Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2001 2
2002 2
2003 1
2006 3
2007 1
2008 1
2009 1
2010 1
2011 1
2013 3
2014 2
2015 1
2016 1
2017 5
2018 3
2019 5
2020 1
2021 4
2022 3
2023 3
2024 4
2025 7
2026 4

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

51 results

Results by year

Filters applied: . Clear all
Page 1
Enhancement of in vitro transcellular absorption and in vivo oral bioavailability of apigenin by self-nanoemulsifying drug delivery systems.
Sato VH, Sato H, Sangfuang M, Nontakham J, Junyaprasert VB, Teeranachaideekul V, Morakul B. Sato VH, et al. Sci Rep. 2024 Dec 30;14(1):32148. doi: 10.1038/s41598-024-84063-2. Sci Rep. 2024. PMID: 39738511 Free PMC article.

The pharmacokinetic analysis in rats revealed that the pharmacokinetic parameters, such as C(max), AUC(0-24), and AUC(0- ), were significantly higher with apigenin-loaded SNEDDS than with apigenin coarse powder (p < 0.05). Apigenin's oral relative

…
The pharmacokinetic analysis in rats revealed that the pharmacokinetic parameters, such as C(max), AUC(0-24), and AUC(0- ), were significant …
Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults.
Borges G, Fong RY, Ensunsa JL, Kimball J, Medici V, Ottaviani JI, Crozier A. Borges G, et al. Free Radic Biol Med. 2022 May 20;185:90-96. doi: 10.1016/j.freeradbiomed.2022.04.007. Epub 2022 Apr 20. Free Radic Biol Med. 2022. PMID: 35452808 Clinical Trial.
The bioavailability of apigenin and its O-glycosides in humans was investigated with apigenin-4'-glucuronide (Ap-4'-GlcUA), apigenin-7-glucuronide and apigenin-7-sulfate being identified as in vivo metabolites. ...Consumption of chamomile …
The bioavailability of apigenin and its O-glycosides in humans was investigated with apigenin-4'-glucuronide (Ap …
Antioxidant and Photoprotective Activity of Apigenin and its Potassium Salt Derivative in Human Keratinocytes and Absorption in Caco-2 Cell Monolayers.
Sánchez-Marzo N, Pérez-Sánchez A, Ruiz-Torres V, Martínez-Tébar A, Castillo J, Herranz-López M, Barrajón-Catalán E. Sánchez-Marzo N, et al. Int J Mol Sci. 2019 Apr 30;20(9):2148. doi: 10.3390/ijms20092148. Int J Mol Sci. 2019. PMID: 31052292 Free PMC article.
However, some of these compounds are poorly soluble, and information regarding their absorption and bioavailability is scarce. The main objective of this study was to compare the intestinal absorption and biological activity of apigenin and its …
However, some of these compounds are poorly soluble, and information regarding their absorption and bioavailability is scarce. …
Pharmacokinetic properties and drug interactions of apigenin, a natural flavone.
Tang D, Chen K, Huang L, Li J. Tang D, et al. Expert Opin Drug Metab Toxicol. 2017 Mar;13(3):323-330. doi: 10.1080/17425255.2017.1251903. Epub 2016 Nov 2. Expert Opin Drug Metab Toxicol. 2017. PMID: 27766890 Review.
Areas covered: This review summarizes and the absorption, distribution, metabolism and excretion (ADME) properties of apigenin, and drug-drug interaction of apigenin. ...Due to apigenin's limitations on absorption and bioavailability …
Areas covered: This review summarizes and the absorption, distribution, metabolism and excretion (ADME) properties of apigenin …
Insights into Pharmacological Potential of Apigenin through Various Pathways on a Nanoplatform in Multitude of Diseases.
Waheed A, Zameer S, Ashrafi K, Ali A, Sultana N, Aqil M, Sultana Y, Iqbal Z. Waheed A, et al. Curr Pharm Des. 2023;29(17):1326-1340. doi: 10.2174/1381612829666230529164321. Curr Pharm Des. 2023. PMID: 37254541 Review.
Apigenin belongs to BCS class II with low solubility, which leads to poor absorption and bioavailability. ...Numerous formulations have been researched to enhance the bioavailability and pharmacological effects of apigenin. Combinatorial therapi …
Apigenin belongs to BCS class II with low solubility, which leads to poor absorption and bioavailability. ...Numerous f …
An Overview on Dietary Polyphenols and Their Biopharmaceutical Classification System (BCS).
Truzzi F, Tibaldi C, Zhang Y, Dinelli G, D Amen E. Truzzi F, et al. Int J Mol Sci. 2021 May 24;22(11):5514. doi: 10.3390/ijms22115514. Int J Mol Sci. 2021. PMID: 34073709 Free PMC article. Review.
These compounds are widely consumed in daily diet and many studies report several benefits to human health thanks to their bioavailability in humans. However, the digestion process of phenolic compounds is still not completely clear. Moreover, bioavailabil …
These compounds are widely consumed in daily diet and many studies report several benefits to human health thanks to their bioavai …
Bioavailability of apigenin from apiin-rich parsley in humans.
Meyer H, Bolarinwa A, Wolfram G, Linseisen J. Meyer H, et al. Ann Nutr Metab. 2006;50(3):167-72. doi: 10.1159/000090736. Epub 2006 Jan 10. Ann Nutr Metab. 2006. PMID: 16407641
AIM: Absorption and excretion of apigenin after the ingestion of apiin-rich food, i.e. parsley, was tested. ...The flavone could be detected in red blood cells without showing dose-response characteristics. CONCLUSIONS: A small portion of apigenin provided by …
AIM: Absorption and excretion of apigenin after the ingestion of apiin-rich food, i.e. parsley, was tested. ...The flavone cou …
Flavones: Food Sources, Bioavailability, Metabolism, and Bioactivity.
Hostetler GL, Ralston RA, Schwartz SJ. Hostetler GL, et al. Adv Nutr. 2017 May 15;8(3):423-435. doi: 10.3945/an.116.012948. Print 2017 May. Adv Nutr. 2017. PMID: 28507008 Free PMC article. Review.
Pharmacokinetic studies in both animals and humans are described, comparing differences between species and the effects of glycosylation on bioavailability. Biological activity in animal models and human dietary intervention studies is also reviewed. . …
Pharmacokinetic studies in both animals and humans are described, comparing differences between species and the effects of glycosylat …
Effects of friedelin on the intestinal permeability and bioavailability of apigenin.
Lee JA, Ha SK, Kim YC, Choi I. Lee JA, et al. Pharmacol Rep. 2017 Oct;69(5):1044-1048. doi: 10.1016/j.pharep.2017.04.012. Epub 2017 Apr 23. Pharmacol Rep. 2017. PMID: 28939344
BACKGROUND: Although apigenin possesses diverse pharmacological activities, its utilization as a bioactive substance is limited by poor oral bioavailability. ...Such increases in the P(app) indicated that friedelin could significantly enhance the absorption o …
BACKGROUND: Although apigenin possesses diverse pharmacological activities, its utilization as a bioactive substance is limited by po …
Oleuropein: Chemistry, extraction techniques and nutraceutical perspectives-An update.
Khalil AA, Rahman MM, Rauf A, Islam MR, Manna SJ, Khan AA, Ullah S, Akhtar MN, Aljohani ASM, Abdulmonem WA, Simal-Gandara J. Khalil AA, et al. Crit Rev Food Sci Nutr. 2024;64(27):9933-9954. doi: 10.1080/10408398.2023.2218495. Epub 2023 Jun 5. Crit Rev Food Sci Nutr. 2024. PMID: 37272499 Review.
Various parts of olive tree are rich source of diverse bioactive compounds such as Apigenin, elenolic acid, Hydroxytyrosol, Ligstroside, Oleoside, Oleuropein, Oleuropein aglycone, Tyrosol, etc. ...This review will benefit the scientific community as it narrates comprehensi …
Various parts of olive tree are rich source of diverse bioactive compounds such as Apigenin, elenolic acid, Hydroxytyrosol, Ligstrosi …
51 results