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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 2
1970 9
1971 5
1972 4
1973 2
1974 2
1975 2
1976 2
1979 2
1980 2
1981 3
1982 3
1983 3
1984 2
1985 2
1986 1
1987 6
1988 1
1989 4
1990 1
1991 5
1992 7
1993 4
1994 1
1995 9
1996 6
1997 2
1998 6
1999 9
2000 11
2001 15
2002 11
2003 20
2004 24
2005 23
2006 31
2007 31
2008 29
2009 22
2010 31
2011 26
2012 40
2013 36
2014 39
2015 34
2016 23
2017 37
2018 31
2019 28
2020 25
2021 16
2022 21
2023 14
2024 16
2025 13

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684 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Placebo-controlled trial of amantadine for severe traumatic brain injury.
Giacino JT, Whyte J, Bagiella E, Kalmar K, Childs N, Khademi A, Eifert B, Long D, Katz DI, Cho S, Yablon SA, Luther M, Hammond FM, Nordenbo A, Novak P, Mercer W, Maurer-Karattup P, Sherer M. Giacino JT, et al. N Engl J Med. 2012 Mar 1;366(9):819-26. doi: 10.1056/NEJMoa1102609. N Engl J Med. 2012. PMID: 22375973 Free article. Clinical Trial.
BACKGROUND: Amantadine hydrochloride is one of the most commonly prescribed medications for patients with prolonged disorders of consciousness after traumatic brain injury. ...Patients were randomly assigned to receive amantadine or placebo for 4 weeks and were foll …
BACKGROUND: Amantadine hydrochloride is one of the most commonly prescribed medications for patients with prolonged disorders of cons …
Assessment of the effect of amantadine in patients with traumatic brain injury: A meta-analysis.
Mohamed MS, El Sayed I, Zaki A, Abdelmonem S. Mohamed MS, et al. J Trauma Acute Care Surg. 2022 Mar 1;92(3):605-614. doi: 10.1097/TA.0000000000003363. J Trauma Acute Care Surg. 2022. PMID: 34284464
Metaregression of the different clinical parameters, which are onset of treatment, age, and severity of traumatic brain injury, showed a statistically significant relation between onset of treatment and the effect size of amantadine. The relation between the other two para …
Metaregression of the different clinical parameters, which are onset of treatment, age, and severity of traumatic brain injury, showed a sta …
Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial.
Nourbakhsh B, Revirajan N, Morris B, Cordano C, Creasman J, Manguinao M, Krysko K, Rutatangwa A, Auvray C, Aljarallah S, Jin C, Mowry E, McCulloch C, Waubant E. Nourbakhsh B, et al. Lancet Neurol. 2021 Jan;20(1):38-48. doi: 10.1016/S1474-4422(20)30354-9. Epub 2020 Nov 23. Lancet Neurol. 2021. PMID: 33242419 Free PMC article. Clinical Trial.
FINDINGS: Between Oct 4, 2017, and Feb 27, 2019, of 169 patients screened, 141 patients were enrolled and randomly assigned to one of four medication administration sequences: 35 (25%) patients to the amantadine, placebo, modafinil, and methylphenidate sequence; 34 (24%) p …
FINDINGS: Between Oct 4, 2017, and Feb 27, 2019, of 169 patients screened, 141 patients were enrolled and randomly assigned to one of four m …
Amantadine and rimantadine for influenza A in children and the elderly.
Alves Galvão MG, Rocha Crispino Santos MA, Alves da Cunha AJ. Alves Galvão MG, et al. Cochrane Database Syst Rev. 2014 Nov 21;2014(11):CD002745. doi: 10.1002/14651858.CD002745.pub4. Cochrane Database Syst Rev. 2014. PMID: 25415374 Free PMC article. Review.
SELECTION CRITERIA: Randomised controlled trials (RCTs) or quasi-RCTs comparing amantadine and/or rimantadine with no intervention, placebo, other antivirals or different doses or schedules of amantadine or rimantadine in children and the elderly with influenza A. . …
SELECTION CRITERIA: Randomised controlled trials (RCTs) or quasi-RCTs comparing amantadine and/or rimantadine with no intervention, p …
Amantadine and rimantadine for influenza A in adults.
Jefferson T, Demicheli V, Di Pietrantonj C, Rivetti D. Jefferson T, et al. Cochrane Database Syst Rev. 2006 Apr 19;2006(2):CD001169. doi: 10.1002/14651858.CD001169.pub3. Cochrane Database Syst Rev. 2006. PMID: 16625539 Free PMC article.
SELECTION CRITERIA: Randomised and quasi-randomised studies comparing amantadine and/or rimantadine with placebo, control medication or no intervention, or comparing doses or schedules of amantadine and/or rimantadine in healthy adults. ...Both amantadine and …
SELECTION CRITERIA: Randomised and quasi-randomised studies comparing amantadine and/or rimantadine with placebo, control medication …
Extended-release amantadine for OFF-related dystonia in Parkinson's disease.
Espay AJ, Ostrem JL, Formella AE, Tanner CM. Espay AJ, et al. Parkinsonism Relat Disord. 2024 May;122:106088. doi: 10.1016/j.parkreldis.2024.106088. Epub 2024 Mar 4. Parkinsonism Relat Disord. 2024. PMID: 38461688 Free article. Clinical Trial.
Twelve-week treatment with extended-release amantadine improved OFF dystonia (treatment differences vs placebo: UDysRS Part 2, -1.0 [-1.9,-0.1]; p = 0.03 and MDS-UPDRS Item 4.6, -0.3 [-0.6,-0.05]; p = 0.02). ...Double-blind improvements in OFF dystonia were sustained throu …
Twelve-week treatment with extended-release amantadine improved OFF dystonia (treatment differences vs placebo: UDysRS Part 2, -1.0 [ …
Efficacy and safety of amantadine for the treatment of fatigue in multiple sclerosis: a systematic review and meta-analysis.
Perez DQ, Espiritu AI, Jamora RDG. Perez DQ, et al. Neurodegener Dis Manag. 2020 Dec;10(6):383-395. doi: 10.2217/nmt-2020-0030. Epub 2020 Oct 5. Neurodegener Dis Manag. 2020. PMID: 33012266
The meta-analysis revealed improvement of MS-related fatigue with amantadine treatment using the patients' subjective responses and validated fatigue scales. Conclusion: Amantadine is the most studied drug that has shown improvement of MS-related fatigue, with mild …
The meta-analysis revealed improvement of MS-related fatigue with amantadine treatment using the patients' subjective responses and v …
Amantadine and pneumonia.
Nakagawa T, Wada H, Sekizawa K, Arai H, Sasaki H. Nakagawa T, et al. Lancet. 1999 Apr 3;353(9159):1157. doi: 10.1016/S0140-6736(98)05805-X. Lancet. 1999. PMID: 10209989 Clinical Trial. No abstract available.
Amantadine in depression.
Vale S, Espejel MA, Dominguez JC. Vale S, et al. Lancet. 1971 Aug 21;2(7721):437. doi: 10.1016/s0140-6736(71)90153-x. Lancet. 1971. PMID: 4105209 Clinical Trial. No abstract available.
684 results