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On the role of pleiotrophin and its receptors in development and angiogenesis.
Papadimitriou E, Mourkogianni E, Ntenekou D, Christopoulou M, Koutsioumpa M, Lamprou M. Papadimitriou E, et al. Int J Dev Biol. 2022;66(1-2-3):115-124. doi: 10.1387/ijdb.210122ep. Int J Dev Biol. 2022. PMID: 34549793 Review.
The secreted growth factor pleiotrophin (PTN) is expressed in all species and is evolutionarily highly conserved, suggesting that it plays a significant role in the regulation of important processes. ...This review highlights what is known to date regarding the role …
The secreted growth factor pleiotrophin (PTN) is expressed in all species and is evolutionarily highly conserved, suggesting t …
Pleiotrophin: Activity and mechanism.
Wang X. Wang X. Adv Clin Chem. 2020;98:51-89. doi: 10.1016/bs.acc.2020.02.003. Epub 2020 Mar 12. Adv Clin Chem. 2020. PMID: 32564788 Free PMC article. Review.
Although it is most strongly associated with neural development during embryogenesis and the neonatal period, its expression has also been linked to a plethora of other physiological events including cancer metastasis, angiogenesis, bone development, and infl …
Although it is most strongly associated with neural development during embryogenesis and the neonatal period, its expression has also …
Functional receptors and intracellular signal pathways of midkine (MK) and pleiotrophin (PTN).
Xu C, Zhu S, Wu M, Han W, Yu Y. Xu C, et al. Biol Pharm Bull. 2014;37(4):511-20. doi: 10.1248/bpb.b13-00845. Biol Pharm Bull. 2014. PMID: 24694599 Free article. Review.
Midkine (MK) and pleiotrophin (PTN) belong to the subfamily of heparin binding growth factors. ...This work reviews the structures of MK and PTN, as well as the receptors and the intracellular signal pathways involving MK and PTN which will pave the wa …
Midkine (MK) and pleiotrophin (PTN) belong to the subfamily of heparin binding growth factors. ...This work reviews the …
Pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta as regulators of angiogenesis and cancer.
Papadimitriou E, Pantazaka E, Castana P, Tsalios T, Polyzos A, Beis D. Papadimitriou E, et al. Biochim Biophys Acta. 2016 Dec;1866(2):252-265. doi: 10.1016/j.bbcan.2016.09.007. Epub 2016 Sep 29. Biochim Biophys Acta. 2016. PMID: 27693125 Review.
Pleiotrophin (PTN) is a secreted heparin-binding growth factor that through its receptor protein tyrosine phosphatase beta/zeta (RPTPbeta/zeta) has a significant regulatory effect on angiogenesis and cancer. ...Insights into the regulatory role of PTN/
Pleiotrophin (PTN) is a secreted heparin-binding growth factor that through its receptor protein tyrosine phosphatase b
Pleiotrophin: a cytokine with diverse functions and a novel signaling pathway.
Deuel TF, Zhang N, Yeh HJ, Silos-Santiago I, Wang ZY. Deuel TF, et al. Arch Biochem Biophys. 2002 Jan 15;397(2):162-71. doi: 10.1006/abbi.2001.2705. Arch Biochem Biophys. 2002. PMID: 11795867 Review.
It is strongly expressed in different human tumor cells and expression of the Ptn gene in tumor cells in vivo accelerates growth and stimulates tumor angiogenesis. Separate independent domains have been identified in PTN to signal transformation and tumor angioge
It is strongly expressed in different human tumor cells and expression of the Ptn gene in tumor cells in vivo accelerates growth and …
The potential role of the heparin-binding growth factor pleiotrophin in breast cancer.
Riegel AT, Wellstein A. Riegel AT, et al. Breast Cancer Res Treat. 1994;31(2-3):309-14. doi: 10.1007/BF00666163. Breast Cancer Res Treat. 1994. PMID: 7533562 Review.
We propose that the secreted protein pleiotrophin (PTN) is a major factor in the malignant progression of breast cancer. ...The stimulation of proliferation and tube formation of endothelial cells by PTN suggests that it can serve as an angiogenesis factor during tu …
We propose that the secreted protein pleiotrophin (PTN) is a major factor in the malignant progression of breast cancer. ...The stimu …
Expression of VEGF and pleiotrophin in deer antler.
Clark DE, Lord EA, Suttie JM. Clark DE, et al. Anat Rec A Discov Mol Cell Evol Biol. 2006 Dec;288(12):1281-93. doi: 10.1002/ar.a.20393. Anat Rec A Discov Mol Cell Evol Biol. 2006. PMID: 17054117 Free article.
High levels of pleiotrophin mRNA were also detected in the precartilage region with possible implications for both angiogenesis and chondrogenesis. This is the first report of cervine angiogenic growth factors within the growing antler tip....
High levels of pleiotrophin mRNA were also detected in the precartilage region with possible implications for both angiogenesis
New paradigms for the treatment of cancer: the role of anti-angiogenesis agents.
Cherrington JM, Strawn LM, Shawver LK. Cherrington JM, et al. Adv Cancer Res. 2000;79:1-38. doi: 10.1016/s0065-230x(00)79001-4. Adv Cancer Res. 2000. PMID: 10818676 Review.
The complexity of the angiogenic process, which involves both positive and negative regulators, provides a number of targets for therapy. Many positive regulators, including growth factor receptors, matrix metalloproteinases, and integrins, have been correlated with …
The complexity of the angiogenic process, which involves both positive and negative regulators, provides a number of targets for therapy. Ma …
Proliferation and migration activities of fibroblast growth factor-2 in endothelial cells are modulated by its direct interaction with heparin affin regulatory peptide.
Dos Santos C, Blanc C, Elahouel R, Prescott M, Carpentier G, Ori A, Courty J, Hamma-Kourbali Y, Fernig DG, Delbé J. Dos Santos C, et al. Biochimie. 2014 Dec;107 Pt B:350-7. doi: 10.1016/j.biochi.2014.10.002. Epub 2014 Oct 12. Biochimie. 2014. PMID: 25315978
In normal or pathological angiogenesis, angiogenic growth factors activate cognate receptors on endothelial cells. ...These results imply that besides a regulation of the proliferation, migration and angiogenesis of HUVEC by direct interaction o …
In normal or pathological angiogenesis, angiogenic growth factors activate cognate receptors on endothelial cell …
Identification of the angiogenesis signaling domain in pleiotrophin defines a mechanism of the angiogenic switch.
Zhang N, Zhong R, Perez-Pinera P, Herradon G, Ezquerra L, Wang ZY, Deuel TF. Zhang N, et al. Biochem Biophys Res Commun. 2006 May 5;343(2):653-8. doi: 10.1016/j.bbrc.2006.03.006. Epub 2006 Mar 10. Biochem Biophys Res Commun. 2006. PMID: 16554021
Neoplasms progress through genetic and epigenetic mutations that deregulate pathways in the malignant cell that stimulate more aggressive growth of the malignant cell itself and/or remodel the tumor microenvironment to support the developing tumor mass. The appearan …
Neoplasms progress through genetic and epigenetic mutations that deregulate pathways in the malignant cell that stimulate more aggressive …
12 results