu S, Sun L, Li Y, Zhu H, Huang L, Ma C, Xu Y, Han Y, Lu Y. Qin C, et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2017 Jun 20;39(3):330-335. doi: 10.3881/j.issn.1000-503X.2017.03.006. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2017. PMID: 28695802
Objective To evaluate the efficacy of Ganoderma lucidum preparation on the behaviors,biochemistry,and autoimmunity parameters of mouse models of APP/PS-1 double transgenic Alzheimer's disease(AD).Methods A total of 44 4-month-old APP/PS-1 double …
Objective To evaluate the efficacy of Ganoderma lucidum preparation on the behaviors,biochemistry,and autoimmunity parameters …
Prophylactic effects of sporoderm-removed Ganoderma lucidum spores in a rat model of streptozotocin-induced sporadic Alzheimer's disease.
Zhao HL, Cui SY, Qin Y, Liu YT, Cui XY, Hu X, Kurban N, Li MY, Li ZH, Xu J, Zhang YH. Zhao HL, et al. J Ethnopharmacol. 2021 Apr 6;269:113725. doi: 10.1016/j.jep.2020.113725. Epub 2020 Dec 25. J Ethnopharmacol. 2021. PMID: 33352241 Free article.
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum, Lingzhi), also known as "immortality mushroom" has been broadly used to improve health and longevity for thousands of years in Asia. ...This species is recorded in Chinese traditional formu …
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum, Lingzhi), also known as "immortality mushroom" ha …
Pathological Changes in APP/PS-1 Transgenic Mouse Models of Alzheimer's Disease Treated with Ganoderma Lucidum Preparation.
Qin C, Wu SQ, Chen BS, Wu XX, Qu KY, Liu JM, Zhang GF, Xu YF, Shu S, Sun L, Li YY, Zhu H, Huang L, Ma CM, Xu YH, Han YL, Lu YZ. Qin C, et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2017 Aug 20;39(4):552-561. doi: 10.3881/j.issn.1000-503X.2017.04.015. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2017. PMID: 28877835 English.
Objective To explore the efficacy of ganoderma lucidum preparation(Ling Zhi) in treating APP/PS-1 transgenic mouse models of Alzheimer's disease(AD).Methods APP/PS-1 transgenic mice of 4 months were randomly divided into model group,ganoderma
Objective To explore the efficacy of ganoderma lucidum preparation(Ling Zhi) in treating APP/PS-1 transgenic mouse models of …
Alcohol Extracts From Ganoderma lucidum Delay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents.
Lai G, Guo Y, Chen D, Tang X, Shuai O, Yong T, Wang D, Xiao C, Zhou G, Xie Y, Yang BB, Wu Q. Lai G, et al. Front Pharmacol. 2019 Mar 26;10:272. doi: 10.3389/fphar.2019.00272. eCollection 2019. Front Pharmacol. 2019. PMID: 30971923 Free PMC article.
Age-related changes in methylation are involved in the occurrence and development of tumors, autoimmune disease, and nervous system disorders, including Alzheimer's disease (AD), in elderly individuals; hence, modulation of these methylation changes ma …
Age-related changes in methylation are involved in the occurrence and development of tumors, autoimmune disease, and nervous system d …
CD33 in Alzheimer's Disease - Biology, Pathogenesis, and Therapeutics: A Mini-Review.
Zhao L. Zhao L. Gerontology. 2019;65(4):323-331. doi: 10.1159/000492596. Epub 2018 Dec 12. Gerontology. 2019. PMID: 30541012 Free article. Review.
Alzheimer's disease (AD) affects nearly 50 million people worldwide, and currently no disease-modifying treatment is available. ...The mechanistic actions of these risk factors in AD etiology have been actively investigated since they were identified.
Alzheimer's disease (AD) affects nearly 50 million people worldwide, and currently no disease-modifying treatmen
Spore powder of Ganoderma lucidum for the treatment of Alzheimer disease: A pilot study.
Wang GH, Wang LH, Wang C, Qin LH. Wang GH, et al. Medicine (Baltimore). 2018 May;97(19):e0636. doi: 10.1097/MD.0000000000010636. Medicine (Baltimore). 2018. PMID: 29742702 Free PMC article. Clinical Trial.
BACKGROUND: This study explored the feasible efficacy and safety of the Spore Powder of Ganoderma Lucidum (SPGL) for treating patients with Alzheimer disease (AD). ...All patients were treated for a total of 6 weeks. The primary outcome was measured by …
BACKGROUND: This study explored the feasible efficacy and safety of the Spore Powder of Ganoderma Lucidum (SPGL) for treating …
Pharmacological effects of natural Ganoderma and its extracts on neurological diseases: A comprehensive review.
Zhao C, Zhang C, Xing Z, Ahmad Z, Li JS, Chang MW. Zhao C, et al. Int J Biol Macromol. 2019 Jan;121:1160-1178. doi: 10.1016/j.ijbiomac.2018.10.076. Epub 2018 Oct 18. Int J Biol Macromol. 2019. PMID: 30342128 Review.
The active components and efficacy of Ganoderma are constantly being explored and supplemented every year. ...Numerous research works on the neuroprotective effects of Ganoderma have been documented (e.g., modulation of neurogenesis, amelioration of Alzheimer
The active components and efficacy of Ganoderma are constantly being explored and supplemented every year. ...Numerous research works …
Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease.
Qin Y, Zhao Y, Hu X, Chen X, Jiang YP, Jin XJ, Li G, Li ZH, Yang JH, Zhang GL, Cui SY, Zhang YH. Qin Y, et al. Front Pharmacol. 2024 Apr 24;15:1390294. doi: 10.3389/fphar.2024.1390294. eCollection 2024. Front Pharmacol. 2024. PMID: 38720773 Free PMC article.
Introduction: Ganoderma lucidum (G. lucidum, Lingzhi) has long been listed as a premium tonic that can be used to improve restlessness, insomnia, and forgetfulness. We previously reported that a rat model of sporadic Alzheimer's diseas
Introduction: Ganoderma lucidum (G. lucidum, Lingzhi) has long been listed as a premium tonic that can be used t …
Rapid Discovery of Abeta(42) Fibril Disintegrators from Ganoderma lucidum via Ligand Fishing and Their Neuroprotective Effects on Alzheimer's Disease.
Li QM, Han HH, Zang DD, Zha XQ, Zhou A, Zhang FY, Luo JP. Li QM, et al. J Agric Food Chem. 2024 Feb 28;72(8):4127-4141. doi: 10.1021/acs.jafc.3c08664. Epub 2024 Feb 16. J Agric Food Chem. 2024. PMID: 38362879
An amyloid-beta (Abeta) fibril is a vital pathogenic factor of Alzheimer's disease (AD). Abeta fibril disintegrators possess great potential to be developed into novel anti-AD agents. Here, a ligand fishing method was employed to rapidly discover Abeta(42) fi …
An amyloid-beta (Abeta) fibril is a vital pathogenic factor of Alzheimer's disease (AD). Abeta fibril disintegrators po …
Protective effect of Ganoderma lucidum-fermented crop extracts against hydrogen peroxide- or beta-amyloid-induced damage in human neuronal SH-SY5Y cells.
Huang CH, Liao YT, Chen CL, Tsai GJ. Huang CH, et al. BMC Complement Med Ther. 2024 Apr 5;24(1):148. doi: 10.1186/s12906-024-04409-1. BMC Complement Med Ther. 2024. PMID: 38580956 Free PMC article.
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of stacked beta-amyloid peptides in the brain and associated with the generation of oxidative stress. So far, there is no cure for AD or a way to stop its p …
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of stacked beta- …
Sporoderm-removed Ganoderma lucidum spores ameliorated early depression-like behavior in a rat model of sporadic Alzheimer's disease.
Zhao Y, Qin Y, Hu X, Chen X, Jiang YP, Jin XJ, Li G, Li ZH, Yang JH, Cui SY, Zhang YH. Zhao Y, et al. Front Pharmacol. 2024 Apr 24;15:1406127. doi: 10.3389/fphar.2024.1406127. eCollection 2024. Front Pharmacol. 2024. PMID: 38720779 Free PMC article.
Introduction: Ganoderma lucidum: (G. lucidum, Lingzhi) is a medicinal and edible homologous traditional Chinese medicine that is used to treat various diseases, including Alzheimer's disease and mood disorders. We previously report …
Introduction: Ganoderma lucidum: (G. lucidum, Lingzhi) is a medicinal and edible homologous traditional Chinese …
Efficient and fast screening and separation based on computer-aided screening and complex chromatography methods for lipoxygenase inhibitors from Ganoderma lucidum.
Nong Y, Zhou X, Li S, Liu Q, Zhang Y, Liang J, Zhang Y, Liu C. Nong Y, et al. Phytochem Anal. 2024 Apr;35(3):599-616. doi: 10.1002/pca.3316. Epub 2024 Jan 29. Phytochem Anal. 2024. PMID: 38287705
OBJECTIVES: This study outlines a new approach for improving the efficiency of natural product preparation, focusing on the rapid and accurate screening of potential active ingredients in Ganoderma lucidum and efficient preparation of lipoxidase inhibitors, with the …
OBJECTIVES: This study outlines a new approach for improving the efficiency of natural product preparation, focusing on the rapid and accura …
A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders.
Yadav SK, Ir R, Jeewon R, Doble M, Hyde KD, Kaliappan I, Jeyaraman R, Reddi RN, Krishnan J, Li M, Durairajan SSK. Yadav SK, et al. Planta Med. 2020 Nov;86(16):1161-1175. doi: 10.1055/a-1177-4834. Epub 2020 Jul 14. Planta Med. 2020. PMID: 32663897 Free article. Review.
This causes problems with movement (ataxia) and mental dysfunction (dementia), both of which are commonly observed symptoms in Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis. ...They are also a rich source …
This causes problems with movement (ataxia) and mental dysfunction (dementia), both of which are commonly observed symptoms in Alzheimer
Long-Term Administration of Triterpenoids From Ganoderma lucidum Mitigates Age-Associated Brain Physiological Decline via Regulating Sphingolipid Metabolism and Enhancing Autophagy in Mice.
Zeng M, Qi L, Guo Y, Zhu X, Tang X, Yong T, Xie Y, Wu Q, Zhang M, Chen D. Zeng M, et al. Front Aging Neurosci. 2021 May 6;13:628860. doi: 10.3389/fnagi.2021.628860. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34025387 Free PMC article.
In this study, long-term administration of triterpenoids of Ganoderma lucidum (TGL) can mitigate brain physiological decline in normal aging mice. In addition, the age-associated pathological features, including cataract formation, hair loss, and skin relaxation, br …
In this study, long-term administration of triterpenoids of Ganoderma lucidum (TGL) can mitigate brain physiological decline i …
Involvement of NFkB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS.
Hilliard A, Mendonca P, Soliman KFA. Hilliard A, et al. J Neuroimmunol. 2020 Aug 15;345:577269. doi: 10.1016/j.jneuroim.2020.577269. Epub 2020 May 26. J Neuroimmunol. 2020. PMID: 32480240 Free PMC article.
Ganoderma lucidum extract (GLE) is a potent ancient Asian remedy for the treatment of various diseases. ...In RT-PCR assays, pre-treatment with GLE decreased mRNA expression of CHUK, NFkappaB1/p150, and IKBKE (NFkB signaling), which may be associated with the neurop
Ganoderma lucidum extract (GLE) is a potent ancient Asian remedy for the treatment of various diseases. ...In RT-PCR assays, p
Highly oxygenated chemical constitutes and rearranged derivatives with neurotrophic activity from Ganoderma cochlear.
Yu C, Cao CY, Shi PD, Yang AA, Yang YX, Huang DS, Chen X, Chen ZM, Gao JM, Yin X. Yu C, et al. J Ethnopharmacol. 2022 Sep 15;295:115393. doi: 10.1016/j.jep.2022.115393. Epub 2022 May 21. J Ethnopharmacol. 2022. PMID: 35609755
Fruiting bodies and spores of G. cochear have been traditionally used for smoothing, sleeping improvement, memory impairment, anti-aging, and prolonging life. Alzheimer's disease (AD) is a chromic progressive neurodegenerative disorder associated with loss of …
Fruiting bodies and spores of G. cochear have been traditionally used for smoothing, sleeping improvement, memory impairment, anti-aging, an …
Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism.
Phan CW, David P, Naidu M, Wong KH, Sabaratnam V. Phan CW, et al. Crit Rev Biotechnol. 2015;35(3):355-68. doi: 10.3109/07388551.2014.887649. Crit Rev Biotechnol. 2015. PMID: 24654802 Review.
Although at its infancy, accumulated evidence suggested that culinary-medicinal mushrooms may play an important role in the prevention of many age-associated neurological dysfunctions, including Alzheimer's and Parkinson's diseases. Therefore, efforts have been devo …
Although at its infancy, accumulated evidence suggested that culinary-medicinal mushrooms may play an important role in the prevention of ma …
Mixed Medicinal Mushroom Mycelia Attenuates Alzheimer's Disease Pathologies In Vitro and In Vivo.
Jeong JH, Hong GL, Jeong YG, Lee NS, Kim DK, Park JY, Park M, Kim HM, Kim YE, Yoo YC, Han SY. Jeong JH, et al. Curr Issues Mol Biol. 2023 Aug 15;45(8):6775-6789. doi: 10.3390/cimb45080428. Curr Issues Mol Biol. 2023. PMID: 37623247 Free PMC article.
Alzheimer's disease (AD) is characterized by memory impairment and existence of amyloid-beta (Abeta) plaques and neuroinflammation. ...Here, the aqueous extract of mixed medicinal mushroom mycelia (MMMM)-Phellinus linteus, Ganoderma lucidum, and
Alzheimer's disease (AD) is characterized by memory impairment and existence of amyloid-beta (Abeta) plaques and neuroi
Two Ganoderma species: profiling of phenolic compounds by HPLC-DAD, antioxidant, antimicrobial and inhibitory activities on key enzymes linked to diabetes mellitus, Alzheimer's disease and skin disorders.
Zengin G, Sarikurkcu C, Gunes E, Uysal A, Ceylan R, Uysal S, Gungor H, Aktumsek A. Zengin G, et al. Food Funct. 2015 Aug;6(8):2794-802. doi: 10.1039/c5fo00665a. Epub 2015 Jul 13. Food Funct. 2015. PMID: 26165701
This work reports the antioxidant, antimicrobial, and inhibitory effects of methanol and water extracts from Ganoderma applanatum (GAM: methanol extract and GAW: water extract) and G. resinaceum (GRM: methanol extract and GRW: water extract) against cholinesterase, tyrosin …
This work reports the antioxidant, antimicrobial, and inhibitory effects of methanol and water extracts from Ganoderma applanatum (GA …
Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer's disease: A review.
Jiang Y, Gao H, Turdu G. Jiang Y, et al. Bioorg Chem. 2017 Dec;75:50-61. doi: 10.1016/j.bioorg.2017.09.004. Epub 2017 Sep 6. Bioorg Chem. 2017. PMID: 28915465 Review.
Alzheimer's disease (AD) is a progressive neurodegenerative disease affecting 25 million people worldwide, and cholinergic hypothesis is considered as an important hypotheses in the processes of improving cognitive function and recognition skills in re
Alzheimer's disease (AD) is a progressive neurodegenerative disease affecting 25 million people worldwide, and c
Structural characterization of a galactoglucomannan with anti-neuroinflammatory activity from Ganoderma lucidum.
Cao C, Liao Y, Yu Q, Zhang D, Huang J, Su Y, Yan C. Cao C, et al. Carbohydr Polym. 2024 Jun 15;334:122030. doi: 10.1016/j.carbpol.2024.122030. Epub 2024 Mar 6. Carbohydr Polym. 2024. PMID: 38553228
According to traditional Chinese medicine theory, Ganoderma lucidum (G. lucidum) presents certain effects for nourishing nerves and calming the mind. ...In this work, the crude polysaccharide GL70 exhibited a remarkable impact on enhancing the spatial learnin …
According to traditional Chinese medicine theory, Ganoderma lucidum (G. lucidum) presents certain effects for nourishin …
Neuroprotective effect of preadministration with Ganoderma lucidum spore on rat hippocampus.
Zhou Y, Qu ZQ, Zeng YS, Lin YK, Li Y, Chung P, Wong R, Hägg U. Zhou Y, et al. Exp Toxicol Pathol. 2012 Nov;64(7-8):673-80. doi: 10.1016/j.etp.2010.12.011. Epub 2011 Jan 15. Exp Toxicol Pathol. 2012. PMID: 21242065
The aim of this study was to investigate if preadministration with Ganoderma lucidum spore (GLS) could (1) alleviate oxidative stress and mitochondrial dysfunction in rat hippocampus of intracerebroventricular (ICV) injection of streptozotocin (STZ), (2) protect neu …
The aim of this study was to investigate if preadministration with Ganoderma lucidum spore (GLS) could (1) alleviate oxidative …
In silico analysis and characterization of medicinal mushroom cystathionine beta-synthase as an angiotensin converting enzyme (ACE) inhibitory protein.
Goh NY, Mohamad Razif MF, Yap YH, Ng CL, Fung SY. Goh NY, et al. Comput Biol Chem. 2022 Feb;96:107620. doi: 10.1016/j.compbiolchem.2021.107620. Epub 2021 Dec 23. Comput Biol Chem. 2022. PMID: 34971900
Angiotensin-converting enzyme (ACE) regulates blood pressure and has been implicated in several conditions including lung injury, fibrosis and Alzheimer's disease. Medicinal mushroom Ganordema lucidum (Reishi) cystathionine beta-synthase (GlCBS) …
Angiotensin-converting enzyme (ACE) regulates blood pressure and has been implicated in several conditions including lung injury, fibrosis a …
Bioprospecting of Wild Mushrooms from India with Respect to Their Medicinal Aspects.
Khan F, Chandra R. Khan F, et al. Int J Med Mushrooms. 2019;21(2):181-192. doi: 10.1615/IntJMedMushrooms.2019029969. Int J Med Mushrooms. 2019. PMID: 30806224
Also, tests such as the alpha-amylase inhibition assay, a measure of antidiabetes activity, and antioxidant assays such as the DPPH, ferric-reducing antioxidant power, and acetylcholinesterase-inhibitory assays, which determine anti-Alzheimer disease properties, wer …
Also, tests such as the alpha-amylase inhibition assay, a measure of antidiabetes activity, and antioxidant assays such as the DPPH, ferric- …
Potentiation of neuritogenic activity of medicinal mushrooms in rat pheochromocytoma cells.
Ling-Sing Seow S, Naidu M, David P, Wong KH, Sabaratnam V. Ling-Sing Seow S, et al. BMC Complement Altern Med. 2013 Jul 4;13:157. doi: 10.1186/1472-6882-13-157. BMC Complement Altern Med. 2013. PMID: 23822837 Free PMC article.
BACKGROUND: Senescence of the neurons is believed to be a focal factor in the development of age-related neurodegenerative diseases such as Alzheimer's disease. Diminutions in the levels of nerve growth factor (NGF) lead to major declines in brain cell perfor …
BACKGROUND: Senescence of the neurons is believed to be a focal factor in the development of age-related neurodegenerative diseases such as …
Identification of diagnostic molecules and potential traditional Chinese medicine components for Alzheimer's disease by single cell RNA sequencing combined with a systematic framework for network pharmacology.
Wang T, Zhang X, Liu W, Ning F, Hu X, Qin L, Cui M, Yang J, Lv S, Wang Q. Wang T, et al. Front Med (Lausanne). 2024 Jan 5;10:1335512. doi: 10.3389/fmed.2023.1335512. eCollection 2023. Front Med (Lausanne). 2024. PMID: 38249960 Free PMC article.
By integrating scRNA-seq with new computational frameworks or specific technologies, better Alzheimer's disease (AD) treatments may be developed. METHODS: The single-cell sequencing dataset GSE158234 was obtained from the GEO database. ...Screening identified …
By integrating scRNA-seq with new computational frameworks or specific technologies, better Alzheimer's disease (AD) tr …
UPLC-ESI-MS/MS-based widely targeted metabolomics reveals differences in metabolite composition among four Ganoderma species.
Wei-Ye L, Hong-Bo G, Rui-Heng Y, Ai-Guo X, Jia-Chen Z, Zhao-Qian Y, Wen-Jun H, Xiao-Dan Y. Wei-Ye L, et al. Front Nutr. 2024 Mar 18;11:1335538. doi: 10.3389/fnut.2024.1335538. eCollection 2024. Front Nutr. 2024. PMID: 38562486 Free PMC article.
The Chinese name "Lingzhi" refers to Ganoderma genus, which are increasingly used in the food and medical industries. ...Network pharmacological analysis showed that SRC, GAPDH, TNF, and AKT1 were the key targets of high-degree advantage metabolites among the four …
The Chinese name "Lingzhi" refers to Ganoderma genus, which are increasingly used in the food and medical industries. ...Netwo …
Antagonizing beta-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum.
Lai CS, Yu MS, Yuen WH, So KF, Zee SY, Chang RC. Lai CS, et al. Brain Res. 2008 Jan 23;1190:215-24. doi: 10.1016/j.brainres.2007.10.103. Epub 2007 Nov 13. Brain Res. 2008. PMID: 18083148
Ganoderma lucidum (Leyss. ex Fr.) Karst. (Lingzhi) is a medicinal fungus used clinically in many Asian countries to promote health and longevity. Synaptic degeneration is another key mode of neurodegeneration in Alzheimer's disease (AD).
Ganoderma lucidum (Leyss. ex Fr.) Karst. (Lingzhi) is a medicinal fungus used clinically in many Asian countries to pro
Ganoderic acid targeting nuclear factor erythroid 2-related factor 2 in lung cancer.
Gill BS, Kumar S, Navgeet. Gill BS, et al. Tumour Biol. 2017 Mar;39(3):1010428317695530. doi: 10.1177/1010428317695530. Tumour Biol. 2017. PMID: 28349780 Free article.
Nuclear factor erythroid 2-related factor 2 is the major regulator of endogenous and exogenous stress by activating numerous antioxidant genes critical in cancer, Alzheimer's, Parkinson's, and inflammatory bowel diseases. Ganoderic acid is a triterpene from basiodio …
Nuclear factor erythroid 2-related factor 2 is the major regulator of endogenous and exogenous stress by activating numerous antioxidant gen …
Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy.
Peng X, Luo R, Ran X, Guo Y, Yao YG, Qiu M. Peng X, et al. Bioorg Chem. 2023 Mar;132:106375. doi: 10.1016/j.bioorg.2023.106375. Epub 2023 Jan 17. Bioorg Chem. 2023. PMID: 36682148
Ganoapplins A and B (1 and 2) with a 6/6/6/5/6-fused pentacyclic skeleton containing an aromatic E ring, were obtained from Ganoderma applanatum. Their structures were established through extensive spectroscopic analyses, quantum chemical calculations, including calculated …
Ganoapplins A and B (1 and 2) with a 6/6/6/5/6-fused pentacyclic skeleton containing an aromatic E ring, were obtained from Ganoderma
Ganoderic Acid A To Alleviate Neuroinflammation of Alzheimer's Disease in Mice by Regulating the Imbalance of the Th17/Tregs Axis.
Zhang Y, Wang X, Yang X, Yang X, Xue J, Yang Y. Zhang Y, et al. J Agric Food Chem. 2021 Dec 1;69(47):14204-14214. doi: 10.1021/acs.jafc.1c06304. Epub 2021 Nov 19. J Agric Food Chem. 2021. PMID: 34798773
Ganoderic acid A (GAA) is a kind of lanostane-type triterpenoid isolated from Ganoderma lucidum. Imbalance of the Th17/Tregs axis exists in the progress of neuroinflammation of Alzheimer's disease (AD). ...
Ganoderic acid A (GAA) is a kind of lanostane-type triterpenoid isolated from Ganoderma lucidum. Imbalance of the Th17/Tregs a …
Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum.
Lee I, Ahn B, Choi J, Hattori M, Min B, Bae K. Lee I, et al. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6603-7. doi: 10.1016/j.bmcl.2011.04.042. Epub 2011 Apr 17. Bioorg Med Chem Lett. 2011. PMID: 21924611
Two new lanostane triterpenes, named methyl ganoderate A acetonide (1) and n-butyl ganoderate H (2), were isolated from the fruiting bodies of Ganoderma lucidum together with 16 known compounds (3-18). Extensive spectroscopic and chemical studies established the str …
Two new lanostane triterpenes, named methyl ganoderate A acetonide (1) and n-butyl ganoderate H (2), were isolated from the fruiting bodies …
Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo.
Lin NH, Goh A, Lin SH, Chuang KA, Chang CH, Li MH, Lu CH, Chen WY, Wei PH, Pan IH, Perng MD, Wen SF. Lin NH, et al. J Alzheimers Dis Rep. 2023 Jan 27;7(1):51-76. doi: 10.3233/ADR-220056. eCollection 2023. J Alzheimers Dis Rep. 2023. PMID: 36777330 Free PMC article.
BACKGROUND: Alzheimer's disease (AD) is a multifactorial disorder characterized by cognitive decline. ...In particular, herbal medicines with multiplicity of actions produce cognitive benefits on AD. Bugu-M is a multi-herbal extract composed of Ganoderma
BACKGROUND: Alzheimer's disease (AD) is a multifactorial disorder characterized by cognitive decline. ...In particular, …
Anti-inflammatory triterpenoids from mysterious mushroom Ganoderma lucidum and their potential possibility in modern medicine.
Patocka J. Patocka J. Acta Medica (Hradec Kralove). 1999;42(4):123-5. Acta Medica (Hradec Kralove). 1999. PMID: 10812678
Ganoderma lucidum, a mushroom long used in the East for a broad range of disorders, contains numerous pharmacologically active compounds. ...
Ganoderma lucidum, a mushroom long used in the East for a broad range of disorders, contains numerous pharmacologically active
Effects of Gardenia jasminoides extracts on cognition and innate immune response in an adult Drosophila model of Alzheimer's disease.
Ma WW, Tao Y, Wang YY, Peng IF. Ma WW, et al. Chin J Nat Med. 2017 Dec;15(12):899-904. doi: 10.1016/S1875-5364(18)30005-0. Chin J Nat Med. 2017. PMID: 29329646
In the present study, the memory loss induced by human Abeta protein over-expression in fruitfly Alzheimer's disease (AD) model was rescued by multiple extracts from Gardenia jasminoides. ...Further investigation on adding gardenoside into a formula of Gan
In the present study, the memory loss induced by human Abeta protein over-expression in fruitfly Alzheimer's disease (A …
COP-22 Alleviates D-Galactose-Induced Brain Aging by Attenuating Oxidative Stress, Inflammation, and Apoptosis in Mice.
Ma Y, Wang X, Li X, Chen X, Teng Z, Wang X, Yang J, Liu G. Ma Y, et al. Mol Neurobiol. 2024 Feb 12. doi: 10.1007/s12035-024-03976-1. Online ahead of print. Mol Neurobiol. 2024. PMID: 38347285
These results indicated that COP-22 had potential anti-aging activity and could be used in the therapy of aging and aging-associated diseases like Alzheimer disease....
These results indicated that COP-22 had potential anti-aging activity and could be used in the therapy of aging and aging-associated disease …