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Page 1
Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy.
Frisch AT, Wang Y, Xie B, Yang A, Ford BR, Joshi S, Kedziora KM, Peralta R, Wilfahrt D, Mullett SJ, Spahr K, Lontos K, Jana JA, Dean VG, Gunn WG, Gelhaus S, Poholek AC, Rivadeneira DB, Delgoffe GM. Frisch AT, et al. Among authors: poholek ac. Cell Metab. 2025 Jan 24:S1550-4131(24)00489-3. doi: 10.1016/j.cmet.2024.12.007. Online ahead of print. Cell Metab. 2025. PMID: 39879981
Gasping for air: HIF2α in asthma.
Giri S, Poholek AC. Giri S, et al. Among authors: poholek ac. Immunity. 2024 Dec 10;57(12):2710-2712. doi: 10.1016/j.immuni.2024.11.015. Immunity. 2024. PMID: 39662085
Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism.
Peralta RM, Xie B, Lontos K, Nieves-Rosado H, Spahr K, Joshi S, Ford BR, Quann K, Frisch AT, Dean V, Philbin M, Cillo AR, Gingras S, Poholek AC, Kane LP, Rivadeneira DB, Delgoffe GM. Peralta RM, et al. Among authors: poholek ac. Nat Immunol. 2024 Dec;25(12):2297-2307. doi: 10.1038/s41590-024-01999-3. Epub 2024 Nov 8. Nat Immunol. 2024. PMID: 39516648 Free PMC article.
IκBζ is an essential mediator of immunity to oropharyngeal candidiasis.
Taylor TC, Coleman BM, Arunkumar SP, Dey I, Dillon JT, Ponde NO, Poholek AC, Schwartz DM, McGeachy MJ, Conti HR, Gaffen SL. Taylor TC, et al. Among authors: poholek ac. Cell Host Microbe. 2023 Oct 11;31(10):1700-1713.e4. doi: 10.1016/j.chom.2023.08.016. Epub 2023 Sep 18. Cell Host Microbe. 2023. PMID: 37725983 Free PMC article.
52 results