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Page 1
The therapeutic potential of apigenin against atherosclerosis.
Jiang X, Huang H. Jiang X, et al. Heliyon. 2024 Dec 19;11(1):e41272. doi: 10.1016/j.heliyon.2024.e41272. eCollection 2025 Jan 15. Heliyon. 2024. PMID: 39811295 Free PMC article. Review.
Numerous in vivo and in vitro studies have shown a protective effect of apigenin against atherosclerosis, attributed to its antioxidant and anti-inflammatory properties, as well as its antihypertensive effect and regulation of lipid metabolism. This study aimed to r …
Numerous in vivo and in vitro studies have shown a protective effect of apigenin against atherosclerosis, attributed to its an …
Apigenin attenuates atherosclerosis and non-alcoholic fatty liver disease through inhibition of NLRP3 inflammasome in mice.
Lu Z, Liu L, Zhao S, Zhao J, Li S, Li M. Lu Z, et al. Sci Rep. 2023 May 17;13(1):7996. doi: 10.1038/s41598-023-34654-2. Sci Rep. 2023. PMID: 37198205 Free PMC article.
Apigenin (APN), a flavone found in several plant foods with various biological properties such as anti-obesity, anti-inflammation and other abilities, alleviates atherosclerosis and non-alcoholic fatty liver disease (NAFLD) induced by a high fat diet (HFD) in mice. …
Apigenin (APN), a flavone found in several plant foods with various biological properties such as anti-obesity, anti-inflammation and …
Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis.
Duan H, Zhang Q, Liu J, Li R, Wang D, Peng W, Wu C. Duan H, et al. Pharmacol Res. 2021 Jun;168:105599. doi: 10.1016/j.phrs.2021.105599. Epub 2021 Apr 7. Pharmacol Res. 2021. PMID: 33838291 Review.
Atherosclerosis, a chronic multifactorial disease, is closely related to the development of cardiovascular diseases and is one of the predominant causes of death worldwide. ...Currently, accumulating evidence has revealed that endothelial cell apoptosis is the first step o …
Atherosclerosis, a chronic multifactorial disease, is closely related to the development of cardiovascular diseases and is one of the …
Effects of Apigenin on the Apoptosis Index of Atherosclerosis.
Jia ZN, Zhang BY, Gao ZY, Wang JX, Liu HB, He XY, Wu JZ, Luo LY, Zhang ZH, Huang YX, Xu Q. Jia ZN, et al. J Cardiovasc Pharmacol. 2025 Oct 1;86(4):350-373. doi: 10.1097/FJC.0000000000001736. J Cardiovasc Pharmacol. 2025. PMID: 40772684
This study aims to evaluate the expression of LOX-1, Bcl-2, and Bax in apigenin-treated atherosclerotic rats and to explore whether apigenin affect the expression of apoptotic genes. ...Western blot was used to detect LOX-1 protein, and RT-qPCR was used to detect Bc …
This study aims to evaluate the expression of LOX-1, Bcl-2, and Bax in apigenin-treated atherosclerotic rats and to explore whether …
Flavonoids as Potential Anti-Inflammatory Molecules: A Review.
Al-Khayri JM, Sahana GR, Nagella P, Joseph BV, Alessa FM, Al-Mssallem MQ. Al-Khayri JM, et al. Molecules. 2022 May 2;27(9):2901. doi: 10.3390/molecules27092901. Molecules. 2022. PMID: 35566252 Free PMC article. Review.
Flavonoids such as quercetin, genistein, apigenin, kaempferol, and epigallocatechin 3-gallate modulate the expression and activation of a cytokine such as interleukin-1beta (IL-1beta), Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-8 (IL-8); …
Flavonoids such as quercetin, genistein, apigenin, kaempferol, and epigallocatechin 3-gallate modulate the expression and activation …
Apigenin ameliorates atherosclerosis by inhibiting macrophage foam cell formation in ApoE(-/-)mice fed a high fat diet.
Huang H, Ran F, Chen J, Wei Y, Wang J, Li W, Niu X. Huang H, et al. Arch Biochem Biophys. 2026 Mar;777:110730. doi: 10.1016/j.abb.2026.110730. Epub 2026 Jan 8. Arch Biochem Biophys. 2026. PMID: 41513215
BACKGROUND: Apigenin is a bioactive flavonoid and widely found in herbs, fruits, and vegetables. Accumulated evidences have demonstrated the protective potential of apigenin on cardiovascular diseases, but its role in atherosclerosis remains unclear. ...Moreo …
BACKGROUND: Apigenin is a bioactive flavonoid and widely found in herbs, fruits, and vegetables. Accumulated evidences have demonstra …
Apigenin inhibits macrophage pyroptosis through regulation of oxidative stress and the NF-kappaB pathway and ameliorates atherosclerosis.
Weng X, Luo X, Dai X, Lv Y, Zhang S, Bai X, Bao X, Wang Y, Zhao C, Zeng M, Hu S, Li J, Jia H, Yu B. Weng X, et al. Phytother Res. 2023 Nov;37(11):5300-5314. doi: 10.1002/ptr.7962. Epub 2023 Aug 1. Phytother Res. 2023. PMID: 37526050
Pyroptosis plays an important role in inflammatory diseases such as viral hepatitis and atherosclerosis. Apigenin exhibits various bioactivities, particularly anti-inflammation, but its effect on pyroptosis remains unclear. ...Apigenin may alleviate athero …
Pyroptosis plays an important role in inflammatory diseases such as viral hepatitis and atherosclerosis. Apigenin exhibits var …
Apigenin attenuates the atherosclerotic lesions through enhancing selective autophagy/lipophagy and promoting RCT process.
Hu Z, Li Y, Yao N, Gan H, Zeng Q, Huang X, Huang D, Cai D, Chen Y. Hu Z, et al. Pharm Biol. 2025 Dec;63(1):387-401. doi: 10.1080/13880209.2025.2509020. Epub 2025 May 23. Pharm Biol. 2025. PMID: 40407263 Free PMC article.
But the therapeutic or ameliorative effects of apigenin on atherosclerosis are not known. OBJECTIVE: Our study aimed to elucidate the underlying mechanism of apigenin on preventing atherosclerosis by enhancing selective autophagy/lipophagy and promotin …
But the therapeutic or ameliorative effects of apigenin on atherosclerosis are not known. OBJECTIVE: Our study aimed to elucid …
Pharmacological and Molecular Insight on the Cardioprotective Role of Apigenin.
Thomas SD, Jha NK, Jha SK, Sadek B, Ojha S. Thomas SD, et al. Nutrients. 2023 Jan 12;15(2):385. doi: 10.3390/nu15020385. Nutrients. 2023. PMID: 36678254 Free PMC article. Review.
Apigenin is a naturally occurring dietary flavonoid found abundantly in fruits and vegetables. ...These potential therapeutic effects advocate the exploration of the cardioprotective actions of apigenin. This review focuses on apigenin, and the possible pharm …
Apigenin is a naturally occurring dietary flavonoid found abundantly in fruits and vegetables. ...These potential therapeutic effects …
Taoren Honghua Decoction alleviates atherosclerosis by inducing autophagy and inhibiting the PI3K-AKT signaling pathway to regulate cholesterol efflux and inflammatory responses.
Chang X, Feng X, Li S, Wang J, Liu P, Wang Y. Chang X, et al. Int Immunopharmacol. 2025 Jan 10;144:113629. doi: 10.1016/j.intimp.2024.113629. Epub 2024 Nov 21. Int Immunopharmacol. 2025. PMID: 39577223
However, the primary active components and the underlying mechanisms by which THD exerts its therapeutic effects on atherosclerosis (AS) remain insufficiently characterized. OBJECTIVE: This study aims to systematically validate the protective effects of THD on AS and eluci …
However, the primary active components and the underlying mechanisms by which THD exerts its therapeutic effects on atherosclerosis ( …
87 results