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Page 1
Muscular Dystrophy Model.
Potikanond S, Nimlamool W, Noordermeer J, Fradkin LG. Potikanond S, et al. Adv Exp Med Biol. 2018;1076:147-172. doi: 10.1007/978-981-13-0529-0_9. Adv Exp Med Biol. 2018. PMID: 29951819 Review.
Muscular dystrophy (MD) is a group of muscle weakness disease involving in inherited genetic conditions. ...This chapter provides an overview of the MD types, its gene mutations, and the Drosophila MD models. Specifically, the Duchenne muscular dystrophy …
Muscular dystrophy (MD) is a group of muscle weakness disease involving in inherited genetic conditions. ...This chapter provi …
Genetic Engineering of Dystroglycan in Animal Models of Muscular Dystrophy.
Sciandra F, Bigotti MG, Giardina B, Bozzi M, Brancaccio A. Sciandra F, et al. Biomed Res Int. 2015;2015:635792. doi: 10.1155/2015/635792. Epub 2015 Aug 24. Biomed Res Int. 2015. PMID: 26380289 Free PMC article. Review.
In skeletal muscle, dystroglycan (DG) is the central component of the dystrophin-glycoprotein complex (DGC), a multimeric protein complex that ensures a strong mechanical link between the extracellular matrix and the cytoskeleton. Several muscular dystrophies arise from mu …
In skeletal muscle, dystroglycan (DG) is the central component of the dystrophin-glycoprotein complex (DGC), a multimeric protein complex th …
Cardiomyopathy in animal models of muscular dystrophy.
Heydemann A, Wheeler MT, McNally EM. Heydemann A, et al. Curr Opin Cardiol. 2001 May;16(3):211-7. doi: 10.1097/00001573-200105000-00009. Curr Opin Cardiol. 2001. PMID: 11357018 Review.
Arrhythmia and cardiomyopathy frequently accompany muscular dystrophy. In the last year, the cardiovascular consequences of muscular dystrophy gene mutations have been established through studies of murine models. ...New findings have shown that cytosk …
Arrhythmia and cardiomyopathy frequently accompany muscular dystrophy. In the last year, the cardiovascular consequences of …
Animal models of Duchenne and Becker muscular dystrophy.
Cooper BJ. Cooper BJ. Br Med Bull. 1989 Jul;45(3):703-18. doi: 10.1093/oxfordjournals.bmb.a072353. Br Med Bull. 1989. PMID: 2688824 Review.
Two animal models have been shown to be related to Duchenne and Becker muscular dystrophy at the molecular level. ...Linkage studies, absence of dystrophin, and reduced levels of message indicate that the mutation in mdx lies in the gene for dystrophin, the g …
Two animal models have been shown to be related to Duchenne and Becker muscular dystrophy at the molecular level. ...Li …
Canine X-linked muscular dystrophy as an animal model of Duchenne muscular dystrophy: a review.
Valentine BA, Winand NJ, Pradhan D, Moise NS, de Lahunta A, Kornegay JN, Cooper BJ. Valentine BA, et al. Am J Med Genet. 1992 Feb 1;42(3):352-6. doi: 10.1002/ajmg.1320420320. Am J Med Genet. 1992. PMID: 1536178 Review.
Canine X-linked muscular dystrophy is a spontaneously occurring, progressive, degenerative myopathy of dogs that is clinically and pathologically similar to Duchenne muscular dystrophy in man. The molecular basis for the disease has been shown to be a …
Canine X-linked muscular dystrophy is a spontaneously occurring, progressive, degenerative myopathy of dogs that is clinically …
Duchenne's muscular dystrophy: animal models used to investigate pathogenesis and develop therapeutic strategies.
Collins CA, Morgan JE. Collins CA, et al. Int J Exp Pathol. 2003 Aug;84(4):165-72. doi: 10.1046/j.1365-2613.2003.00354.x. Int J Exp Pathol. 2003. PMID: 14632630 Free PMC article. Review.
Duchenne's muscular dystrophy (DMD) is a lethal childhood disease caused by mutations of the dystrophin gene, the protein product of which, dystrophin, has a vital role in maintaining muscle structure and function. ...The most notable of these are the extensively st …
Duchenne's muscular dystrophy (DMD) is a lethal childhood disease caused by mutations of the dystrophin gene, the protein prod …
Expression of full-length dystrophin reverses muscular dystrophy defects in young and old mdx4cv mice.
Tasfaout H, McMillen TS, Reyes TR, Halbert CL, Tian R, Regnier M, Chamberlain JS. Tasfaout H, et al. J Clin Invest. 2025 Jun 10;135(15):e189075. doi: 10.1172/JCI189075. eCollection 2025 Aug 1. J Clin Invest. 2025. PMID: 40493400 Free PMC article.
However, their modest packaging capacity (~4.7 kb) remains an important constraint and significantly limits their application for genetic disorders involving large genes. A prominent example is Duchenne muscular dystrophy (DMD), whose protein product dystrophin is g …
However, their modest packaging capacity (~4.7 kb) remains an important constraint and significantly limits their application for genetic di …
Behavioral Responses in Animal Model of Congenital Muscular Dystrophy 1D.
Comim CM, Schactae AL, Soares JA, Ventura L, Freiberger V, Mina F, Dominguini D, Vainzof M, Quevedo J. Comim CM, et al. Mol Neurobiol. 2016 Jan;53(1):402-407. doi: 10.1007/s12035-014-9024-y. Epub 2014 Dec 3. Mol Neurobiol. 2016. PMID: 25465243
However, in the animal model of CMD1D, the brain involvement remains unclear. Therefore, the objective of this study is to evaluate the cognitive involvement in the Large(myd) mice. ...This study shows the first evidence that abnormal glycosylation of alpha-DG may be affec …
However, in the animal model of CMD1D, the brain involvement remains unclear. Therefore, the objective of this study is to evaluate t …
Animal models for muscular dystrophy show different patterns of sarcolemmal disruption.
Straub V, Rafael JA, Chamberlain JS, Campbell KP. Straub V, et al. J Cell Biol. 1997 Oct 20;139(2):375-85. doi: 10.1083/jcb.139.2.375. J Cell Biol. 1997. PMID: 9334342 Free PMC article.
Using tracer molecules, we compared sarcolemmal integrity in animal models for muscular dystrophy and in muscular dystrophy patient samples. Evans blue, a low molecular weight diazo dye, does not cross into skeletal muscle fibers in normal mice. …
Using tracer molecules, we compared sarcolemmal integrity in animal models for muscular dystrophy and in muscular …
6,628 results