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Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis.
Duan H, Zhang Q, Liu J, Li R, Wang D, Peng W, Wu C. Duan H, et al. Pharmacol Res. 2021 Jun;168:105599. doi: 10.1016/j.phrs.2021.105599. Epub 2021 Apr 7. Pharmacol Res. 2021. PMID: 33838291 Review.
Atherosclerosis, a chronic multifactorial disease, is closely related to the development of cardiovascular diseases and is one of the predominant causes of death worldwide. ...Currently, accumulating evidence has revealed that endothelial cell apoptosis is the first step o
Atherosclerosis, a chronic multifactorial disease, is closely related to the development of cardiovascular diseases and is one of the
Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging.
Clayton ZS, Hutton DA, Brunt VE, VanDongen NS, Ziemba BP, Casso AG, Greenberg NT, Mercer AN, Rossman MJ, Campisi J, Melov S, Seals DR. Clayton ZS, et al. Am J Physiol Heart Circ Physiol. 2021 Jul 1;321(1):H185-H196. doi: 10.1152/ajpheart.00118.2021. Epub 2021 Jun 11. Am J Physiol Heart Circ Physiol. 2021. PMID: 34114892 Free PMC article.
Moreover, apigenin prevented foam cell formation in vitro (initiating step in atherosclerosis) and mitigated age-associated aortic stiffening (PWV 373 5 cm/s) by normalizing aortic intrinsic wall stiffness, collagen, elastin, AGEs, and inflammation. Thus, …
Moreover, apigenin prevented foam cell formation in vitro (initiating step in atherosclerosis) and mitigated age-associated ao …
Flavonoids as Potential Anti-Inflammatory Molecules: A Review.
Al-Khayri JM, Sahana GR, Nagella P, Joseph BV, Alessa FM, Al-Mssallem MQ. Al-Khayri JM, et al. Molecules. 2022 May 2;27(9):2901. doi: 10.3390/molecules27092901. Molecules. 2022. PMID: 35566252 Free PMC article. Review.
They inhibit the secretions of enzymes such as lysozymes and beta-glucuronidase and inhibit the secretion of arachidonic acid, which reduces inflammatory reactions. Flavonoids such as quercetin, genistein, apigenin, kaempferol, and epigallocatechin 3-gallate modulate the e …
They inhibit the secretions of enzymes such as lysozymes and beta-glucuronidase and inhibit the secretion of arachidonic acid, which reduces …
Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2/ARE Signaling Pathway and Epigenetic Regulation.
Thiruvengadam M, Venkidasamy B, Subramanian U, Samynathan R, Ali Shariati M, Rebezov M, Girish S, Thangavel S, Dhanapal AR, Fedoseeva N, Lee J, Chung IM. Thiruvengadam M, et al. Antioxidants (Basel). 2021 Nov 23;10(12):1859. doi: 10.3390/antiox10121859. Antioxidants (Basel). 2021. PMID: 34942962 Free PMC article. Review.
In the present review, we discussed the role of NRF2 in diabetes, Alzheimer's disease (AD), Parkinson's disease (PD), cancer, and atherosclerosis. Additionally, we discussed the phytochemicals like curcumin, quercetin, resveratrol, epigallocatechin gallate, …
In the present review, we discussed the role of NRF2 in diabetes, Alzheimer's disease (AD), Parkinson's disease (PD), cancer, …
Vitexin inhibits APEX1 to counteract the flow-induced endothelial inflammation.
Zhao CR, Yang FF, Cui Q, Wang D, Zhou Y, Li YS, Zhang YP, Tang RZ, Yao WJ, Wang X, Pang W, Zhao JN, Jiang ZT, Zhu JJ, Chien S, Zhou J. Zhao CR, et al. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2115158118. doi: 10.1073/pnas.2115158118. Proc Natl Acad Sci U S A. 2021. PMID: 34810252 Free PMC article.
In hyperlipidemic mice, treatment with vitexin ameliorated atherosclerosis. Using SuperPred, we predicted that apurinic/apyrimidinic endonuclease1 (APEX1) may directly interact with vitexin, and we experimentally verified their physical interactions. ...We thus propose tar …
In hyperlipidemic mice, treatment with vitexin ameliorated atherosclerosis. Using SuperPred, we predicted that apurinic/apyrimidinic …
Effects of Apigenin on the Expression of LOX-1, Bcl-2, and Bax in Hyperlipidemia Rats.
Xu Q, Li YC, Du C, Wang LN, Xiao YH. Xu Q, et al. Chem Biodivers. 2021 Aug;18(8):e2100049. doi: 10.1002/cbdv.202100049. Epub 2021 Jul 1. Chem Biodivers. 2021. PMID: 34118114
We aimed to investigate the impact of apigenin on LOX-1, Bcl-2, and Bax expression in hyperlipidemia rats and explore the possible molecular pathological mechanism of apigenin in improving hyperlipidemia and preventing atherosclerosis. ...Apigenin can …
We aimed to investigate the impact of apigenin on LOX-1, Bcl-2, and Bax expression in hyperlipidemia rats and explore the possible mo …
Apigenin in the regulation of cholesterol metabolism and protection of blood vessels.
Zhang K, Song W, Li D, Jin X. Zhang K, et al. Exp Ther Med. 2017 May;13(5):1719-1724. doi: 10.3892/etm.2017.4165. Epub 2017 Feb 24. Exp Ther Med. 2017. PMID: 28565758 Free PMC article.
Apigenin improved the blood lipid metabolism of the hyper-lipidemia model mice. ...Apigenin also has a role in resisting oxidization and protecting blood vessels....
Apigenin improved the blood lipid metabolism of the hyper-lipidemia model mice. ...Apigenin also has a role in resisting oxidi
Apigenin Retards Atherogenesis by Promoting ABCA1-Mediated Cholesterol Efflux and Suppressing Inflammation.
Ren K, Jiang T, Zhou HF, Liang Y, Zhao GJ. Ren K, et al. Cell Physiol Biochem. 2018;47(5):2170-2184. doi: 10.1159/000491528. Epub 2018 Jul 5. Cell Physiol Biochem. 2018. PMID: 29975943 Free article.
BACKGROUND/AIMS: The development of atherosclerosis is accompanied by escalating inflammation and lipid accumulation within blood vessel walls. ...In LPS-treated macrophages, the expression levels of TLR-4, MyD88 and p-IkappaB-alpha as well as nuclear NF-kappaB p65 were de …
BACKGROUND/AIMS: The development of atherosclerosis is accompanied by escalating inflammation and lipid accumulation within blood ves …
Apigenin Modulates AnxA6- and TNAP-Mediated Osteoblast Mineralization.
Mroczek J, Pikula S, Suski S, Weremiejczyk L, Biesaga M, Strzelecka-Kiliszek A. Mroczek J, et al. Int J Mol Sci. 2022 Oct 29;23(21):13179. doi: 10.3390/ijms232113179. Int J Mol Sci. 2022. PMID: 36361965 Free PMC article.
We compared the mineralization competence, the morphology and composition of minerals, and the protein distribution in control and apigenin-treated cells and vesicles. The mineralization ability was monitored by AR-S/CPC analysis, and TNAP activity was determined by …
We compared the mineralization competence, the morphology and composition of minerals, and the protein distribution in control and apigen
Co-administrating apigenin in a high-cholesterol diet prevents hypercholesterolaemia in golden hamsters.
Wong TY, Tan YQ, Lin SM, Leung LK. Wong TY, et al. J Pharm Pharmacol. 2018 Sep;70(9):1253-1261. doi: 10.1111/jphp.12953. Epub 2018 Jun 25. J Pharm Pharmacol. 2018. PMID: 29943490
In this study, the hypocholesterolaemic effect of apigenin and luteolin was evaluated in a hamster model. METHODS: Hamsters were put on a high-cholesterol diet for 9 weeks, and apigenin or luteolin was administered in the diet at 60 and 300 ppm. KEY FINDINGS: Both …
In this study, the hypocholesterolaemic effect of apigenin and luteolin was evaluated in a hamster model. METHODS: Hamsters were put …
57 results