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Page 1
Red blood cell storage lesion: causes and potential clinical consequences.
Yoshida T, Prudent M, D'alessandro A. Yoshida T, et al. Among authors: d alessandro a. Blood Transfus. 2019 Jan;17(1):27-52. doi: 10.2450/2019.0217-18. Blood Transfus. 2019. PMID: 30653459 Free PMC article. Review.
These elaborate evolutionary adaptions, however, are no longer effective when RBCs are removed from the circulation and stored hypothermically in blood banks, where they develop storage-induced damages ("storage lesions") that accumulate over the shelf life o …
These elaborate evolutionary adaptions, however, are no longer effective when RBCs are removed from the circulation and stored hypothermical …
Blood-related proteomics.
Liumbruno G, D'Alessandro A, Grazzini G, Zolla L. Liumbruno G, et al. Among authors: d alessandro a. J Proteomics. 2010 Jan 3;73(3):483-507. doi: 10.1016/j.jprot.2009.06.010. Epub 2009 Jun 27. J Proteomics. 2010. PMID: 19567275 Review.
The main strides in proteomic investigations on red blood cells, platelets, plasma and white blood cells are hereby presented in a chronological order. ...A well-rounded portrait of the usefulness of proteomics in blood-related research is accurately given. I …
The main strides in proteomic investigations on red blood cells, platelets, plasma and white blood cells are hereby presented …
Supercooled storage of red blood cells slows down the metabolic storage lesion.
Nemkov T, Isiksacan Z, William N, Senturk R, Boudreau LE, Yarmush ML, Acker JP, D'Alessandro A, Usta OB. Nemkov T, et al. Among authors: d alessandro a. Sci Rep. 2025 Oct 3;15(1):34574. doi: 10.1038/s41598-025-18028-4. Sci Rep. 2025. PMID: 41044137 Free PMC article.
Cold storage at +4 C for up to 42 days can reduce transfusion efficacy due to alterations termed the "storage lesion." Strategies to mitigate the storage lesion include alkaline additive solutions and supercooled storage to extend storage by re …
Cold storage at +4 C for up to 42 days can reduce transfusion efficacy due to alterations termed the "storage lesion." Strate …
Age-related decline of chaperone-mediated autophagy in skeletal muscle leads to progressive myopathy.
Santiago-Fernández O, Coletto L, Tasset I, Kaushik S, Concepcion AR, Qaisar R, Macho-González A, Lindenau K, Diaz A, Khawaja RR, Donega S, Banskota N, Ubaida-Mohien C, Pharaoh G, Ahn B, Hartnell LM, Ramírez-Pardo I, Chavda B, Gazteluiturri A, Kinter M, Ferrucci L, Reisz JA, D'Alessandro A, Van Remmen H, Muñoz-Cánoves P, Feske S, Cuervo AM. Santiago-Fernández O, et al. Among authors: d alessandro a. Nat Metab. 2025 Dec;7(12):2589-2611. doi: 10.1038/s42255-025-01412-9. Epub 2025 Dec 3. Nat Metab. 2025. PMID: 41339969 Free PMC article.
Impaired SERCA turnover in CMA-deficient skeletal muscle is associated with defective calcium (Ca(2+)) storage and dysregulated Ca(2+) dynamics. We confirm that CMA is also downregulated with age in human skeletal muscle. ...
Impaired SERCA turnover in CMA-deficient skeletal muscle is associated with defective calcium (Ca(2+)) storage and dysregulated Ca(2+ …
Ferroptosis regulates hemolysis in stored murine and human red blood cells.
D'Alessandro A, Keele GR, Hay A, Nemkov T, Earley EJ, Stephenson D, Vincent M, Deng X, Stone M, Dzieciatkowska M, Hansen KC, Kleinman S, Spitalnik SL, Roubinian N, Norris PJ, Busch MP, Page GP, Stockwell BR, Churchill GA, Zimring JC. D'Alessandro A, et al. Blood. 2025 Feb 13;145(7):765-783. doi: 10.1182/blood.2024026109. Blood. 2025. PMID: 39541586 Free PMC article.
Red blood cell (RBC) metabolism regulates hemolysis during aging in vivo and in the blood bank. ...Metabolite and lipid quantitative trait loci (QTL) mapped >400 gene-metabolite associations, which we collated into an online interactive portal. Relevant to RBC …
Red blood cell (RBC) metabolism regulates hemolysis during aging in vivo and in the blood bank. ...Metabolite and lipid quanti …
Blood-storage duration affects hematological and metabolic profiles in patients with sickle cell disease receiving transfusions.
Karafin MS, Grier AL, Fasano RM, Ilich A, Wichlan D, Chang A, James SM, Butler HE, Kolupaev O, Caughey MC, Stephenson DJ, Reisz JA, Key NS, Field JJ, Little JA, Spitalnik SL, D'Alessandro A. Karafin MS, et al. Among authors: d alessandro a. J Clin Invest. 2025 Jul 3;135(17):e192920. doi: 10.1172/JCI192920. eCollection 2025 Sep 2. J Clin Invest. 2025. PMID: 40608427 Free PMC article. Clinical Trial.
BACKGROUNDPatients with sickle cell disease (SCD) frequently receive RBC units stored near the end of their permissible storage duration. We aimed to determine whether RBC storage duration influences recipient hematological, metabolic, and clinical chemistry paramet …
BACKGROUNDPatients with sickle cell disease (SCD) frequently receive RBC units stored near the end of their permissible storage durat …
From metabolomics to transfusion-associated immunomodulation.
D'Alessandro A, Zimring JC. D'Alessandro A, et al. Curr Opin Immunol. 2025 Oct;96:102646. doi: 10.1016/j.coi.2025.102646. Epub 2025 Aug 22. Curr Opin Immunol. 2025. PMID: 40848579 Review.
PURPOSE OF REVIEW: This review summarizes recent advances in metabolomics that have enhanced our understanding of transfusion-related immunomodulation (TRIM), highlighting how biochemical changes in stored blood products - with a focus on packed red blood cells - af …
PURPOSE OF REVIEW: This review summarizes recent advances in metabolomics that have enhanced our understanding of transfusion-related immuno …
From omics technologies to personalized transfusion medicine.
D'Alessandro A. D'Alessandro A. Expert Rev Proteomics. 2019 Mar;16(3):215-225. doi: 10.1080/14789450.2019.1571917. Epub 2019 Jan 28. Expert Rev Proteomics. 2019. PMID: 30654673 Review.
Storage in the blood bank is an enabling strategy for this critical procedure, as it logistically solves the issue of making ~110 million units available for transfusion every year. Unfortunately, storage in the blood bank promotes a series of biochemi …
Storage in the blood bank is an enabling strategy for this critical procedure, as it logistically solves the issue of making ~ …
Red Blood Cell Storage: From Genome to Exposome Towards Personalized Transfusion Medicine.
D'Alessandro A, Hod EA. D'Alessandro A, et al. Transfus Med Rev. 2023 Oct;37(4):150750. doi: 10.1016/j.tmrv.2023.150750. Epub 2023 Aug 2. Transfus Med Rev. 2023. PMID: 37574398 Free PMC article. Review.
Over the last decade, the introduction of omics technologies-especially high-throughput genomics and metabolomics-has contributed significantly to our understanding of the role of donor genetics and nongenetic determinants of red blood cell storage biology. Here we …
Over the last decade, the introduction of omics technologies-especially high-throughput genomics and metabolomics-has contributed significan …
Molecular communication between red blood cells of different phenotypes during blood storage in mice.
Zimring JC, Hay AM, Dzieciatkowska M, D'Alessandro A. Zimring JC, et al. Among authors: d alessandro a. Transfusion. 2024 Sep;64(9):1762-1771. doi: 10.1111/trf.17960. Epub 2024 Aug 2. Transfusion. 2024. PMID: 39095932 Free PMC article.
BACKGROUND: The cellular and molecular changes during red blood cell (RBC) storage that affect posttransfusion recovery (PTR) remain incompletely understood. ...In the current study, we tested the hypothesis that CSCR involves acquisition of molecular signatures ass …
BACKGROUND: The cellular and molecular changes during red blood cell (RBC) storage that affect posttransfusion recovery (PTR) …
145 results