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Scutellarin protects against vascular endothelial dysfunction and prevents atherosclerosis via antioxidation.
Mo J, Yang R, Li F, Zhang X, He B, Zhang Y, Chen P, Shen Z. Mo J, et al. Phytomedicine. 2018 Mar 15;42:66-74. doi: 10.1016/j.phymed.2018.03.021. Epub 2018 Mar 14. Phytomedicine. 2018. PMID: 29655699
PURPOSE: This study aims to examine the effects of scutellarin on oxidative stress-induced vascular endothelial dysfunction and endothelial cell damage, and then to evaluate the therapeutic efficacy of scutellarin in preventing atherosclerosis in rats. METHODS: Radical sca …
PURPOSE: This study aims to examine the effects of scutellarin on oxidative stress-induced vascular endothelial dysfunction and endothelial …
Apigenin Retards Atherogenesis by Promoting ABCA1-Mediated Cholesterol Efflux and Suppressing Inflammation.
Ren K, Jiang T, Zhou HF, Liang Y, Zhao GJ. Ren K, et al. Cell Physiol Biochem. 2018;47(5):2170-2184. doi: 10.1159/000491528. Epub 2018 Jul 5. Cell Physiol Biochem. 2018. PMID: 29975943 Free article.
BACKGROUND/AIMS: The development of atherosclerosis is accompanied by escalating inflammation and lipid accumulation within blood vessel walls. ...In LPS-treated macrophages, the expression levels of TLR-4, MyD88 and p-IkappaB-alpha as well as nuclear NF-kappaB p65 were de …
BACKGROUND/AIMS: The development of atherosclerosis is accompanied by escalating inflammation and lipid accumulation within blood ves …
Scutellarin exerts protective effects against atherosclerosis in rats by regulating the Hippo-FOXO3A and PI3K/AKT signaling pathways.
Fu Y, Sun S, Sun H, Peng J, Ma X, Bao L, Ji R, Luo C, Gao C, Zhang X, Jin Y. Fu Y, et al. J Cell Physiol. 2019 Aug;234(10):18131-18145. doi: 10.1002/jcp.28446. Epub 2019 Mar 19. J Cell Physiol. 2019. PMID: 30891776
Atherosclerosis (AS), a progressive disorder, is one of the tough challenges in the clinic. ...
Atherosclerosis (AS), a progressive disorder, is one of the tough challenges in the clinic. ...
Apigenin in the regulation of cholesterol metabolism and protection of blood vessels.
Zhang K, Song W, Li D, Jin X. Zhang K, et al. Exp Ther Med. 2017 May;13(5):1719-1724. doi: 10.3892/etm.2017.4165. Epub 2017 Feb 24. Exp Ther Med. 2017. PMID: 28565758 Free PMC article.
Apigenin improved the blood lipid metabolism of the hyper-lipidemia model mice. ...Apigenin also has a role in resisting oxidization and protecting blood vessels....
Apigenin improved the blood lipid metabolism of the hyper-lipidemia model mice. ...Apigenin also has a role in resisting oxidi
Food Antioxidants and Their Anti-Inflammatory Properties: A Potential Role in Cardiovascular Diseases and Cancer Prevention.
Griffiths K, Aggarwal BB, Singh RB, Buttar HS, Wilson D, De Meester F. Griffiths K, et al. Diseases. 2016 Aug 1;4(3):28. doi: 10.3390/diseases4030028. Diseases. 2016. PMID: 28933408 Free PMC article. Review.
Conversely, the increase in oxidative stress causing inflammation is a unifying hypothesis for predisposing people to atherosclerosis, carcinogenesis, and osteoporosis. The impact of antioxidants and anti-inflammatory agents on cancer and cardiovascular disease, and the in …
Conversely, the increase in oxidative stress causing inflammation is a unifying hypothesis for predisposing people to atherosclerosis
Co-administrating apigenin in a high-cholesterol diet prevents hypercholesterolaemia in golden hamsters.
Wong TY, Tan YQ, Lin SM, Leung LK. Wong TY, et al. J Pharm Pharmacol. 2018 Sep;70(9):1253-1261. doi: 10.1111/jphp.12953. Epub 2018 Jun 25. J Pharm Pharmacol. 2018. PMID: 29943490
In this study, the hypocholesterolaemic effect of apigenin and luteolin was evaluated in a hamster model. METHODS: Hamsters were put on a high-cholesterol diet for 9 weeks, and apigenin or luteolin was administered in the diet at 60 and 300 ppm. KEY FINDINGS: Both …
In this study, the hypocholesterolaemic effect of apigenin and luteolin was evaluated in a hamster model. METHODS: Hamsters were put …
Inhibition of autophagy ameliorates atherogenic inflammation by augmenting apigenin-induced macrophage apoptosis.
Wang Q, Zeng P, Liu Y, Wen G, Fu X, Sun X. Wang Q, et al. Int Immunopharmacol. 2015 Jul;27(1):24-31. doi: 10.1016/j.intimp.2015.04.018. Epub 2015 Apr 18. Int Immunopharmacol. 2015. PMID: 25899084
Results illustrated that autophagy inhibition increased apigenin-induced apoptosis through activation of Bax. The present findings suggest that oxLDL maintained the survival of macrophages and activated the secretion of pro-inflammatory cytokines to initiate atheroscler
Results illustrated that autophagy inhibition increased apigenin-induced apoptosis through activation of Bax. The present findings su …
Dietary Apigenin Reduces Induction of LOX-1 and NLRP3 Expression, Leukocyte Adhesion, and Acetylated Low-Density Lipoprotein Uptake in Human Endothelial Cells Exposed to Trimethylamine-N-Oxide.
Yamagata K, Hashiguchi K, Yamamoto H, Tagami M. Yamagata K, et al. J Cardiovasc Pharmacol. 2019 Dec;74(6):558-565. doi: 10.1097/FJC.0000000000000747. J Cardiovasc Pharmacol. 2019. PMID: 31815868
Scavenger receptors, adhesion molecules, and other genes associated with atherosclerosis were induced in endothelial cells exposed to TMAO. On the other hand, apigenin, a flavonoid that is abundant in parsley and celery, prevents initial arteriosclerosis events in e …
Scavenger receptors, adhesion molecules, and other genes associated with atherosclerosis were induced in endothelial cells exposed to …
Flavonoid apigenin inhibits lipopolysaccharide-induced inflammatory response through multiple mechanisms in macrophages.
Zhang X, Wang G, Gurley EC, Zhou H. Zhang X, et al. PLoS One. 2014 Sep 5;9(9):e107072. doi: 10.1371/journal.pone.0107072. eCollection 2014. PLoS One. 2014. PMID: 25192391 Free PMC article.
BACKGROUND: Apigenin is a non-toxic natural flavonoid that is abundantly present in common fruits and vegetables. ...In addition, apigenin significantly inhibited TNF-alpha and IL-1beta-induced activation of NF-kappaB. ...
BACKGROUND: Apigenin is a non-toxic natural flavonoid that is abundantly present in common fruits and vegetables. ...In addition, …
Isolation, identification and characterization of apigenin from Justicia gendarussa and its anti-inflammatory activity.
Kumar KS, Sabu V, Sindhu G, Rauf AA, Helen A. Kumar KS, et al. Int Immunopharmacol. 2018 Jun;59:157-167. doi: 10.1016/j.intimp.2018.04.004. Epub 2018 Apr 11. Int Immunopharmacol. 2018. PMID: 29655057
These results indicate the therapeutic efficacy of bioflavonoid apigenin which was isolated from Justicia gendarussa against ox-LDL induced inflammation. Therefore apigenin can be treated as a suitable therapeutic agent against inflammatory diseases....
These results indicate the therapeutic efficacy of bioflavonoid apigenin which was isolated from Justicia gendarussa against ox-LDL i …
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