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2011 1
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2019 7
2020 2
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Different pro-angiogenic potential of γ-irradiated PBMC-derived secretome and its subfractions.
Wagner T, Traxler D, Simader E, Beer L, Narzt MS, Gruber F, Madlener S, Laggner M, Erb M, Vorstandlechner V, Gugerell A, Radtke C, Gnecchi M, Peterbauer A, Gschwandtner M, Tschachler E, Keibl C, Slezak P, Ankersmit HJ, Mildner M. Wagner T, et al. Sci Rep. 2018 Dec 20;8(1):18016. doi: 10.1038/s41598-018-36928-6. Sci Rep. 2018. PMID: 30573762 Free PMC article.
Therefore, we sought to dissect the molecular composition of EVs present in the secretome and compared wound healing-related activities of these EVs to other subfractions of the secretome and the fully supplemented secretome (MNC(aposec)). ...Reporter gene assays and aorti …
Therefore, we sought to dissect the molecular composition of EVs present in the secretome and compared wound healing-related activities of t …
Secretome of apoptotic peripheral blood cells (APOSEC) attenuates microvascular obstruction in a porcine closed chest reperfused acute myocardial infarction model: role of platelet aggregation and vasodilation.
Hoetzenecker K, Assinger A, Lichtenauer M, Mildner M, Schweiger T, Starlinger P, Jakab A, Berényi E, Pavo N, Zimmermann M, Gabriel C, Plass C, Gyöngyösi M, Volf I, Ankersmit HJ. Hoetzenecker K, et al. Basic Res Cardiol. 2012 Sep;107(5):292. doi: 10.1007/s00395-012-0292-2. Epub 2012 Aug 17. Basic Res Cardiol. 2012. PMID: 22899170 Free PMC article.
The aim of this study was to determine the influence of APOSEC on microvascular obstruction (MVO) in a porcine AMI model. A single dose of APOSEC was intravenously injected in a closed chest reperfused infarction model. ...Treatment of AMI with APOSEC resulte …
The aim of this study was to determine the influence of APOSEC on microvascular obstruction (MVO) in a porcine AMI model. A single do …
Long-acting beneficial effect of percutaneously intramyocardially delivered secretome of apoptotic peripheral blood cells on porcine chronic ischemic left ventricular dysfunction.
Pavo N, Zimmermann M, Pils D, Mildner M, Petrási Z, Petneházy Ö, Fuzik J, Jakab A, Gabriel C, Sipos W, Maurer G, Gyöngyösi M, Ankersmit HJ. Pavo N, et al. Biomaterials. 2014 Apr;35(11):3541-50. doi: 10.1016/j.biomaterials.2013.12.071. Epub 2014 Jan 16. Biomaterials. 2014. PMID: 24439416 Free article.
A trend towards higher LV ejection fraction was observed in APOSEC vs. controls (45.4 ± 5.9% vs. 37.4 ± 8.9%, p = 0.052). Transcriptome analysis revealed significant downregulation of caspase-1, tumor necrosis factor and other inflammatory genes in APOSEC-affected a …
A trend towards higher LV ejection fraction was observed in APOSEC vs. controls (45.4 ± 5.9% vs. 37.4 ± 8.9%, p = 0.052). Transcripto …
Toxicological testing of allogeneic secretome derived from peripheral mononuclear cells (APOSEC): a novel cell-free therapeutic agent in skin disease.
Wuschko S, Gugerell A, Chabicovsky M, Hofbauer H, Laggner M, Erb M, Ostler T, Peterbauer A, Suessner S, Demyanets S, Leuschner J, Moser B, Mildner M, Ankersmit HJ. Wuschko S, et al. Sci Rep. 2019 Apr 3;9(1):5598. doi: 10.1038/s41598-019-42057-5. Sci Rep. 2019. PMID: 30944367 Free PMC article.
A secretome of stressed peripheral blood mononuclear cells (APOSEC) was successfully tested in a toxicology program, supporting clinical use of the new drug candidate. ...The non-clinical data support the safe topical use of APOSEC in skin diseases related to defici …
A secretome of stressed peripheral blood mononuclear cells (APOSEC) was successfully tested in a toxicology program, supporting clini …
Peripheral blood mononuclear cell secretome for tissue repair.
Beer L, Mildner M, Gyöngyösi M, Ankersmit HJ. Beer L, et al. Apoptosis. 2016 Dec;21(12):1336-1353. doi: 10.1007/s10495-016-1292-8. Apoptosis. 2016. PMID: 27696124 Free PMC article. Review.
Secretome of apoptotic peripheral blood cells (APOSEC) confers cytoprotection to cardiomyocytes and inhibits tissue remodelling after acute myocardial infarction: a preclinical study.
Lichtenauer M, Mildner M, Hoetzenecker K, Zimmermann M, Podesser BK, Sipos W, Berényi E, Dworschak M, Tschachler E, Gyöngyösi M, Ankersmit HJ. Lichtenauer M, et al. Basic Res Cardiol. 2011 Nov;106(6):1283-97. doi: 10.1007/s00395-011-0224-6. Epub 2011 Sep 28. Basic Res Cardiol. 2011. PMID: 21952733 Free PMC article.
Analysis of soluble factors present in APOSEC was performed by enzyme-linked immunosorbent assay (ELISA) and activation of signalling cascades in human cardiomyocytes by APOSEC in vitro was studied by immunoblot analysis. Intravenous administration of a single dose …
Analysis of soluble factors present in APOSEC was performed by enzyme-linked immunosorbent assay (ELISA) and activation of signalling …
Safety and tolerability of topically administered autologous, apoptotic PBMC secretome (APOSEC) in dermal wounds: a randomized Phase 1 trial (MARSYAS I).
Simader E, Traxler D, Kasiri MM, Hofbauer H, Wolzt M, Glogner C, Storka A, Mildner M, Gouya G, Geusau A, Fuchs C, Eder C, Graf A, Schaden M, Golabi B, Aretin MB, Suessner S, Gabriel C, Klepetko W, Tschachler E, Ankersmit HJ. Simader E, et al. Sci Rep. 2017 Jul 24;7(1):6216. doi: 10.1038/s41598-017-06223-x. Sci Rep. 2017. PMID: 28740204 Free PMC article. Clinical Trial.
The primary outcome was the tolerability of the topical application of APOSEC. All adverse events were recorded until 17 days after the biopsy. ...Wound closure was not affected by APOSEC therapy....
The primary outcome was the tolerability of the topical application of APOSEC. All adverse events were recorded until 17 days after t …
Viral safety of APOSECTM: a novel peripheral blood mononuclear cell derived-biological for regenerative medicine.
Gugerell A, Sorgenfrey D, Laggner M, Raimann J, Peterbauer A, Bormann D, Suessner S, Gabriel C, Moser B, Ostler T, Mildner M, Ankersmit HJ. Gugerell A, et al. Blood Transfus. 2020 Jan;18(1):30-39. doi: 10.2450/2019.0249-18. Epub 2019 Feb 21. Blood Transfus. 2020. PMID: 30865581 Free PMC article.
APOSEC(TM), the secretome harvested from selected human blood cells, is a new biological with promising regenerative capabilities. ...It could be demonstrated that all three steps contribute to the viral safety of APOSEC(TM)....
APOSEC(TM), the secretome harvested from selected human blood cells, is a new biological with promising regenerative capabilities. ..
Tissue-regenerative potential of the secretome of γ-irradiated peripheral blood mononuclear cells is mediated via TNFRSF1B-induced necroptosis.
Simader E, Beer L, Laggner M, Vorstandlechner V, Gugerell A, Erb M, Kalinina P, Copic D, Moser D, Spittler A, Tschachler E, Jan Ankersmit H, Mildner M. Simader E, et al. Cell Death Dis. 2019 Sep 30;10(10):729. doi: 10.1038/s41419-019-1974-6. Cell Death Dis. 2019. PMID: 31570701 Free PMC article.
Follistatin impacts Tumor Angiogenesis and Outcome in Thymic Epithelial Tumors.
Janik S, Bekos C, Hacker P, Raunegger T, Schiefer AI, Müllauer L, Veraar C, Dome B, Klepetko W, Ankersmit HJ, Moser B. Janik S, et al. Sci Rep. 2019 Nov 22;9(1):17359. doi: 10.1038/s41598-019-53671-8. Sci Rep. 2019. PMID: 31757999 Free PMC article.
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