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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 5
1946 27
1947 56
1948 57
1949 60
1950 62
1951 67
1952 56
1953 60
1954 68
1955 78
1956 85
1957 103
1958 189
1959 412
1960 402
1961 475
1962 632
1963 952
1964 1281
1965 1031
1966 950
1967 1226
1968 1377
1969 1438
1970 1413
1971 1680
1972 1692
1973 1629
1974 1824
1975 1761
1976 1696
1977 1689
1978 1736
1979 1847
1980 1931
1981 1934
1982 2193
1983 2241
1984 2303
1985 2317
1986 2322
1987 2204
1988 2303
1989 2504
1990 2677
1991 2793
1992 2704
1993 2690
1994 2754
1995 2833
1996 2948
1997 3088
1998 3194
1999 3401
2000 3650
2001 3820
2002 4052
2003 4433
2004 4746
2005 5005
2006 5364
2007 5731
2008 5853
2009 5847
2010 5916
2011 6017
2012 6183
2013 6366
2014 6228
2015 6319
2016 6073
2017 5773
2018 5928
2019 5739
2020 3491
2021 8
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179,747 results
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Page 1
[Progress of new antidepressant drugs development].
Zhang X, Tian JS, Liu H, Qin XM. Zhang X, et al. Zhongguo Zhong Yao Za Zhi. 2017 Jan;42(1):29-33. doi: 10.19540/j.cnki.cjcmm.20161222.056. Zhongguo Zhong Yao Za Zhi. 2017. PMID: 28945021 Review. Chinese.
There is still the drug treatment as the first-line antidepressive therapy, but the effect of listed antidepressant drugs is not ideal. ...The traditional Chinese medicine (TCM) of anti-depression and natural antidepressant in currently listed, drug developme …
There is still the drug treatment as the first-line antidepressive therapy, but the effect of listed antidepressant drugs is n …
Antidepressant-Induced Hyponatremia in Older Adults.
Viramontes TS, Truong H, Linnebur SA. Viramontes TS, et al. Consult Pharm. 2016 Mar;31(3):139-50. doi: 10.4140/TCP.n.2016.139. Consult Pharm. 2016. PMID: 26975593 Review.
OBJECTIVE: To describe the prevalence of hyponatremia in older adults related to antidepressive agents and identify potential alternative options in older adults with a low-baseline serum sodium concentration and/or when a patient has experienced hyponatremia as a r …
OBJECTIVE: To describe the prevalence of hyponatremia in older adults related to antidepressive agents and identify potential …
Mechanism of action of antidepressant medications.
Feighner JP. Feighner JP. J Clin Psychiatry. 1999;60 Suppl 4:4-11; discussion 12-3. J Clin Psychiatry. 1999. PMID: 10086478 Free article. Review.
Early antidepressant medications--tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs)--were discovered through astute clinical observations. ...This paper discusses the new antidepressants, particularly with regard to mechanism of action …
Early antidepressant medications--tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs)--were discovered t …
[Antidepressant and tolerance: Determinants and management of major side effects].
David DJ, Gourion D. David DJ, et al. Encephale. 2016 Dec;42(6):553-561. doi: 10.1016/j.encep.2016.05.006. Epub 2016 Jul 14. Encephale. 2016. PMID: 27423475 Review. French.
Antidepressant therapy aims to reach remission of depressive symptoms while reducing the complications and risks of relapse. ...Among the causes responsible for weight gain under antidepressant therapy, monoamine neurotransmission still plays an important role. ...
Antidepressant therapy aims to reach remission of depressive symptoms while reducing the complications and risks of relapse. ...Among
Antidepressant pharmacotherapy in old-age depression-a review and clinical approach.
Pruckner N, Holthoff-Detto V. Pruckner N, et al. Eur J Clin Pharmacol. 2017 Jun;73(6):661-667. doi: 10.1007/s00228-017-2219-1. Epub 2017 Mar 10. Eur J Clin Pharmacol. 2017. PMID: 28280892 Review.
Studies specifically investigating antidepressant treatment for this special cohort of patients remain scarce and results are often conflicting. ...Tricyclic antidepressants (TCAs) are only considered for second-line treatment, due to their cardiac risk profile and …
Studies specifically investigating antidepressant treatment for this special cohort of patients remain scarce and results are often c …
The Use of Antidepressant Medications During Pregnancy and the Risk of Neonatal Seizures: A Systematic Review.
Uguz F. Uguz F. J Clin Psychopharmacol. 2019 Sep/Oct;39(5):479-484. doi: 10.1097/JCP.0000000000001093. J Clin Psychopharmacol. 2019. PMID: 31425466
The prevalence rates of neonatal seizures in the antidepressant groups and control groups were 0.30% to 0.91% and 0.10% to 0.30%, respectively. ...Compared with the controls, higher risks were reported in newborns of pregnant women using any antidepressant or tricyc …
The prevalence rates of neonatal seizures in the antidepressant groups and control groups were 0.30% to 0.91% and 0.10% to 0.30%, res …
Efficacy and safety of antidepressant's use in the treatment of depressive episodes in bipolar disorder - review of research.
Antosik-Wójcińska AZ, Stefanowski B, Święcicki Ł. Antosik-Wójcińska AZ, et al. Psychiatr Pol. 2015;49(6):1223-39. doi: 10.12740/PP/37914. Psychiatr Pol. 2015. PMID: 26909398 Free article. Review. English, Polish.
There are different opinions concerning recommended duration of antidepressant treatment. Generally antidepressant use should end after 2-3 months of remission, the risk of recurrence of depression after discontinuation of antidepressants is, however, higher …
There are different opinions concerning recommended duration of antidepressant treatment. Generally antidepressant use should …
Antidepressant and immunosuppressive activities of two polysaccharides from Poria cocos (Schw.) Wolf.
Zhang W, Chen L, Li P, Zhao J, Duan J. Zhang W, et al. Int J Biol Macromol. 2018 Dec;120(Pt B):1696-1704. doi: 10.1016/j.ijbiomac.2018.09.171. Epub 2018 Sep 26. Int J Biol Macromol. 2018. PMID: 30267822
Pursuit of novel effective antidepressants is an urgent task. Poria cocos (Schw.) Wolf (PCW) is a traditional herb with antidepressant effects. ...These findings implied that PCWPW and PCWPS might be a candidate for developing antidepressant or immunosuppress …
Pursuit of novel effective antidepressants is an urgent task. Poria cocos (Schw.) Wolf (PCW) is a traditional herb with antidepres
Relative Efficacy and Acceptability of Antidepressant Drugs in Adults With Major Depressive Disorder: Commentary on a Network Meta-Analysis.
Andrade C. Andrade C. J Clin Psychiatry. 2018 Mar/Apr;79(2):18f12254. doi: 10.4088/JCP.18f12254. J Clin Psychiatry. 2018. PMID: 29718600 Free article.
A large number of antidepressant drugs are available across the world. All have been compared against placebo, and many have been compared with some but not all other antidepressants. ...In general, it appears that antidepressant drugs are associated with cli …
A large number of antidepressant drugs are available across the world. All have been compared against placebo, and many have been com …
Antidepressant use in the elderly: the role of pharmacodynamics and pharmacokinetics in drug safety.
Sultana J, Spina E, Trifirò G. Sultana J, et al. Expert Opin Drug Metab Toxicol. 2015 Jun;11(6):883-92. doi: 10.1517/17425255.2015.1021684. Epub 2015 Mar 3. Expert Opin Drug Metab Toxicol. 2015. PMID: 25736834 Review.
INTRODUCTION: Antidepressants (ADs) are widely used among elderly persons, making AD-related safety an important issue. AREAS COVERED: This review highlights safety considerations related to AD use including risks associated with inappropriate and off-label use. ...The use …
INTRODUCTION: Antidepressants (ADs) are widely used among elderly persons, making AD-related safety an important issue. AREAS COVERED …
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