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114 results

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Page 1
ApoB, LDL-C, and non-HDL-C as markers of cardiovascular risk.
Sehayek D, Cole J, Björnson E, Wilkins JT, Mortensen MB, Dufresne L, Pencina KM, Pencina MJ, Thanassoulis G, Sniderman AD. Sehayek D, et al. J Clin Lipidol. 2025 Jul-Aug;19(4):844-859. doi: 10.1016/j.jacl.2025.05.024. Epub 2025 Jun 6. J Clin Lipidol. 2025. PMID: 40681368
OBJECTIVE: This systematic review compiled all discordance studies that compare the predictive powers of LDL-C and non-HDL-C vs LDL particle number (LDL P) or apoB as markers of atherosclerotic disease risk to determine which is the most accurat …
OBJECTIVE: This systematic review compiled all discordance studies that compare the predictive powers of LDL-C and non-HDL-C v …
Discordance among apoB, non-high-density lipoprotein cholesterol, and triglycerides: implications for cardiovascular prevention.
Sniderman AD, Dufresne L, Pencina KM, Bilgic S, Thanassoulis G, Pencina MJ. Sniderman AD, et al. Eur Heart J. 2024 Jul 12;45(27):2410-2418. doi: 10.1093/eurheartj/ehae258. Eur Heart J. 2024. PMID: 38700053 Free PMC article.
None of the residuals of LDL-C, non-HDL-C, or of log triglycerides remained significant when apoB was included in the model. CONCLUSIONS: High variability of apoB at individual levels of LDL-C, non-HDL-C, and triglycerides coupled with meaningful diffe …
None of the residuals of LDL-C, non-HDL-C, or of log triglycerides remained significant when apoB was included in the model. C …
Apolipoprotein B: Bridging the Gap Between Evidence and Clinical Practice.
De Oliveira-Gomes D, Joshi PH, Peterson ED, Rohatgi A, Khera A, Navar AM. De Oliveira-Gomes D, et al. Circulation. 2024 Jul 2;150(1):62-79. doi: 10.1161/CIRCULATIONAHA.124.068885. Epub 2024 Jul 1. Circulation. 2024. PMID: 38950110 Free PMC article. Review.
One barrier for use of apoB measurement is lack of consistent guidance for clinicians on how to interpret and apply apoB results in clinical context. Whereas guidelines have often provided clear low-density lipoprotein cholesterol targets or triggers to initiate tre …
One barrier for use of apoB measurement is lack of consistent guidance for clinicians on how to interpret and apply apoB resul …
Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study.
Quispe R, Martin SS, Michos ED, Lamba I, Blumenthal RS, Saeed A, Lima J, Puri R, Nomura S, Tsai M, Wilkins J, Ballantyne CM, Nicholls S, Jones SR, Elshazly MB. Quispe R, et al. Eur Heart J. 2021 Nov 7;42(42):4324-4332. doi: 10.1093/eurheartj/ehab432. Eur Heart J. 2021. PMID: 34293083 Free PMC article.
We also performed discordance analyses examining relative ASCVD risk in RC vs. LDL-C discordant/concordant groups using difference in percentile units (>10 units) and clinically relevant LDL-C targets. ...Similar results were shown when examining …
We also performed discordance analyses examining relative ASCVD risk in RC vs. LDL-C discordant/concordant groups using …
Role of apolipoprotein B in the clinical management of cardiovascular risk in adults: An Expert Clinical Consensus from the National Lipid Association.
Soffer DE, Marston NA, Maki KC, Jacobson TA, Bittner VA, Peña JM, Thanassoulis G, Martin SS, Kirkpatrick CF, Virani SS, Dixon DL, Ballantyne CM, Remaley AT. Soffer DE, et al. J Clin Lipidol. 2024 Sep-Oct;18(5):e647-e663. doi: 10.1016/j.jacl.2024.08.013. Epub 2024 Sep 5. J Clin Lipidol. 2024. PMID: 39256087 Free PMC article.
In individuals, there can be discordance between levels of LDL-C and apoB, as well as LDL-C and non-high-density lipoprotein cholesterol (non-HDL-C), despite high levels of population-wide correlation. When there is discordance between LDL …
In individuals, there can be discordance between levels of LDL-C and apoB, as well as LDL-C and non-high-density …
The Role of Lipids and Lipoproteins in Atherosclerosis.
Linton MF, Yancey PG, Davies SS, Jerome WG, Linton EF, Song WL, Doran AC, Vickers KC. Linton MF, et al. 2019 Jan 3. In: Feingold KR, Adler RA, Ahmed SF, Anawalt B, Blackman MR, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hamilton E, Hofland J, Jan de Beur S, Kalra S, Kaltsas G, Kapoor N, Kim M, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, Muzumdar R, Purnell J, Rey R, Sahay R, Shah AS, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. 2019 Jan 3. In: Feingold KR, Adler RA, Ahmed SF, Anawalt B, Blackman MR, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hamilton E, Hofland J, Jan de Beur S, Kalra S, Kaltsas G, Kapoor N, Kim M, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, Muzumdar R, Purnell J, Rey R, Sahay R, Shah AS, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. PMID: 26844337 Free Books & Documents. Review.
Population studies have demonstrated that elevated levels of LDL cholesterol and apolipoprotein B (apoB) 100, the main structural protein of LDL, are directly associated with risk for atherosclerotic cardiovascular events (ASCVE). ...Measures of apoB a …
Population studies have demonstrated that elevated levels of LDL cholesterol and apolipoprotein B (apoB) 100, the main structu …
Physiological Bases for the Superiority of Apolipoprotein B Over Low-Density Lipoprotein Cholesterol and Non-High-Density Lipoprotein Cholesterol as a Marker of Cardiovascular Risk.
Glavinovic T, Thanassoulis G, de Graaf J, Couture P, Hegele RA, Sniderman AD. Glavinovic T, et al. J Am Heart Assoc. 2022 Oct 18;11(20):e025858. doi: 10.1161/JAHA.122.025858. Epub 2022 Oct 10. J Am Heart Assoc. 2022. PMID: 36216435 Free PMC article. Review.
Next, the mechanisms that govern the number of very low-density lipoprotein and low-density lipoprotein particles will be outlined because, except for dysbetalipoproteinemia, the total number of apoB particles determines cardiovascular risk, Then, the mechanisms that gover …
Next, the mechanisms that govern the number of very low-density lipoprotein and low-density lipoprotein particles will be outlined because, …
Discordance analysis and the Gordian Knot of LDL and non-HDL cholesterol versus apoB.
Sniderman AD, Lamarche B, Contois JH, de Graaf J. Sniderman AD, et al. Curr Opin Lipidol. 2014 Dec;25(6):461-7. doi: 10.1097/MOL.0000000000000127. Curr Opin Lipidol. 2014. PMID: 25340478 Review.
However, although highly correlated, apolipoprotein B particles may contain a normal mass of cholesterol or may be cholesterol-depleted or cholesterol-enriched. Discordance analysis compares the predictive power of LDL-C and non-HDL-C to apolipoprotein B and LDL …
However, although highly correlated, apolipoprotein B particles may contain a normal mass of cholesterol or may be cholesterol-depleted or c …
Calculation of LDL apoB.
Sniderman AD, Tremblay AJ, De Graaf J, Couture P. Sniderman AD, et al. Atherosclerosis. 2014 Jun;234(2):373-6. doi: 10.1016/j.atherosclerosis.2014.03.012. Epub 2014 Apr 2. Atherosclerosis. 2014. PMID: 24747110
OBJECTIVES: This study tests the validity of the Hattori formula to calculate LDL apoB based on plasma lipids and total apoB. METHODS: In 2178 patients in a tertiary care lipid clinic, LDL apoB calculated as suggested by Hattori et al. was compa …
OBJECTIVES: This study tests the validity of the Hattori formula to calculate LDL apoB based on plasma lipids and total apo …
Apolipoprotein B and Non-HDL Cholesterol Better Reflect Residual Risk Than LDL Cholesterol in Statin-Treated Patients.
Johannesen CDL, Mortensen MB, Langsted A, Nordestgaard BG. Johannesen CDL, et al. J Am Coll Cardiol. 2021 Mar 23;77(11):1439-1450. doi: 10.1016/j.jacc.2021.01.027. J Am Coll Cardiol. 2021. PMID: 33736827 Free article.
Corresponding values for high non-HDL cholesterol with low LDL cholesterol were 1.18 (95% CI: 1.02 to 1.36) and 1.78 (95% CI: 1.35 to 2.34). In contrast, discordant high LDL cholesterol with low apoB or non-HDL cholesterol was not associated with incre …
Corresponding values for high non-HDL cholesterol with low LDL cholesterol were 1.18 (95% CI: 1.02 to 1.36) and 1.78 (95% CI: 1.35 to …
114 results