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REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1.
Chun AC, Kok KH, Jin DY. Chun AC, et al. Cell Cycle. 2013 Jan 15;12(2):365-78. doi: 10.4161/cc.23214. Epub 2012 Jan 15. Cell Cycle. 2013. PMID: 23287467 Free PMC article.
Here, we show that human REV1 undergoes proteosomal degradation mediated by the E3 ubiquitin ligase known as anaphase-promoting complex (APC). REV1 associates with APC. Overexpression of APC coactivator CDH1 or CDC20 promotes polyubiquitination and proteosomal degra …
Here, we show that human REV1 undergoes proteosomal degradation mediated by the E3 ubiquitin ligase known as anaphase-promoting …
Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells.
Wäsch R, Engelbert D. Wäsch R, et al. Oncogene. 2005 Jan 6;24(1):1-10. doi: 10.1038/sj.onc.1208017. Oncogene. 2005. PMID: 15637585 Review.
Regulation of cyclin oscillation by ubiquitin-dependent proteolysis thereby has a central role in cell cycle regulation. The anaphase-promoting complex (APC) is a specific ubiquitin ligase and is essential for chromosome segregation, exit from mitosis and a stable s …
Regulation of cyclin oscillation by ubiquitin-dependent proteolysis thereby has a central role in cell cycle regulation. The anaphase …
Anaphase promoting complex-dependent degradation of transcriptional repressors Nrm1 and Yhp1 in Saccharomyces cerevisiae.
Ostapenko D, Solomon MJ. Ostapenko D, et al. Mol Biol Cell. 2011 Jul 1;22(13):2175-84. doi: 10.1091/mbc.E11-01-0031. Epub 2011 May 11. Mol Biol Cell. 2011. PMID: 21562221 Free PMC article.
The anaphase-promoting complex/cyclosome (APC/C) is an essential ubiquitin ligase that targets cell cycle proteins for proteasome-mediated degradation in mitosis and G1. ...
The anaphase-promoting complex/cyclosome (APC/C) is an essential ubiquitin ligase that targets cell cycle proteins for proteas …
A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I.
Sullivan M, Morgan DO. Sullivan M, et al. J Biol Chem. 2007 Jul 6;282(27):19710-5. doi: 10.1074/jbc.M701507200. Epub 2007 May 10. J Biol Chem. 2007. PMID: 17493939 Free article.
The anaphase-promoting complex (APC) or cyclosome is a multisubunit ubiquitin-protein ligase that ubiquitinates and thereby promotes the destruction of the mitotic cyclins and the separase inhibitor, securin. ...
The anaphase-promoting complex (APC) or cyclosome is a multisubunit ubiquitin-protein ligase that ubiquitinates and thereby pr …
Interstitial cystitis: a phenotype and rare variant exome sequencing study.
Motelow JE, Malakar A, Krishna Murthy SB, Verbitsky M, Kahn A, Estrella E, Shao W, Kunkel L, Wiesenhahn M, Beckett J, Harris N, Lee R, Adam R, Barbour KE, Hakonarson H, Luo Y, Weng C, Mendelsohn CL, Kiryluk K, Gharavi AG, Brownstein CA. Motelow JE, et al. EBioMedicine. 2026 Mar;125:106150. doi: 10.1016/j.ebiom.2026.106150. Epub 2026 Feb 18. EBioMedicine. 2026. PMID: 41713163 Free PMC article.
Pathway analysis detected associations with "anaphase-promoting complex-dependent catabolic process" (P = 6.2 10(-6), Fisher's exact tests [FET]), the "regulation of MAPK cascade" (P = 5.5 10(-6), FET) and "integrin binding" (P = 1.1 …
Pathway analysis detected associations with "anaphase-promoting complex-dependent catabolic process …
Screening and verifying key genes with poor prognosis in colon cancer through bioinformatics analysis.
Dong B, Chai M, Chen H, Feng Q, Jin R, Hu S. Dong B, et al. Transl Cancer Res. 2020 Nov;9(11):6720-6732. doi: 10.21037/tcr-20-2309. Transl Cancer Res. 2020. PMID: 35117282 Free PMC article.
RESULTS: A total of 78 up-regulated DEGs were enriched in the mitotic nuclear division, cell division, cell proliferation, anaphase-promoting complex-dependent catabolic process and G2/M transition of the mitotic cell cycle. In total, 130 …
RESULTS: A total of 78 up-regulated DEGs were enriched in the mitotic nuclear division, cell division, cell proliferation, anaphase- …
Interstitial Cystitis: a phenotype and rare variant exome sequencing study: Interstitial Cystitis: a phenotype and exome sequencing study.
Motelow JE, Malakar A, Murthy SBK, Verbitsky M, Kahn A, Estrella E, Kunkel L, Wiesenhahn M, Becket J, Harris N, Lee R, Adam R, Kiryluk K, Gharavi AG, Brownstein CA. Motelow JE, et al. medRxiv [Preprint]. 2025 Feb 18:2025.02.16.25322147. doi: 10.1101/2025.02.16.25322147. medRxiv. 2025. Update in: EBioMedicine. 2026 Mar;125:106150. doi: 10.1016/j.ebiom.2026.106150. PMID: 40034785 Free PMC article. Updated. Preprint.
Pathway analysis detected new associations with "anaphase-promoting complex-dependent catabolic process", the "regulation of MAPK cascade" and "integrin binding". ...
Pathway analysis detected new associations with "anaphase-promoting complex-dependent catabolic proces …
Activated PTHLH coupling feedback phosphoinositide to G-protein receptor signal-induced cell adhesion network in human hepatocellular carcinoma by systems-theoretic analysis.
Wang L, Huang J, Jiang M, Lin H, Qi L, Diao H. Wang L, et al. ScientificWorldJournal. 2012;2012:428979. doi: 10.1100/2012/428979. Epub 2012 Sep 10. ScientificWorldJournal. 2012. PMID: 22997493 Free PMC article.
Activated PTHLH feedback-mediated cell adhesion network consisted of anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism, cell adhesion, cell differentiation, cell-cell signaling, G-protein-coupled receptor protein s …
Activated PTHLH feedback-mediated cell adhesion network consisted of anaphase-promoting complex-dependent protea …
BubR1 is frequently repressed in acute myeloid leukemia and its re-expression sensitizes cells to antimitotic therapy.
Schnerch D, Schmidts A, Follo M, Udi J, Felthaus J, Pfeifer D, Engelhardt M, Wäsch R. Schnerch D, et al. Haematologica. 2013 Dec;98(12):1886-95. doi: 10.3324/haematol.2013.087452. Epub 2013 Jun 28. Haematologica. 2013. PMID: 23812934 Free PMC article.
Mitotic delay by the spindle assembly checkpoint is achieved by inhibition of anaphase-promoting complex-dependent proteolysis of cyclin B and securin. We demonstrated a link between the repression of the spindle assembly checkpoint protein BubR1 in ac …
Mitotic delay by the spindle assembly checkpoint is achieved by inhibition of anaphase-promoting complex-dependent …
Sensitivity of yeast strains with long G-tails to levels of telomere-bound telomerase.
Vega LR, Phillips JA, Thornton BR, Benanti JA, Onigbanjo MT, Toczyski DP, Zakian VA. Vega LR, et al. PLoS Genet. 2007 Jun;3(6):e105. doi: 10.1371/journal.pgen.0030105. PLoS Genet. 2007. PMID: 17590086 Free PMC article.
Pif1p abundance was cell cycle regulated, low in G1 and early S phase and peaking late in the cell cycle. Low Pif1p abundance in G1 phase was anaphase-promoting complex dependent. Thus, endogenous Pif1p is unlikely to act on G1 bound Est2p. ...
Pif1p abundance was cell cycle regulated, low in G1 and early S phase and peaking late in the cell cycle. Low Pif1p abundance in G1 phase wa …
13 results