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38 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Efficacy and tolerability of amorolfine 5% nail lacquer in combination with systemic antifungal agents for onychomycosis: A meta-analysis and systematic review.
Feng X, Xiong X, Ran Y. Feng X, et al. Dermatol Ther. 2017 May;30(3). doi: 10.1111/dth.12457. Epub 2017 Jan 18. Dermatol Ther. 2017. PMID: 28097731
The efficacy and safety of amorolfine 5% nail lacquer in combination with systemic antifungal agents in the treatment of the onychomycosis were evaluated. According to our meta-analysis, combination treatment of amorolfine 5% nail lacquer and systemic antifungals ca …
The efficacy and safety of amorolfine 5% nail lacquer in combination with systemic antifungal agents in the treatment of the onychomy …
How effective is topical miconazole or amorolfine for mild to moderately severe onychomycosis in primary care: the Onycho Trial - a randomised double-blind placebo-controlled trial.
Watjer RM, Bonten TN, Sayed K, Quint KD, van der Beek MT, Mertens BJA, Numans ME, Eekhof JAH. Watjer RM, et al. BMJ Open. 2024 May 3;14(5):e081914. doi: 10.1136/bmjopen-2023-081914. BMJ Open. 2024. PMID: 38702077 Free PMC article. Clinical Trial.
OBJECTIVES: To evaluate the efficacy of topical miconazole or amorolfine compared to placebo for mild to moderately severe onychomycosis. DESIGN: Randomised, double-blind, placebo-controlled trial, with computer-generated treatment allocation at a 1:1:1 ratio. ...INTERVENT …
OBJECTIVES: To evaluate the efficacy of topical miconazole or amorolfine compared to placebo for mild to moderately severe onychomyco …
Comparison of a fractional 2940-nm Er:YAG laser and 5% amorolfine lacquer combination therapy versus a 5% amorolfine lacquer monotherapy for the treatment of onychomycosis: a randomized controlled trial.
Zhang J, Zhang Y, Qin J, Lu S, Cai W, Li J, Huang H, Yang S, Xi L. Zhang J, et al. Lasers Med Sci. 2021 Feb;36(1):147-152. doi: 10.1007/s10103-020-03054-7. Epub 2020 Jun 17. Lasers Med Sci. 2021. PMID: 32557000 Clinical Trial.
In the combination therapy group, the included toenails were treated with a fractional 2940-nm Er:YAG laser at weeks 1, 2, 3, 4, 8, and 12, combined with a 5% amorolfine lacquer twice a week for 12 weeks, while in the monotherapy group, the included toenails were treated w …
In the combination therapy group, the included toenails were treated with a fractional 2940-nm Er:YAG laser at weeks 1, 2, 3, 4, 8, and 12, …
A randomized, double-blind trial of amorolfine 0.25% cream and sertaconazole 2% cream in limited dermatophytosis.
Das A, Sil A, Sarkar TK, Sen A, Chakravorty S, Sengupta M, Das A, Chandra S, Pal S, Bandyopadhyay D, Das NK. Das A, et al. Indian J Dermatol Venereol Leprol. 2019 May-Jun;85(3):276-281. doi: 10.4103/ijdvl.IJDVL_907_17. Indian J Dermatol Venereol Leprol. 2019. PMID: 30409926 Free article. Clinical Trial.
Fungal cultures became negative in 92.3% of the sertaconazole group as compared to 80% in the amorolfine group (P = 0.010). LIMITATIONS: Antifungal susceptibility testing could not be done. CONCLUSION: Sertaconazole 2% is superior to amorolfine 0.25%, both in terms …
Fungal cultures became negative in 92.3% of the sertaconazole group as compared to 80% in the amorolfine group (P = 0.010). LIMITATIO …
Comparative efficacy and safety of amorolfine nail lacquer 5% in onychomycosis, once-weekly versus twice-weekly.
Reinel D, Clarke C. Reinel D, et al. Clin Exp Dermatol. 1992 Sep;17 Suppl 1:44-9. doi: 10.1111/j.1365-2230.1992.tb00278.x. Clin Exp Dermatol. 1992. PMID: 1458665 Clinical Trial.
Human pharmacological studies have established that amorolfine has a persistent antifungal effect in the nail bed and in the skin without being systemically absorbed. ...In earlier studies a 5% concentration of amorolfine nail lacquer was found to produce a better c …
Human pharmacological studies have established that amorolfine has a persistent antifungal effect in the nail bed and in the skin wit …
Efficacy of topical resin lacquer, amorolfine and oral terbinafine for treating toenail onychomycosis: a prospective, randomized, controlled, investigator-blinded, parallel-group clinical trial.
Auvinen T, Tiihonen R, Soini M, Wangel M, Sipponen A, Jokinen JJ. Auvinen T, et al. Br J Dermatol. 2015 Oct;173(4):940-8. doi: 10.1111/bjd.13934. Epub 2015 Oct 1. Br J Dermatol. 2015. PMID: 26036329 Clinical Trial.

At 10 months, clinical responses were complete in four patients (16%) treated with terbinafine, and partial in seven (30%), seven (28%) and nine (36%) patients treated with resin, amorolfine and terbinafine, respectively (P < 0.05). Resin, amorolfine and terbinaf

…
At 10 months, clinical responses were complete in four patients (16%) treated with terbinafine, and partial in seven (30%), seven (28%) and …
Amorolfine spray in the treatment of foot mycoses (a dose-finding study).
Nolting S, Reinel D, Semig G, Reckers-Czaschka R, Bergstraesser M, Zaug M. Nolting S, et al. Br J Dermatol. 1993 Aug;129(2):170-4. doi: 10.1111/j.1365-2133.1993.tb03522.x. Br J Dermatol. 1993. PMID: 7654578 Clinical Trial.
A total of 382 patients with foot mycosis were entered into a dose-finding study. Patients were randomly treated with amorolfine spray 0.5% or 2% (double-blind) or cream 0.5% (open; used as a reference agent). ...Further studies should show if more widely spaced treatment …
A total of 382 patients with foot mycosis were entered into a dose-finding study. Patients were randomly treated with amorolfine spra …
A clinical study for the treatment of onychomycosis patients using a novel ROS producing onychomycosis treatment when compared against 5% amorolfine topical lacquer to reduce the visible size of infected toenails.
Ehrensberger M, Boal CWC, Brennan J, Barrett J, Makarus J, Callanan S, Spillane E, Patton T. Ehrensberger M, et al. J Mycol Med. 2022 Aug;32(3):101256. doi: 10.1016/j.mycmed.2022.101256. Epub 2022 Feb 18. J Mycol Med. 2022. PMID: 35219908 Free article. Clinical Trial.
The aim of this first in human study was to compare the safety and efficacy of the novel compound Mycosinate against an approved toenail lacquer containing 5% Amorolfine. DESIGN: A randomized, single-blinded, controlled parallel group study with allocation concealment was …
The aim of this first in human study was to compare the safety and efficacy of the novel compound Mycosinate against an approved toenail lac …
Patient-reported outcomes from two randomised studies comparing once-weekly application of amorolfine 5% nail lacquer to other methods of topical treatment in distal and lateral subungual onychomycosis.
Schaller M, Sigurgeirsson B, Sarkany M. Schaller M, et al. Mycoses. 2017 Dec;60(12):800-807. doi: 10.1111/myc.12676. Epub 2017 Sep 19. Mycoses. 2017. PMID: 28925059 Clinical Trial.
Study A: Subjects received amorolfine and ciclopirox on opposite feet for 12 weeks. Study B: Subjects received amorolfine and urea/bifonazole on opposite feet for 6-7 weeks. ...At the end of study, 85.7% of subjects preferred amorolfine versus 14.3% for urea/ …
Study A: Subjects received amorolfine and ciclopirox on opposite feet for 12 weeks. Study B: Subjects received amorolfine and …
38 results