LC-MS/MS-Based Determination of Ambroxol in Human Plasma and Cerebrospinal Fluid: Validation and Applicability in a Phase II Study on GBA-Associated Parkinson's Disease Patients.
Franco V, Palmisani M, Colucci F, De Micco R, Aloisio S, Cazzaniga F, Cerri S, Crema F, Dattrino F, Garavaglia B, Gastaldi M, Mitrotti P, Moda F, Rota P, Stiuso R, Tassorelli C, Eleopra R, Tessitore A, Valente EM, Avenali M, Cilia R.
Franco V, et al.
Int J Mol Sci. 2025 Jun 25;26(13):6094. doi: 10.3390/ijms26136094.
Int J Mol Sci. 2025.
PMID: 40649871
Free PMC article.
Clinical Trial.
This study aimed to develop a method to quantify ambroxol levels in human plasma and cerebrospinal fluid (CSF) using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Ambroxol was determined by online solid-phase extraction (SPE), coupled with LC-MS/MS, by …
This study aimed to develop a method to quantify ambroxol levels in human plasma and cerebrospinal fluid (CSF) using liquid chromatog …