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Page 1
Lactate regulates cell cycle by remodelling the anaphase promoting complex.
Liu W, Wang Y, Bozi LHM, Fischer PD, Jedrychowski MP, Xiao H, Wu T, Darabedian N, He X, Mills EL, Burger N, Shin S, Reddy A, Sprenger HG, Tran N, Winther S, Hinshaw SM, Shen J, Seo HS, Song K, Xu AZ, Sebastian L, Zhao JJ, Dhe-Paganon S, Che J, Gygi SP, Arthanari H, Chouchani ET. Liu W, et al. Nature. 2023 Apr;616(7958):790-797. doi: 10.1038/s41586-023-05939-3. Epub 2023 Mar 15. Nature. 2023. PMID: 36921622 Free PMC article.
From these data, we identify a mechanism of cell cycle regulation whereby accumulated lactate remodels the anaphase promoting complex (APC/C). Remodelling of APC/C in this way is caused by direct inhibition of the SUMO protease SENP1 by lactate. We find that …
From these data, we identify a mechanism of cell cycle regulation whereby accumulated lactate remodels the anaphase promoting …
The Arabidopsis APC4 subunit of the anaphase-promoting complex/cyclosome (APC/C) is critical for both female gametogenesis and embryogenesis.
Wang Y, Hou Y, Gu H, Kang D, Chen Z, Liu J, Qu LJ. Wang Y, et al. Plant J. 2012 Jan;69(2):227-40. doi: 10.1111/j.1365-313X.2011.04785.x. Epub 2011 Oct 21. Plant J. 2012. PMID: 21910774 Free article.
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that is involved in regulating cell-cycle progression. ...Some ovules and embryos of apc4/+ plants also accumulated cyclin B protein, a known substrate of APC/C, s …
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that is involved in regulating cell-c …
The Arabidopsis anaphase-promoting complex/cyclosome subunit 1 is critical for both female gametogenesis and embryogenesis(F).
Wang Y, Hou Y, Gu H, Kang D, Chen ZL, Liu J, Qu LJ. Wang Y, et al. J Integr Plant Biol. 2013 Jan;55(1):64-74. doi: 10.1111/jipb.12018. J Integr Plant Biol. 2013. PMID: 23206231
Anaphase-promoting complex/cyclosome (APC/C), a multisubunit E3 ligase, plays a critical role in cell cycle control, but the functional characterization of each subunit has not yet been completed. ...In the apc1 apc4 double mutants, the f …
Anaphase-promoting complex/cyclosome (APC/C), a multisubunit E3 ligase, plays a critical role in cell cycle cont …
Studies on the Contribution of Human Cytomegalovirus UL21a and UL97 to Viral Growth and Inactivation of the Anaphase-Promoting Complex/Cyclosome (APC/C) E3 Ubiquitin Ligase Reveal a Unique Cellular Mechanism for Downmodulation of the APC/C Subunits APC1, APC4, and APC5.
Clark AE, Spector DH. Clark AE, et al. J Virol. 2015 Jul;89(13):6928-39. doi: 10.1128/JVI.00403-15. Epub 2015 Apr 22. J Virol. 2015. PMID: 25903336 Free PMC article.
Human cytomegalovirus (HCMV) deregulates the cell cycle by several means, including inactivation of the anaphase-promoting complex/cyclosome (APC/C) E3 ubiquitin ligase. Viral proteins UL97 and UL21a, respectively, affect the APC/C by phosphorylation o …
Human cytomegalovirus (HCMV) deregulates the cell cycle by several means, including inactivation of the anaphase-promoting …
A minimal anaphase promoting complex/cyclosome (APC/C) in Trypanosoma brucei.
Bessat M, Knudsen G, Burlingame AL, Wang CC. Bessat M, et al. PLoS One. 2013;8(3):e59258. doi: 10.1371/journal.pone.0059258. Epub 2013 Mar 22. PLoS One. 2013. PMID: 23533609 Free PMC article.
The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that initiates chromosome segregation and mitotic exit by targeting critical cell-cycle regulators for proteolytic destruction. ...Subunit homologues …
The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that initiates ch …
Upregulation of anaphase promoting complex (APC) 7 as a prognostic marker for esophageal squamous cell carcinoma: A hospital based study.
Ali E, Kalita MJ, Kalita S, Talukdar J, Deka AJ, Sultana J, Choudhury BN, Baruah MN, Bhattacharjee S, Medhi S. Ali E, et al. Heliyon. 2022 Jun 12;8(6):e09722. doi: 10.1016/j.heliyon.2022.e09722. eCollection 2022 Jun. Heliyon. 2022. PMID: 35761933 Free PMC article.
The search for new molecular prognostic biomarkers revealed that dysregulation of anaphase promoting complex/cyclosome (APC/C) activation due to altered expression of APC molecules might lead to perturbed mitotic progression leading to malignancy. We a …
The search for new molecular prognostic biomarkers revealed that dysregulation of anaphase promoting complex/cycloso …
Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.
Tran K, Kamil JP, Coen DM, Spector DH. Tran K, et al. J Virol. 2010 Oct;84(20):10832-43. doi: 10.1128/JVI.01260-10. Epub 2010 Aug 4. J Virol. 2010. PMID: 20686030 Free PMC article.
Infection of quiescent cells by human cytomegalovirus (HCMV) elicits severe cell cycle deregulation, resulting in a G(1)/S arrest, which can be partly attributed to the inactivation of the anaphase-promoting complex (APC). As we previously reported, the prema …
Infection of quiescent cells by human cytomegalovirus (HCMV) elicits severe cell cycle deregulation, resulting in a G(1)/S arrest, which can …
Fission yeast APC/cyclosome subunits, Cut20/Apc4 and Cut23/Apc8, in regulating metaphase-anaphase progression and cellular stress responses.
Yamashita YM, Nakaseko Y, Kumada K, Nakagawa T, Yanagida M. Yamashita YM, et al. Genes Cells. 1999 Aug;4(8):445-63. doi: 10.1046/j.1365-2443.1999.00274.x. Genes Cells. 1999. PMID: 10526233 Free article.
BACKGROUND: The 20S cyclosome/APC complex promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor Cut2/Pds1/securin. ...CONCLUSIONS: We identified two new subunits of fissio …
BACKGROUND: The 20S cyclosome/APC complex promotes metaphase-anaphase transition by ubiquitinating its specific substra …
An architectural map of the anaphase-promoting complex.
Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, Toczyski DP. Thornton BR, et al. Genes Dev. 2006 Feb 15;20(4):449-60. doi: 10.1101/gad.1396906. Genes Dev. 2006. PMID: 16481473 Free PMC article.
The anaphase-promoting complex or cyclosome (APC) is an unusually complicated ubiquitin ligase, composed of 13 core subunits and either of two loosely associated regulatory subunits, Cdc20 and Cdh1. ...Apc4, Apc5, Cdc23, and Apc1 a …
The anaphase-promoting complex or cyclosome (APC) is an unusually complicated ubiquitin ligase, composed of 13 c …
Identification of a cullin homology region in a subunit of the anaphase-promoting complex.
Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW. Yu H, et al. Science. 1998 Feb 20;279(5354):1219-22. doi: 10.1126/science.279.5354.1219. Science. 1998. PMID: 9469815
The anaphase-promoting complex is composed of eight protein subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6), and CDC23 (APC8). The remaining four human APC subunits, APC2, APC4, APC5, and APC7, as well as human CDC23, w …
The anaphase-promoting complex is composed of eight protein subunits, including BimE (APC1), CDC27 (APC3) …
28 results