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Anti-CdtB and anti-vinculin antibodies to diagnose irritable bowel syndrome in inflammatory bowel disease patients.
Barros LL, Leite G, Morales W, Barlow GM, de Azevedo MFC, de Sousa Carlos A, Damião AOMC, Pimentel M, Farias AQ. Barros LL, et al. BMC Gastroenterol. 2024 Dec 3;24(1):448. doi: 10.1186/s12876-024-03509-z. BMC Gastroenterol. 2024. PMID: 39627697 Free PMC article.
Samples were collected at the time of colonoscopy for assessment of serum levels of anti-CdtB and anti-vinculin antibodies. RESULTS: A total of 160 subjects were included in 4 groups: active IBD (n = 44); quiescent IBD and chronic diarrhea IBD-IBS …
Samples were collected at the time of colonoscopy for assessment of serum levels of anti-CdtB and anti-vinculin …
Second-Generation Biomarker Testing for Irritable Bowel Syndrome Using Plasma Anti-CdtB and Anti-Vinculin Levels.
Morales W, Rezaie A, Barlow G, Pimentel M. Morales W, et al. Dig Dis Sci. 2019 Nov;64(11):3115-3121. doi: 10.1007/s10620-019-05684-6. Epub 2019 May 31. Dig Dis Sci. 2019. PMID: 31152332 Clinical Trial.
BACKGROUND: ELISA testing for anti-CdtB and anti-vinculin can discriminate patients with irritable bowel syndrome with diarrhea (IBS-D) from those with inflammatory bowel disease (IBD). ...IBS-D subjects had higher anti-CdtB …
BACKGROUND: ELISA testing for anti-CdtB and anti-vinculin can discriminate patients with irritable bowel syndrom …
Gut microbiota profiles and the role of anti-CdtB and anti-vinculin antibodies in patients with functional gastrointestinal disorders (FGID).
Vasapolli R, Schulz C, Schweden M, Casèn C, Kirubakaran GT, Kirste KH, Macke L, Link A, Schütte K, Malfertheiner P. Vasapolli R, et al. Eur J Clin Invest. 2021 Dec;51(12):e13666. doi: 10.1111/eci.13666. Epub 2021 Aug 24. Eur J Clin Invest. 2021. PMID: 34390492
RESULTS: Positivity rate either for anti-CdtB or anti-vinculin antibodies was higher in the IBS-C group (76.9%) compared to IBS-D (40.0%), FD (60%) and healthy (63.6%) groups. ...Dysbiosis was more frequent in patients presenting with …
RESULTS: Positivity rate either for anti-CdtB or anti-vinculin antibodies was higher in the IBS-C group ( …
Clinical experience with the use of anti-CdtB and anti-vinculin antibodies in patients with diarrhea in Mexico.
Schmulson M, Balbuena R, Corona de Law C. Schmulson M, et al. Rev Gastroenterol Mex. 2016 Oct-Dec;81(4):236-239. doi: 10.1016/j.rgmx.2016.07.001. Epub 2016 Sep 24. Rev Gastroenterol Mex. 2016. PMID: 27681080 Free article. English, Spanish.
INTRODUCTION: Circulating anti-CdtB/anti-vinculin antibodies have been validated as biomarkers to distinguish IBS-D from IBD, but there is no experience with them in Latin America. ...Positive biomarkers were found in IBS-D and IBS …
INTRODUCTION: Circulating anti-CdtB/anti-vinculin antibodies have been validated as biomarkers to distinguish …
Assessment of Anti-vinculin and Anti-cytolethal Distending Toxin B Antibodies in Subtypes of Irritable Bowel Syndrome.
Rezaie A, Park SC, Morales W, Marsh E, Lembo A, Kim JH, Weitsman S, Chua KS, Barlow GM, Pimentel M. Rezaie A, et al. Dig Dis Sci. 2017 Jun;62(6):1480-1485. doi: 10.1007/s10620-017-4585-z. Epub 2017 Apr 27. Dig Dis Sci. 2017. PMID: 28451914
Optical densities of 1.68 and 2.80 were considered positive for anti-vinculin and anti-CdtB, respectively. Plasma levels of anti-CdtB and anti-vinculin antibodies were highest in IBS-D and lowest in IBS-C and …
Optical densities of 1.68 and 2.80 were considered positive for anti-vinculin and anti-CdtB, respectively. Pla …
Tracking Anti-cytolethal Distending Toxin B and Anti-vinculin Over Time and Their Roles in Symptoms.
Sharabi E, Busam JA, Mathur K, Rezaie A, Mathur R, Hosseini A, Rashid M, Pimentel M. Sharabi E, et al. Dig Dis Sci. 2025 Jun;70(6):2016-2020. doi: 10.1007/s10620-025-09068-x. Epub 2025 May 4. Dig Dis Sci. 2025. PMID: 40319417 Free PMC article.
METHODS: A retrospective chart review of 417 IBS patients who had been tested for anti-CdtB and anti-vinculin antibodies was performed. Anti-vinculin and anti-CdtB antibody levels, time to normalization of antibody le …
METHODS: A retrospective chart review of 417 IBS patients who had been tested for anti-CdtB and anti-vinculin …
Circulating Anti-cytolethal Distending Toxin B and Anti-vinculin Antibodies as Biomarkers in Community and Healthcare Populations With Functional Dyspepsia and Irritable Bowel Syndrome.
Talley NJ, Holtmann G, Walker MM, Burns G, Potter M, Shah A, Jones M, Koloski NA, Keely S. Talley NJ, et al. Clin Transl Gastroenterol. 2019 Jul;10(7):e00064. doi: 10.14309/ctg.0000000000000064. Clin Transl Gastroenterol. 2019. PMID: 31356481 Free PMC article.
Serum levels of anti-CdtB/anti-vinculin antibodies were determined by enzyme-linked immunosorbent assay. ...DISCUSSION: We did not confirm that anti-CdtB/anti-vinculin discriminated IBS diarrhea from organic GI diseas …
Serum levels of anti-CdtB/anti-vinculin antibodies were determined by enzyme-linked immunosorbent assay. ...DISC …
Study of Antibodies to Cytolethal Distending Toxin B (CdtB) and Antibodies to Vinculin in Patients with Irritable Bowel Syndrome.
Zaki MES, Elhammady D, Foda Salama M, Abdelsalam M, Osman AOB. Zaki MES, et al. F1000Res. 2021 Apr 19;10:303. doi: 10.12688/f1000research.52086.4. eCollection 2021. F1000Res. 2021. PMID: 34754418 Free PMC article.
Results: The optical density (OD) results of the anti-vinculin and anti-CdtB levels were significantly elevated in patients with IBS (1.58 0.496 OD, 2.47 0.60 OD) when compared to control subjects (1.13 0.249 OD, 2.1 0.24 OD), respectively with …
Results: The optical density (OD) results of the anti-vinculin and anti-CdtB levels were significantly elevated …
Development and validation of a biomarker for diarrhea-predominant irritable bowel syndrome in human subjects.
Pimentel M, Morales W, Rezaie A, Marsh E, Lembo A, Mirocha J, Leffler DA, Marsh Z, Weitsman S, Chua KS, Barlow GM, Bortey E, Forbes W, Yu A, Chang C. Pimentel M, et al. PLoS One. 2015 May 13;10(5):e0126438. doi: 10.1371/journal.pone.0126438. eCollection 2015. PLoS One. 2015. PMID: 25970536 Free PMC article.
The area-under-the-receiver operating curves (AUCs) were 0.81 and 0.62 for diagnosis of D-IBS against IBD for anti-CdtB and anti-vinculin, respectively. Both tests were less specific in differentiating IBS from celiac disease. ...These re …
The area-under-the-receiver operating curves (AUCs) were 0.81 and 0.62 for diagnosis of D-IBS against IBD for anti-CdtB …
Immunization with cytolethal distending toxin B produces autoantibodies to vinculin and small bowel bacterial changes in a rat model of postinfectious irritable bowel syndrome.
Morales W, Triantafyllou K, Parodi G, Weitsman S, Park SC, Rezaie A, Pichetshote N, Lin E, Pimentel M. Morales W, et al. Neurogastroenterol Motil. 2020 Oct;32(10):e13875. doi: 10.1111/nmo.13875. Epub 2020 May 21. Neurogastroenterol Motil. 2020. PMID: 32436301
Serum was collected for anti-CdtB and anti-vinculin titers. Duodenal and ileal luminal contents for total eubacterial qPCR, and ileal bowel segments were harvested for vinculin and ileal expression. ...KEY RESULTS: Rats that received CdtB increased in …
Serum was collected for anti-CdtB and anti-vinculin titers. Duodenal and ileal luminal contents for total eubact …