Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 1
2006 1
2007 1
2009 1
2010 1
2011 2
2012 1
2016 1
2023 1
2026 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

9 results

Results by year

Filters applied: . Clear all
Page 1
Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator andarine (S-4) for routine doping control purposes.
Thevis M, Thomas A, Fusshöller G, Beuck S, Geyer H, Schänzer W. Thevis M, et al. Rapid Commun Mass Spectrom. 2010 Aug 15;24(15):2245-54. doi: 10.1002/rcm.4637. Rapid Commun Mass Spectrom. 2010. PMID: 20623476
In the present communication, the mass spectrometric characterization of urinary metabolites of the SARM Andarine (also referred to as S-4) compared with earlier in vitro and animal studies is reported. ...The obtained data will support future efforts to effectively …
In the present communication, the mass spectrometric characterization of urinary metabolites of the SARM Andarine (also referr …
Detection of the arylpropionamide-derived selective androgen receptor modulator (SARM) S-4 (Andarine) in a black-market product.
Thevis M, Geyer H, Kamber M, Schänzer W. Thevis M, et al. Drug Test Anal. 2009 Aug;1(8):387-92. doi: 10.1002/dta.91. Drug Test Anal. 2009. PMID: 20355219
That SARMs are the subject of misuse even without clinical approval was proved for the first time by the detection of the drug candidate Andarine (also referred to as S-4, S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide), ad …
That SARMs are the subject of misuse even without clinical approval was proved for the first time by the detection of the drug candidate …
SARM-S4 and metabolites detection in sports drug testing: a case report.
Grata E, Perrenoud L, Saugy M, Baume N. Grata E, et al. Forensic Sci Int. 2011 Dec 10;213(1-3):104-8. doi: 10.1016/j.forsciint.2011.07.014. Epub 2011 Aug 3. Forensic Sci Int. 2011. PMID: 21816554
Recently, pharmaceutical industry developed a new class of therapeutics called Selective Androgen Receptor Modulator (SARM) to substitute the synthetic anabolic drugs used in medical treatments. Since the beginning of the anti-doping testing in sports in the 1970s, steroid …
Recently, pharmaceutical industry developed a new class of therapeutics called Selective Androgen Receptor Modulator (SARM) to substi …
A selective androgen receptor modulator, S4, displays robust anti-cancer activity on hepatocellular cancer cells by negatively regulating PI3K/AKT/mTOR signalling pathway.
Yavuz M, Takanlou LS, Avcı ÇB, Demircan T. Yavuz M, et al. Gene. 2023 Jun 15;869:147390. doi: 10.1016/j.gene.2023.147390. Epub 2023 Mar 27. Gene. 2023. PMID: 36990257
In this study, AR signaling was targeted by a novel Selective Androgen Receptor Modulator (SARM), S4, in HCC cells to evaluate its potential anti-cancer effect. To date, S4 activity in cancer has not been demonstrated, and our data unrevealed that S4 s …
In this study, AR signaling was targeted by a novel Selective Androgen Receptor Modulator (SARM), S4, in HCC cells to evaluate …
Investigation of the selective androgen receptor modulators S1, S4 and S22 and their metabolites in equine plasma using high-resolution mass spectrometry.
Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M. Hansson A, et al. Rapid Commun Mass Spectrom. 2016 Apr 15;30(7):833-42. doi: 10.1002/rcm.7512. Rapid Commun Mass Spectrom. 2016. PMID: 26969924
This is the first study where the equine metabolites of SARMs S1, S4 (Andarine) and S22 (Ostarine) have been studied in plasma. METHODS: Each SARM was administered to three horses as an intravenous bolus dose and plasma samples were collected. ...The values o …
This is the first study where the equine metabolites of SARMs S1, S4 (Andarine) and S22 (Ostarine) have been studied in plasma …
Sensitive determination of prohibited drugs in dried blood spots (DBS) for doping controls by means of a benchtop quadrupole/Orbitrap mass spectrometer.
Thomas A, Geyer H, Schänzer W, Crone C, Kellmann M, Moehring T, Thevis M. Thomas A, et al. Anal Bioanal Chem. 2012 May;403(5):1279-89. doi: 10.1007/s00216-011-5655-2. Epub 2012 Jan 10. Anal Bioanal Chem. 2012. PMID: 22231507
The chosen experimental design enables the determination of various drugs from different classes with one generic sample preparation which is shown for 26 selected model compounds (delta(9)-tetrahydrocannabinol (THC), tetrahydrocannabinol-9-carboxylic acid (THC-COOH), methylhexan …
The chosen experimental design enables the determination of various drugs from different classes with one generic sample preparation which i …
Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats.
Gao W, Reiser PJ, Coss CC, Phelps MA, Kearbey JD, Miller DD, Dalton JT. Gao W, et al. Endocrinology. 2005 Nov;146(11):4887-97. doi: 10.1210/en.2005-0572. Epub 2005 Aug 11. Endocrinology. 2005. PMID: 16099859 Free PMC article.
The partial agonist activity of a selective androgen receptor modulator (SARM) in the prostate was demonstrated in orchidectomized rats. In the current study, we characterized the full agonist activity of S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluor …
The partial agonist activity of a selective androgen receptor modulator (SARM) in the prostate was demonstrated in orchidectomized ra …
Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats.
Kearbey JD, Gao W, Narayanan R, Fisher SJ, Wu D, Miller DD, Dalton JT. Kearbey JD, et al. Pharm Res. 2007 Feb;24(2):328-35. doi: 10.1007/s11095-006-9152-9. Epub 2006 Oct 25. Pharm Res. 2007. PMID: 17063395 Free PMC article.
PURPOSE: This study was conducted to examine the bone and body composition effects of S-4, an aryl-propionamide derived Selective Androgen Receptor Modulator (SARM) in an ovariectomy induced model of accelerated bone loss. METHODS: One hundred twenty female Sprague-Dawley …
PURPOSE: This study was conducted to examine the bone and body composition effects of S-4, an aryl-propionamide derived Selective Androgen R …
Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator S-22 to identify potential targets for routine doping controls.
Thevis M, Thomas A, Möller I, Geyer H, Dalton JT, Schänzer W. Thevis M, et al. Rapid Commun Mass Spectrom. 2011 Aug 15;25(15):2187-95. doi: 10.1002/rcm.5100. Rapid Commun Mass Spectrom. 2011. PMID: 21710598
SARMs have the potential to complement or even replace anabolic androgenic steroidal use with the benefit of a reduction of the undesirable side effects associated with steroid administration alone. Arylpropionamide-based SARMs such as andarine (S-4) and S-22 have shown pr …
SARMs have the potential to complement or even replace anabolic androgenic steroidal use with the benefit of a reduction of the undesirable …