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3,215 results

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Page 1
The Plant Anaphase-Promoting Complex/Cyclosome.
Willems A, De Veylder L. Willems A, et al. Annu Rev Cell Dev Biol. 2022 Oct 6;38:25-48. doi: 10.1146/annurev-cellbio-120420-092421. Epub 2022 Apr 8. Annu Rev Cell Dev Biol. 2022. PMID: 35395166 Review.
The anaphase-promoting complex/cyclosome (APC/C) represents a large multisubunit E3-ubiquitin ligase complex that controls the unidirectional progression through the cell cycle by the ubiquitination of specific target proteins, marking them for …
The anaphase-promoting complex/cyclosome (APC/C) represents a large multisubunit E3-ubiquitin ligase complex …
Lactate regulates cell cycle by remodelling the anaphase promoting complex.
Liu W, Wang Y, Bozi LHM, Fischer PD, Jedrychowski MP, Xiao H, Wu T, Darabedian N, He X, Mills EL, Burger N, Shin S, Reddy A, Sprenger HG, Tran N, Winther S, Hinshaw SM, Shen J, Seo HS, Song K, Xu AZ, Sebastian L, Zhao JJ, Dhe-Paganon S, Che J, Gygi SP, Arthanari H, Chouchani ET. Liu W, et al. Nature. 2023 Apr;616(7958):790-797. doi: 10.1038/s41586-023-05939-3. Epub 2023 Mar 15. Nature. 2023. PMID: 36921622 Free PMC article.
From these data, we identify a mechanism of cell cycle regulation whereby accumulated lactate remodels the anaphase promoting complex (APC/C). Remodelling of APC/C in this way is caused by direct inhibition of the SUMO protease SENP1 by lactate. We find that …
From these data, we identify a mechanism of cell cycle regulation whereby accumulated lactate remodels the anaphase promoting …
The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator.
Hu X, Jin X, Cao X, Liu B. Hu X, et al. Int J Mol Sci. 2022 Dec 5;23(23):15327. doi: 10.3390/ijms232315327. Int J Mol Sci. 2022. PMID: 36499653 Free PMC article. Review.
The anaphase-promoting complex/cyclosome (APC/C) is a complicated cellular component that plays significant roles in regulating the cell cycle process of eukaryotic organisms. The spatiotemporal regulation mechanisms of APC/C in distinct cell cycle tra …
The anaphase-promoting complex/cyclosome (APC/C) is a complicated cellular component that plays significant role …
The Anaphase Promoting Complex/Cyclosome (APC/C): A Versatile E3 Ubiquitin Ligase.
Curtis NL, Bolanos-Garcia VM. Curtis NL, et al. Subcell Biochem. 2019;93:539-623. doi: 10.1007/978-3-030-28151-9_18. Subcell Biochem. 2019. PMID: 31939164 Review.
In the present chapter we discuss the essential roles of the human E3 ubiquitin ligase Anaphase Promoting Complex/Cyclosome (APC/C) in mitosis as well as the emerging evidence of important APC/C roles in cellular processes beyond cell division control …
In the present chapter we discuss the essential roles of the human E3 ubiquitin ligase Anaphase Promoting Complex/Cy …
Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis.
Kataria M, Yamano H. Kataria M, et al. Cells. 2019 Aug 2;8(8):814. doi: 10.3390/cells8080814. Cells. 2019. PMID: 31382469 Free PMC article. Review.
Protein phosphatases catalyze dephosphorylation of thousands of sites on proteins, steering the cells through establishment of the mitotic phase and exit from it. A large E3 ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C) becomes act …
Protein phosphatases catalyze dephosphorylation of thousands of sites on proteins, steering the cells through establishment of the mitotic p …
The anaphase-promoting complex/cyclosome: APC/C.
Acquaviva C, Pines J. Acquaviva C, et al. J Cell Sci. 2006 Jun 15;119(Pt 12):2401-4. doi: 10.1242/jcs.02937. J Cell Sci. 2006. PMID: 16763193 Review. No abstract available.
A decade of the anaphase-promoting complex in the nervous system.
Huang J, Bonni A. Huang J, et al. Genes Dev. 2016 Mar 15;30(6):622-38. doi: 10.1101/gad.274324.115. Genes Dev. 2016. PMID: 26980187 Free PMC article. Review.
Just over a decade ago, the first post-mitotic function of the anaphase-promoting complex, a major cell cycle-regulated E3 ubiquitin ligase, was discovered in the control of axon growth and patterning in the mammalian brain. ...We also provide a perspective o …
Just over a decade ago, the first post-mitotic function of the anaphase-promoting complex, a major cell cycle-regulated …
Suppressing Anaphase-Promoting Complex/Cyclosome-Cell Division Cycle 20 Activity to Enhance the Effectiveness of Anti-Cancer Drugs That Induce Multipolar Mitotic Spindles.
Schuyler SC, Chen HY, Chang KP. Schuyler SC, et al. Int J Mol Sci. 2024 Jun 7;25(12):6329. doi: 10.3390/ijms25126329. Int J Mol Sci. 2024. PMID: 38928036 Free PMC article. Review.
Eribulin and vinorelbine have also been reported to cause increases in multipolar spindles in cancer cells. Recently, suppression of Anaphase-Promoting Complex/Cyclosome-Cell Division Cycle 20 (APC/C-CDC20) activity using CRISPR/Cas9 mutagenesis has be …
Eribulin and vinorelbine have also been reported to cause increases in multipolar spindles in cancer cells. Recently, suppression of Anap …
Anaphase-promoting complex/cyclosome-Cdc-20 promotes Zwint-1 degradation.
He Y, Li R, Gu L, Deng H, Zhao Y, Guo Y, Yu S, Wang G. He Y, et al. Cell Biochem Funct. 2020 Jun;38(4):451-459. doi: 10.1002/cbf.3499. Epub 2020 Jan 16. Cell Biochem Funct. 2020. PMID: 31945194
Collectively, our data indicated that Zwint-1 was ubiquitinated by anaphase-promoting complex/cyclosome (APC/C)-Cdc20 in a D-box-dependent manner. Therefore, the APC/C-Cdc20 controls the stability of Zwint-1, ensuring accurate regulation of the spindle …
Collectively, our data indicated that Zwint-1 was ubiquitinated by anaphase-promoting complex/cyclosome (APC/C)- …
The anaphase-promoting complex: A key mitotic regulator associated with somatic mutations occurring in cancer.
Melloy PG. Melloy PG. Genes Chromosomes Cancer. 2020 Mar;59(3):189-202. doi: 10.1002/gcc.22820. Epub 2019 Nov 13. Genes Chromosomes Cancer. 2020. PMID: 31652364 Review.
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that helps control chromosome separation and exit from mitosis in many different kinds of organisms, including yeast, flies, worms, and humans. This review represents a new pers …
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that helps control chromosome separat …
3,215 results