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MicroRNA-based therapeutics in central nervous system injuries.
Sun P, Liu DZ, Jickling GC, Sharp FR, Yin KJ. Sun P, et al. J Cereb Blood Flow Metab. 2018 Jul;38(7):1125-1148. doi: 10.1177/0271678X18773871. Epub 2018 Apr 30. J Cereb Blood Flow Metab. 2018. PMID: 29708005 Free PMC article. Review.
MiRNA-based therapeutics include miRNA mimics and inhibitors (antagomiRs) to respectively decrease and increase the expression of target genes. ...Pharmacological agents that protect against CNS injuries by targeting specific miRNAs are p …
MiRNA-based therapeutics include miRNA mimics and inhibitors (antagomiRs) to respectively decrease and in …
Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of miR-125b.
Xiao C, Wang K, Xu Y, Hu H, Zhang N, Wang Y, Zhong Z, Zhao J, Li Q, Zhu D, Ke C, Zhong S, Wu X, Yu H, Zhu W, Chen J, Zhang J, Wang J, Hu X. Xiao C, et al. Circ Res. 2018 Aug 17;123(5):564-578. doi: 10.1161/CIRCRESAHA.118.312758. Circ Res. 2018. PMID: 29921652
In the in vivo mouse myocardial infarction model, MSC-exo, but not the exosomes obtained from MSCs pretreated with the anti-miR-125b oligonucleotide (MSC-exo(anti-miR-125b)), recapitulated the same results as the in vitro experiments. Moreover, measure …
In the in vivo mouse myocardial infarction model, MSC-exo, but not the exosomes obtained from MSCs pretreated with the anti-miR …
IRE1alpha inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats.
Chen D, Dixon BJ, Doycheva DM, Li B, Zhang Y, Hu Q, He Y, Guo Z, Nowrangi D, Flores J, Filippov V, Zhang JH, Tang J. Chen D, et al. J Neuroinflammation. 2018 Feb 2;15(1):32. doi: 10.1186/s12974-018-1077-9. J Neuroinflammation. 2018. PMID: 29394934 Free PMC article.
STF-083010, an IRE1alpha RNase inhibitor, was intranasally delivered at 1 h post-HI or followed by an additional one administration per day for 2 days. MiR-17-5p mimic or anti-miR-17-5p inhibitor was injected intracerebroventricularly at 48 h before HI …
STF-083010, an IRE1alpha RNase inhibitor, was intranasally delivered at 1 h post-HI or followed by an additional one administration per day …
Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis.
Zhang H, Wang D, Li M, Plecitá-Hlavatá L, D'Alessandro A, Tauber J, Riddle S, Kumar S, Flockton A, McKeon BA, Frid MG, Reisz JA, Caruso P, El Kasmi KC, Ježek P, Morrell NW, Hu CJ, Stenmark KR. Zhang H, et al. Circulation. 2017 Dec 19;136(25):2468-2485. doi: 10.1161/CIRCULATIONAHA.117.028069. Epub 2017 Sep 26. Circulation. 2017. PMID: 28972001 Free PMC article.
However, the mechanisms responsible for these metabolic alterations in PH-Fibs remain unknown. We hypothesized that in PH-Fibs microRNA-124 (miR-124) regulates PTBP1 (polypyrimidine tract binding protein 1) expression to control alternative splicing of pyruvate kina …
However, the mechanisms responsible for these metabolic alterations in PH-Fibs remain unknown. We hypothesized that in PH-Fibs microRNA …
Disturbed Flow Increases UBE2C (Ubiquitin E2 Ligase C) via Loss of miR-483-3p, Inducing Aortic Valve Calcification by the pVHL (von Hippel-Lindau Protein) and HIF-1alpha (Hypoxia-Inducible Factor-1alpha) Pathway in Endothelial Cells.
Fernandez Esmerats J, Villa-Roel N, Kumar S, Gu L, Salim MT, Ohh M, Taylor WR, Nerem RM, Yoganathan AP, Jo H. Fernandez Esmerats J, et al. Arterioscler Thromb Vasc Biol. 2019 Mar;39(3):467-481. doi: 10.1161/ATVBAHA.118.312233. Arterioscler Thromb Vasc Biol. 2019. PMID: 30602302 Free PMC article.
Here, we tested the role of novel flow-sensitive UBE2C (ubiquitin E2 ligase C) and microRNA-483-3p (miR-483) in flow-dependent AV endothelial function and AV calcification. ...The miR-483 mimic and HIF-1alpha pathway inhibitors may serve as potential …
Here, we tested the role of novel flow-sensitive UBE2C (ubiquitin E2 ligase C) and microRNA-483-3p (miR-483) in flow-dependent …
SNHG12 Promotes Angiogenesis Following Ischemic Stroke via Regulating miR-150/VEGF Pathway.
Zhao M, Wang J, Xi X, Tan N, Zhang L. Zhao M, et al. Neuroscience. 2018 Oct 15;390:231-240. doi: 10.1016/j.neuroscience.2018.08.029. Epub 2018 Sep 4. Neuroscience. 2018. PMID: 30193860
The role and mechanism of SNHG12 in the angiogenesis after ischemic stroke were investigated using gain- and loss-of function approaches both in OGD-exposed bEnd.3 cells and in MCAO mouse models. We found SNHG12 expression was elevated, whereas miR-150 reduced in OGD-expos …
The role and mechanism of SNHG12 in the angiogenesis after ischemic stroke were investigated using gain- and loss-of function approaches bot …
Delivery of therapeutic miRNA using polymer-based formulation.
Ban E, Kwon TH, Kim A. Ban E, et al. Drug Deliv Transl Res. 2019 Dec;9(6):1043-1056. doi: 10.1007/s13346-019-00645-y. Drug Deliv Transl Res. 2019. PMID: 31049843 Review.
For this reason, miRNAs have been proposed and investigated as biomarkers and therapeutics for various diseases such as cancer, diabetes, and cardiovascular disease. ...In particular, non-viral, polymer-based carriers have shown advantages such …
For this reason, miRNAs have been proposed and investigated as biomarkers and therapeutics for various diseases such as …
The Role of Non-coding RNAs in Ischemic Myocardial Reperfusion Injury.
Siebert V, Allencherril J, Ye Y, Wehrens XHT, Birnbaum Y. Siebert V, et al. Cardiovasc Drugs Ther. 2019 Aug;33(4):489-498. doi: 10.1007/s10557-019-06893-x. Cardiovasc Drugs Ther. 2019. PMID: 31332654 Review.
MicroRNAs (miRNA) are non-coding RNAs that regulate gene expression in up to 90% of the human genome through interactions with messenger RNA (mRNA). ...Levels of target miRNA can be increased using molecular mimics ("agomirs"), or can be decreased by u …
MicroRNAs (miRNA) are non-coding RNAs that regulate gene expression in up to 90% of the human genome through interactions with …
MicroRNA-122 promotes cardiomyocyte hypertrophy via targeting FoxO3.
Song G, Zhu L, Ruan Z, Wang R, Shen Y. Song G, et al. Biochem Biophys Res Commun. 2019 Nov 19;519(4):682-688. doi: 10.1016/j.bbrc.2019.09.035. Epub 2019 Sep 19. Biochem Biophys Res Commun. 2019. PMID: 31543343
OBJECTIVE: -microRNAs (miRNAs) have emerged as novel regulators for cardiac hypertrophy. MiR-122 is well recognized as a promising therapeutic target in liver disease, whereas recently plays important roles in cardiovascular diseases …
OBJECTIVE: -microRNAs (miRNAs) have emerged as novel regulators for cardiac hypertrophy. MiR-122 is well recognized as …
Downregulation of miR-200a protects cardiomyocyte against apoptosis.
Wang Y, Jiang Y, Sun X, Shen X, Wang H, Dong C, Lu B, Yan Y, Lu Y, Fasae MB, Liu B, Bai Y. Wang Y, et al. Biomed Pharmacother. 2020 Mar;123:109303. doi: 10.1016/j.biopha.2019.109303. Epub 2019 Dec 30. Biomed Pharmacother. 2020. PMID: 31896068 Free article.
However, key regulators in the pathogenesis of ischemic heart disease remain controversial. The present study was designed to investigate the involvement of miR-200a and its related mechanism in AMI. ...The infarct size was measured by TTC staining. H(2)O(2) was use …
However, key regulators in the pathogenesis of ischemic heart disease remain controversial. The present study was designed to investi …
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