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54 results

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Page 1
Apigenin Inhibits the Progression of Osteoarthritis by Mediating Macrophage Polarization.
Ji X, Du W, Che W, Wang L, Zhao L. Ji X, et al. Molecules. 2023 Mar 24;28(7):2915. doi: 10.3390/molecules28072915. Molecules. 2023. PMID: 37049677 Free PMC article.
The experimental groups were the N group, LPS group, and LPS+ apigenin group. The effect of macrophage polarization on chondrocyte inflammation and the protective effect of apigenin on chondrocytes were verified by the drug administration. ...Apigen …
The experimental groups were the N group, LPS group, and LPS+ apigenin group. The effect of macrophage polarization on …
Apigenin accelerates wound healing in diabetic mice by promoting macrophage M2-type polarization via increasing miR-21 expression.
Li K, Wu L, Jiang J. Li K, et al. Mol Cell Biochem. 2024 Nov;479(11):3119-3127. doi: 10.1007/s11010-023-04885-y. Epub 2024 Jan 23. Mol Cell Biochem. 2024. PMID: 38261238
The alteration of inflammatory phenotype by macrophage polarization plays an important role in diabetic wound repair. Apigenin has been reported to be anti-inflammatory and promote tissue repair; however, whether it regulates macrophage polarization …
The alteration of inflammatory phenotype by macrophage polarization plays an important role in diabetic wound repair. Apige …
Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense.
Gu P, Wei R, Liu R, Yang Q, He Y, Guan J, He W, Li J, Zhao Y, Xie L, He J, Guo Q, Hu J, Bao J, Wang W, Guo J, Zeng Z, Chen Z, Jiang Y, Liu Z, Chen P. Gu P, et al. Adv Sci (Weinh). 2025 Mar;12(12):e2411008. doi: 10.1002/advs.202411008. Epub 2025 Jan 10. Adv Sci (Weinh). 2025. PMID: 39792643 Free PMC article.
Metabolomic profiling reveals a protective compound, apigenin, generated by P. goldsteinii, antagonizes bacterial clearance defects in aged mice. AMP-binding protein (ampB) is identified as a key gene involved in apigenin synthesis in P. goldsteinii using homologous …
Metabolomic profiling reveals a protective compound, apigenin, generated by P. goldsteinii, antagonizes bacterial clearance defects i …
Discovery of vitexin as a novel VDR agonist that mitigates the transition from chronic intestinal inflammation to colorectal cancer.
Chen Y, Liang J, Chen S, Lin N, Xu S, Miao J, Zhang J, Chen C, Yuan X, Xie Z, Zhu E, Cai M, Wei X, Hou S, Tang H. Chen Y, et al. Mol Cancer. 2024 Sep 13;23(1):196. doi: 10.1186/s12943-024-02108-6. Mol Cancer. 2024. PMID: 39272040 Free PMC article.
Furthermore, ChIP-seq analysis revealed that vitexin regulates the transcriptional activation of phenazine biosynthesis-like domain protein (PBLD) via VDR. ChIP assays and dual luciferase reporter assays were employed to identify the functional PBLD regulatory region, conf …
Furthermore, ChIP-seq analysis revealed that vitexin regulates the transcriptional activation of phenazine biosynthesis-like domain p …
Scutellarin Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting M1 Macrophage Polarization via the GBP2/JAK2/STAT3 Signaling Pathway.
Tang J, Ding Y, Chen W, Shi J, Zhang C, Zhao X, Li J, Han Z, Chen X. Tang J, et al. Phytother Res. 2025 Nov;39(11):5140-5158. doi: 10.1002/ptr.70099. Epub 2025 Sep 18. Phytother Res. 2025. PMID: 40968089
Macrophage polarization and lung injury severity were assessed histologically and by cytokine analysis. ...Mechanistically, SCU downregulated GBP2 expression and suppressed activation of the JAK2/STAT3 signaling pathway in LPS-stimulated models. SCU ameliorat …
Macrophage polarization and lung injury severity were assessed histologically and by cytokine analysis. ...Mechanistically, SC …
Activation of PPARgamma by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization.
Feng X, Weng D, Zhou F, Owen YD, Qin H, Zhao J, WenYu, Huang Y, Chen J, Fu H, Yang N, Chen D, Li J, Tan R, Shen P. Feng X, et al. EBioMedicine. 2016 Jul;9:61-76. doi: 10.1016/j.ebiom.2016.06.017. Epub 2016 Jun 15. EBioMedicine. 2016. PMID: 27374313 Free PMC article.
PPARgamma has emerged as a master regulator of macrophage polarization and is the molecular target of the thiazolidinedione drugs. Here we show that apigenin binds and activates PPARgamma by acting as a modulator. Activation of PPARgamma by apigenin …
PPARgamma has emerged as a master regulator of macrophage polarization and is the molecular target of the thiazolidinedione dr …
Apigenin inhibits macrophage pyroptosis through regulation of oxidative stress and the NF-kappaB pathway and ameliorates atherosclerosis.
Weng X, Luo X, Dai X, Lv Y, Zhang S, Bai X, Bao X, Wang Y, Zhao C, Zeng M, Hu S, Li J, Jia H, Yu B. Weng X, et al. Phytother Res. 2023 Nov;37(11):5300-5314. doi: 10.1002/ptr.7962. Epub 2023 Aug 1. Phytother Res. 2023. PMID: 37526050
In conclusion, apigenin exhibited a preventive effect on macrophage pyroptosis by reducing oxidative stress and inhibiting the NF-kappaB pathway. Apigenin may alleviate atherosclerosis at least partially by inhibiting macrophage pyroptosis. ...
In conclusion, apigenin exhibited a preventive effect on macrophage pyroptosis by reducing oxidative stress and inhibiting the …
Apigenin attenuated sepsis induced acute lung injury via polarizing macrophage towards M2 by blocking miR-146a TLR7 interaction.
Geng J, Zheng Z, Li L, Ren Z, Tian G, Qin J, Zhao T, Feng X. Geng J, et al. Int Immunopharmacol. 2025 Apr 16;152:114446. doi: 10.1016/j.intimp.2025.114446. Epub 2025 Mar 14. Int Immunopharmacol. 2025. PMID: 40088874 Free article.
Cumulative results show that macrophages contribute to the development and progression of ALI through the secretion of inflammatory cytokines/chemokines. Here we show that macrophage polarizes towards M1 phenotype and TLR7 signaling is activated in septic mice. Moreover, T …
Cumulative results show that macrophages contribute to the development and progression of ALI through the secretion of inflammatory cytokine …
Diosmetin-7-O-beta-D-glucopyranoside from Pogostemonis Herba alleviated SARS-CoV-2-induced pneumonia by reshaping macrophage polarization and limiting viral replication.
Xu YL, Li XJ, Cai W, Yu WY, Chen J, Lee Q, Choi YJ, Wu F, Lou YJ, Ying HZ, Yu CH, Wu QF. Xu YL, et al. J Ethnopharmacol. 2025 Jan 10;336:118704. doi: 10.1016/j.jep.2024.118704. Epub 2024 Aug 23. J Ethnopharmacol. 2025. PMID: 39182703
Intervention with DG at the concentrations of 0.625-2.5 muM not only reduced the viral replication, cell apoptosis, and the productions of inflammatory cytokines (IL-6 and TNF-alpha) in SARS-CoV-2-infected RAW264.7 cells, but also reversed macrophage polarity from M1 to M2 …
Intervention with DG at the concentrations of 0.625-2.5 muM not only reduced the viral replication, cell apoptosis, and the productions of i …
Scutellarin alleviates renal ischemia-reperfusion injury by inhibiting the MAPK pathway and pro-inflammatory macrophage polarization.
Deng G, Zheng B, Dou M, Gao Y, Zhang X, Niu Z, Wei T, Han F, Ding C, Tian P. Deng G, et al. FASEB J. 2024 Jul 15;38(13):e23769. doi: 10.1096/fj.202302243R. FASEB J. 2024. PMID: 38958951
In this study, we investigated whether scutellarin (SCU) could protect against renal IRI by regulating macrophage polarization. Mice were given SCU (5-50 mg/kg) by gavage 1 h earlier, followed by a unilateral renal IRI. ...However, SCU has no influence on anti-infla …
In this study, we investigated whether scutellarin (SCU) could protect against renal IRI by regulating macrophage polarization …
54 results