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Ketamine for Depression, 4: In What Dose, at What Rate, by What Route, for How Long, and at What Frequency?
Andrade C. Andrade C. J Clin Psychiatry. 2017 Jul;78(7):e852-e857. doi: 10.4088/JCP.17f11738. J Clin Psychiatry. 2017. PMID: 28749092 Free article. Review.
BACKGROUND: Ketamine, administered in subanesthetic doses, is an effective off-label treatment for severe and even treatment-refractory depression; however, despite dozens of studies across nearly 2 decades of research, there is no definitive guidance on matters rel …
BACKGROUND: Ketamine, administered in subanesthetic doses, is an effective off-label treatment for severe and even treatment-refracto …
Oral Ketamine for Depression, 2: Practical Considerations.
Andrade C. Andrade C. J Clin Psychiatry. 2019 Apr 9;80(2):19f12838. doi: 10.4088/JCP.19f12838. J Clin Psychiatry. 2019. PMID: 30997961 Free article. Review.
The oral route of administration is probably the least expensive and most convenient way to administer ketamine in indicated contexts in depressed patients. Because only 20%-25% of orally administered ketamine reaches systemic circulation, oral doses of about …
The oral route of administration is probably the least expensive and most convenient way to administer ketamine in indicated contexts …
Ketamine for Depression, 3: Does Chirality Matter?
Andrade C. Andrade C. J Clin Psychiatry. 2017 Jun;78(6):e674-e677. doi: 10.4088/JCP.17f11681. J Clin Psychiatry. 2017. PMID: 28682536 Free article. Review.
Ketamine is a racemic mixture of the enantiomers R-ketamine and S-ketamine (esketamine). ...However, there are no direct comparisons between S-ketamine and either R-ketamine or racemic ketamine in depressed patients; therefo …
Ketamine is a racemic mixture of the enantiomers R-ketamine and S-ketamine (esketamine). ...However, there are n …
Ketamine for Depression, 2: Diagnostic and Contextual Indications.
Andrade C. Andrade C. J Clin Psychiatry. 2017 May;78(5):e555-e558. doi: 10.4088/JCP.17f11629. J Clin Psychiatry. 2017. PMID: 28570803 Free article. Review.
Ketamine is indicated in patients who are in a major depressive episode. Most of the research data have been collected from patients with major depressive disorder, but patients with bipolar depression have also been studied. Ketamine is …
Ketamine is indicated in patients who are in a major depressive episode. Most of the research data have been collected from pa …
Ketamine vs Electroconvulsive Therapy for Major Depressive Episode: A Systematic Review and Meta-analysis.
Menon V, Varadharajan N, Faheem A, Andrade C. Menon V, et al. Among authors: andrade c. JAMA Psychiatry. 2023 Jun 1;80(6):639-642. doi: 10.1001/jamapsychiatry.2023.0562. JAMA Psychiatry. 2023. PMID: 37043224 Free PMC article.
IMPORTANCE: The relative efficacy of ketamine and electroconvulsive therapy (ECT) in adults with major depressive episode (MDE) needs clarification. OBJECTIVE: To compare depression rating outcomes with ketamine vs ECT in adults with MDE and to compare …
IMPORTANCE: The relative efficacy of ketamine and electroconvulsive therapy (ECT) in adults with major depressive episode (MDE …
Ketamine for Depression, 5: Potential Pharmacokinetic and Pharmacodynamic Drug Interactions.
Andrade C. Andrade C. J Clin Psychiatry. 2017 Jul;78(7):e858-e861. doi: 10.4088/JCP.17f11802. J Clin Psychiatry. 2017. PMID: 28858450 Free article. Review.
Ketamine, administered in subanesthetic doses, is gaining recognition as an off-label treatment for severe and even treatment-refractory depression. This article explores potential pharmacokinetic and pharmacodynamic drug interactions of relevance to the use of k …
Ketamine, administered in subanesthetic doses, is gaining recognition as an off-label treatment for severe and even treatment-refract …
Ketamine for Depression-Knowns, Unknowns, Possibilities, Barriers, and Opportunities.
Andrade C. Andrade C. JAMA Psychiatry. 2023 Dec 1;80(12):1189-1190. doi: 10.1001/jamapsychiatry.2023.3982. JAMA Psychiatry. 2023. PMID: 37878329
This Viewpoint discusses ketamine and its new and experimentally investigated on- and off-label indications that span different medical disciplines....
This Viewpoint discusses ketamine and its new and experimentally investigated on- and off-label indications that span different medic …
Oral Ketamine for Depression, 1: Pharmacologic Considerations and Clinical Evidence.
Andrade C. Andrade C. J Clin Psychiatry. 2019 Apr 2;80(2):19f12820. doi: 10.4088/JCP.19f12820. J Clin Psychiatry. 2019. PMID: 30946543 Free article. Review.
A quarter- century of experience supports the use of oral ketamine for treating acute and chronic pain in children and adults. Case reports, case series, chart reviews, and 3 recent randomized controlled trials (RCTs) show that oral ketamine is effective in treating …
A quarter- century of experience supports the use of oral ketamine for treating acute and chronic pain in children and adults. Case r …
Ketamine for Depression, 1: Clinical Summary of Issues Related to Efficacy, Adverse Effects, and Mechanism of Action.
Andrade C. Andrade C. J Clin Psychiatry. 2017 Apr;78(4):e415-e419. doi: 10.4088/JCP.17f11567. J Clin Psychiatry. 2017. PMID: 28448702 Free article. Review.
As an antidepressant, is strikingly different from conventional antidepressant drugs in that it brings about rapid and marked attenuation of depressive symptoms even in patients with refractory depression. The benefits are observed within hours of administration, pe …
As an antidepressant, is strikingly different from conventional antidepressant drugs in that it brings about rapid and marked attenuation of …
23 results