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Long-term outcome of kidney transplantation in AL amyloidosis.
Angel-Korman A, et al. Kidney Int 2019. Among authors: Havasi A. PMID 30580886
Therapies for AL amyloidosis have dramatically improved, leading to longer patient survival; however, more AL amyloidosis patients are reaching end-stage renal disease (ESRD). There are no clear guidelines regarding eligibility for kidney transplantation in patients with AL amyloidosis, and data on outcomes are limited. ...
Therapies for AL amyloidosis have dramatically improved, leading to longer patient survival; however, more AL amyloidosis pati …
Renal transplantation in amyloidosis and MIDD.
Stern L and Havasi A. Front Biosci (Elite Ed) 2015 - Review. PMID 25553370
Amyloidosis and monoclonal immunoglobulin deposition disease, though rare entities, can wreak havoc on the architecture and functioning of the kidneys. ...
Amyloidosis and monoclonal immunoglobulin deposition disease, though rare entities, can wreak havoc on the architecture and functioni
High-Dose Melphalan and Stem Cell Transplantation in Patients on Dialysis Due to Immunoglobulin Light-Chain Amyloidosis and Monoclonal Immunoglobulin Deposition Disease.
Batalini F, et al. Biol Blood Marrow Transplant 2018. Among authors: Havasi A. PMID 28865972 Free article.
Data on tolerability and response to HDM/SCT in patients with ESRD due to AL amyloidosis and MIDD are limited. We analyzed data on toxicity, efficacy, and hematologic and renal response of HDM/SCT in 32 patients with AL amyloidosis and 4 patients with MIDD who were dialysis-dependent for ESRD treated at Boston Medical Center between 1994 and 2016. ...HDM/SCT is safe and effective in inducing hematologic complete responses and prolonging survival in patients with ESRD from AL amyloidosis and MIDD. ...
Data on tolerability and response to HDM/SCT in patients with ESRD due to AL amyloidosis and MIDD are limited. We analyzed data on to …
Risk factors for venous thromboembolism in immunoglobulin light chain amyloidosis.
Bever KM, et al. Haematologica 2016. Among authors: Havasi A. PMID 26452981 Free PMC article.
Patients with immunoglobulin light chain amyloidosis are at risk for both thrombotic and bleeding complications. While the hemostatic defects have been extensively studied, less is known about thrombotic complications in this disease. This retrospective study examined the frequency of venous thromboembolism in 929 patients with immunoglobulin light chain amyloidosis presenting to a single referral center, correlated risk of venous thromboembolism with clinical and laboratory factors, and examined complications of anticoagulation in this population. ...
Patients with immunoglobulin light chain amyloidosis are at risk for both thrombotic and bleeding complications. While the hemostatic …
The utility of repeat kidney biopsy in systemic immunoglobulin light chain amyloidosis.
Angel-Korman A, et al. Amyloid 2020. Among authors: Havasi A. PMID 31595786 Free PMC article.
Background: The diagnostic utility of repeat kidney biopsy in AL amyloidosis patients in complete (CR) or very good partial hematologic response (VGPR) but with renal organ relapse is not clear.Methods: We present eight patients with AL amyloidosis who had a repeat kidney biopsy performed.Results: AL amyloidosis was initially diagnosed by a kidney biopsy. ...This patient had subacute kidney injury with decreasing proteinuria and was found to have granulomatous interstitial nephritis in addition to amyloid deposits and responded well to steroid treatment with rapid improvement in renal function.Conclusions: In AL amyloidosis patients who achieve a favorable hematologic response to treatment (CR/VGPR) but subsequently develop worsening renal insufficiency or proteinuria, a repeat kidney biopsy should generally not be performed. ...
Background: The diagnostic utility of repeat kidney biopsy in AL amyloidosis patients in complete (CR) or very good partial hematolog …
Kidney Transplantation in Systemic Amyloidosis.
Angel-Korman A and Havasi A. Transplantation 2020. PMID 32053574
The present review discusses current developments and outcomes of renal transplantation in systemic amyloidosis. Amyloidosis can wreak havoc on the architecture and functioning of the kidneys, leading to end stage renal disease (ESRD). In recent years, the available treatments, especially for AL amyloidosis but also for several of the underlying inflammatory diseases that cause AA amyloidosis have expanded leading to prolonged survival albeit frequently with renal failure. ...
The present review discusses current developments and outcomes of renal transplantation in systemic amyloidosis. Amyloidosis c …
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