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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 4
1966 7
1967 7
1968 10
1969 18
1970 14
1971 22
1972 11
1973 14
1974 20
1975 8
1976 11
1977 11
1978 17
1979 21
1980 10
1981 10
1982 18
1983 13
1984 22
1985 16
1986 24
1987 55
1988 44
1989 38
1990 37
1991 50
1992 36
1993 63
1994 54
1995 91
1996 102
1997 89
1998 86
1999 128
2000 131
2001 136
2002 168
2003 139
2004 153
2005 163
2006 210
2007 273
2008 246
2009 328
2010 345
2011 353
2012 302
2013 287
2014 322
2015 344
2016 373
2017 395
2018 393
2019 394
2020 351
2021 307
2022 173
2023 185
2024 395
2025 474
2026 193

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7,844 results

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Page 1
Understanding Amyotrophic Lateral Sclerosis: Pathophysiology, Diagnosis, and Therapeutic Advances.
Rizea RE, Corlatescu AD, Costin HP, Dumitru A, Ciurea AV. Rizea RE, et al. Int J Mol Sci. 2024 Sep 15;25(18):9966. doi: 10.3390/ijms25189966. Int J Mol Sci. 2024. PMID: 39337454 Free PMC article. Review.
This review offers an in-depth examination of amyotrophic lateral sclerosis (ALS), addressing its epidemiology, pathophysiology, clinical presentation, diagnostic techniques, and current as well as emerging treatments. ...
This review offers an in-depth examination of amyotrophic lateral sclerosis (ALS), addressing its epidemiology, path …
Amyotrophic Lateral Sclerosis.
Brown RH, Al-Chalabi A. Brown RH, et al. N Engl J Med. 2017 Jul 13;377(2):162-172. doi: 10.1056/NEJMra1603471. N Engl J Med. 2017. PMID: 28700839 Free article. Review. No abstract available.
Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS).
Grad LI, Rouleau GA, Ravits J, Cashman NR. Grad LI, et al. Cold Spring Harb Perspect Med. 2017 Aug 1;7(8):a024117. doi: 10.1101/cshperspect.a024117. Cold Spring Harb Perspect Med. 2017. PMID: 28003278 Free PMC article. Review.
Amyotrophic lateral sclerosis (ALS) is primarily characterized by progressive loss of motor neurons, although there is marked phenotypic heterogeneity between cases. Typical, or "classical," ALS is associated with simultaneous upper motor neuron (UMN) and low …
Amyotrophic lateral sclerosis (ALS) is primarily characterized by progressive loss of motor neurons, although there is …
Amyotrophic lateral sclerosis.
Kiernan MC, Vucic S, Cheah BC, Turner MR, Eisen A, Hardiman O, Burrell JR, Zoing MC. Kiernan MC, et al. Lancet. 2011 Mar 12;377(9769):942-55. doi: 10.1016/S0140-6736(10)61156-7. Epub 2011 Feb 4. Lancet. 2011. PMID: 21296405 Free article. Review.
Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal neurodegenerative disease of the human motor system. ...
Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal neurodegenerative disease of the human motor system. ...
Amyotrophic Lateral Sclerosis: Pathophysiological Mechanisms and Treatment Strategies (Part 2).
Tolochko C, Shiryaeva O, Alekseeva T, Dyachuk V. Tolochko C, et al. Int J Mol Sci. 2025 May 29;26(11):5240. doi: 10.3390/ijms26115240. Int J Mol Sci. 2025. PMID: 40508048 Free PMC article. Review.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease associated with damage to motor neurons and leading to severe muscle weakness and, eventually, death. ...
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease associated with damage to motor neurons …
Amyotrophic lateral sclerosis; clinical features, differential diagnosis and pathology.
Van Es MA. Van Es MA. Int Rev Neurobiol. 2024;176:1-47. doi: 10.1016/bs.irn.2024.04.011. Epub 2024 May 22. Int Rev Neurobiol. 2024. PMID: 38802173 Review.
Amyotrophic lateral sclerosis (ALS) is a late-onset syndrome characterized by the progressive degeneration of both upper motor neurons (UMN) and lower motor neurons (LMN). ...
Amyotrophic lateral sclerosis (ALS) is a late-onset syndrome characterized by the progressive degeneration of both uppe …
Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases.
Quinn C, Elman L. Quinn C, et al. Continuum (Minneap Minn). 2020 Oct;26(5):1323-1347. doi: 10.1212/CON.0000000000000911. Continuum (Minneap Minn). 2020. PMID: 33003004 Review.
PURPOSE OF REVIEW: This article reviews the clinical features, diagnostic approach, and treatments available for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases. The article also provides an update on the genetics and pathophysiology …
PURPOSE OF REVIEW: This article reviews the clinical features, diagnostic approach, and treatments available for amyotrophic later …
Amyotrophic Lateral Sclerosis Pathoetiology and Pathophysiology: Roles of Astrocytes, Gut Microbiome, and Muscle Interactions via the Mitochondrial Melatonergic Pathway, with Disruption by Glyphosate-Based Herbicides.
Anderson G. Anderson G. Int J Mol Sci. 2022 Dec 29;24(1):587. doi: 10.3390/ijms24010587. Int J Mol Sci. 2022. PMID: 36614029 Free PMC article. Review.
The pathoetiology and pathophysiology of motor neuron loss in amyotrophic lateral sclerosis (ALS) are still to be determined, with only a small percentage of ALS patients having a known genetic risk factor. The article looks to integrate wider bodies o …
The pathoetiology and pathophysiology of motor neuron loss in amyotrophic lateral sclerosis (ALS) are still to b …
Pathophysiology and Treatment of Non-motor Dysfunction in Amyotrophic Lateral Sclerosis.
Mahoney CJ, Ahmed RM, Huynh W, Tu S, Rohrer JD, Bedlack RS, Hardiman O, Kiernan MC. Mahoney CJ, et al. CNS Drugs. 2021 May;35(5):483-505. doi: 10.1007/s40263-021-00820-1. Epub 2021 May 15. CNS Drugs. 2021. PMID: 33993457 Review.
Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease typically presenting with bulbar or limb weakness. There is increasing evidence that amyotrophic lateral sclerosis is a multisystem disease with early and …
Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease typically presenting with bulbar or …
Silence superoxide dismutase 1 (SOD1): a promising therapeutic target for amyotrophic lateral sclerosis (ALS).
Abati E, Bresolin N, Comi G, Corti S. Abati E, et al. Expert Opin Ther Targets. 2020 Apr;24(4):295-310. doi: 10.1080/14728222.2020.1738390. Epub 2020 Mar 14. Expert Opin Ther Targets. 2020. PMID: 32125907 Free article. Review.
Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive and incurable neurodegenerative disorder that targets upper and lower motor neurons and leads to fatal muscle paralysis. ...
Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive and incurable neurodegenerative disorder that target …
7,844 results